WGS CADB00000000 data, contig 73

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein

Species:

Leishmania mexicana

UniProt:

E8NHP1_LEIMU

TriTrypDb:

LmxM.15.0440a

Length:

842

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E8NHP1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E8NHP1

Function

Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	2
GO:0006807	nitrogen compound metabolic process	2	2
GO:0008152	metabolic process	1	2
GO:0019538	protein metabolic process	3	2
GO:0043170	macromolecule metabolic process	3	2
GO:0044238	primary metabolic process	2	2
GO:0071704	organic substance metabolic process	2	2
GO:1901564	organonitrogen compound metabolic process	3	2
GO:0006996	organelle organization	4	1
GO:0009987	cellular process	1	1
GO:0016043	cellular component organization	3	1
GO:0071840	cellular component organization or biogenesis	2	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	2
GO:0004175	endopeptidase activity	4	2
GO:0004197	cysteine-type endopeptidase activity	5	2
GO:0004198	calcium-dependent cysteine-type endopeptidase activity	6	2
GO:0008233	peptidase activity	3	2
GO:0008234	cysteine-type peptidase activity	4	2
GO:0016787	hydrolase activity	2	2
GO:0140096	catalytic activity, acting on a protein	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	146	150	PF00656	0.376
CLV_C14_Caspase3-7	339	343	PF00656	0.504
CLV_C14_Caspase3-7	500	504	PF00656	0.309
CLV_C14_Caspase3-7	768	772	PF00656	0.431
CLV_NRD_NRD_1	13	15	PF00675	0.705
CLV_NRD_NRD_1	23	25	PF00675	0.703
CLV_NRD_NRD_1	375	377	PF00675	0.709
CLV_NRD_NRD_1	381	383	PF00675	0.725
CLV_NRD_NRD_1	436	438	PF00675	0.461
CLV_NRD_NRD_1	44	46	PF00675	0.547
CLV_NRD_NRD_1	596	598	PF00675	0.358
CLV_NRD_NRD_1	666	668	PF00675	0.428
CLV_PCSK_FUR_1	21	25	PF00082	0.464
CLV_PCSK_KEX2_1	13	15	PF00082	0.498
CLV_PCSK_KEX2_1	23	25	PF00082	0.703
CLV_PCSK_KEX2_1	340	342	PF00082	0.393
CLV_PCSK_KEX2_1	374	376	PF00082	0.687
CLV_PCSK_KEX2_1	381	383	PF00082	0.680
CLV_PCSK_KEX2_1	436	438	PF00082	0.458
CLV_PCSK_KEX2_1	44	46	PF00082	0.547
CLV_PCSK_KEX2_1	596	598	PF00082	0.442
CLV_PCSK_KEX2_1	666	668	PF00082	0.396
CLV_PCSK_KEX2_1	710	712	PF00082	0.353
CLV_PCSK_KEX2_1	88	90	PF00082	0.454
CLV_PCSK_PC1ET2_1	340	342	PF00082	0.451
CLV_PCSK_PC1ET2_1	374	376	PF00082	0.610
CLV_PCSK_PC1ET2_1	710	712	PF00082	0.311
CLV_PCSK_PC1ET2_1	88	90	PF00082	0.366
CLV_PCSK_SKI1_1	341	345	PF00082	0.455
CLV_PCSK_SKI1_1	471	475	PF00082	0.404
CLV_Separin_Metazoa	273	277	PF03568	0.396
CLV_Separin_Metazoa	279	283	PF03568	0.348
CLV_Separin_Metazoa	514	518	PF03568	0.349
DEG_APCC_DBOX_1	314	322	PF00400	0.412
DEG_APCC_DBOX_1	547	555	PF00400	0.352
DOC_CDC14_PxL_1	475	483	PF14671	0.337
DOC_CYCLIN_RxL_1	172	184	PF00134	0.436
DOC_CYCLIN_RxL_1	794	806	PF00134	0.400
DOC_MAPK_DCC_7	548	556	PF00069	0.312
DOC_MAPK_gen_1	548	556	PF00069	0.518
DOC_MAPK_gen_1	596	605	PF00069	0.319
DOC_MAPK_gen_1	710	717	PF00069	0.408
DOC_MAPK_gen_1	88	95	PF00069	0.443
DOC_MAPK_MEF2A_6	548	556	PF00069	0.312
DOC_PP2B_LxvP_1	252	255	PF13499	0.462
DOC_USP7_MATH_1	153	157	PF00917	0.406
DOC_USP7_MATH_1	25	29	PF00917	0.405
DOC_USP7_MATH_1	560	564	PF00917	0.279
DOC_USP7_MATH_1	775	779	PF00917	0.347
DOC_WW_Pin1_4	27	32	PF00397	0.401
DOC_WW_Pin1_4	47	52	PF00397	0.459
DOC_WW_Pin1_4	669	674	PF00397	0.442
LIG_14-3-3_CanoR_1	23	33	PF00244	0.407
LIG_14-3-3_CanoR_1	381	387	PF00244	0.561
LIG_14-3-3_CanoR_1	427	431	PF00244	0.383
LIG_Actin_WH2_1	341	358	PF00022	0.398
LIG_APCC_ABBA_1	165	170	PF00400	0.384
LIG_APCC_ABBA_1	454	459	PF00400	0.389
LIG_APCC_ABBA_1	787	792	PF00400	0.446
LIG_APCC_ABBAyCdc20_2	330	336	PF00400	0.370
LIG_deltaCOP1_diTrp_1	567	572	PF00928	0.320
LIG_DLG_GKlike_1	29	36	PF00625	0.369
LIG_EH_1	162	166	PF12763	0.398
LIG_EH_1	784	788	PF12763	0.400
LIG_FHA_1	404	410	PF00498	0.687
LIG_FHA_2	375	381	PF00498	0.522
LIG_FHA_2	387	393	PF00498	0.558
LIG_FHA_2	615	621	PF00498	0.327
LIG_LIR_Gen_1	103	114	PF02991	0.427
LIG_LIR_Gen_1	331	338	PF02991	0.476
LIG_LIR_Gen_1	417	428	PF02991	0.405
LIG_LIR_Gen_1	571	579	PF02991	0.327
LIG_LIR_Gen_1	725	736	PF02991	0.391
LIG_LIR_Nem_3	103	109	PF02991	0.423
LIG_LIR_Nem_3	30	36	PF02991	0.542
LIG_LIR_Nem_3	331	337	PF02991	0.399
LIG_LIR_Nem_3	417	423	PF02991	0.459
LIG_LIR_Nem_3	476	481	PF02991	0.457
LIG_LIR_Nem_3	567	572	PF02991	0.356
LIG_LIR_Nem_3	629	634	PF02991	0.376
LIG_LIR_Nem_3	652	658	PF02991	0.379
LIG_LIR_Nem_3	725	731	PF02991	0.340
LIG_LYPXL_yS_3	478	481	PF13949	0.361
LIG_LYPXL_yS_3	705	708	PF13949	0.356
LIG_LYPXL_yS_3	83	86	PF13949	0.426
LIG_RPA_C_Fungi	286	298	PF08784	0.349
LIG_RPA_C_Fungi	462	474	PF08784	0.349
LIG_SH2_NCK_1	611	615	PF00017	0.328
LIG_SH2_PTP2	323	326	PF00017	0.394
LIG_SH2_SRC	323	326	PF00017	0.519
LIG_SH2_SRC	611	614	PF00017	0.328
LIG_SH2_STAP1	438	442	PF00017	0.387
LIG_SH2_STAP1	611	615	PF00017	0.328
LIG_SH2_STAT5	187	190	PF00017	0.344
LIG_SH2_STAT5	323	326	PF00017	0.394
LIG_SH2_STAT5	809	812	PF00017	0.333
LIG_SH3_1	323	329	PF00018	0.382
LIG_SH3_3	161	167	PF00018	0.411
LIG_SH3_3	237	243	PF00018	0.353
LIG_SH3_3	323	329	PF00018	0.382
LIG_SH3_3	412	418	PF00018	0.451
LIG_SH3_3	476	482	PF00018	0.334
LIG_SH3_3	629	635	PF00018	0.380
LIG_SH3_3	637	643	PF00018	0.370
LIG_SH3_3	647	653	PF00018	0.391
LIG_SH3_3	783	789	PF00018	0.370
LIG_TRAF2_1	357	360	PF00917	0.438
LIG_TRAF2_1	444	447	PF00917	0.359
LIG_TRAF2_1	504	507	PF00917	0.306
LIG_TRAF2_1	542	545	PF00917	0.393
LIG_TRAF2_1	697	700	PF00917	0.431
LIG_TRAF2_1	75	78	PF00917	0.620
LIG_UBA3_1	333	340	PF00899	0.446
LIG_UBA3_1	575	584	PF00899	0.353
MOD_CDK_SPxxK_3	27	34	PF00069	0.388
MOD_CK1_1	27	33	PF00069	0.386
MOD_CK1_1	8	14	PF00069	0.502
MOD_CK2_1	343	349	PF00069	0.552
MOD_CK2_1	374	380	PF00069	0.746
MOD_CK2_1	386	392	PF00069	0.562
MOD_CK2_1	408	414	PF00069	0.559
MOD_CK2_1	426	432	PF00069	0.325
MOD_CK2_1	565	571	PF00069	0.380
MOD_GlcNHglycan	410	413	PF01048	0.518
MOD_GSK3_1	1	8	PF00069	0.516
MOD_GSK3_1	19	26	PF00069	0.461
MOD_GSK3_1	382	389	PF00069	0.561
MOD_NEK2_1	248	253	PF00069	0.430
MOD_NEK2_1	426	431	PF00069	0.486
MOD_NEK2_2	300	305	PF00069	0.379
MOD_NEK2_2	438	443	PF00069	0.388
MOD_PIKK_1	179	185	PF00454	0.351
MOD_PIKK_1	614	620	PF00454	0.333
MOD_PIKK_1	801	807	PF00454	0.581
MOD_PKA_1	23	29	PF00069	0.425
MOD_PKA_1	374	380	PF00069	0.515
MOD_PKA_1	381	387	PF00069	0.513
MOD_PKA_2	1	7	PF00069	0.517
MOD_PKA_2	12	18	PF00069	0.472
MOD_PKA_2	23	29	PF00069	0.425
MOD_PKA_2	374	380	PF00069	0.515
MOD_PKA_2	381	387	PF00069	0.513
MOD_PKA_2	426	432	PF00069	0.390
MOD_PKA_2	695	701	PF00069	0.355
MOD_PKA_2	73	79	PF00069	0.380
MOD_PKB_1	21	29	PF00069	0.436
MOD_Plk_1	300	306	PF00069	0.389
MOD_Plk_4	426	432	PF00069	0.606
MOD_ProDKin_1	27	33	PF00069	0.395
MOD_ProDKin_1	47	53	PF00069	0.457
MOD_ProDKin_1	669	675	PF00069	0.439
TRG_AP2beta_CARGO_1	103	113	PF09066	0.425
TRG_AP2beta_CARGO_1	331	341	PF09066	0.356
TRG_AP2beta_CARGO_1	725	735	PF09066	0.342
TRG_DiLeu_BaEn_1	571	576	PF01217	0.368
TRG_DiLeu_BaEn_2	475	481	PF01217	0.331
TRG_DiLeu_BaEn_2	548	554	PF01217	0.350
TRG_DiLeu_BaEn_2	628	634	PF01217	0.431
TRG_DiLeu_BaLyEn_6	112	117	PF01217	0.353
TRG_DiLeu_BaLyEn_6	244	249	PF01217	0.340
TRG_DiLeu_BaLyEn_6	405	410	PF01217	0.539
TRG_DiLeu_BaLyEn_6	734	739	PF01217	0.311
TRG_ENDOCYTIC_2	420	423	PF00928	0.502
TRG_ENDOCYTIC_2	478	481	PF00928	0.361
TRG_ENDOCYTIC_2	705	708	PF00928	0.354
TRG_ENDOCYTIC_2	83	86	PF00928	0.426
TRG_ER_diArg_1	13	16	PF00400	0.618
TRG_ER_diArg_1	134	137	PF00400	0.358
TRG_ER_diArg_1	194	197	PF00400	0.432
TRG_ER_diArg_1	21	24	PF00400	0.493
TRG_ER_diArg_1	375	378	PF00400	0.632
TRG_ER_diArg_1	381	383	PF00400	0.727
TRG_ER_diArg_1	43	45	PF00400	0.437
TRG_ER_diArg_1	435	437	PF00400	0.502
TRG_ER_diArg_1	508	511	PF00400	0.445
TRG_ER_diArg_1	529	532	PF00400	0.519
TRG_ER_diArg_1	596	598	PF00400	0.415
TRG_ER_diArg_1	665	667	PF00400	0.615
TRG_ER_diArg_1	756	759	PF00400	0.418
TRG_ER_diArg_1	816	819	PF00400	0.445
TRG_NLS_MonoExtC_3	373	378	PF00514	0.585
TRG_Pf-PMV_PEXEL_1	311	316	PF00026	0.600
TRG_Pf-PMV_PEXEL_1	34	39	PF00026	0.483
TRG_Pf-PMV_PEXEL_1	656	661	PF00026	0.314

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A1X0NDF7	Trypanosomatidae	28%	67%
A0A1X0NYQ1	Trypanosomatidae	31%	89%
A4I2N7	Leishmania infantum	28%	100%
D0A5Q2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	26%	68%
E8NHH1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	50%	100%
E8NHS4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	32%	100%
V5BG02	Trypanosoma cruzi	40%	100%