WGS CADB00000000 data, contig 7

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein

Species:

Leishmania mexicana

UniProt:

E8NHN8_LEIMU

TriTrypDb:

LmxM.33.1740

Length:

343

Annotations

LeishMANIAdb annotations

Publication identifier(s): 26641088 15760660
Amastin, Kinetoplastid host adhesion protein. A host adhesion protein family greatly expanded in Leishmaniids.. Localization: Cell surface (experimental)

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 13
NetGPI	no	yes: 0, no: 13

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	13
GO:0110165	cellular anatomical entity	1	13

Expansion

Sequence features

E8NHN8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E8NHN8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	326	330	PF00656	0.595
CLV_MEL_PAP_1	296	302	PF00089	0.414
CLV_NRD_NRD_1	181	183	PF00675	0.447
CLV_NRD_NRD_1	30	32	PF00675	0.608
CLV_NRD_NRD_1	85	87	PF00675	0.635
CLV_PCSK_FUR_1	83	87	PF00082	0.610
CLV_PCSK_KEX2_1	181	183	PF00082	0.427
CLV_PCSK_KEX2_1	200	202	PF00082	0.403
CLV_PCSK_KEX2_1	30	32	PF00082	0.608
CLV_PCSK_KEX2_1	337	339	PF00082	0.421
CLV_PCSK_KEX2_1	85	87	PF00082	0.634
CLV_PCSK_PC1ET2_1	200	202	PF00082	0.414
CLV_PCSK_PC1ET2_1	337	339	PF00082	0.421
CLV_PCSK_PC7_1	81	87	PF00082	0.629
CLV_PCSK_SKI1_1	183	187	PF00082	0.414
DEG_MDM2_SWIB_1	307	315	PF02201	0.259
DOC_CDC14_PxL_1	122	130	PF14671	0.219
DOC_CKS1_1	173	178	PF01111	0.489
DOC_CKS1_1	57	62	PF01111	0.392
DOC_CYCLIN_RxL_1	94	102	PF00134	0.386
DOC_CYCLIN_yCln2_LP_2	121	124	PF00134	0.249
DOC_MAPK_DCC_7	36	45	PF00069	0.391
DOC_MAPK_MEF2A_6	258	266	PF00069	0.607
DOC_MAPK_MEF2A_6	36	45	PF00069	0.391
DOC_PP2B_LxvP_1	104	107	PF13499	0.391
DOC_PP2B_LxvP_1	121	124	PF13499	0.242
DOC_PP2B_LxvP_1	321	324	PF13499	0.502
DOC_USP7_MATH_1	110	114	PF00917	0.436
DOC_USP7_MATH_1	16	20	PF00917	0.382
DOC_USP7_MATH_1	187	191	PF00917	0.231
DOC_USP7_MATH_1	282	286	PF00917	0.214
DOC_USP7_MATH_1	288	292	PF00917	0.209
DOC_WW_Pin1_4	172	177	PF00397	0.489
DOC_WW_Pin1_4	56	61	PF00397	0.403
DOC_WW_Pin1_4	90	95	PF00397	0.414
LIG_14-3-3_CanoR_1	44	48	PF00244	0.425
LIG_14-3-3_CanoR_1	52	57	PF00244	0.395
LIG_14-3-3_CanoR_1	83	91	PF00244	0.437
LIG_EH1_1	152	160	PF00400	0.432
LIG_EH1_1	231	239	PF00400	0.219
LIG_eIF4E_1	153	159	PF01652	0.442
LIG_EVH1_1	104	108	PF00568	0.372
LIG_EVH1_1	38	42	PF00568	0.383
LIG_EVH1_1	57	61	PF00568	0.392
LIG_FHA_1	269	275	PF00498	0.520
LIG_FHA_1	316	322	PF00498	0.239
LIG_FHA_1	57	63	PF00498	0.398
LIG_FHA_2	173	179	PF00498	0.499
LIG_FHA_2	324	330	PF00498	0.550
LIG_LIR_Gen_1	190	199	PF02991	0.240
LIG_LIR_Gen_1	247	256	PF02991	0.239
LIG_LIR_Nem_3	190	194	PF02991	0.262
LIG_LIR_Nem_3	247	251	PF02991	0.319
LIG_MYND_1	123	127	PF01753	0.226
LIG_Pex14_2	165	169	PF04695	0.299
LIG_Pex14_2	244	248	PF04695	0.231
LIG_Pex14_2	300	304	PF04695	0.322
LIG_Pex14_2	307	311	PF04695	0.294
LIG_SH2_CRK	153	157	PF00017	0.472
LIG_SH2_CRK	254	258	PF00017	0.414
LIG_SH2_PTP2	160	163	PF00017	0.349
LIG_SH2_STAT5	160	163	PF00017	0.349
LIG_SH2_STAT5	208	211	PF00017	0.265
LIG_SH3_1	36	42	PF00018	0.387
LIG_SH3_2	39	44	PF14604	0.387
LIG_SH3_3	10	16	PF00018	0.397
LIG_SH3_3	102	108	PF00018	0.419
LIG_SH3_3	120	126	PF00018	0.237
LIG_SH3_3	130	136	PF00018	0.220
LIG_SH3_3	170	176	PF00018	0.471
LIG_SH3_3	31	37	PF00018	0.394
LIG_SH3_3	55	61	PF00018	0.392
LIG_SUMO_SIM_anti_2	318	324	PF11976	0.235
LIG_TRAF2_1	340	343	PF00917	0.654
LIG_TYR_ITIM	151	156	PF00017	0.611
LIG_TYR_ITIM	158	163	PF00017	0.482
LIG_UBA3_1	209	214	PF00899	0.214
LIG_WRC_WIRS_1	245	250	PF05994	0.219
LIG_WW_2	123	126	PF00397	0.219
LIG_WW_2	39	42	PF00397	0.381
MOD_CDK_SPxxK_3	90	97	PF00069	0.404
MOD_CK1_1	142	148	PF00069	0.633
MOD_GlcNHglycan	114	117	PF01048	0.591
MOD_GSK3_1	323	330	PF00069	0.593
MOD_GSK3_1	43	50	PF00069	0.396
MOD_GSK3_1	52	59	PF00069	0.393
MOD_GSK3_1	71	78	PF00069	0.428
MOD_GSK3_1	95	102	PF00069	0.407
MOD_NEK2_1	131	136	PF00069	0.273
MOD_NEK2_1	244	249	PF00069	0.264
MOD_NEK2_1	43	48	PF00069	0.469
MOD_NEK2_1	95	100	PF00069	0.398
MOD_PIKK_1	214	220	PF00454	0.214
MOD_PKA_2	43	49	PF00069	0.397
MOD_PKA_2	75	81	PF00069	0.434
MOD_PKA_2	84	90	PF00069	0.429
MOD_Plk_1	201	207	PF00069	0.276
MOD_Plk_4	252	258	PF00069	0.279
MOD_Plk_4	315	321	PF00069	0.235
MOD_Plk_4	52	58	PF00069	0.393
MOD_ProDKin_1	172	178	PF00069	0.489
MOD_ProDKin_1	56	62	PF00069	0.403
MOD_ProDKin_1	90	96	PF00069	0.413
MOD_SUMO_rev_2	285	291	PF00179	0.245
MOD_SUMO_rev_2	329	336	PF00179	0.613
TRG_DiLeu_BaLyEn_6	124	129	PF01217	0.219
TRG_DiLeu_BaLyEn_6	91	96	PF01217	0.390
TRG_ENDOCYTIC_2	153	156	PF00928	0.532
TRG_ENDOCYTIC_2	160	163	PF00928	0.444
TRG_ENDOCYTIC_2	254	257	PF00928	0.414
TRG_ER_diArg_1	180	182	PF00400	0.250
TRG_ER_diArg_1	30	32	PF00400	0.405
TRG_ER_diArg_1	83	86	PF00400	0.484

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7X7E5	Leishmania donovani	53%	100%
A0A3S7X7U4	Leishmania donovani	48%	100%
A4H595	Leishmania braziliensis	43%	100%
A4H597	Leishmania braziliensis	43%	100%
A4HAJ6	Leishmania braziliensis	43%	100%
A4HDI3	Leishmania braziliensis	34%	100%
A4I4J3	Leishmania infantum	45%	100%
A4I9W8	Leishmania infantum	48%	100%
A4IA59	Leishmania infantum	41%	100%
E8NHS5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	41%	100%
E9AMF4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	41%	100%
Q4Q397	Leishmania major	51%	100%