WGS CADB00000000 data, contig 66

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein

Species:

Leishmania mexicana

UniProt:

E8NHM8_LEIMU

TriTrypDb:

LmxM.30.0460d

Length:

581

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 1
Forrest at al. (metacyclic)	no	yes: 2
Forrest at al. (procyclic)	no	yes: 3
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 34

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 16

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 16

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 78
NetGPI	no	yes: 0, no: 79

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	5
GO:0005737	cytoplasm	2	3
GO:0005930	axoneme	2	1
GO:0005815	microtubule organizing center	2	1
GO:0005856	cytoskeleton	5	1
GO:0020016	ciliary pocket	2	1
GO:0020038	subpellicular network	2	1
GO:0030863	cortical cytoskeleton	6	1
GO:0036064	ciliary basal body	3	1
GO:0043226	organelle	2	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1

Expansion

Sequence features

E8NHM8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

No structure information available for this entry

Related structures:

Function

Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	80
GO:0006807	nitrogen compound metabolic process	2	80
GO:0008152	metabolic process	1	80
GO:0019538	protein metabolic process	3	80
GO:0043170	macromolecule metabolic process	3	80
GO:0044238	primary metabolic process	2	80
GO:0071704	organic substance metabolic process	2	80
GO:1901564	organonitrogen compound metabolic process	3	80

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	80
GO:0004175	endopeptidase activity	4	80
GO:0004197	cysteine-type endopeptidase activity	5	80
GO:0004198	calcium-dependent cysteine-type endopeptidase activity	6	80
GO:0008233	peptidase activity	3	80
GO:0008234	cysteine-type peptidase activity	4	80
GO:0016787	hydrolase activity	2	80
GO:0140096	catalytic activity, acting on a protein	2	80

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	361	365	PF00656	0.521
CLV_NRD_NRD_1	142	144	PF00675	0.234
CLV_NRD_NRD_1	253	255	PF00675	0.375
CLV_NRD_NRD_1	345	347	PF00675	0.274
CLV_NRD_NRD_1	403	405	PF00675	0.397
CLV_NRD_NRD_1	418	420	PF00675	0.466
CLV_NRD_NRD_1	43	45	PF00675	0.401
CLV_NRD_NRD_1	80	82	PF00675	0.268
CLV_PCSK_KEX2_1	142	144	PF00082	0.235
CLV_PCSK_KEX2_1	345	347	PF00082	0.273
CLV_PCSK_KEX2_1	418	420	PF00082	0.475
CLV_PCSK_KEX2_1	554	556	PF00082	0.532
CLV_PCSK_KEX2_1	63	65	PF00082	0.325
CLV_PCSK_KEX2_1	80	82	PF00082	0.260
CLV_PCSK_PC1ET2_1	554	556	PF00082	0.562
CLV_PCSK_PC1ET2_1	63	65	PF00082	0.331
CLV_PCSK_SKI1_1	13	17	PF00082	0.547
CLV_PCSK_SKI1_1	131	135	PF00082	0.250
CLV_PCSK_SKI1_1	248	252	PF00082	0.232
CLV_PCSK_SKI1_1	313	317	PF00082	0.273
CLV_PCSK_SKI1_1	408	412	PF00082	0.456
CLV_PCSK_SKI1_1	431	435	PF00082	0.526
CLV_PCSK_SKI1_1	491	495	PF00082	0.555
CLV_PCSK_SKI1_1	501	505	PF00082	0.543
DEG_APCC_DBOX_1	310	318	PF00400	0.518
DEG_MDM2_SWIB_1	358	366	PF02201	0.449
DEG_Nend_UBRbox_1	1	3	PF02207	0.261
DEG_ODPH_VHL_1	508	520	PF01847	0.304
DEG_SPOP_SBC_1	124	128	PF00917	0.500
DOC_AGCK_PIF_1	224	229	PF00069	0.507
DOC_CKS1_1	262	267	PF01111	0.462
DOC_CYCLIN_RxL_1	404	414	PF00134	0.504
DOC_CYCLIN_RxL_1	428	438	PF00134	0.522
DOC_MAPK_DCC_7	305	314	PF00069	0.571
DOC_MAPK_gen_1	252	262	PF00069	0.437
DOC_MAPK_gen_1	404	411	PF00069	0.370
DOC_MAPK_gen_1	42	51	PF00069	0.337
DOC_MAPK_gen_1	516	525	PF00069	0.547
DOC_MAPK_gen_1	560	567	PF00069	0.323
DOC_MAPK_HePTP_8	302	314	PF00069	0.480
DOC_MAPK_MEF2A_6	305	314	PF00069	0.480
DOC_MAPK_MEF2A_6	44	53	PF00069	0.303
DOC_MAPK_MEF2A_6	471	479	PF00069	0.474
DOC_MAPK_RevD_3	391	405	PF00069	0.454
DOC_PP1_RVXF_1	406	412	PF00149	0.435
DOC_PP1_RVXF_1	517	523	PF00149	0.455
DOC_PP4_FxxP_1	134	137	PF00568	0.448
DOC_PP4_FxxP_1	307	310	PF00568	0.497
DOC_USP7_MATH_1	241	245	PF00917	0.461
DOC_USP7_MATH_1	30	34	PF00917	0.496
DOC_USP7_MATH_1	320	324	PF00917	0.499
DOC_USP7_MATH_1	510	514	PF00917	0.517
DOC_USP7_UBL2_3	197	201	PF12436	0.448
DOC_WW_Pin1_4	261	266	PF00397	0.469
LIG_14-3-3_CanoR_1	345	353	PF00244	0.563
LIG_14-3-3_CanoR_1	491	500	PF00244	0.494
LIG_14-3-3_CanoR_1	519	523	PF00244	0.472
LIG_14-3-3_CanoR_1	533	539	PF00244	0.424
LIG_14-3-3_CanoR_1	98	106	PF00244	0.506
LIG_Actin_WH2_2	518	535	PF00022	0.285
LIG_BRCT_BRCA1_1	243	247	PF00533	0.502
LIG_deltaCOP1_diTrp_1	325	331	PF00928	0.442
LIG_deltaCOP1_diTrp_1	361	369	PF00928	0.454
LIG_FHA_1	125	131	PF00498	0.436
LIG_FHA_1	21	27	PF00498	0.484
LIG_FHA_1	288	294	PF00498	0.464
LIG_FHA_1	444	450	PF00498	0.519
LIG_FHA_2	564	570	PF00498	0.505
LIG_IRF3_LxIS_1	429	436	PF10401	0.498
LIG_LIR_Apic_2	132	137	PF02991	0.462
LIG_LIR_Apic_2	574	580	PF02991	0.547
LIG_LIR_Apic_2	78	82	PF02991	0.427
LIG_LIR_Gen_1	189	199	PF02991	0.432
LIG_LIR_Gen_1	205	214	PF02991	0.457
LIG_LIR_Gen_1	298	307	PF02991	0.485
LIG_LIR_Gen_1	463	473	PF02991	0.440
LIG_LIR_Gen_1	521	530	PF02991	0.403
LIG_LIR_Nem_3	173	177	PF02991	0.478
LIG_LIR_Nem_3	189	194	PF02991	0.440
LIG_LIR_Nem_3	196	202	PF02991	0.448
LIG_LIR_Nem_3	205	209	PF02991	0.448
LIG_LIR_Nem_3	222	227	PF02991	0.455
LIG_LIR_Nem_3	244	250	PF02991	0.430
LIG_LIR_Nem_3	298	302	PF02991	0.481
LIG_LIR_Nem_3	427	433	PF02991	0.460
LIG_LIR_Nem_3	463	468	PF02991	0.470
LIG_LIR_Nem_3	521	525	PF02991	0.433
LIG_MLH1_MIPbox_1	243	247	PF16413	0.516
LIG_Pex14_2	229	233	PF04695	0.441
LIG_Pex14_2	358	362	PF04695	0.453
LIG_Pex14_2	386	390	PF04695	0.400
LIG_REV1ctd_RIR_1	244	252	PF16727	0.467
LIG_SH2_CRK	174	178	PF00017	0.569
LIG_SH2_CRK	199	203	PF00017	0.447
LIG_SH2_CRK	206	210	PF00017	0.451
LIG_SH2_CRK	299	303	PF00017	0.461
LIG_SH2_CRK	384	388	PF00017	0.342
LIG_SH2_CRK	430	434	PF00017	0.479
LIG_SH2_SRC	258	261	PF00017	0.448
LIG_SH2_SRC	465	468	PF00017	0.524
LIG_SH2_SRC	577	580	PF00017	0.318
LIG_SH2_SRC	85	88	PF00017	0.462
LIG_SH2_STAP1	188	192	PF00017	0.488
LIG_SH2_STAP1	206	210	PF00017	0.441
LIG_SH2_STAP1	299	303	PF00017	0.471
LIG_SH2_STAP1	465	469	PF00017	0.516
LIG_SH2_STAT5	170	173	PF00017	0.459
LIG_SH2_STAT5	179	182	PF00017	0.460
LIG_SH2_STAT5	258	261	PF00017	0.459
LIG_SH2_STAT5	467	470	PF00017	0.422
LIG_SH2_STAT5	50	53	PF00017	0.476
LIG_SH2_STAT5	577	580	PF00017	0.501
LIG_SH2_STAT5	85	88	PF00017	0.432
LIG_SH3_3	420	426	PF00018	0.530
LIG_SH3_3	456	462	PF00018	0.524
LIG_SH3_3	520	526	PF00018	0.480
LIG_SH3_3	533	539	PF00018	0.487
LIG_SUMO_SIM_anti_2	119	128	PF11976	0.486
LIG_SUMO_SIM_par_1	258	264	PF11976	0.421
LIG_SUMO_SIM_par_1	433	438	PF11976	0.434
LIG_TRAF2_1	237	240	PF00917	0.492
LIG_TRAF2_1	90	93	PF00917	0.351
LIG_UBA3_1	409	416	PF00899	0.475
LIG_WRC_WIRS_1	226	231	PF05994	0.485
MOD_CK1_1	205	211	PF00069	0.429
MOD_CK1_1	261	267	PF00069	0.427
MOD_CK1_1	351	357	PF00069	0.488
MOD_CK1_1	70	76	PF00069	0.477
MOD_CK2_1	138	144	PF00069	0.434
MOD_CK2_1	190	196	PF00069	0.445
MOD_CK2_1	30	36	PF00069	0.440
MOD_CK2_1	320	326	PF00069	0.458
MOD_CMANNOS	359	362	PF00535	0.244
MOD_GlcNHglycan	101	104	PF01048	0.308
MOD_GlcNHglycan	268	272	PF01048	0.252
MOD_GlcNHglycan	275	278	PF01048	0.262
MOD_GlcNHglycan	322	325	PF01048	0.304
MOD_GSK3_1	166	173	PF00069	0.481
MOD_GSK3_1	225	232	PF00069	0.456
MOD_GSK3_1	260	267	PF00069	0.463
MOD_GSK3_1	287	294	PF00069	0.515
MOD_GSK3_1	344	351	PF00069	0.478
MOD_N-GLC_1	333	338	PF02516	0.292
MOD_N-GLC_1	510	515	PF02516	0.566
MOD_NEK2_1	116	121	PF00069	0.461
MOD_NEK2_1	180	185	PF00069	0.458
MOD_NEK2_1	190	195	PF00069	0.453
MOD_NEK2_1	20	25	PF00069	0.504
MOD_NEK2_1	202	207	PF00069	0.463
MOD_NEK2_1	229	234	PF00069	0.507
MOD_NEK2_1	409	414	PF00069	0.396
MOD_NEK2_1	433	438	PF00069	0.381
MOD_NEK2_1	518	523	PF00069	0.432
MOD_NEK2_1	568	573	PF00069	0.436
MOD_NEK2_2	563	568	PF00069	0.318
MOD_PIKK_1	136	142	PF00454	0.579
MOD_PIKK_1	20	26	PF00454	0.517
MOD_PIKK_1	241	247	PF00454	0.520
MOD_PIKK_1	411	417	PF00454	0.440
MOD_PIKK_1	443	449	PF00454	0.611
MOD_PKA_2	181	187	PF00069	0.475
MOD_PKA_2	344	350	PF00069	0.499
MOD_PKA_2	43	49	PF00069	0.470
MOD_PKA_2	518	524	PF00069	0.457
MOD_Plk_1	124	130	PF00069	0.471
MOD_Plk_1	267	273	PF00069	0.464
MOD_Plk_1	280	286	PF00069	0.508
MOD_Plk_1	501	507	PF00069	0.580
MOD_Plk_1	568	574	PF00069	0.464
MOD_Plk_4	125	131	PF00069	0.485
MOD_Plk_4	166	172	PF00069	0.483
MOD_Plk_4	190	196	PF00069	0.430
MOD_Plk_4	205	211	PF00069	0.448
MOD_Plk_4	297	303	PF00069	0.472
MOD_Plk_4	339	345	PF00069	0.482
MOD_Plk_4	354	360	PF00069	0.444
MOD_Plk_4	393	399	PF00069	0.337
MOD_Plk_4	518	524	PF00069	0.531
MOD_Plk_4	573	579	PF00069	0.473
MOD_ProDKin_1	261	267	PF00069	0.469
MOD_SUMO_for_1	399	402	PF00179	0.384
MOD_SUMO_rev_2	92	97	PF00179	0.351
TRG_ENDOCYTIC_2	174	177	PF00928	0.497
TRG_ENDOCYTIC_2	199	202	PF00928	0.450
TRG_ENDOCYTIC_2	206	209	PF00928	0.451
TRG_ENDOCYTIC_2	299	302	PF00928	0.470
TRG_ENDOCYTIC_2	430	433	PF00928	0.439
TRG_ENDOCYTIC_2	465	468	PF00928	0.483
TRG_ENDOCYTIC_2	50	53	PF00928	0.462
TRG_ER_diArg_1	344	346	PF00400	0.486
TRG_ER_diArg_1	418	420	PF00400	0.541
TRG_ER_diArg_1	79	81	PF00400	0.470
TRG_NLS_MonoExtC_3	403	408	PF00514	0.390
TRG_NLS_MonoExtN_4	404	409	PF00514	0.398
TRG_NLS_MonoExtN_4	42	48	PF00514	0.469

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8T6	Leptomonas seymouri	67%	83%
A0A0N1IGQ2	Leptomonas seymouri	36%	82%
A0A0N1ILF1	Leptomonas seymouri	35%	84%
A0A0N1IMH1	Leptomonas seymouri	35%	74%
A0A0N1P9P1	Leptomonas seymouri	34%	68%
A0A0N1PCA9	Leptomonas seymouri	30%	79%
A0A0N1PFI4	Leptomonas seymouri	33%	75%
A0A0S4JLK6	Bodo saltans	32%	72%
A0A0S4JS70	Bodo saltans	26%	76%
A0A0S4KGT2	Bodo saltans	40%	77%
A0A0S4KKP7	Bodo saltans	22%	78%
A0A1X0NJ61	Trypanosomatidae	42%	100%
A0A1X0NJK2	Trypanosomatidae	45%	77%
A0A1X0NJX8	Trypanosomatidae	36%	75%
A0A1X0NKT7	Trypanosomatidae	29%	73%
A0A1X0NKX8	Trypanosomatidae	33%	71%
A0A1X0NMT3	Trypanosomatidae	35%	68%
A0A1X0NW84	Trypanosomatidae	34%	84%
A0A1X0NW85	Trypanosomatidae	32%	86%
A0A1X0NW89	Trypanosomatidae	34%	67%
A0A1X0NWA6	Trypanosomatidae	26%	67%
A0A1X0NWW1	Trypanosomatidae	33%	80%
A0A3Q8IDD4	Leishmania donovani	36%	82%
A0A3Q8IJT4	Leishmania donovani	25%	77%
A0A3S5H5A5	Leishmania donovani	32%	68%
A0A3S5ISG2	Trypanosoma rangeli	35%	75%
A0A3S7WW18	Leishmania donovani	34%	71%
A0A3S7WW41	Leishmania donovani	30%	78%
A0A3S7WW71	Leishmania donovani	34%	85%
A0A3S7X430	Leishmania donovani	35%	74%
A0A3S7X460	Leishmania donovani	88%	75%
A0A3S7X470	Leishmania donovani	33%	80%
A0A422MYX0	Trypanosoma rangeli	33%	80%
A4H3W4	Leishmania braziliensis	31%	68%
A4HE81	Leishmania braziliensis	39%	100%
A4HJ14	Leishmania braziliensis	34%	100%
A4HJ23	Leishmania braziliensis	34%	100%
A4HJ24	Leishmania braziliensis	81%	100%
A4HS39	Leishmania infantum	32%	68%
A4HYN0	Leishmania infantum	35%	71%
A4HYW2	Leishmania infantum	34%	85%
A4HYW3	Leishmania infantum	29%	78%
A4I1J4	Leishmania infantum	36%	82%
A4I6E4	Leishmania infantum	33%	80%
A4I6E6	Leishmania infantum	88%	75%
A4I6K4	Leishmania infantum	34%	74%
A4I6K6	Leishmania infantum	26%	77%
C9ZIE8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	32%	85%
C9ZIE9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	79%
C9ZN52	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	35%	73%
C9ZN53	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	68%
C9ZWY4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	32%	72%
C9ZY36	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	68%
E8NHF1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	98%	100%
E8NHG6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	36%	100%
E8NHG8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	99%	100%
E8NHM2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	99%	100%
E8NHM4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	99%	100%
E8NHQ2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	34%	100%
E9AIH1	Leishmania braziliensis	35%	100%
E9AIH3	Leishmania braziliensis	35%	100%
E9AIH4	Leishmania braziliensis	29%	100%
E9AIH6	Leishmania braziliensis	29%	100%
E9AK26	Leishmania mexicana (strain MHOM/GT/2001/U1103)	31%	73%
E9AUQ8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	35%	89%
E9AUQ9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	35%	85%
E9AUR0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	28%	78%
E9AUR1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	28%	100%
E9AXM9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	37%	82%
E9B1J0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	34%	74%
E9B1J2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	26%	77%
E9B1J6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	99%	82%
O08688	Mus musculus	27%	91%
O15484	Homo sapiens	26%	91%
Q4Q6L7	Leishmania major	88%	100%
Q4Q6L9	Leishmania major	33%	100%
Q4Q6M2	Leishmania major	25%	100%
Q4Q6M4	Leishmania major	35%	68%
Q4Q9U3	Leishmania major	38%	100%
Q4QCS5	Leishmania major	28%	97%
Q4QCS6	Leishmania major	30%	100%
Q4QCS7	Leishmania major	35%	100%
Q4QCS8	Leishmania major	35%	100%
Q5BK10	Rattus norvegicus	25%	87%
Q8R4C0	Rattus norvegicus	27%	91%
Q9TTH8	Ovis aries	29%	71%
Q9U0T9	Leishmania major	31%	68%
V5AYJ1	Trypanosoma cruzi	40%	81%
V5B5I4	Trypanosoma cruzi	34%	69%
V5BA05	Trypanosoma cruzi	35%	87%
V5BEL3	Trypanosoma cruzi	35%	84%
V5BN20	Trypanosoma cruzi	36%	75%
V5D5V8	Trypanosoma cruzi	30%	78%
V5D9Y2	Trypanosoma cruzi	31%	68%
V5DES7	Trypanosoma cruzi	36%	73%