WGS CADB00000000 data, contig 8

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein

Species:

Leishmania mexicana

UniProt:

E8NHQ2_LEIMU

TriTrypDb:

LmxM.30.0440b

Length:

445

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 10

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E8NHQ2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E8NHQ2

Function

Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	11
GO:0006807	nitrogen compound metabolic process	2	11
GO:0008152	metabolic process	1	11
GO:0019538	protein metabolic process	3	11
GO:0043170	macromolecule metabolic process	3	11
GO:0044238	primary metabolic process	2	11
GO:0071704	organic substance metabolic process	2	11
GO:1901564	organonitrogen compound metabolic process	3	11

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	11
GO:0004175	endopeptidase activity	4	11
GO:0004197	cysteine-type endopeptidase activity	5	11
GO:0004198	calcium-dependent cysteine-type endopeptidase activity	6	11
GO:0008233	peptidase activity	3	11
GO:0008234	cysteine-type peptidase activity	4	11
GO:0016787	hydrolase activity	2	11
GO:0140096	catalytic activity, acting on a protein	2	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	219	223	PF00656	0.476
CLV_C14_Caspase3-7	257	261	PF00656	0.325
CLV_C14_Caspase3-7	89	93	PF00656	0.419
CLV_NRD_NRD_1	119	121	PF00675	0.230
CLV_NRD_NRD_1	302	304	PF00675	0.421
CLV_PCSK_KEX2_1	298	300	PF00082	0.440
CLV_PCSK_PC1ET2_1	298	300	PF00082	0.398
CLV_PCSK_SKI1_1	15	19	PF00082	0.253
CLV_PCSK_SKI1_1	267	271	PF00082	0.408
CLV_PCSK_SKI1_1	288	292	PF00082	0.356
CLV_PCSK_SKI1_1	371	375	PF00082	0.408
DEG_MDM2_SWIB_1	238	246	PF02201	0.442
DEG_Nend_UBRbox_4	1	3	PF02207	0.225
DOC_ANK_TNKS_1	378	385	PF00023	0.277
DOC_CKS1_1	141	146	PF01111	0.453
DOC_CYCLIN_yCln2_LP_2	309	315	PF00134	0.388
DOC_PP1_RVXF_1	286	292	PF00149	0.330
DOC_PP2B_LxvP_1	309	312	PF13499	0.405
DOC_PP2B_LxvP_1	363	366	PF13499	0.259
DOC_PP4_FxxP_1	256	259	PF00568	0.441
DOC_USP7_MATH_1	157	161	PF00917	0.461
DOC_USP7_MATH_1	199	203	PF00917	0.628
DOC_USP7_MATH_1	283	287	PF00917	0.318
DOC_USP7_MATH_1	414	418	PF00917	0.332
DOC_USP7_UBL2_3	76	80	PF12436	0.485
DOC_WW_Pin1_4	100	105	PF00397	0.457
DOC_WW_Pin1_4	140	145	PF00397	0.464
DOC_WW_Pin1_4	19	24	PF00397	0.434
LIG_14-3-3_CanoR_1	288	294	PF00244	0.343
LIG_BRCT_BRCA1_1	159	163	PF00533	0.419
LIG_BRCT_BRCA1_1	338	342	PF00533	0.389
LIG_BRCT_BRCA1_1	405	409	PF00533	0.393
LIG_FHA_1	175	181	PF00498	0.452
LIG_FHA_1	285	291	PF00498	0.507
LIG_FHA_1	359	365	PF00498	0.277
LIG_FHA_1	408	414	PF00498	0.341
LIG_FHA_2	275	281	PF00498	0.277
LIG_FHA_2	87	93	PF00498	0.566
LIG_LIR_Apic_2	375	380	PF02991	0.341
LIG_LIR_Apic_2	62	66	PF02991	0.434
LIG_LIR_Gen_1	339	350	PF02991	0.467
LIG_LIR_Gen_1	359	370	PF02991	0.266
LIG_LIR_Gen_1	52	60	PF02991	0.519
LIG_LIR_Gen_1	68	78	PF02991	0.477
LIG_LIR_Gen_1	84	93	PF02991	0.544
LIG_LIR_Nem_3	339	345	PF02991	0.406
LIG_LIR_Nem_3	359	365	PF02991	0.327
LIG_LIR_Nem_3	406	412	PF02991	0.469
LIG_LIR_Nem_3	68	73	PF02991	0.472
LIG_LIR_Nem_3	84	88	PF02991	0.485
LIG_MAD2	288	296	PF02301	0.283
LIG_Pex14_2	108	112	PF04695	0.485
LIG_Pex14_2	238	242	PF04695	0.467
LIG_SH2_CRK	31	35	PF00017	0.419
LIG_SH2_CRK	377	381	PF00017	0.323
LIG_SH2_CRK	78	82	PF00017	0.503
LIG_SH2_CRK	85	89	PF00017	0.493
LIG_SH2_NCK_1	167	171	PF00017	0.449
LIG_SH2_NCK_1	377	381	PF00017	0.323
LIG_SH2_NCK_1	63	67	PF00017	0.485
LIG_SH2_NCK_1	85	89	PF00017	0.472
LIG_SH2_SRC	167	170	PF00017	0.435
LIG_SH2_SRC	381	384	PF00017	0.273
LIG_SH2_SRC	63	66	PF00017	0.519
LIG_SH2_STAP1	176	180	PF00017	0.461
LIG_SH2_STAT5	151	154	PF00017	0.496
LIG_SH2_STAT5	176	179	PF00017	0.480
LIG_SH2_STAT5	248	251	PF00017	0.503
LIG_SH2_STAT5	362	365	PF00017	0.328
LIG_SH2_STAT5	381	384	PF00017	0.383
LIG_SH2_STAT5	412	415	PF00017	0.342
LIG_SH2_STAT5	439	442	PF00017	0.363
LIG_SH2_STAT5	49	52	PF00017	0.493
LIG_SH3_3	193	199	PF00018	0.510
LIG_SH3_3	332	338	PF00018	0.488
LIG_SH3_3	426	432	PF00018	0.329
LIG_SUMO_SIM_anti_2	181	188	PF11976	0.490
LIG_SUMO_SIM_par_1	181	188	PF11976	0.434
LIG_SUMO_SIM_par_1	276	282	PF11976	0.321
LIG_SUMO_SIM_par_1	311	316	PF11976	0.450
LIG_SUMO_SIM_par_1	42	48	PF11976	0.431
LIG_TRAF2_1	22	25	PF00917	0.434
LIG_TRAF2_1	338	341	PF00917	0.370
LIG_TRFH_1	362	366	PF08558	0.322
LIG_UBA3_1	290	298	PF00899	0.349
LIG_WRC_WIRS_1	50	55	PF05994	0.420
MOD_CDK_SPxxK_3	100	107	PF00069	0.419
MOD_CDK_SPxxK_3	19	26	PF00069	0.434
MOD_CK1_1	211	217	PF00069	0.446
MOD_CK1_1	284	290	PF00069	0.299
MOD_CK2_1	19	25	PF00069	0.497
MOD_CK2_1	274	280	PF00069	0.287
MOD_CMANNOS	239	242	PF00535	0.298
MOD_GlcNHglycan	134	137	PF01048	0.253
MOD_GlcNHglycan	159	162	PF01048	0.308
MOD_GlcNHglycan	206	209	PF01048	0.274
MOD_GlcNHglycan	386	389	PF01048	0.301
MOD_GlcNHglycan	405	408	PF01048	0.361
MOD_GlcNHglycan	99	103	PF01048	0.301
MOD_GSK3_1	200	207	PF00069	0.497
MOD_GSK3_1	270	277	PF00069	0.582
MOD_GSK3_1	279	286	PF00069	0.449
MOD_GSK3_1	329	336	PF00069	0.564
MOD_GSK3_1	403	410	PF00069	0.373
MOD_GSK3_1	435	442	PF00069	0.340
MOD_N-GLC_1	329	334	PF02516	0.362
MOD_NEK2_1	13	18	PF00069	0.485
MOD_NEK2_1	132	137	PF00069	0.431
MOD_NEK2_1	270	275	PF00069	0.541
MOD_NEK2_1	279	284	PF00069	0.448
MOD_NEK2_1	291	296	PF00069	0.387
MOD_PIKK_1	291	297	PF00454	0.387
MOD_PKA_2	157	163	PF00069	0.433
MOD_PKA_2	200	206	PF00069	0.437
MOD_Plk_1	284	290	PF00069	0.347
MOD_Plk_1	329	335	PF00069	0.315
MOD_Plk_1	358	364	PF00069	0.453
MOD_Plk_2-3	419	425	PF00069	0.345
MOD_Plk_4	147	153	PF00069	0.458
MOD_Plk_4	188	194	PF00069	0.570
MOD_Plk_4	234	240	PF00069	0.485
MOD_Plk_4	274	280	PF00069	0.377
MOD_Plk_4	358	364	PF00069	0.325
MOD_Plk_4	435	441	PF00069	0.380
MOD_Plk_4	69	75	PF00069	0.503
MOD_ProDKin_1	100	106	PF00069	0.457
MOD_ProDKin_1	140	146	PF00069	0.464
MOD_ProDKin_1	19	25	PF00069	0.434
MOD_SUMO_rev_2	22	28	PF00179	0.558
MOD_SUMO_rev_2	392	402	PF00179	0.306
TRG_DiLeu_BaEn_1	188	193	PF01217	0.439
TRG_DiLeu_BaEn_1	359	364	PF01217	0.279
TRG_DiLeu_BaEn_2	339	345	PF01217	0.337
TRG_ENDOCYTIC_2	31	34	PF00928	0.606
TRG_ENDOCYTIC_2	362	365	PF00928	0.383
TRG_ENDOCYTIC_2	78	81	PF00928	0.510
TRG_ENDOCYTIC_2	85	88	PF00928	0.485
TRG_ER_diArg_1	163	166	PF00400	0.457

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A1X0NJ61	Trypanosomatidae	34%	78%
A4HJ23	Leishmania braziliensis	69%	100%
E8NHF1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	34%	100%
E8NHM8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	34%	100%
E9AIH6	Leishmania braziliensis	29%	100%
E9AUQ8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	37%	68%
E9AUR1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	27%	81%
Q22036	Caenorhabditis elegans	26%	69%
Q4QCS5	Leishmania major	27%	99%
V5BA05	Trypanosoma cruzi	37%	67%