WGS CADB00000000 data, contig 81

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E8NHP9_LEIMU

TriTrypDb:

LmxM.30.3040 , LmxM.30.3040a

Length:

248

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	6
GO:0110165	cellular anatomical entity	1	6

Expansion

Sequence features

E8NHP9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E8NHP9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	24	28	PF00656	0.606
CLV_C14_Caspase3-7	52	56	PF00656	0.581
CLV_C14_Caspase3-7	78	82	PF00656	0.426
CLV_NRD_NRD_1	128	130	PF00675	0.400
CLV_NRD_NRD_1	132	134	PF00675	0.423
CLV_NRD_NRD_1	6	8	PF00675	0.707
CLV_PCSK_KEX2_1	128	130	PF00082	0.399
CLV_PCSK_KEX2_1	132	134	PF00082	0.425
CLV_PCSK_KEX2_1	215	217	PF00082	0.545
CLV_PCSK_KEX2_1	6	8	PF00082	0.740
CLV_PCSK_KEX2_1	85	87	PF00082	0.689
CLV_PCSK_PC1ET2_1	215	217	PF00082	0.594
CLV_PCSK_PC1ET2_1	85	87	PF00082	0.739
CLV_PCSK_PC7_1	128	134	PF00082	0.450
CLV_PCSK_SKI1_1	154	158	PF00082	0.436
CLV_Separin_Metazoa	151	155	PF03568	0.657
DEG_MDM2_SWIB_1	117	124	PF02201	0.502
DEG_Nend_Nbox_1	1	3	PF02207	0.602
DOC_CKS1_1	51	56	PF01111	0.550
DOC_USP7_MATH_1	191	195	PF00917	0.655
DOC_USP7_MATH_1	209	213	PF00917	0.608
DOC_USP7_MATH_1	233	237	PF00917	0.752
DOC_USP7_MATH_1	45	49	PF00917	0.550
DOC_USP7_MATH_1	63	67	PF00917	0.479
DOC_USP7_UBL2_3	139	143	PF12436	0.658
DOC_WW_Pin1_4	50	55	PF00397	0.527
LIG_14-3-3_CanoR_1	154	162	PF00244	0.655
LIG_14-3-3_CanoR_1	6	15	PF00244	0.498
LIG_BRCT_BRCA1_1	236	240	PF00533	0.615
LIG_FHA_1	180	186	PF00498	0.599
LIG_FHA_1	187	193	PF00498	0.607
LIG_FHA_1	208	214	PF00498	0.770
LIG_FHA_1	94	100	PF00498	0.445
LIG_FHA_2	41	47	PF00498	0.523
LIG_LIR_Apic_2	105	110	PF02991	0.446
LIG_LIR_Gen_1	11	18	PF02991	0.575
LIG_LIR_Gen_1	237	246	PF02991	0.614
LIG_LIR_Gen_1	87	95	PF02991	0.437
LIG_LIR_Nem_3	11	17	PF02991	0.576
LIG_LIR_Nem_3	237	243	PF02991	0.616
LIG_Pex14_1	103	107	PF04695	0.466
LIG_Pex14_2	117	121	PF04695	0.482
LIG_SH2_CRK	107	111	PF00017	0.356
LIG_SH2_CRK	72	76	PF00017	0.448
LIG_SH2_NCK_1	107	111	PF00017	0.356
LIG_SH3_3	48	54	PF00018	0.571
LIG_SUMO_SIM_anti_2	146	155	PF11976	0.613
LIG_SUMO_SIM_anti_2	210	215	PF11976	0.731
MOD_CK1_1	179	185	PF00069	0.643
MOD_CK1_1	50	56	PF00069	0.600
MOD_CK2_1	152	158	PF00069	0.534
MOD_CMANNOS	123	126	PF00535	0.430
MOD_GlcNHglycan	202	205	PF01048	0.494
MOD_GlcNHglycan	223	227	PF01048	0.420
MOD_GlcNHglycan	23	26	PF01048	0.722
MOD_GlcNHglycan	46	50	PF01048	0.744
MOD_GlcNHglycan	60	63	PF01048	0.749
MOD_GlcNHglycan	65	68	PF01048	0.639
MOD_GSK3_1	1	8	PF00069	0.537
MOD_GSK3_1	187	194	PF00069	0.647
MOD_GSK3_1	222	229	PF00069	0.686
MOD_GSK3_1	36	43	PF00069	0.560
MOD_N-GLC_1	36	41	PF02516	0.800
MOD_N-GLC_1	57	62	PF02516	0.638
MOD_NEK2_1	1	6	PF00069	0.493
MOD_NEK2_1	98	103	PF00069	0.439
MOD_PIKK_1	98	104	PF00454	0.526
MOD_PK_1	193	199	PF00069	0.682
MOD_PKA_1	6	12	PF00069	0.529
MOD_PKA_2	127	133	PF00069	0.589
MOD_PKA_2	186	192	PF00069	0.605
MOD_PKA_2	197	203	PF00069	0.672
MOD_PKA_2	5	11	PF00069	0.487
MOD_Plk_4	209	215	PF00069	0.730
MOD_ProDKin_1	50	56	PF00069	0.525
TRG_ER_diArg_1	131	133	PF00400	0.623
TRG_ER_diArg_1	5	7	PF00400	0.543

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HR85	Leptomonas seymouri	63%	100%
A0A3S7X4Y5	Leishmania donovani	92%	100%
A4HJU4	Leishmania braziliensis	80%	100%
A4I7A9	Leishmania infantum	92%	100%
C9ZWJ4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	100%
Q4Q5V3	Leishmania major	90%	100%