LeishMANIAdb
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WGS CADB00000000 data, contig 48

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
WGS CADB00000000 data, contig 48
Gene product:
flagellar attachment zone protein, putative (fragment)
Species:
Leishmania mexicana
UniProt:
E8NHK1_LEIMU
TriTrypDb:
LmxM.16.1460a
Length:
694

Annotations

LeishMANIAdb annotations

A family of very long coiled-coil proteins, likely performing cytoskeletal functions.. Two varieties have evolved, one with an N-terminal FYVE domain (Non-TM) and another with a C-terminal PDZ domain (might be TM)

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. yes yes: 10
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 3
NetGPI no yes: 0, no: 3
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E8NHK1
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E8NHK1

Function

Biological processes
Term Name Level Count
GO:0007017 microtubule-based process 2 3
GO:0007018 microtubule-based movement 3 3
GO:0009987 cellular process 1 3
Molecular functions
Term Name Level Count
GO:0003774 cytoskeletal motor activity 1 3
GO:0003777 microtubule motor activity 2 3
GO:0140657 ATP-dependent activity 1 3
GO:0003824 catalytic activity 1 1
GO:0016787 hydrolase activity 2 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 31 35 PF00656 0.486
CLV_NRD_NRD_1 48 50 PF00675 0.574
CLV_PCSK_KEX2_1 130 132 PF00082 0.506
CLV_PCSK_KEX2_1 19 21 PF00082 0.477
CLV_PCSK_KEX2_1 48 50 PF00082 0.574
CLV_PCSK_PC1ET2_1 130 132 PF00082 0.506
CLV_PCSK_PC1ET2_1 19 21 PF00082 0.477
DEG_Nend_UBRbox_2 1 2 PF02207 0.589
DOC_MIT_MIM_1 67 75 PF04212 0.473
DOC_USP7_MATH_1 152 156 PF00917 0.564
DOC_USP7_MATH_1 28 32 PF00917 0.485
LIG_14-3-3_CanoR_1 143 147 PF00244 0.500
LIG_14-3-3_CanoR_1 148 152 PF00244 0.480
LIG_14-3-3_CanoR_1 27 37 PF00244 0.485
LIG_14-3-3_CanoR_1 71 79 PF00244 0.471
LIG_14-3-3_CanoR_1 88 97 PF00244 0.384
LIG_FHA_1 39 45 PF00498 0.583
LIG_FHA_2 185 191 PF00498 0.703
LIG_FHA_2 199 205 PF00498 0.587
LIG_FHA_2 213 219 PF00498 0.598
LIG_FHA_2 227 233 PF00498 0.760
LIG_FHA_2 241 247 PF00498 0.606
LIG_FHA_2 255 261 PF00498 0.608
LIG_FHA_2 269 275 PF00498 0.760
LIG_FHA_2 283 289 PF00498 0.591
LIG_FHA_2 297 303 PF00498 0.582
LIG_FHA_2 311 317 PF00498 0.743
LIG_FHA_2 325 331 PF00498 0.579
LIG_FHA_2 339 345 PF00498 0.573
LIG_FHA_2 353 359 PF00498 0.733
LIG_FHA_2 367 373 PF00498 0.571
LIG_FHA_2 381 387 PF00498 0.567
LIG_FHA_2 409 415 PF00498 0.754
LIG_FHA_2 423 429 PF00498 0.613
LIG_FHA_2 437 443 PF00498 0.619
LIG_FHA_2 465 471 PF00498 0.687
LIG_FHA_2 479 485 PF00498 0.604
LIG_FHA_2 493 499 PF00498 0.767
LIG_FHA_2 521 527 PF00498 0.674
LIG_FHA_2 591 597 PF00498 0.748
LIG_FHA_2 619 625 PF00498 0.719
LIG_FHA_2 633 639 PF00498 0.546
LIG_FHA_2 647 653 PF00498 0.691
LIG_GBD_Chelix_1 50 58 PF00786 0.464
LIG_SH2_STAP1 22 26 PF00017 0.483
LIG_TRAF2_1 155 158 PF00917 0.671
LIG_TRAF2_1 187 190 PF00917 0.822
LIG_TRAF2_1 201 204 PF00917 0.621
LIG_TRAF2_1 215 218 PF00917 0.638
LIG_TRAF2_1 229 232 PF00917 0.873
LIG_TRAF2_1 243 246 PF00917 0.636
LIG_TRAF2_1 257 260 PF00917 0.650
LIG_TRAF2_1 271 274 PF00917 0.877
LIG_TRAF2_1 285 288 PF00917 0.623
LIG_TRAF2_1 299 302 PF00917 0.619
LIG_TRAF2_1 313 316 PF00917 0.771
LIG_TRAF2_1 327 330 PF00917 0.688
LIG_TRAF2_1 341 344 PF00917 0.611
LIG_TRAF2_1 355 358 PF00917 0.730
LIG_TRAF2_1 369 372 PF00917 0.569
LIG_TRAF2_1 383 386 PF00917 0.565
LIG_TRAF2_1 411 414 PF00917 0.868
LIG_TRAF2_1 425 428 PF00917 0.647
LIG_TRAF2_1 439 442 PF00917 0.659
LIG_TRAF2_1 467 470 PF00917 0.685
LIG_TRAF2_1 481 484 PF00917 0.604
LIG_TRAF2_1 495 498 PF00917 0.886
LIG_TRAF2_1 523 526 PF00917 0.710
LIG_TRAF2_1 593 596 PF00917 0.762
LIG_TRAF2_1 621 624 PF00917 0.834
LIG_TRAF2_1 635 638 PF00917 0.561
LIG_TRAF2_1 649 652 PF00917 0.807
LIG_TRAF2_1 691 694 PF00917 0.724
MOD_CK1_1 126 132 PF00069 0.502
MOD_CK1_1 33 39 PF00069 0.482
MOD_CK2_1 152 158 PF00069 0.604
MOD_CK2_1 184 190 PF00069 0.816
MOD_CK2_1 198 204 PF00069 0.615
MOD_CK2_1 212 218 PF00069 0.609
MOD_CK2_1 226 232 PF00069 0.877
MOD_CK2_1 240 246 PF00069 0.641
MOD_CK2_1 254 260 PF00069 0.621
MOD_CK2_1 268 274 PF00069 0.878
MOD_CK2_1 282 288 PF00069 0.625
MOD_CK2_1 296 302 PF00069 0.581
MOD_CK2_1 310 316 PF00069 0.741
MOD_CK2_1 324 330 PF00069 0.578
MOD_CK2_1 338 344 PF00069 0.572
MOD_CK2_1 352 358 PF00069 0.731
MOD_CK2_1 366 372 PF00069 0.569
MOD_CK2_1 37 43 PF00069 0.475
MOD_CK2_1 380 386 PF00069 0.566
MOD_CK2_1 408 414 PF00069 0.866
MOD_CK2_1 422 428 PF00069 0.648
MOD_CK2_1 436 442 PF00069 0.619
MOD_CK2_1 464 470 PF00069 0.688
MOD_CK2_1 478 484 PF00069 0.604
MOD_CK2_1 492 498 PF00069 0.884
MOD_CK2_1 520 526 PF00069 0.669
MOD_CK2_1 590 596 PF00069 0.861
MOD_CK2_1 618 624 PF00069 0.835
MOD_CK2_1 632 638 PF00069 0.580
MOD_CK2_1 646 652 PF00069 0.806
MOD_CK2_1 688 694 PF00069 0.686
MOD_CK2_1 88 94 PF00069 0.534
MOD_GlcNHglycan 162 166 PF01048 0.657
MOD_GlcNHglycan 177 180 PF01048 0.470
MOD_GlcNHglycan 190 194 PF01048 0.598
MOD_GlcNHglycan 204 208 PF01048 0.606
MOD_GlcNHglycan 218 222 PF01048 0.777
MOD_GlcNHglycan 232 236 PF01048 0.608
MOD_GlcNHglycan 246 250 PF01048 0.616
MOD_GlcNHglycan 260 264 PF01048 0.773
MOD_GlcNHglycan 274 278 PF01048 0.603
MOD_GlcNHglycan 288 292 PF01048 0.591
MOD_GlcNHglycan 302 306 PF01048 0.747
MOD_GlcNHglycan 316 320 PF01048 0.748
MOD_GlcNHglycan 330 334 PF01048 0.583
MOD_GlcNHglycan 344 348 PF01048 0.738
MOD_GlcNHglycan 358 362 PF01048 0.572
MOD_GlcNHglycan 372 376 PF01048 0.574
MOD_GlcNHglycan 386 390 PF01048 0.569
MOD_GlcNHglycan 401 404 PF01048 0.575
MOD_GlcNHglycan 414 418 PF01048 0.700
MOD_GlcNHglycan 428 432 PF01048 0.618
MOD_GlcNHglycan 442 446 PF01048 0.786
MOD_GlcNHglycan 457 460 PF01048 0.608
MOD_GlcNHglycan 470 474 PF01048 0.617
MOD_GlcNHglycan 484 488 PF01048 0.780
MOD_GlcNHglycan 498 502 PF01048 0.609
MOD_GlcNHglycan 513 516 PF01048 0.583
MOD_GlcNHglycan 526 530 PF01048 0.612
MOD_GlcNHglycan 541 544 PF01048 0.681
MOD_GlcNHglycan 555 558 PF01048 0.707
MOD_GlcNHglycan 569 572 PF01048 0.597
MOD_GlcNHglycan 583 586 PF01048 0.624
MOD_GlcNHglycan 596 600 PF01048 0.746
MOD_GlcNHglycan 611 614 PF01048 0.707
MOD_GlcNHglycan 624 628 PF01048 0.658
MOD_GlcNHglycan 638 642 PF01048 0.703
MOD_GlcNHglycan 652 656 PF01048 0.525
MOD_GlcNHglycan 667 670 PF01048 0.570
MOD_GlcNHglycan 681 684 PF01048 0.556
MOD_GlcNHglycan 72 75 PF01048 0.472
MOD_GSK3_1 138 145 PF00069 0.555
MOD_GSK3_1 170 177 PF00069 0.548
MOD_GSK3_1 184 191 PF00069 0.700
MOD_GSK3_1 198 205 PF00069 0.582
MOD_GSK3_1 212 219 PF00069 0.598
MOD_GSK3_1 226 233 PF00069 0.762
MOD_GSK3_1 240 247 PF00069 0.607
MOD_GSK3_1 254 261 PF00069 0.607
MOD_GSK3_1 268 275 PF00069 0.761
MOD_GSK3_1 282 289 PF00069 0.589
MOD_GSK3_1 296 303 PF00069 0.581
MOD_GSK3_1 310 317 PF00069 0.742
MOD_GSK3_1 324 331 PF00069 0.578
MOD_GSK3_1 33 40 PF00069 0.479
MOD_GSK3_1 338 345 PF00069 0.572
MOD_GSK3_1 352 359 PF00069 0.731
MOD_GSK3_1 366 373 PF00069 0.569
MOD_GSK3_1 380 387 PF00069 0.565
MOD_GSK3_1 394 401 PF00069 0.562
MOD_GSK3_1 408 415 PF00069 0.671
MOD_GSK3_1 422 429 PF00069 0.612
MOD_GSK3_1 436 443 PF00069 0.619
MOD_GSK3_1 450 457 PF00069 0.770
MOD_GSK3_1 464 471 PF00069 0.607
MOD_GSK3_1 478 485 PF00069 0.604
MOD_GSK3_1 492 499 PF00069 0.767
MOD_GSK3_1 506 513 PF00069 0.576
MOD_GSK3_1 520 527 PF00069 0.591
MOD_GSK3_1 534 541 PF00069 0.604
MOD_GSK3_1 548 555 PF00069 0.674
MOD_GSK3_1 562 569 PF00069 0.760
MOD_GSK3_1 576 583 PF00069 0.587
MOD_GSK3_1 590 597 PF00069 0.670
MOD_GSK3_1 604 611 PF00069 0.729
MOD_GSK3_1 618 625 PF00069 0.694
MOD_GSK3_1 632 639 PF00069 0.542
MOD_GSK3_1 646 653 PF00069 0.691
MOD_GSK3_1 660 667 PF00069 0.489
MOD_GSK3_1 674 681 PF00069 0.474
MOD_N-GLC_1 101 106 PF02516 0.494
MOD_NEK2_1 160 165 PF00069 0.657
MOD_NEK2_1 174 179 PF00069 0.476
MOD_NEK2_1 188 193 PF00069 0.712
MOD_NEK2_1 202 207 PF00069 0.598
MOD_NEK2_1 216 221 PF00069 0.770
MOD_NEK2_1 230 235 PF00069 0.602
MOD_NEK2_1 244 249 PF00069 0.609
MOD_NEK2_1 258 263 PF00069 0.772
MOD_NEK2_1 272 277 PF00069 0.607
MOD_NEK2_1 286 291 PF00069 0.593
MOD_NEK2_1 300 305 PF00069 0.584
MOD_NEK2_1 314 319 PF00069 0.746
MOD_NEK2_1 328 333 PF00069 0.583
MOD_NEK2_1 342 347 PF00069 0.576
MOD_NEK2_1 356 361 PF00069 0.737
MOD_NEK2_1 370 375 PF00069 0.575
MOD_NEK2_1 384 389 PF00069 0.572
MOD_NEK2_1 398 403 PF00069 0.571
MOD_NEK2_1 412 417 PF00069 0.687
MOD_NEK2_1 426 431 PF00069 0.617
MOD_NEK2_1 440 445 PF00069 0.621
MOD_NEK2_1 454 459 PF00069 0.773
MOD_NEK2_1 468 473 PF00069 0.608
MOD_NEK2_1 482 487 PF00069 0.774
MOD_NEK2_1 496 501 PF00069 0.611
MOD_NEK2_1 510 515 PF00069 0.590
MOD_NEK2_1 524 529 PF00069 0.601
MOD_NEK2_1 538 543 PF00069 0.605
MOD_NEK2_1 552 557 PF00069 0.763
MOD_NEK2_1 566 571 PF00069 0.598
MOD_NEK2_1 580 585 PF00069 0.755
MOD_NEK2_1 594 599 PF00069 0.550
MOD_NEK2_1 608 613 PF00069 0.729
MOD_NEK2_1 622 627 PF00069 0.555
MOD_NEK2_1 636 641 PF00069 0.531
MOD_NEK2_1 650 655 PF00069 0.692
MOD_NEK2_1 664 669 PF00069 0.492
MOD_NEK2_1 678 683 PF00069 0.484
MOD_PIKK_1 83 89 PF00454 0.472
MOD_PKA_2 142 148 PF00069 0.504
MOD_PKA_2 70 76 PF00069 0.473
MOD_Plk_1 138 144 PF00069 0.497
MOD_Plk_1 170 176 PF00069 0.546
MOD_Plk_1 184 190 PF00069 0.699
MOD_Plk_1 198 204 PF00069 0.580
MOD_Plk_1 212 218 PF00069 0.597
MOD_Plk_1 226 232 PF00069 0.761
MOD_Plk_1 240 246 PF00069 0.606
MOD_Plk_1 254 260 PF00069 0.609
MOD_Plk_1 268 274 PF00069 0.761
MOD_Plk_1 282 288 PF00069 0.590
MOD_Plk_1 296 302 PF00069 0.581
MOD_Plk_1 310 316 PF00069 0.741
MOD_Plk_1 324 330 PF00069 0.578
MOD_Plk_1 33 39 PF00069 0.482
MOD_Plk_1 338 344 PF00069 0.572
MOD_Plk_1 352 358 PF00069 0.731
MOD_Plk_1 366 372 PF00069 0.569
MOD_Plk_1 380 386 PF00069 0.566
MOD_Plk_1 394 400 PF00069 0.562
MOD_Plk_1 408 414 PF00069 0.668
MOD_Plk_1 422 428 PF00069 0.613
MOD_Plk_1 436 442 PF00069 0.619
MOD_Plk_1 450 456 PF00069 0.768
MOD_Plk_1 464 470 PF00069 0.607
MOD_Plk_1 478 484 PF00069 0.604
MOD_Plk_1 492 498 PF00069 0.767
MOD_Plk_1 506 512 PF00069 0.577
MOD_Plk_1 520 526 PF00069 0.588
MOD_Plk_1 534 540 PF00069 0.605
MOD_Plk_1 548 554 PF00069 0.673
MOD_Plk_1 562 568 PF00069 0.762
MOD_Plk_1 576 582 PF00069 0.587
MOD_Plk_1 590 596 PF00069 0.744
MOD_Plk_1 604 610 PF00069 0.729
MOD_Plk_1 618 624 PF00069 0.718
MOD_Plk_1 632 638 PF00069 0.545
MOD_Plk_1 646 652 PF00069 0.689
MOD_Plk_1 660 666 PF00069 0.487
MOD_Plk_1 674 680 PF00069 0.507
MOD_Plk_1 688 694 PF00069 0.517
TRG_ER_diArg_1 100 103 PF00400 0.496
TRG_ER_diArg_1 47 49 PF00400 0.588
TRG_NES_CRM1_1 140 154 PF08389 0.506
TRG_Pf-PMV_PEXEL_1 27 32 PF00026 0.485
TRG_Pf-PMV_PEXEL_1 48 53 PF00026 0.463

Homologs

Protein Taxonomy Sequence identity Coverage
A4H8S4 Leishmania braziliensis 89% 100%
A4HBI8 Leishmania braziliensis 29% 67%
H0YM25 Homo sapiens 24% 86%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS