Uncharacterized protein LmxM_30_0460g_1

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein

Species:

Leishmania mexicana

UniProt:

E8NHK8_LEIMU

TriTrypDb:

LmxM.30.0460g

Length:

279

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 2
NetGPI	no	yes: 0, no: 2

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E8NHK8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E8NHK8

Function

Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	2
GO:0006807	nitrogen compound metabolic process	2	2
GO:0008152	metabolic process	1	2
GO:0019538	protein metabolic process	3	2
GO:0043170	macromolecule metabolic process	3	2
GO:0044238	primary metabolic process	2	2
GO:0071704	organic substance metabolic process	2	2
GO:1901564	organonitrogen compound metabolic process	3	2

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	3
GO:0004175	endopeptidase activity	4	2
GO:0004197	cysteine-type endopeptidase activity	5	2
GO:0004198	calcium-dependent cysteine-type endopeptidase activity	6	2
GO:0008233	peptidase activity	3	2
GO:0008234	cysteine-type peptidase activity	4	2
GO:0016787	hydrolase activity	2	3
GO:0140096	catalytic activity, acting on a protein	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	59	63	PF00656	0.429
CLV_NRD_NRD_1	101	103	PF00675	0.331
CLV_NRD_NRD_1	116	118	PF00675	0.432
CLV_NRD_NRD_1	43	45	PF00675	0.266
CLV_PCSK_KEX2_1	116	118	PF00082	0.462
CLV_PCSK_KEX2_1	252	254	PF00082	0.437
CLV_PCSK_KEX2_1	43	45	PF00082	0.264
CLV_PCSK_PC1ET2_1	252	254	PF00082	0.437
CLV_PCSK_SKI1_1	106	110	PF00082	0.295
CLV_PCSK_SKI1_1	11	15	PF00082	0.229
CLV_PCSK_SKI1_1	129	133	PF00082	0.298
CLV_PCSK_SKI1_1	189	193	PF00082	0.348
CLV_PCSK_SKI1_1	199	203	PF00082	0.318
DEG_APCC_DBOX_1	8	16	PF00400	0.240
DEG_MDM2_SWIB_1	56	64	PF02201	0.429
DEG_ODPH_VHL_1	206	218	PF01847	0.335
DOC_CYCLIN_RxL_1	102	112	PF00134	0.308
DOC_CYCLIN_RxL_1	126	136	PF00134	0.311
DOC_MAPK_DCC_7	3	12	PF00069	0.311
DOC_MAPK_gen_1	102	109	PF00069	0.308
DOC_MAPK_gen_1	214	223	PF00069	0.318
DOC_MAPK_gen_1	258	265	PF00069	0.315
DOC_MAPK_MEF2A_6	169	177	PF00069	0.308
DOC_MAPK_MEF2A_6	3	12	PF00069	0.402
DOC_MAPK_RevD_3	89	103	PF00069	0.289
DOC_PP1_RVXF_1	104	110	PF00149	0.298
DOC_PP1_RVXF_1	215	221	PF00149	0.311
DOC_PP4_FxxP_1	5	8	PF00568	0.319
DOC_USP7_MATH_1	18	22	PF00917	0.527
DOC_USP7_MATH_1	208	212	PF00917	0.338
LIG_14-3-3_CanoR_1	189	198	PF00244	0.381
LIG_14-3-3_CanoR_1	217	221	PF00244	0.309
LIG_14-3-3_CanoR_1	231	237	PF00244	0.327
LIG_14-3-3_CanoR_1	43	51	PF00244	0.429
LIG_Actin_WH2_2	216	233	PF00022	0.321
LIG_deltaCOP1_diTrp_1	24	29	PF00928	0.429
LIG_deltaCOP1_diTrp_1	59	67	PF00928	0.429
LIG_FHA_1	142	148	PF00498	0.371
LIG_FHA_2	262	268	PF00498	0.380
LIG_IRF3_LxIS_1	127	134	PF10401	0.312
LIG_LIR_Apic_2	272	278	PF02991	0.451
LIG_LIR_Gen_1	161	171	PF02991	0.377
LIG_LIR_Gen_1	219	228	PF02991	0.463
LIG_LIR_Nem_3	125	131	PF02991	0.372
LIG_LIR_Nem_3	161	166	PF02991	0.368
LIG_LIR_Nem_3	219	223	PF02991	0.489
LIG_Pex14_2	56	60	PF04695	0.429
LIG_Pex14_2	84	88	PF04695	0.318
LIG_SH2_CRK	128	132	PF00017	0.347
LIG_SH2_CRK	82	86	PF00017	0.276
LIG_SH2_PTP2	185	188	PF00017	0.333
LIG_SH2_SRC	163	166	PF00017	0.330
LIG_SH2_SRC	185	188	PF00017	0.294
LIG_SH2_SRC	275	278	PF00017	0.477
LIG_SH2_STAP1	163	167	PF00017	0.335
LIG_SH2_STAT5	165	168	PF00017	0.332
LIG_SH2_STAT5	185	188	PF00017	0.292
LIG_SH2_STAT5	275	278	PF00017	0.477
LIG_SH3_3	118	124	PF00018	0.461
LIG_SH3_3	154	160	PF00018	0.370
LIG_SH3_3	218	224	PF00018	0.303
LIG_SH3_3	231	237	PF00018	0.352
LIG_SUMO_SIM_par_1	131	136	PF11976	0.323
LIG_SUMO_SIM_par_1	146	153	PF11976	0.318
LIG_UBA3_1	107	114	PF00899	0.306
MOD_CK1_1	49	55	PF00069	0.429
MOD_CK2_1	18	24	PF00069	0.429
MOD_CMANNOS	57	60	PF00535	0.229
MOD_GlcNHglycan	20	23	PF01048	0.330
MOD_GSK3_1	42	49	PF00069	0.429
MOD_N-GLC_1	208	213	PF02516	0.341
MOD_N-GLC_1	31	36	PF02516	0.229
MOD_NEK2_1	107	112	PF00069	0.442
MOD_NEK2_1	131	136	PF00069	0.290
MOD_NEK2_1	216	221	PF00069	0.307
MOD_NEK2_1	266	271	PF00069	0.338
MOD_NEK2_2	261	266	PF00069	0.311
MOD_PIKK_1	109	115	PF00454	0.362
MOD_PIKK_1	141	147	PF00454	0.347
MOD_PKA_2	216	222	PF00069	0.310
MOD_PKA_2	42	48	PF00069	0.464
MOD_Plk_1	199	205	PF00069	0.347
MOD_Plk_1	266	272	PF00069	0.348
MOD_Plk_4	216	222	PF00069	0.348
MOD_Plk_4	271	277	PF00069	0.428
MOD_Plk_4	37	43	PF00069	0.470
MOD_Plk_4	52	58	PF00069	0.407
MOD_Plk_4	91	97	PF00069	0.273
MOD_SUMO_for_1	97	100	PF00179	0.267
TRG_ENDOCYTIC_2	128	131	PF00928	0.351
TRG_ENDOCYTIC_2	163	166	PF00928	0.334
TRG_ER_diArg_1	116	118	PF00400	0.421
TRG_ER_diArg_1	42	44	PF00400	0.429
TRG_NLS_MonoExtC_3	101	106	PF00514	0.316
TRG_NLS_MonoExtN_4	102	107	PF00514	0.315

Homologs


Protein	Taxonomy	Sequence identity	Coverage
E9AIH2	Leishmania braziliensis	32%	98%