WGS CADB00000000 data, contig 50

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

flagellar attachment zone protein, putative (fragment)

Species:

Leishmania mexicana

UniProt:

E8NHK3_LEIMU

TriTrypDb:

LmxM.14.1120a

Length:

753

Annotations

LeishMANIAdb annotations

A family of very long coiled-coil proteins, likely performing cytoskeletal functions.. Two varieties have evolved, one with an N-terminal FYVE domain (Non-TM) and another with a C-terminal PDZ domain (might be TM)

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 5

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E8NHK3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E8NHK3

Function

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Biological processes
Term	Name	Level	Count
GO:0007017	microtubule-based process	2	4
GO:0007018	microtubule-based movement	3	4
GO:0009987	cellular process	1	4

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Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	1
GO:0003774	cytoskeletal motor activity	1	4
GO:0003777	microtubule motor activity	2	4
GO:0005488	binding	1	1
GO:0005515	protein binding	2	1
GO:0005524	ATP binding	5	1
GO:0008017	microtubule binding	5	1
GO:0008092	cytoskeletal protein binding	3	1
GO:0015631	tubulin binding	4	1
GO:0017076	purine nucleotide binding	4	1

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	101	105	PF00656	0.519
CLV_C14_Caspase3-7	108	112	PF00656	0.512
CLV_C14_Caspase3-7	136	140	PF00656	0.568
CLV_C14_Caspase3-7	143	147	PF00656	0.518
CLV_C14_Caspase3-7	171	175	PF00656	0.583
CLV_C14_Caspase3-7	178	182	PF00656	0.529
CLV_C14_Caspase3-7	206	210	PF00656	0.589
CLV_C14_Caspase3-7	213	217	PF00656	0.535
CLV_C14_Caspase3-7	241	245	PF00656	0.584
CLV_C14_Caspase3-7	248	252	PF00656	0.536

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A4H7T4	Leishmania braziliensis	72%	100%
A4HBI8	Leishmania braziliensis	35%	100%
A4HW56	Leishmania infantum	80%	88%
C9ZVU8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	67%

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