WGS CADB00000000 data, contig 60

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein

Species:

Leishmania mexicana

UniProt:

E8NHL6_LEIMU

TriTrypDb:

LmxM.02.0200partial

Length:

286

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 4
NetGPI	no	yes: 0, no: 4

Cellular components
Term	Name	Level	Count
GO:0000139	Golgi membrane	5	1
GO:0016020	membrane	2	1
GO:0031090	organelle membrane	3	1
GO:0098588	bounding membrane of organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E8NHL6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E8NHL6

Function

Biological processes
Term	Name	Level	Count
GO:0006486	protein glycosylation	4	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0019538	protein metabolic process	3	1
GO:0036211	protein modification process	4	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043412	macromolecule modification	4	1
GO:0043413	macromolecule glycosylation	3	1
GO:0044238	primary metabolic process	2	1
GO:0070085	glycosylation	2	1
GO:0071704	organic substance metabolic process	2	1
GO:1901564	organonitrogen compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	3
GO:0016740	transferase activity	2	3
GO:0016757	glycosyltransferase activity	3	3
GO:0016758	hexosyltransferase activity	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	109	111	PF00675	0.334
CLV_NRD_NRD_1	114	116	PF00675	0.376
CLV_NRD_NRD_1	247	249	PF00675	0.439
CLV_NRD_NRD_1	7	9	PF00675	0.560
CLV_NRD_NRD_1	79	81	PF00675	0.517
CLV_NRD_NRD_1	93	95	PF00675	0.454
CLV_PCSK_KEX2_1	108	110	PF00082	0.338
CLV_PCSK_KEX2_1	114	116	PF00082	0.371
CLV_PCSK_KEX2_1	247	249	PF00082	0.439
CLV_PCSK_KEX2_1	6	8	PF00082	0.561
CLV_PCSK_KEX2_1	79	81	PF00082	0.517
CLV_PCSK_KEX2_1	92	94	PF00082	0.477
CLV_PCSK_PC1ET2_1	108	110	PF00082	0.365
CLV_PCSK_PC7_1	110	116	PF00082	0.356
CLV_PCSK_PC7_1	243	249	PF00082	0.442
CLV_PCSK_SKI1_1	109	113	PF00082	0.453
CLV_PCSK_SKI1_1	115	119	PF00082	0.464
CLV_PCSK_SKI1_1	200	204	PF00082	0.460
DEG_APCC_DBOX_1	91	99	PF00400	0.463
DEG_Nend_UBRbox_2	1	2	PF02207	0.551
DOC_ANK_TNKS_1	6	13	PF00023	0.551
DOC_MAPK_gen_1	247	255	PF00069	0.378
DOC_MAPK_gen_1	89	97	PF00069	0.516
DOC_PP1_RVXF_1	112	119	PF00149	0.390
DOC_USP7_MATH_1	178	182	PF00917	0.383
DOC_USP7_MATH_1	88	92	PF00917	0.701
LIG_14-3-3_CanoR_1	109	114	PF00244	0.417
LIG_14-3-3_CanoR_1	248	254	PF00244	0.539
LIG_14-3-3_CanoR_1	45	50	PF00244	0.477
LIG_deltaCOP1_diTrp_1	150	155	PF00928	0.506
LIG_FHA_1	161	167	PF00498	0.413
LIG_FHA_1	250	256	PF00498	0.611
LIG_FHA_2	201	207	PF00498	0.437
LIG_Integrin_isoDGR_2	142	144	PF01839	0.386
LIG_LIR_Gen_1	150	160	PF02991	0.419
LIG_LIR_Gen_1	167	173	PF02991	0.411
LIG_LIR_Nem_3	112	116	PF02991	0.530
LIG_LIR_Nem_3	150	155	PF02991	0.413
LIG_LIR_Nem_3	167	171	PF02991	0.410
LIG_LIR_Nem_3	180	186	PF02991	0.413
LIG_LIR_Nem_3	230	236	PF02991	0.439
LIG_LIR_Nem_3	278	283	PF02991	0.457
LIG_LIR_Nem_3	34	40	PF02991	0.477
LIG_Pex14_1	151	155	PF04695	0.528
LIG_RPA_C_Fungi	74	86	PF08784	0.473
LIG_SH2_CRK	113	117	PF00017	0.434
LIG_SH2_CRK	130	134	PF00017	0.543
LIG_SH2_CRK	280	284	PF00017	0.407
LIG_SH2_CRK	37	41	PF00017	0.480
LIG_SH2_GRB2like	262	265	PF00017	0.400
LIG_SH2_STAP1	262	266	PF00017	0.580
LIG_SH2_STAT5	147	150	PF00017	0.425
LIG_SH2_STAT5	183	186	PF00017	0.562
LIG_SH2_STAT5	187	190	PF00017	0.494
LIG_SH3_3	37	43	PF00018	0.481
LIG_SUMO_SIM_par_1	15	21	PF11976	0.535
LIG_SUMO_SIM_par_1	251	257	PF11976	0.395
LIG_TRAF2_1	202	205	PF00917	0.439
LIG_TYR_ITIM	111	116	PF00017	0.356
LIG_WW_3	3	7	PF00397	0.630
MOD_CK2_1	200	206	PF00069	0.507
MOD_CK2_1	45	51	PF00069	0.530
MOD_GlcNHglycan	233	236	PF01048	0.427
MOD_GSK3_1	160	167	PF00069	0.444
MOD_GSK3_1	267	274	PF00069	0.477
MOD_GSK3_1	27	34	PF00069	0.651
MOD_N-GLC_1	164	169	PF02516	0.399
MOD_N-GLC_1	231	236	PF02516	0.444
MOD_N-GLC_1	243	248	PF02516	0.535
MOD_NEK2_1	231	236	PF00069	0.444
MOD_NEK2_2	57	62	PF00069	0.306
MOD_PIKK_1	64	70	PF00454	0.330
MOD_PKA_1	109	115	PF00069	0.359
MOD_PKA_2	109	115	PF00069	0.468
MOD_PKA_2	176	182	PF00069	0.416
MOD_Plk_1	103	109	PF00069	0.480
MOD_Plk_1	164	170	PF00069	0.398
MOD_Plk_4	167	173	PF00069	0.596
MOD_Plk_4	178	184	PF00069	0.381
MOD_Plk_4	71	77	PF00069	0.399
TRG_ENDOCYTIC_2	113	116	PF00928	0.498
TRG_ENDOCYTIC_2	130	133	PF00928	0.430
TRG_ENDOCYTIC_2	152	155	PF00928	0.449
TRG_ENDOCYTIC_2	280	283	PF00928	0.399
TRG_ENDOCYTIC_2	37	40	PF00928	0.475
TRG_ER_diArg_1	109	111	PF00400	0.295
TRG_ER_diArg_1	113	115	PF00400	0.386
TRG_ER_diArg_1	175	178	PF00400	0.478
TRG_ER_diArg_1	247	249	PF00400	0.439
TRG_ER_diArg_1	44	47	PF00400	0.479
TRG_ER_diArg_1	5	8	PF00400	0.558
TRG_ER_diArg_1	79	81	PF00400	0.469
TRG_ER_diArg_1	92	94	PF00400	0.512
TRG_NLS_Bipartite_1	92	112	PF00514	0.385
TRG_Pf-PMV_PEXEL_1	281	285	PF00026	0.411
TRG_Pf-PMV_PEXEL_1	47	51	PF00026	0.439

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I172	Leptomonas seymouri	35%	100%
A4H3H1	Leishmania braziliensis	43%	100%
E9AI30	Leishmania braziliensis	27%	100%