WGS CADB00000000 data, contig 75

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein

Species:

Leishmania mexicana

UniProt:

E8NHP3_LEIMU

TriTrypDb:

LmxM.28.1930partial

Length:

187

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	6
GO:0110165	cellular anatomical entity	1	6

Expansion

Sequence features

E8NHP3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E8NHP3

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005215	transporter activity	1	6
GO:0008324	monoatomic cation transmembrane transporter activity	4	6
GO:0015075	monoatomic ion transmembrane transporter activity	3	6
GO:0015318	inorganic molecular entity transmembrane transporter activity	3	6
GO:0022857	transmembrane transporter activity	2	6
GO:0022890	inorganic cation transmembrane transporter activity	4	6
GO:0046873	metal ion transmembrane transporter activity	5	6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_KEX2_1	160	162	PF00082	0.273
CLV_PCSK_KEX2_1	165	167	PF00082	0.237
CLV_PCSK_PC1ET2_1	160	162	PF00082	0.273
CLV_PCSK_PC1ET2_1	165	167	PF00082	0.237
CLV_PCSK_PC7_1	161	167	PF00082	0.211
CLV_PCSK_SKI1_1	112	116	PF00082	0.455
DEG_Nend_UBRbox_2	1	3	PF02207	0.604
DOC_MAPK_MEF2A_6	55	63	PF00069	0.269
DOC_MAPK_MEF2A_6	82	91	PF00069	0.507
DOC_MAPK_NFAT4_5	82	90	PF00069	0.411
DOC_PP4_FxxP_1	95	98	PF00568	0.301
DOC_USP7_MATH_1	121	125	PF00917	0.334
DOC_USP7_MATH_1	77	81	PF00917	0.445
LIG_Clathr_ClatBox_1	142	146	PF01394	0.301
LIG_CtBP_PxDLS_1	16	20	PF00389	0.644
LIG_eIF4E_1	137	143	PF01652	0.378
LIG_FHA_1	103	109	PF00498	0.239
LIG_FHA_1	117	123	PF00498	0.161
LIG_FXI_DFP_1	144	148	PF00024	0.255
LIG_LIR_Apic_2	94	98	PF02991	0.301
LIG_LIR_Gen_1	118	127	PF02991	0.272
LIG_LIR_Nem_3	118	123	PF02991	0.272
LIG_LIR_Nem_3	39	44	PF02991	0.320
LIG_PDZ_Wminus1_1	185	187	PF00595	0.395
LIG_Pex14_2	140	144	PF04695	0.301
LIG_Pex14_2	63	67	PF04695	0.330
LIG_SH2_CRK	120	124	PF00017	0.255
LIG_SH2_NCK_1	120	124	PF00017	0.255
LIG_SH2_STAT5	137	140	PF00017	0.367
LIG_SH3_3	10	16	PF00018	0.646
LIG_SH3_3	142	148	PF00018	0.275
LIG_SUMO_SIM_anti_2	86	91	PF11976	0.264
LIG_TYR_ITSM	116	123	PF00017	0.211
LIG_WRC_WIRS_1	92	97	PF05994	0.301
MOD_CK1_1	116	122	PF00069	0.214
MOD_CK1_1	49	55	PF00069	0.237
MOD_GlcNHglycan	115	118	PF01048	0.339
MOD_GlcNHglycan	123	126	PF01048	0.307
MOD_GlcNHglycan	95	98	PF01048	0.327
MOD_GSK3_1	77	84	PF00069	0.455
MOD_N-GLC_1	49	54	PF02516	0.455
MOD_NEK2_1	115	120	PF00069	0.318
MOD_NEK2_1	33	38	PF00069	0.320
MOD_NEK2_1	46	51	PF00069	0.320
MOD_NEK2_1	91	96	PF00069	0.286
MOD_NEK2_2	77	82	PF00069	0.455
MOD_Plk_1	77	83	PF00069	0.415
MOD_Plk_4	36	42	PF00069	0.285
TRG_ENDOCYTIC_2	120	123	PF00928	0.225
TRG_ENDOCYTIC_2	137	140	PF00928	0.428
TRG_ENDOCYTIC_2	170	173	PF00928	0.353

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2E9	Leptomonas seymouri	79%	67%
A0A0N0P5K7	Leptomonas seymouri	38%	67%
A0A0S4ITW9	Bodo saltans	33%	94%
A4HJU6	Leishmania braziliensis	52%	100%