Uncharacterized protein LmxM_08_1030a_1

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein

Species:

Leishmania mexicana

UniProt:

E8NHL3_LEIMU

TriTrypDb:

LmxM.08.1030a

Length:

533

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 95

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 21

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 27, no: 5
NetGPI	no	yes: 0, no: 32

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	4
GO:0000323	lytic vacuole	6	3
GO:0005615	extracellular space	2	3
GO:0005764	lysosome	7	3
GO:0005773	vacuole	5	3
GO:0043226	organelle	2	3
GO:0043227	membrane-bounded organelle	3	3
GO:0043229	intracellular organelle	3	3
GO:0043231	intracellular membrane-bounded organelle	4	3

Expansion

Sequence features

E8NHL3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E8NHL3

Function

Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	33
GO:0006807	nitrogen compound metabolic process	2	33
GO:0008152	metabolic process	1	33
GO:0019538	protein metabolic process	3	33
GO:0043170	macromolecule metabolic process	3	33
GO:0044238	primary metabolic process	2	33
GO:0071704	organic substance metabolic process	2	33
GO:1901564	organonitrogen compound metabolic process	3	33
GO:0051603	proteolysis involved in protein catabolic process	5	3

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	33
GO:0004175	endopeptidase activity	4	24
GO:0004197	cysteine-type endopeptidase activity	5	24
GO:0008233	peptidase activity	3	33
GO:0008234	cysteine-type peptidase activity	4	33
GO:0016787	hydrolase activity	2	33
GO:0140096	catalytic activity, acting on a protein	2	33

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	273	277	PF00656	0.380
CLV_C14_Caspase3-7	512	516	PF00656	0.486
CLV_NRD_NRD_1	206	208	PF00675	0.659
CLV_NRD_NRD_1	39	41	PF00675	0.578
CLV_NRD_NRD_1	466	468	PF00675	0.469
CLV_PCSK_KEX2_1	132	134	PF00082	0.639
CLV_PCSK_KEX2_1	199	201	PF00082	0.547
CLV_PCSK_KEX2_1	39	41	PF00082	0.394
CLV_PCSK_PC1ET2_1	132	134	PF00082	0.639
CLV_PCSK_PC1ET2_1	199	201	PF00082	0.542
CLV_PCSK_SKI1_1	95	99	PF00082	0.411
CLV_Separin_Metazoa	157	161	PF03568	0.383
DEG_APCC_DBOX_1	209	217	PF00400	0.455
DEG_APCC_DBOX_1	94	102	PF00400	0.613
DEG_SPOP_SBC_1	436	440	PF00917	0.399
DEG_SPOP_SBC_1	46	50	PF00917	0.604
DOC_CDC14_PxL_1	17	25	PF14671	0.583
DOC_CKS1_1	120	125	PF01111	0.543
DOC_CKS1_1	511	516	PF01111	0.310
DOC_CYCLIN_RxL_1	148	161	PF00134	0.383
DOC_CYCLIN_yCln2_LP_2	8	14	PF00134	0.565
DOC_MAPK_MEF2A_6	347	355	PF00069	0.339
DOC_PP2B_LxvP_1	8	11	PF13499	0.559
DOC_PP4_FxxP_1	511	514	PF00568	0.258
DOC_USP7_MATH_1	236	240	PF00917	0.447
DOC_USP7_MATH_1	305	309	PF00917	0.327
DOC_USP7_MATH_1	314	318	PF00917	0.327
DOC_USP7_MATH_1	436	440	PF00917	0.278
DOC_USP7_MATH_1	47	51	PF00917	0.711
DOC_USP7_MATH_1	64	68	PF00917	0.655
DOC_USP7_UBL2_3	468	472	PF12436	0.271
DOC_WW_Pin1_4	119	124	PF00397	0.513
DOC_WW_Pin1_4	22	27	PF00397	0.581
DOC_WW_Pin1_4	226	231	PF00397	0.358
DOC_WW_Pin1_4	441	446	PF00397	0.293
DOC_WW_Pin1_4	487	492	PF00397	0.223
DOC_WW_Pin1_4	49	54	PF00397	0.597
DOC_WW_Pin1_4	510	515	PF00397	0.436
DOC_WW_Pin1_4	70	75	PF00397	0.581
LIG_14-3-3_CanoR_1	40	46	PF00244	0.596
LIG_14-3-3_CanoR_1	467	471	PF00244	0.365
LIG_14-3-3_CanoR_1	57	63	PF00244	0.581
LIG_BRCT_BRCA1_1	499	503	PF00533	0.222
LIG_FHA_1	367	373	PF00498	0.353
LIG_FHA_1	386	392	PF00498	0.291
LIG_FHA_2	139	145	PF00498	0.413
LIG_FHA_2	31	37	PF00498	0.599
LIG_FHA_2	438	444	PF00498	0.304
LIG_LIR_Gen_1	406	416	PF02991	0.355
LIG_LIR_Gen_1	67	77	PF02991	0.583
LIG_LIR_LC3C_4	319	324	PF02991	0.241
LIG_LIR_Nem_3	174	179	PF02991	0.385
LIG_LIR_Nem_3	301	307	PF02991	0.360
LIG_LIR_Nem_3	358	363	PF02991	0.318
LIG_LIR_Nem_3	390	396	PF02991	0.332
LIG_LIR_Nem_3	406	412	PF02991	0.307
LIG_LIR_Nem_3	67	72	PF02991	0.589
LIG_LYPXL_yS_3	304	307	PF13949	0.293
LIG_MYND_1	11	15	PF01753	0.564
LIG_PCNA_PIPBox_1	170	179	PF02747	0.250
LIG_PCNA_yPIPBox_3	165	177	PF02747	0.250
LIG_SH2_GRB2like	188	191	PF00017	0.404
LIG_SH2_GRB2like	499	502	PF00017	0.374
LIG_SH2_PTP2	409	412	PF00017	0.318
LIG_SH2_SRC	188	191	PF00017	0.450
LIG_SH2_STAP1	139	143	PF00017	0.344
LIG_SH2_STAP1	499	503	PF00017	0.222
LIG_SH2_STAT5	188	191	PF00017	0.397
LIG_SH2_STAT5	194	197	PF00017	0.395
LIG_SH2_STAT5	254	257	PF00017	0.264
LIG_SH2_STAT5	306	309	PF00017	0.311
LIG_SH2_STAT5	312	315	PF00017	0.310
LIG_SH2_STAT5	409	412	PF00017	0.318
LIG_SH2_STAT5	521	524	PF00017	0.396
LIG_SH2_STAT5	55	58	PF00017	0.595
LIG_SH3_3	117	123	PF00018	0.507
LIG_SH3_3	25	31	PF00018	0.580
LIG_SH3_3	3	9	PF00018	0.567
LIG_SH3_3	81	87	PF00018	0.660
LIG_Sin3_3	10	17	PF02671	0.568
LIG_SUMO_SIM_par_1	259	265	PF11976	0.331
LIG_SUMO_SIM_par_1	448	453	PF11976	0.242
LIG_TRFH_1	80	84	PF08558	0.582
LIG_TYR_ITIM	391	396	PF00017	0.380
MOD_CDC14_SPxK_1	490	493	PF00782	0.222
MOD_CDK_SPK_2	22	27	PF00069	0.581
MOD_CDK_SPK_2	70	75	PF00069	0.581
MOD_CDK_SPxK_1	226	232	PF00069	0.358
MOD_CDK_SPxK_1	487	493	PF00069	0.222
MOD_CDK_SPxxK_3	441	448	PF00069	0.314
MOD_CDK_SPxxK_3	510	517	PF00069	0.324
MOD_CK1_1	317	323	PF00069	0.384
MOD_CK1_1	359	365	PF00069	0.328
MOD_CK1_1	439	445	PF00069	0.330
MOD_CK1_1	73	79	PF00069	0.579
MOD_CK2_1	138	144	PF00069	0.371
MOD_CK2_1	177	183	PF00069	0.320
MOD_CK2_1	259	265	PF00069	0.311
MOD_CK2_1	437	443	PF00069	0.297
MOD_GlcNHglycan	212	216	PF01048	0.718
MOD_GlcNHglycan	243	246	PF01048	0.615
MOD_GlcNHglycan	307	310	PF01048	0.528
MOD_GlcNHglycan	364	367	PF01048	0.593
MOD_GlcNHglycan	426	429	PF01048	0.548
MOD_GlcNHglycan	432	435	PF01048	0.503
MOD_GlcNHglycan	66	69	PF01048	0.390
MOD_GlcNHglycan	88	91	PF01048	0.483
MOD_GSK3_1	355	362	PF00069	0.341
MOD_GSK3_1	41	48	PF00069	0.664
MOD_GSK3_1	435	442	PF00069	0.350
MOD_GSK3_1	49	56	PF00069	0.638
MOD_GSK3_1	522	529	PF00069	0.388
MOD_GSK3_1	82	89	PF00069	0.575
MOD_N-GLC_1	317	322	PF02516	0.587
MOD_N-GLC_1	460	465	PF02516	0.472
MOD_N-GLC_2	417	419	PF02516	0.540
MOD_N-GLC_2	474	476	PF02516	0.536
MOD_N-GLC_2	528	530	PF02516	0.521
MOD_NEK2_1	131	136	PF00069	0.421
MOD_NEK2_1	171	176	PF00069	0.432
MOD_NEK2_1	291	296	PF00069	0.286
MOD_NEK2_1	355	360	PF00069	0.385
MOD_NEK2_1	45	50	PF00069	0.729
MOD_NEK2_1	522	527	PF00069	0.382
MOD_NEK2_1	91	96	PF00069	0.741
MOD_PIKK_1	460	466	PF00454	0.252
MOD_PKA_2	430	436	PF00069	0.239
MOD_PKA_2	466	472	PF00069	0.234
MOD_Plk_1	211	217	PF00069	0.523
MOD_Plk_1	300	306	PF00069	0.312
MOD_Plk_1	355	361	PF00069	0.291
MOD_Plk_2-3	259	265	PF00069	0.241
MOD_Plk_4	30	36	PF00069	0.644
MOD_Plk_4	356	362	PF00069	0.304
MOD_Plk_4	41	47	PF00069	0.740
MOD_Plk_4	466	472	PF00069	0.367
MOD_Plk_4	482	488	PF00069	0.241
MOD_Plk_4	522	528	PF00069	0.349
MOD_ProDKin_1	119	125	PF00069	0.507
MOD_ProDKin_1	22	28	PF00069	0.579
MOD_ProDKin_1	226	232	PF00069	0.358
MOD_ProDKin_1	441	447	PF00069	0.298
MOD_ProDKin_1	487	493	PF00069	0.223
MOD_ProDKin_1	49	55	PF00069	0.598
MOD_ProDKin_1	510	516	PF00069	0.438
MOD_ProDKin_1	70	76	PF00069	0.581
MOD_SUMO_rev_2	129	134	PF00179	0.432
MOD_SUMO_rev_2	512	519	PF00179	0.331
TRG_DiLeu_BaEn_4	144	150	PF01217	0.365
TRG_DiLeu_BaLyEn_6	18	23	PF01217	0.583
TRG_ENDOCYTIC_2	139	142	PF00928	0.374
TRG_ENDOCYTIC_2	304	307	PF00928	0.309
TRG_ENDOCYTIC_2	393	396	PF00928	0.318
TRG_ENDOCYTIC_2	409	412	PF00928	0.318
TRG_ER_diArg_1	39	41	PF00400	0.594
TRG_NES_CRM1_1	147	161	PF08389	0.383
TRG_NLS_MonoExtC_3	206	212	PF00514	0.490

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PA65	Leptomonas seymouri	44%	100%
A0A0S4ISD8	Bodo saltans	41%	100%
A0A0S4J628	Bodo saltans	45%	97%
A0A0S4KJA5	Bodo saltans	42%	100%
A0A3R7L7E7	Trypanosoma rangeli	47%	100%
A0A3S5H682	Leishmania donovani	80%	100%
A0A3S5H683	Leishmania donovani	80%	100%
A0A3S5H684	Leishmania donovani	80%	100%
A0A3S5H685	Leishmania donovani	80%	100%
A0A3S7WQD0	Leishmania donovani	80%	100%
A0A6L0WJ22	Leishmania infantum	81%	100%
A4H5E4	Leishmania braziliensis	67%	100%
A4H5E5	Leishmania braziliensis	65%	100%
A4H5E6	Leishmania braziliensis	65%	100%
A4HA92	Leishmania braziliensis	44%	100%
A4HTP0	Leishmania infantum	78%	100%
A4HYH2	Leishmania infantum	47%	100%
A5HII1	Actinidia deliciosa	31%	100%
C9ZQB3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	46%	100%
C9ZQB5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	46%	100%
C9ZQB6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	47%	100%
E8NHD8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	98%	100%
E8NHJ1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	100%	100%
E8NHS3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	99%	100%
E9AMH5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	98%	100%
E9AMH6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	98%	100%
E9AMH7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	98%	100%
E9AS96	Leishmania mexicana (strain MHOM/GT/2001/U1103)	48%	100%
F4JNL3	Arabidopsis thaliana	31%	100%
P14658	Trypanosoma brucei brucei	46%	100%
P25779	Trypanosoma cruzi	47%	100%
P36400	Leishmania mexicana	100%	100%
P42666	Plasmodium vivax (strain Salvador I)	28%	91%
P43510	Caenorhabditis elegans	25%	100%
Q05094	Leishmania pifanoi	100%	100%
Q4QD68	Leishmania major	48%	100%
Q4QI61	Leishmania major	74%	100%
Q4QI66	Leishmania major	74%	100%
Q93VC9	Arabidopsis thaliana	27%	100%
Q9BIE1	Leishmania donovani	47%	100%