Ribosome production factor 2 homolog

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

brix domain containing-like protein

Species:

Leishmania mexicana

UniProt:

E8NHL4_LEIMU

TriTrypDb:

LmxM.26.0010 , LmxM.26.0010a

Length:

362

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005730	nucleolus	5	12
GO:0043226	organelle	2	12
GO:0043228	non-membrane-bounded organelle	3	12
GO:0043229	intracellular organelle	3	12
GO:0043232	intracellular non-membrane-bounded organelle	4	12
GO:0110165	cellular anatomical entity	1	12

Expansion

Sequence features

E8NHL4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E8NHL4

Function

Biological processes
Term	Name	Level	Count
GO:0000027	ribosomal large subunit assembly	7	12
GO:0000470	maturation of LSU-rRNA	9	12
GO:0006139	nucleobase-containing compound metabolic process	3	12
GO:0006364	rRNA processing	8	12
GO:0006396	RNA processing	6	12
GO:0006725	cellular aromatic compound metabolic process	3	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008152	metabolic process	1	12
GO:0009987	cellular process	1	12
GO:0016043	cellular component organization	3	12
GO:0016070	RNA metabolic process	5	12
GO:0016072	rRNA metabolic process	7	12
GO:0022607	cellular component assembly	4	12
GO:0022618	ribonucleoprotein complex assembly	6	12
GO:0034470	ncRNA processing	7	12
GO:0034641	cellular nitrogen compound metabolic process	3	12
GO:0034660	ncRNA metabolic process	6	12
GO:0043170	macromolecule metabolic process	3	12
GO:0043933	protein-containing complex organization	4	12
GO:0044237	cellular metabolic process	2	12
GO:0044238	primary metabolic process	2	12
GO:0046483	heterocycle metabolic process	3	12
GO:0065003	protein-containing complex assembly	5	12
GO:0071704	organic substance metabolic process	2	12
GO:0071826	ribonucleoprotein complex subunit organization	5	12
GO:0071840	cellular component organization or biogenesis	2	12
GO:0090304	nucleic acid metabolic process	4	12
GO:1901360	organic cyclic compound metabolic process	3	12
GO:0000463	maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	10	1

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	12
GO:0003723	RNA binding	4	12
GO:0005488	binding	1	12
GO:0019843	rRNA binding	5	12
GO:0097159	organic cyclic compound binding	2	12
GO:1901363	heterocyclic compound binding	2	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	286	290	PF00656	0.600
CLV_C14_Caspase3-7	352	356	PF00656	0.629
CLV_NRD_NRD_1	18	20	PF00675	0.463
CLV_NRD_NRD_1	260	262	PF00675	0.258
CLV_NRD_NRD_1	316	318	PF00675	0.462
CLV_NRD_NRD_1	322	324	PF00675	0.496
CLV_NRD_NRD_1	345	347	PF00675	0.641
CLV_NRD_NRD_1	9	11	PF00675	0.474
CLV_PCSK_FUR_1	343	347	PF00082	0.613
CLV_PCSK_KEX2_1	100	102	PF00082	0.241
CLV_PCSK_KEX2_1	18	20	PF00082	0.463
CLV_PCSK_KEX2_1	22	24	PF00082	0.464
CLV_PCSK_KEX2_1	260	262	PF00082	0.258
CLV_PCSK_KEX2_1	316	318	PF00082	0.462
CLV_PCSK_KEX2_1	322	324	PF00082	0.496
CLV_PCSK_KEX2_1	33	35	PF00082	0.341
CLV_PCSK_KEX2_1	343	345	PF00082	0.631
CLV_PCSK_KEX2_1	8	10	PF00082	0.481
CLV_PCSK_PC1ET2_1	100	102	PF00082	0.247
CLV_PCSK_PC1ET2_1	22	24	PF00082	0.464
CLV_PCSK_PC1ET2_1	33	35	PF00082	0.411
CLV_PCSK_PC1ET2_1	8	10	PF00082	0.481
CLV_PCSK_PC7_1	18	24	PF00082	0.518
CLV_PCSK_SKI1_1	10	14	PF00082	0.482
CLV_PCSK_SKI1_1	145	149	PF00082	0.243
CLV_PCSK_SKI1_1	165	169	PF00082	0.116
CLV_PCSK_SKI1_1	187	191	PF00082	0.308
CLV_PCSK_SKI1_1	19	23	PF00082	0.442
CLV_PCSK_SKI1_1	241	245	PF00082	0.333
CLV_PCSK_SKI1_1	316	320	PF00082	0.482
CLV_PCSK_SKI1_1	33	37	PF00082	0.442
CLV_PCSK_SKI1_1	64	68	PF00082	0.251
DEG_APCC_DBOX_1	277	285	PF00400	0.577
DEG_APCC_DBOX_1	76	84	PF00400	0.447
DOC_CKS1_1	264	269	PF01111	0.404
DOC_CYCLIN_RxL_1	162	170	PF00134	0.471
DOC_CYCLIN_RxL_1	31	42	PF00134	0.450
DOC_MAPK_gen_1	99	107	PF00069	0.447
DOC_MAPK_JIP1_4	101	107	PF00069	0.442
DOC_MAPK_MEF2A_6	173	182	PF00069	0.490
DOC_PP1_RVXF_1	185	192	PF00149	0.458
DOC_PP1_RVXF_1	258	265	PF00149	0.542
DOC_PP1_RVXF_1	31	38	PF00149	0.396
DOC_PP4_FxxP_1	264	267	PF00568	0.389
DOC_USP7_MATH_1	353	357	PF00917	0.677
DOC_USP7_UBL2_3	59	63	PF12436	0.449
DOC_USP7_UBL2_3	64	68	PF12436	0.444
DOC_WW_Pin1_4	263	268	PF00397	0.393
LIG_14-3-3_CanoR_1	260	265	PF00244	0.522
LIG_14-3-3_CanoR_1	278	282	PF00244	0.486
LIG_14-3-3_CanoR_1	285	289	PF00244	0.492
LIG_Actin_WH2_2	269	287	PF00022	0.530
LIG_BIR_II_1	1	5	PF00653	0.519
LIG_EH1_1	112	120	PF00400	0.447
LIG_FHA_1	132	138	PF00498	0.533
LIG_FHA_2	194	200	PF00498	0.355
LIG_FHA_2	264	270	PF00498	0.404
LIG_LIR_Apic_2	263	267	PF02991	0.401
LIG_LIR_Gen_1	112	121	PF02991	0.431
LIG_LIR_Gen_1	158	169	PF02991	0.447
LIG_LIR_Nem_3	112	116	PF02991	0.431
LIG_LIR_Nem_3	158	164	PF02991	0.447
LIG_LIR_Nem_3	81	85	PF02991	0.458
LIG_NRBOX	163	169	PF00104	0.471
LIG_PDZ_Class_1	357	362	PF00595	0.638
LIG_REV1ctd_RIR_1	188	198	PF16727	0.552
LIG_SH2_GRB2like	210	213	PF00017	0.533
LIG_SH2_STAT5	171	174	PF00017	0.552
LIG_SH2_STAT5	210	213	PF00017	0.533
LIG_SH2_STAT5	61	64	PF00017	0.533
LIG_SH3_3	227	233	PF00018	0.500
LIG_SH3_3	26	32	PF00018	0.447
LIG_SH3_4	59	66	PF00018	0.458
LIG_TRAF2_1	266	269	PF00917	0.497
LIG_TRAF2_1	335	338	PF00917	0.493
LIG_UBA3_1	54	59	PF00899	0.506
MOD_CK1_1	157	163	PF00069	0.492
MOD_CK1_1	192	198	PF00069	0.477
MOD_CK1_1	234	240	PF00069	0.506
MOD_CK1_1	263	269	PF00069	0.415
MOD_CK2_1	193	199	PF00069	0.355
MOD_CK2_1	263	269	PF00069	0.397
MOD_CK2_1	353	359	PF00069	0.676
MOD_GlcNHglycan	205	208	PF01048	0.291
MOD_GlcNHglycan	233	236	PF01048	0.334
MOD_GlcNHglycan	326	329	PF01048	0.695
MOD_GSK3_1	150	157	PF00069	0.508
MOD_GSK3_1	189	196	PF00069	0.502
MOD_GSK3_1	280	287	PF00069	0.486
MOD_GSK3_1	333	340	PF00069	0.657
MOD_GSK3_1	353	360	PF00069	0.676
MOD_LATS_1	321	327	PF00433	0.495
MOD_N-GLC_1	103	108	PF02516	0.317
MOD_N-GLC_1	13	18	PF02516	0.553
MOD_N-GLC_2	87	89	PF02516	0.247
MOD_NEK2_1	129	134	PF00069	0.508
MOD_NEK2_1	189	194	PF00069	0.458
MOD_NEK2_1	94	99	PF00069	0.533
MOD_PIKK_1	129	135	PF00454	0.533
MOD_PKA_1	231	237	PF00069	0.533
MOD_PKA_1	260	266	PF00069	0.525
MOD_PKA_1	8	14	PF00069	0.571
MOD_PKA_2	193	199	PF00069	0.355
MOD_PKA_2	260	266	PF00069	0.509
MOD_PKA_2	277	283	PF00069	0.486
MOD_PKA_2	284	290	PF00069	0.479
MOD_PKA_2	8	14	PF00069	0.571
MOD_PKB_1	346	354	PF00069	0.669
MOD_Plk_1	103	109	PF00069	0.447
MOD_Plk_1	87	93	PF00069	0.447
MOD_Plk_2-3	333	339	PF00069	0.493
MOD_Plk_4	157	163	PF00069	0.477
MOD_Plk_4	87	93	PF00069	0.447
MOD_ProDKin_1	263	269	PF00069	0.397
MOD_SUMO_rev_2	263	273	PF00179	0.426
TRG_ER_diArg_1	259	261	PF00400	0.458
TRG_ER_diArg_1	315	317	PF00400	0.467
TRG_ER_diArg_1	342	345	PF00400	0.626
TRG_ER_diArg_1	346	349	PF00400	0.630
TRG_NES_CRM1_1	294	309	PF08389	0.468

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3Z8	Leptomonas seymouri	84%	100%
A0A0S4IUC1	Bodo saltans	57%	100%
A0A1X0NSB0	Trypanosomatidae	63%	93%
A0A3S7WZF9	Leishmania donovani	94%	100%
A0A422N200	Trypanosoma rangeli	67%	100%
A4HEK9	Leishmania braziliensis	83%	100%
A4I1U0	Leishmania infantum	95%	100%
C9ZRP9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	63%	98%
P36160	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	32%	100%
Q2YDN6	Bos taurus	33%	100%
Q4Q9J0	Leishmania major	94%	100%
Q54DJ0	Dictyostelium discoideum	31%	100%
Q9AWM9	Oryza sativa subsp. japonica	30%	100%
Q9H7B2	Homo sapiens	33%	100%
Q9JJ80	Mus musculus	33%	100%
Q9LUG5	Arabidopsis thaliana	29%	100%
Q9N3F0	Caenorhabditis elegans	32%	100%
Q9UUG1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	32%	100%
Q9VEB3	Drosophila melanogaster	33%	100%
V5BAA9	Trypanosoma cruzi	70%	100%