WGS CADB00000000 data, contig 68

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

flagellar attachment zone protein, putative (fragment)

Species:

Leishmania mexicana

UniProt:

E8NHN1_LEIMU

TriTrypDb:

LmxM.14.1100partial

Length:

955

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 5

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 3
NetGPI	no	yes: 0, no: 3

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005871	kinesin complex	3	1
GO:0005874	microtubule	6	1
GO:0005875	microtubule associated complex	2	1
GO:0032991	protein-containing complex	1	1
GO:0099080	supramolecular complex	2	1
GO:0099081	supramolecular polymer	3	1
GO:0099512	supramolecular fiber	4	1
GO:0099513	polymeric cytoskeletal fiber	5	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E8NHN1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E8NHN1

Function

Biological processes
Term	Name	Level	Count
GO:0007017	microtubule-based process	2	3
GO:0007018	microtubule-based movement	3	3
GO:0009987	cellular process	1	3

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	3
GO:0003774	cytoskeletal motor activity	1	3
GO:0003777	microtubule motor activity	2	3
GO:0005488	binding	1	3
GO:0005515	protein binding	2	3
GO:0005524	ATP binding	5	3
GO:0008017	microtubule binding	5	3
GO:0008092	cytoskeletal protein binding	3	3
GO:0015631	tubulin binding	4	3
GO:0017076	purine nucleotide binding	4	3
GO:0030554	adenyl nucleotide binding	5	3
GO:0032553	ribonucleotide binding	3	3
GO:0032555	purine ribonucleotide binding	4	3
GO:0032559	adenyl ribonucleotide binding	5	3
GO:0035639	purine ribonucleoside triphosphate binding	4	3
GO:0036094	small molecule binding	2	3
GO:0043167	ion binding	2	3
GO:0043168	anion binding	3	3
GO:0097159	organic cyclic compound binding	2	3
GO:0097367	carbohydrate derivative binding	2	3
GO:0140657	ATP-dependent activity	1	3
GO:1901265	nucleoside phosphate binding	3	3
GO:1901363	heterocyclic compound binding	2	3
GO:0003824	catalytic activity	1	1
GO:0016462	pyrophosphatase activity	5	1
GO:0016787	hydrolase activity	2	1
GO:0016817	hydrolase activity, acting on acid anhydrides	3	1
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	1
GO:0016887	ATP hydrolysis activity	7	1
GO:0017111	ribonucleoside triphosphate phosphatase activity	6	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	176	178	PF00675	0.496
CLV_NRD_NRD_1	194	196	PF00675	0.359
CLV_NRD_NRD_1	235	237	PF00675	0.416
CLV_NRD_NRD_1	89	91	PF00675	0.551
CLV_PCSK_FUR_1	87	91	PF00082	0.487
CLV_PCSK_KEX2_1	129	131	PF00082	0.468
CLV_PCSK_KEX2_1	176	178	PF00082	0.496
CLV_PCSK_KEX2_1	300	302	PF00082	0.471
CLV_PCSK_KEX2_1	89	91	PF00082	0.530
CLV_PCSK_PC1ET2_1	129	131	PF00082	0.468
CLV_PCSK_PC1ET2_1	300	302	PF00082	0.471
CLV_PCSK_SKI1_1	119	123	PF00082	0.445
CLV_PCSK_SKI1_1	17	21	PF00082	0.316
CLV_PCSK_SKI1_1	198	202	PF00082	0.489
CLV_PCSK_SKI1_1	267	271	PF00082	0.478
CLV_PCSK_SKI1_1	323	327	PF00082	0.402
DEG_APCC_DBOX_1	197	205	PF00400	0.488
DEG_Nend_Nbox_1	1	2	PF02207	0.246
DOC_CYCLIN_RxL_1	115	126	PF00134	0.448
DOC_CYCLIN_RxL_1	195	203	PF00134	0.486
DOC_MAPK_gen_1	117	123	PF00069	0.384
DOC_MAPK_gen_1	274	281	PF00069	0.389
DOC_MAPK_gen_1	72	79	PF00069	0.316
DOC_MAPK_MEF2A_6	181	189	PF00069	0.484
DOC_MAPK_MEF2A_6	274	281	PF00069	0.389
DOC_PP1_RVXF_1	30	36	PF00149	0.316
DOC_USP7_MATH_1	111	115	PF00917	0.521
DOC_USP7_MATH_1	156	160	PF00917	0.435
DOC_USP7_UBL2_3	202	206	PF12436	0.486
DOC_USP7_UBL2_3	428	432	PF12436	0.527
DOC_WW_Pin1_4	51	56	PF00397	0.316
LIG_14-3-3_CanoR_1	236	243	PF00244	0.480
LIG_14-3-3_CanoR_1	267	277	PF00244	0.468
LIG_14-3-3_CanoR_1	461	466	PF00244	0.498
LIG_14-3-3_CanoR_1	469	479	PF00244	0.452
LIG_APCC_ABBA_1	25	30	PF00400	0.316
LIG_BRCT_BRCA1_1	44	48	PF00533	0.316
LIG_CaM_IQ_9	131	147	PF13499	0.486
LIG_Clathr_ClatBox_1	120	124	PF01394	0.369
LIG_Clathr_ClatBox_1	476	480	PF01394	0.507
LIG_FHA_1	32	38	PF00498	0.316
LIG_FHA_1	363	369	PF00498	0.485
LIG_FHA_1	45	51	PF00498	0.240
LIG_FHA_2	152	158	PF00498	0.483
LIG_FHA_2	300	306	PF00498	0.481
LIG_FHA_2	359	365	PF00498	0.469
LIG_FHA_2	405	411	PF00498	0.446
LIG_FHA_2	441	447	PF00498	0.445
LIG_LIR_Gen_1	302	312	PF02991	0.484
LIG_LIR_Gen_1	321	331	PF02991	0.503
LIG_LIR_Nem_3	302	307	PF02991	0.483
LIG_LIR_Nem_3	321	327	PF02991	0.504
LIG_RPA_C_Fungi	69	81	PF08784	0.316
LIG_SH2_CRK	23	27	PF00017	0.246
LIG_SH2_NCK_1	23	27	PF00017	0.316
LIG_SH2_STAP1	60	64	PF00017	0.393
LIG_SH2_STAP1	69	73	PF00017	0.404
LIG_SH2_STAT5	112	115	PF00017	0.465
LIG_SH2_STAT5	291	294	PF00017	0.468
LIG_SUMO_SIM_par_1	119	126	PF11976	0.372
LIG_TRAF2_1	248	251	PF00917	0.465
LIG_TYR_ITSM	300	307	PF00017	0.482
LIG_UBA3_1	200	207	PF00899	0.490
LIG_UBA3_1	253	260	PF00899	0.501
LIG_UBA3_1	295	300	PF00899	0.464
MOD_CK1_1	31	37	PF00069	0.414
MOD_CK1_1	388	394	PF00069	0.527
MOD_CK1_1	405	411	PF00069	0.477
MOD_CK1_1	440	446	PF00069	0.445
MOD_CK2_1	151	157	PF00069	0.483
MOD_CK2_1	299	305	PF00069	0.478
MOD_CK2_1	358	364	PF00069	0.465
MOD_CK2_1	404	410	PF00069	0.484
MOD_CK2_1	440	446	PF00069	0.445
MOD_GlcNHglycan	396	399	PF01048	0.480
MOD_GlcNHglycan	446	450	PF01048	0.503
MOD_GlcNHglycan	55	58	PF01048	0.316
MOD_GSK3_1	156	163	PF00069	0.413
MOD_GSK3_1	358	365	PF00069	0.492
MOD_GSK3_1	394	401	PF00069	0.535
MOD_GSK3_1	404	411	PF00069	0.443
MOD_GSK3_1	440	447	PF00069	0.468
MOD_GSK3_1	457	464	PF00069	0.448
MOD_GSK3_1	49	56	PF00069	0.386
MOD_LATS_1	392	398	PF00433	0.493
MOD_NEK2_1	172	177	PF00069	0.491
MOD_NEK2_1	28	33	PF00069	0.414
MOD_NEK2_1	37	42	PF00069	0.419
MOD_NEK2_1	402	407	PF00069	0.526
MOD_NEK2_1	437	442	PF00069	0.471
MOD_NEK2_1	444	449	PF00069	0.468
MOD_NEK2_1	49	54	PF00069	0.303
MOD_PIKK_1	314	320	PF00454	0.474
MOD_PIKK_1	339	345	PF00454	0.411
MOD_PIKK_1	385	391	PF00454	0.540
MOD_PKA_2	151	157	PF00069	0.483
MOD_PKA_2	235	241	PF00069	0.486
MOD_PKA_2	28	34	PF00069	0.316
MOD_Plk_1	372	378	PF00069	0.560
MOD_Plk_1	60	66	PF00069	0.337
MOD_Plk_4	287	293	PF00069	0.460
MOD_Plk_4	31	37	PF00069	0.316
MOD_Plk_4	373	379	PF00069	0.497
MOD_Plk_4	44	50	PF00069	0.240
MOD_ProDKin_1	51	57	PF00069	0.316
MOD_SUMO_for_1	189	192	PF00179	0.477
MOD_SUMO_for_1	435	438	PF00179	0.456
MOD_SUMO_rev_2	231	238	PF00179	0.412
MOD_SUMO_rev_2	24	34	PF00179	0.316
MOD_SUMO_rev_2	452	460	PF00179	0.529
TRG_DiLeu_BaEn_1	213	218	PF01217	0.484
TRG_DiLeu_BaEn_1	373	378	PF01217	0.495
TRG_DiLeu_BaLyEn_6	146	151	PF01217	0.496
TRG_DiLeu_BaLyEn_6	291	296	PF01217	0.463
TRG_ENDOCYTIC_2	304	307	PF00928	0.488
TRG_ENDOCYTIC_2	324	327	PF00928	0.386
TRG_ER_diArg_1	86	89	PF00400	0.563
TRG_Pf-PMV_PEXEL_1	198	203	PF00026	0.488
TRG_Pf-PMV_PEXEL_1	294	298	PF00026	0.465
TRG_Pf-PMV_PEXEL_1	366	371	PF00026	0.477
TRG_Pf-PMV_PEXEL_1	414	419	PF00026	0.522
TRG_Pf-PMV_PEXEL_1	89	93	PF00026	0.489

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A4H7T4	Leishmania braziliensis	29%	90%
Q4QFM3	Leishmania major	66%	100%