WGS CADB00000000 data, contig 80

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein

Species:

Leishmania mexicana

UniProt:

E8NHP8_LEIMU

TriTrypDb:

LmxM.30.1460

Length:

303

Annotations

LeishMANIAdb annotations

Publication identifier(s): 8702946
A surface coat protein involved in immune evasion in Leishmaniids. Extremely fast evolving, almost completely disordered mucin-like protein. . Localization: Cell surface (experimental)

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 70

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 37, no: 6
NetGPI	no	yes: 0, no: 43

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	44
GO:0042995	cell projection	2	44
GO:0043226	organelle	2	44
GO:0043227	membrane-bounded organelle	3	44
GO:0110165	cellular anatomical entity	1	44
GO:0120025	plasma membrane bounded cell projection	3	44
GO:0016020	membrane	2	8

Expansion

Sequence features

E8NHP8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E8NHP8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	215	217	PF00675	0.475
CLV_NRD_NRD_1	230	232	PF00675	0.327
CLV_NRD_NRD_1	50	52	PF00675	0.479
CLV_PCSK_KEX2_1	215	217	PF00082	0.279
CLV_PCSK_SKI1_1	107	111	PF00082	0.260
CLV_PCSK_SKI1_1	15	19	PF00082	0.658
CLV_PCSK_SKI1_1	159	163	PF00082	0.446
CLV_PCSK_SKI1_1	183	187	PF00082	0.309
CLV_PCSK_SKI1_1	51	55	PF00082	0.402
DEG_APCC_DBOX_1	14	22	PF00400	0.608
DOC_CDC14_PxL_1	94	102	PF14671	0.257
DOC_CYCLIN_yClb5_NLxxxL_5	190	199	PF00134	0.269
DOC_CYCLIN_yClb5_NLxxxL_5	238	247	PF00134	0.392
DOC_CYCLIN_yCln2_LP_2	28	31	PF00134	0.370
DOC_MAPK_gen_1	13	21	PF00069	0.618
DOC_MAPK_gen_1	231	238	PF00069	0.284
DOC_MAPK_MEF2A_6	15	23	PF00069	0.415
DOC_PP2B_LxvP_1	27	30	PF13499	0.601
DOC_USP7_MATH_1	178	182	PF00917	0.448
DOC_USP7_MATH_1	274	278	PF00917	0.503
DOC_USP7_MATH_1	293	297	PF00917	0.478
DOC_USP7_MATH_2	248	254	PF00917	0.307
DOC_USP7_UBL2_3	120	124	PF12436	0.340
DOC_WW_Pin1_4	34	39	PF00397	0.499
LIG_14-3-3_CanoR_1	183	188	PF00244	0.452
LIG_14-3-3_CanoR_1	231	238	PF00244	0.465
LIG_APCC_ABBA_1	85	90	PF00400	0.285
LIG_BIR_III_2	59	63	PF00653	0.503
LIG_BRCT_BRCA1_1	276	280	PF00533	0.501
LIG_BRCT_BRCA1_1	68	72	PF00533	0.541
LIG_FHA_1	146	152	PF00498	0.414
LIG_FHA_1	170	176	PF00498	0.320
LIG_FHA_1	194	200	PF00498	0.351
LIG_FHA_1	218	224	PF00498	0.378
LIG_FHA_1	22	28	PF00498	0.546
LIG_FHA_1	242	248	PF00498	0.408
LIG_FHA_2	133	139	PF00498	0.405
LIG_FHA_2	172	178	PF00498	0.531
LIG_FHA_2	235	241	PF00498	0.472
LIG_GBD_Chelix_1	19	27	PF00786	0.588
LIG_KLC1_Yacidic_2	86	90	PF13176	0.267
LIG_LIR_Gen_1	138	147	PF02991	0.323
LIG_LIR_Gen_1	154	161	PF02991	0.289
LIG_LIR_Gen_1	177	185	PF02991	0.457
LIG_LIR_Gen_1	186	195	PF02991	0.412
LIG_LIR_Gen_1	40	48	PF02991	0.502
LIG_LIR_Nem_3	130	134	PF02991	0.308
LIG_LIR_Nem_3	138	142	PF02991	0.289
LIG_LIR_Nem_3	177	182	PF02991	0.322
LIG_LIR_Nem_3	186	190	PF02991	0.373
LIG_LIR_Nem_3	226	230	PF02991	0.417
LIG_LIR_Nem_3	36	42	PF02991	0.531
LIG_Pex14_1	163	167	PF04695	0.265
LIG_Pex14_2	53	57	PF04695	0.324
LIG_SH2_CRK	42	46	PF00017	0.408
LIG_SH2_GRB2like	143	146	PF00017	0.359
LIG_SH2_NCK_1	42	46	PF00017	0.328
LIG_SH2_PTP2	108	111	PF00017	0.242
LIG_SH2_PTP2	139	142	PF00017	0.233
LIG_SH2_STAP1	143	147	PF00017	0.355
LIG_SH2_STAT5	108	111	PF00017	0.271
LIG_SH2_STAT5	139	142	PF00017	0.398
LIG_SH2_STAT5	77	80	PF00017	0.458
LIG_SH2_STAT5	88	91	PF00017	0.595
LIG_SH3_3	92	98	PF00018	0.542
LIG_SUMO_SIM_par_1	19	24	PF11976	0.487
LIG_TYR_ITIM	137	142	PF00017	0.246
LIG_TYR_ITSM	38	45	PF00017	0.320
MOD_CK1_1	101	107	PF00069	0.342
MOD_CK1_1	130	136	PF00069	0.353
MOD_CK1_1	141	147	PF00069	0.363
MOD_CK1_1	202	208	PF00069	0.421
MOD_CK1_1	234	240	PF00069	0.429
MOD_CK1_1	253	259	PF00069	0.509
MOD_CK1_1	37	43	PF00069	0.526
MOD_CK2_1	132	138	PF00069	0.266
MOD_CK2_1	171	177	PF00069	0.521
MOD_CK2_1	234	240	PF00069	0.301
MOD_GlcNHglycan	101	104	PF01048	0.468
MOD_GlcNHglycan	204	207	PF01048	0.452
MOD_GlcNHglycan	252	255	PF01048	0.486
MOD_GlcNHglycan	272	275	PF01048	0.463
MOD_GlcNHglycan	42	45	PF01048	0.472
MOD_GSK3_1	110	117	PF00069	0.427
MOD_GSK3_1	119	126	PF00069	0.483
MOD_GSK3_1	141	148	PF00069	0.373
MOD_GSK3_1	195	202	PF00069	0.401
MOD_GSK3_1	219	226	PF00069	0.365
MOD_GSK3_1	232	239	PF00069	0.400
MOD_GSK3_1	270	277	PF00069	0.422
MOD_N-GLC_1	193	198	PF02516	0.373
MOD_N-GLC_1	241	246	PF02516	0.380
MOD_N-GLC_2	266	268	PF02516	0.291
MOD_N-GLC_2	299	301	PF02516	0.580
MOD_NEK2_1	110	115	PF00069	0.404
MOD_NEK2_1	123	128	PF00069	0.336
MOD_NEK2_1	147	152	PF00069	0.385
MOD_NEK2_1	171	176	PF00069	0.317
MOD_NEK2_1	195	200	PF00069	0.343
MOD_NEK2_1	219	224	PF00069	0.376
MOD_NEK2_1	243	248	PF00069	0.384
MOD_NEK2_2	119	124	PF00069	0.354
MOD_NEK2_2	178	183	PF00069	0.245
MOD_PK_1	232	238	PF00069	0.273
MOD_PK_1	66	72	PF00069	0.294
MOD_PKA_1	231	237	PF00069	0.286
MOD_PKA_2	217	223	PF00069	0.440
MOD_Plk_4	138	144	PF00069	0.354
MOD_Plk_4	253	259	PF00069	0.403
MOD_Plk_4	286	292	PF00069	0.487
MOD_ProDKin_1	34	40	PF00069	0.499
TRG_DiLeu_BaEn_1	14	19	PF01217	0.364
TRG_DiLeu_BaLyEn_6	59	64	PF01217	0.317
TRG_ENDOCYTIC_2	108	111	PF00928	0.395
TRG_ENDOCYTIC_2	139	142	PF00928	0.400
TRG_ENDOCYTIC_2	42	45	PF00928	0.414
TRG_ER_diArg_1	215	218	PF00400	0.248

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P227	Leptomonas seymouri	31%	97%
A0A0N0P276	Leptomonas seymouri	29%	98%
A0A0N0P2L4	Leptomonas seymouri	30%	100%
A0A0N0P4M2	Leptomonas seymouri	25%	100%
A0A0N1HY53	Leptomonas seymouri	35%	100%
A0A0S4IIK7	Bodo saltans	26%	73%
A0A0S4IN83	Bodo saltans	31%	100%
A0A0S4IQP4	Bodo saltans	35%	77%
A0A0S4IR61	Bodo saltans	27%	75%
A0A0S4IVN7	Bodo saltans	34%	79%
A0A0S4IZC7	Bodo saltans	31%	74%
A0A0S4J2R4	Bodo saltans	30%	90%
A0A0S4J353	Bodo saltans	24%	100%
A0A0S4J3T7	Bodo saltans	33%	67%
A0A0S4J805	Bodo saltans	29%	100%
A0A0S4JEK1	Bodo saltans	28%	74%
A0A0S4JEZ2	Bodo saltans	29%	95%
A0A0S4JS12	Bodo saltans	28%	67%
A0A0S4KHE4	Bodo saltans	34%	82%
A0A1X0NKN8	Trypanosomatidae	27%	100%
A0A3Q8I9A6	Leishmania donovani	32%	78%
A0A3Q8I9D0	Leishmania donovani	36%	100%
A0A3Q8IFC2	Leishmania donovani	32%	69%
A0A3Q8IIJ9	Leishmania donovani	87%	100%
A0A3S5H6D6	Leishmania donovani	27%	100%
A0A3S7WPB2	Leishmania donovani	26%	100%
A0A3S7X4J4	Leishmania donovani	86%	100%
A4H4G6	Leishmania braziliensis	27%	100%
A4H5P0	Leishmania braziliensis	29%	100%
A4HBX3	Leishmania braziliensis	36%	67%
A4HJC8	Leishmania braziliensis	70%	100%
A4HJX1	Leishmania braziliensis	32%	100%
A4HTX9	Leishmania infantum	27%	100%
A4HVB0	Leishmania infantum	32%	75%
A4I6S2	Leishmania infantum	30%	69%
A4I6S4	Leishmania infantum	87%	100%
E8NHG5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	32%	68%
E9ACQ0	Leishmania major	26%	100%
E9AG65	Leishmania infantum	26%	100%
E9AGG5	Leishmania infantum	31%	73%
E9AGH0	Leishmania infantum	35%	80%
E9AKM8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	26%	100%
E9AMQ9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	28%	100%
E9AP02	Leishmania mexicana (strain MHOM/GT/2001/U1103)	33%	89%
E9AP03	Leishmania mexicana (strain MHOM/GT/2001/U1103)	36%	77%
E9AP07	Leishmania mexicana (strain MHOM/GT/2001/U1103)	33%	83%
E9AP08	Leishmania mexicana (strain MHOM/GT/2001/U1103)	34%	72%
E9B1U3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	31%	67%
E9B1U4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	31%	89%
E9B1U5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	33%	72%
E9B1U6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	99%	100%
F4HTV6	Arabidopsis thaliana	25%	100%
P58822	Phaseolus vulgaris	25%	89%
P58823	Phaseolus vulgaris	25%	89%
Q25331	Leishmania major	31%	100%
Q4PSE6	Arabidopsis thaliana	26%	70%
Q4Q6B6	Leishmania major	88%	100%
Q4Q6B7	Leishmania major	88%	100%
Q4QC79	Leishmania major	33%	66%
Q4QGJ4	Leishmania major	31%	100%
Q4QGJ7	Leishmania major	31%	100%
Q4QGK6	Leishmania major	31%	100%
Q4QGL4	Leishmania major	35%	100%
Q4QHW6	Leishmania major	27%	100%
Q8GT95	Oryza sativa subsp. japonica	26%	91%
Q8W3M4	Arabidopsis thaliana	24%	75%
Q9LH52	Arabidopsis thaliana	24%	93%
Q9M5J8	Arabidopsis thaliana	28%	92%
Q9M5J9	Arabidopsis thaliana	26%	92%