Uncharacterized protein LmxM_05_1070a_1

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein

Species:

Leishmania mexicana

UniProt:

E8NHN5_LEIMU

TriTrypDb:

LmxM.05.1070a

Length:

611

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 5

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 8

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 5, no: 6
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	10
GO:0110165	cellular anatomical entity	1	10
GO:0000139	Golgi membrane	5	1
GO:0005737	cytoplasm	2	1
GO:0005789	endoplasmic reticulum membrane	4	1
GO:0005793	endoplasmic reticulum-Golgi intermediate compartment	5	1
GO:0030134	COPII-coated ER to Golgi transport vesicle	8	1
GO:0030135	coated vesicle	7	1
GO:0031090	organelle membrane	3	1
GO:0031410	cytoplasmic vesicle	6	1
GO:0031982	vesicle	4	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0097708	intracellular vesicle	5	1
GO:0098588	bounding membrane of organelle	4	1

Expansion

Sequence features

E8NHN5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E8NHN5

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	1
GO:0006888	endoplasmic reticulum to Golgi vesicle-mediated transport	4	1
GO:0006996	organelle organization	4	1
GO:0007029	endoplasmic reticulum organization	5	1
GO:0007030	Golgi organization	5	1
GO:0009987	cellular process	1	1
GO:0016043	cellular component organization	3	1
GO:0016192	vesicle-mediated transport	4	1
GO:0046907	intracellular transport	3	1
GO:0048193	Golgi vesicle transport	5	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1
GO:0051641	cellular localization	2	1
GO:0051649	establishment of localization in cell	3	1
GO:0071840	cellular component organization or biogenesis	2	1

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	2
GO:0005537	mannose binding	4	1
GO:0030246	carbohydrate binding	2	2
GO:0036094	small molecule binding	2	1
GO:0048029	monosaccharide binding	3	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	267	271	PF00656	0.513
CLV_NRD_NRD_1	311	313	PF00675	0.657
CLV_NRD_NRD_1	316	318	PF00675	0.638
CLV_NRD_NRD_1	324	326	PF00675	0.681
CLV_NRD_NRD_1	416	418	PF00675	0.596
CLV_NRD_NRD_1	473	475	PF00675	0.538
CLV_NRD_NRD_1	534	536	PF00675	0.656
CLV_NRD_NRD_1	537	539	PF00675	0.675
CLV_NRD_NRD_1	592	594	PF00675	0.626
CLV_NRD_NRD_1	92	94	PF00675	0.389
CLV_PCSK_FUR_1	535	539	PF00082	0.714
CLV_PCSK_KEX2_1	311	313	PF00082	0.648
CLV_PCSK_KEX2_1	316	318	PF00082	0.631
CLV_PCSK_KEX2_1	324	326	PF00082	0.678
CLV_PCSK_KEX2_1	328	330	PF00082	0.614
CLV_PCSK_KEX2_1	416	418	PF00082	0.478
CLV_PCSK_KEX2_1	473	475	PF00082	0.541
CLV_PCSK_KEX2_1	479	481	PF00082	0.602
CLV_PCSK_KEX2_1	536	538	PF00082	0.694
CLV_PCSK_KEX2_1	592	594	PF00082	0.623
CLV_PCSK_KEX2_1	92	94	PF00082	0.389
CLV_PCSK_PC1ET2_1	316	318	PF00082	0.649
CLV_PCSK_PC1ET2_1	328	330	PF00082	0.628
CLV_PCSK_PC1ET2_1	479	481	PF00082	0.625
CLV_PCSK_PC1ET2_1	536	538	PF00082	0.710
CLV_PCSK_PC7_1	312	318	PF00082	0.669
CLV_PCSK_PC7_1	324	330	PF00082	0.608
CLV_PCSK_PC7_1	412	418	PF00082	0.491
CLV_PCSK_SKI1_1	10	14	PF00082	0.351
CLV_PCSK_SKI1_1	311	315	PF00082	0.659
CLV_PCSK_SKI1_1	324	328	PF00082	0.589
CLV_PCSK_SKI1_1	33	37	PF00082	0.351
CLV_PCSK_SKI1_1	448	452	PF00082	0.667
CLV_PCSK_SKI1_1	530	534	PF00082	0.732
CLV_PCSK_SKI1_1	541	545	PF00082	0.711
CLV_PCSK_SKI1_1	550	554	PF00082	0.665
CLV_Separin_Metazoa	497	501	PF03568	0.466
DEG_APCC_DBOX_1	32	40	PF00400	0.557
DEG_APCC_DBOX_1	536	544	PF00400	0.545
DEG_APCC_DBOX_1	561	569	PF00400	0.348
DEG_Nend_UBRbox_1	1	4	PF02207	0.556
DOC_CYCLIN_RxL_1	318	331	PF00134	0.503
DOC_MAPK_gen_1	30	39	PF00069	0.564
DOC_MAPK_gen_1	338	347	PF00069	0.464
DOC_MAPK_gen_1	462	472	PF00069	0.331
DOC_MAPK_gen_1	549	557	PF00069	0.510
DOC_MAPK_gen_1	592	598	PF00069	0.497
DOC_MAPK_HePTP_8	27	39	PF00069	0.545
DOC_MAPK_JIP1_4	33	39	PF00069	0.547
DOC_MAPK_MEF2A_6	30	39	PF00069	0.545
DOC_MAPK_MEF2A_6	338	347	PF00069	0.464
DOC_MAPK_MEF2A_6	465	472	PF00069	0.318
DOC_PP1_RVXF_1	593	599	PF00149	0.515
DOC_PP2B_LxvP_1	37	40	PF13499	0.547
DOC_PP2B_LxvP_1	391	394	PF13499	0.377
DOC_PP4_FxxP_1	154	157	PF00568	0.270
DOC_SPAK_OSR1_1	212	216	PF12202	0.270
DOC_SPAK_OSR1_1	42	46	PF12202	0.186
DOC_USP7_MATH_1	125	129	PF00917	0.456
DOC_USP7_MATH_1	157	161	PF00917	0.324
DOC_USP7_MATH_1	539	543	PF00917	0.514
DOC_WW_Pin1_4	258	263	PF00397	0.528
DOC_WW_Pin1_4	415	420	PF00397	0.348
DOC_WW_Pin1_4	602	607	PF00397	0.431
LIG_14-3-3_CanoR_1	101	107	PF00244	0.552
LIG_14-3-3_CanoR_1	111	117	PF00244	0.358
LIG_14-3-3_CanoR_1	184	190	PF00244	0.284
LIG_14-3-3_CanoR_1	2	12	PF00244	0.554
LIG_14-3-3_CanoR_1	329	334	PF00244	0.466
LIG_14-3-3_CanoR_1	423	427	PF00244	0.455
LIG_14-3-3_CanoR_1	538	544	PF00244	0.503
LIG_14-3-3_CanoR_1	84	90	PF00244	0.620
LIG_deltaCOP1_diTrp_1	205	213	PF00928	0.357
LIG_deltaCOP1_diTrp_1	272	280	PF00928	0.489
LIG_eIF4E_1	53	59	PF01652	0.186
LIG_FHA_1	185	191	PF00498	0.303
LIG_FHA_1	197	203	PF00498	0.308
LIG_FHA_1	382	388	PF00498	0.417
LIG_FHA_1	467	473	PF00498	0.364
LIG_FHA_1	491	497	PF00498	0.448
LIG_FHA_1	578	584	PF00498	0.505
LIG_FHA_2	184	190	PF00498	0.358
LIG_FHA_2	296	302	PF00498	0.541
LIG_FHA_2	329	335	PF00498	0.450
LIG_FHA_2	449	455	PF00498	0.373
LIG_FHA_2	499	505	PF00498	0.407
LIG_FHA_2	551	557	PF00498	0.405
LIG_FHA_2	95	101	PF00498	0.553
LIG_LIR_Apic_2	151	157	PF02991	0.270
LIG_LIR_Gen_1	180	190	PF02991	0.270
LIG_LIR_Gen_1	385	394	PF02991	0.424
LIG_LIR_Gen_1	551	560	PF02991	0.434
LIG_LIR_Nem_3	180	185	PF02991	0.270
LIG_LIR_Nem_3	320	326	PF02991	0.407
LIG_LIR_Nem_3	385	391	PF02991	0.417
LIG_LIR_Nem_3	551	555	PF02991	0.450
LIG_NRBOX	67	73	PF00104	0.186
LIG_PDZ_Class_3	606	611	PF00595	0.573
LIG_Pex14_2	323	327	PF04695	0.503
LIG_Pex14_2	350	354	PF04695	0.366
LIG_PTB_Apo_2	176	183	PF02174	0.284
LIG_REV1ctd_RIR_1	78	88	PF16727	0.560
LIG_SH2_STAP1	256	260	PF00017	0.506
LIG_SH2_STAP1	502	506	PF00017	0.429
LIG_SH2_STAP1	577	581	PF00017	0.428
LIG_SH2_STAT3	241	244	PF00017	0.284
LIG_SH2_STAT3	463	466	PF00017	0.328
LIG_SH2_STAT5	241	244	PF00017	0.270
LIG_SH2_STAT5	388	391	PF00017	0.414
LIG_SH2_STAT5	502	505	PF00017	0.375
LIG_SH2_STAT5	53	56	PF00017	0.455
LIG_SH3_1	600	606	PF00018	0.471
LIG_SH3_3	28	34	PF00018	0.553
LIG_SH3_3	432	438	PF00018	0.497
LIG_SH3_3	600	606	PF00018	0.471
LIG_SUMO_SIM_anti_2	454	461	PF11976	0.318
LIG_SUMO_SIM_anti_2	493	501	PF11976	0.469
LIG_SUMO_SIM_anti_2	55	60	PF11976	0.177
LIG_SUMO_SIM_anti_2	64	70	PF11976	0.172
LIG_TRAF2_1	153	156	PF00917	0.401
LIG_TRAF2_1	298	301	PF00917	0.535
LIG_TRAF2_1	452	455	PF00917	0.404
LIG_UBA3_1	322	328	PF00899	0.642
LIG_WRC_WIRS_1	23	28	PF05994	0.428
MOD_CDK_SPxxK_3	258	265	PF00069	0.673
MOD_CK1_1	25	31	PF00069	0.439
MOD_CK1_1	400	406	PF00069	0.665
MOD_CK1_1	524	530	PF00069	0.437
MOD_CK1_1	605	611	PF00069	0.560
MOD_CK1_1	94	100	PF00069	0.527
MOD_CK2_1	150	156	PF00069	0.443
MOD_CK2_1	295	301	PF00069	0.679
MOD_CK2_1	333	339	PF00069	0.538
MOD_CK2_1	448	454	PF00069	0.528
MOD_CK2_1	498	504	PF00069	0.511
MOD_CK2_1	94	100	PF00069	0.433
MOD_GlcNHglycan	174	177	PF01048	0.318
MOD_GlcNHglycan	27	30	PF01048	0.422
MOD_GlcNHglycan	399	402	PF01048	0.672
MOD_GlcNHglycan	523	526	PF01048	0.399
MOD_GSK3_1	254	261	PF00069	0.674
MOD_GSK3_1	329	336	PF00069	0.545
MOD_GSK3_1	396	403	PF00069	0.683
MOD_GSK3_1	444	451	PF00069	0.611
MOD_GSK3_1	486	493	PF00069	0.617
MOD_GSK3_1	498	505	PF00069	0.457
MOD_GSK3_1	80	87	PF00069	0.496
MOD_LATS_1	82	88	PF00433	0.443
MOD_N-GLC_1	224	229	PF02516	0.425
MOD_N-GLC_1	394	399	PF02516	0.650
MOD_NEK2_1	107	112	PF00069	0.442
MOD_NEK2_1	183	188	PF00069	0.420
MOD_NEK2_1	22	27	PF00069	0.438
MOD_NEK2_1	224	229	PF00069	0.403
MOD_NEK2_1	521	526	PF00069	0.379
MOD_NEK2_1	54	59	PF00069	0.403
MOD_NEK2_1	575	580	PF00069	0.510
MOD_NEK2_1	596	601	PF00069	0.671
MOD_NEK2_1	71	76	PF00069	0.583
MOD_NEK2_1	80	85	PF00069	0.515
MOD_NEK2_2	211	216	PF00069	0.217
MOD_NEK2_2	539	544	PF00069	0.660
MOD_PK_1	329	335	PF00069	0.593
MOD_PKA_1	311	317	PF00069	0.660
MOD_PKA_1	328	334	PF00069	0.496
MOD_PKA_2	100	106	PF00069	0.286
MOD_PKA_2	183	189	PF00069	0.336
MOD_PKA_2	211	217	PF00069	0.321
MOD_PKA_2	311	317	PF00069	0.641
MOD_PKA_2	328	334	PF00069	0.445
MOD_PKA_2	422	428	PF00069	0.516
MOD_PKA_2	91	97	PF00069	0.663
MOD_Plk_1	150	156	PF00069	0.337
MOD_Plk_1	480	486	PF00069	0.554
MOD_Plk_2-3	295	301	PF00069	0.686
MOD_Plk_2-3	481	487	PF00069	0.522
MOD_Plk_4	112	118	PF00069	0.383
MOD_Plk_4	22	28	PF00069	0.622
MOD_Plk_4	383	389	PF00069	0.496
MOD_Plk_4	400	406	PF00069	0.572
MOD_Plk_4	466	472	PF00069	0.396
MOD_Plk_4	481	487	PF00069	0.497
MOD_Plk_4	54	60	PF00069	0.207
MOD_Plk_4	61	67	PF00069	0.175
MOD_Plk_4	85	91	PF00069	0.480
MOD_ProDKin_1	258	264	PF00069	0.674
MOD_ProDKin_1	415	421	PF00069	0.426
MOD_ProDKin_1	602	608	PF00069	0.543
MOD_SUMO_for_1	478	481	PF00179	0.597
MOD_SUMO_rev_2	542	552	PF00179	0.635
MOD_SUMO_rev_2	567	575	PF00179	0.438
TRG_DiLeu_BaEn_1	455	460	PF01217	0.460
TRG_DiLeu_BaEn_2	14	20	PF01217	0.421
TRG_DiLeu_BaLyEn_6	144	149	PF01217	0.475
TRG_ENDOCYTIC_2	388	391	PF00928	0.518
TRG_ENDOCYTIC_2	53	56	PF00928	0.455
TRG_ER_diArg_1	210	213	PF00400	0.326
TRG_ER_diArg_1	323	325	PF00400	0.609
TRG_ER_diArg_1	415	417	PF00400	0.517
TRG_ER_diArg_1	472	474	PF00400	0.408
TRG_ER_diArg_1	535	538	PF00400	0.661
TRG_NES_CRM1_1	559	571	PF08389	0.552
TRG_NLS_MonoCore_2	314	319	PF00514	0.632
TRG_NLS_MonoCore_2	534	539	PF00514	0.655
TRG_NLS_MonoExtC_3	314	319	PF00514	0.632
TRG_NLS_MonoExtC_3	534	539	PF00514	0.655
TRG_NLS_MonoExtN_4	312	319	PF00514	0.645
TRG_NLS_MonoExtN_4	533	540	PF00514	0.660

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IIA0	Leptomonas seymouri	77%	100%
A0A1X0NKB0	Trypanosomatidae	43%	94%
A0A3R7LT82	Trypanosoma rangeli	47%	100%
A0A3S5H5L7	Leishmania donovani	88%	100%
A4H4F2	Leishmania braziliensis	88%	100%
A4HSM9	Leishmania infantum	93%	100%
C9ZU67	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	41%	98%
E9AKL4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	100%	100%
Q4QJ95	Leishmania major	94%	100%
V5ARI9	Trypanosoma cruzi	47%	100%