WGS CADB00000000 data, contig 52

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Protein of unknown function (DUF2946), putative

Species:

Leishmania mexicana

UniProt:

E8NHK6_LEIMU

TriTrypDb:

Length:

1898

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 30

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

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Cellular components
Term	Name	Level	Count
GO:0005856	cytoskeleton	5	1
GO:0005871	kinesin complex	3	1
GO:0005874	microtubule	6	1
GO:0005875	microtubule associated complex	2	1
GO:0020016	ciliary pocket	2	1
GO:0030863	cortical cytoskeleton	6	1
GO:0032991	protein-containing complex	1	1
GO:0043226	organelle	2	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1

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Expansion

Sequence features

E8NHK6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

No structure information available for this entry

Related structures:

Function

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Biological processes
Term	Name	Level	Count
GO:0007017	microtubule-based process	2	8
GO:0007018	microtubule-based movement	3	8
GO:0009987	cellular process	1	8

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Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	8
GO:0003774	cytoskeletal motor activity	1	8
GO:0003777	microtubule motor activity	2	8
GO:0003824	catalytic activity	1	2
GO:0005488	binding	1	8
GO:0005515	protein binding	2	8
GO:0005524	ATP binding	5	8
GO:0008017	microtubule binding	5	8
GO:0008092	cytoskeletal protein binding	3	8
GO:0015631	tubulin binding	4	8

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	334	338	PF00656	0.291
CLV_C14_Caspase3-7	507	511	PF00656	0.477
CLV_NRD_NRD_1	170	172	PF00675	0.315
CLV_NRD_NRD_1	2	4	PF00675	0.497
CLV_NRD_NRD_1	384	386	PF00675	0.379
CLV_NRD_NRD_1	524	526	PF00675	0.419
CLV_PCSK_KEX2_1	2	4	PF00082	0.559
CLV_PCSK_KEX2_1	495	497	PF00082	0.445
CLV_PCSK_KEX2_1	524	526	PF00082	0.419
CLV_PCSK_KEX2_1	606	608	PF00082	0.505

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A4H7R4	Leishmania braziliensis	28%	88%
A4HX43	Leishmania infantum	93%	68%
C9ZVU7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	100%
E9APV7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	24%	82%
E9AQV9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	96%	75%
Q4QEL9	Leishmania major	94%	100%

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