60S acidic ribosomal protein P0

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

60S acidic ribosomal protein P0, putative

Species:

Leishmania mexicana

UniProt:

E8NHJ8_LEIMU

TriTrypDb:

LmxM.27.1380 , LmxM.27.1390

Length:

322

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 30

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 7

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 21

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 14
NetGPI	no	yes: 0, no: 14

Cellular components
Term	Name	Level	Count
GO:0005840	ribosome	5	14
GO:0032991	protein-containing complex	1	15
GO:0043226	organelle	2	14
GO:0043228	non-membrane-bounded organelle	3	14
GO:0043229	intracellular organelle	3	14
GO:0043232	intracellular non-membrane-bounded organelle	4	14
GO:0110165	cellular anatomical entity	1	15
GO:1990904	ribonucleoprotein complex	2	15
GO:0005737	cytoplasm	2	1
GO:0015934	large ribosomal subunit	4	1
GO:0022625	cytosolic large ribosomal subunit	5	1
GO:0044391	ribosomal subunit	3	1

Expansion

Sequence features

E8NHJ8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E8NHJ8

Function

Biological processes
Term	Name	Level	Count
GO:0009987	cellular process	1	15
GO:0022613	ribonucleoprotein complex biogenesis	4	14
GO:0042254	ribosome biogenesis	5	14
GO:0044085	cellular component biogenesis	3	14
GO:0071840	cellular component organization or biogenesis	2	15
GO:0000027	ribosomal large subunit assembly	7	1
GO:0002181	cytoplasmic translation	5	1
GO:0006412	translation	4	1
GO:0006518	peptide metabolic process	4	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009058	biosynthetic process	2	1
GO:0009059	macromolecule biosynthetic process	4	1
GO:0016043	cellular component organization	3	1
GO:0019538	protein metabolic process	3	1
GO:0022607	cellular component assembly	4	1
GO:0022618	ribonucleoprotein complex assembly	6	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0034645	obsolete cellular macromolecule biosynthetic process	4	1
GO:0043043	peptide biosynthetic process	5	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043603	amide metabolic process	3	1
GO:0043604	amide biosynthetic process	4	1
GO:0043933	protein-containing complex organization	4	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044249	cellular biosynthetic process	3	1
GO:0044260	obsolete cellular macromolecule metabolic process	3	1
GO:0044271	cellular nitrogen compound biosynthetic process	4	1
GO:0065003	protein-containing complex assembly	5	1
GO:0071704	organic substance metabolic process	2	1
GO:0071826	ribonucleoprotein complex subunit organization	5	1
GO:1901564	organonitrogen compound metabolic process	3	1
GO:1901566	organonitrogen compound biosynthetic process	4	1
GO:1901576	organic substance biosynthetic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	1
GO:0003723	RNA binding	4	1
GO:0003735	structural constituent of ribosome	2	1
GO:0005198	structural molecule activity	1	1
GO:0005488	binding	1	1
GO:0019843	rRNA binding	5	1
GO:0070180	large ribosomal subunit rRNA binding	6	1
GO:0097159	organic cyclic compound binding	2	1
GO:1901363	heterocyclic compound binding	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	107	111	PF00656	0.517
CLV_C14_Caspase3-7	172	176	PF00656	0.459
CLV_NRD_NRD_1	42	44	PF00675	0.277
CLV_PCSK_KEX2_1	42	44	PF00082	0.283
CLV_PCSK_KEX2_1	65	67	PF00082	0.264
CLV_PCSK_KEX2_1	8	10	PF00082	0.267
CLV_PCSK_PC1ET2_1	65	67	PF00082	0.277
CLV_PCSK_PC1ET2_1	8	10	PF00082	0.267
CLV_PCSK_SKI1_1	153	157	PF00082	0.349
CLV_PCSK_SKI1_1	165	169	PF00082	0.259
CLV_PCSK_SKI1_1	202	206	PF00082	0.442
CLV_PCSK_SKI1_1	253	257	PF00082	0.277
CLV_PCSK_SKI1_1	42	46	PF00082	0.347
DEG_SPOP_SBC_1	239	243	PF00917	0.431
DOC_CYCLIN_RxL_1	250	259	PF00134	0.459
DOC_MAPK_gen_1	153	161	PF00069	0.459
DOC_MAPK_MEF2A_6	21	30	PF00069	0.496
DOC_MAPK_MEF2A_6	253	260	PF00069	0.566
DOC_PP1_RVXF_1	200	207	PF00149	0.443
DOC_USP7_MATH_1	131	135	PF00917	0.496
DOC_USP7_MATH_1	239	243	PF00917	0.512
DOC_USP7_MATH_1	299	303	PF00917	0.561
DOC_USP7_MATH_1	308	312	PF00917	0.424
DOC_USP7_UBL2_3	61	65	PF12436	0.472
DOC_WW_Pin1_4	185	190	PF00397	0.509
DOC_WW_Pin1_4	70	75	PF00397	0.460
LIG_BIR_III_2	71	75	PF00653	0.431
LIG_BRCT_BRCA1_1	262	266	PF00533	0.571
LIG_FHA_1	104	110	PF00498	0.459
LIG_FHA_1	176	182	PF00498	0.571
LIG_FHA_1	91	97	PF00498	0.476
LIG_FHA_2	133	139	PF00498	0.483
LIG_FHA_2	205	211	PF00498	0.482
LIG_FHA_2	260	266	PF00498	0.444
LIG_GBD_Chelix_1	150	158	PF00786	0.371
LIG_IRF3_LxIS_1	181	188	PF10401	0.459
LIG_LIR_Gen_1	142	151	PF02991	0.497
LIG_LIR_Gen_1	20	30	PF02991	0.478
LIG_LIR_Nem_3	142	148	PF02991	0.461
LIG_LIR_Nem_3	188	194	PF02991	0.348
LIG_LIR_Nem_3	20	25	PF02991	0.467
LIG_LIR_Nem_3	250	255	PF02991	0.459
LIG_LIR_Nem_3	84	89	PF02991	0.529
LIG_NBox_RRM_1	144	154	PF00076	0.459
LIG_PCNA_yPIPBox_3	193	202	PF02747	0.353
LIG_SH2_CRK	22	26	PF00017	0.467
LIG_SH2_CRK	86	90	PF00017	0.591
LIG_SH2_STAP1	11	15	PF00017	0.467
LIG_SH2_STAP1	22	26	PF00017	0.467
LIG_SH3_3	111	117	PF00018	0.401
LIG_SH3_3	125	131	PF00018	0.459
LIG_SH3_3	295	301	PF00018	0.468
LIG_SUMO_SIM_par_1	157	164	PF11976	0.497
LIG_SUMO_SIM_par_1	195	201	PF11976	0.505
LIG_SUMO_SIM_par_1	254	259	PF11976	0.571
LIG_TRAF2_1	101	104	PF00917	0.485
LIG_TRAF2_1	304	307	PF00917	0.469
LIG_TYR_ITSM	18	25	PF00017	0.467
MOD_CDK_SPxxK_3	70	77	PF00069	0.460
MOD_CK1_1	177	183	PF00069	0.459
MOD_CK1_1	259	265	PF00069	0.459
MOD_CK1_1	3	9	PF00069	0.467
MOD_CK1_1	90	96	PF00069	0.508
MOD_CK2_1	132	138	PF00069	0.492
MOD_CK2_1	259	265	PF00069	0.444
MOD_Cter_Amidation	53	56	PF01082	0.275
MOD_GlcNHglycan	279	282	PF01048	0.394
MOD_GlcNHglycan	285	288	PF01048	0.367
MOD_GlcNHglycan	301	304	PF01048	0.269
MOD_GlcNHglycan	89	92	PF01048	0.369
MOD_GSK3_1	256	263	PF00069	0.575
MOD_N-GLC_1	175	180	PF02516	0.259
MOD_N-GLC_1	185	190	PF02516	0.309
MOD_NEK2_1	256	261	PF00069	0.459
MOD_NEK2_1	283	288	PF00069	0.490
MOD_NEK2_1	95	100	PF00069	0.502
MOD_OFUCOSY	18	24	PF10250	0.296
MOD_PIKK_1	137	143	PF00454	0.580
MOD_PIKK_1	32	38	PF00454	0.459
MOD_Plk_1	103	109	PF00069	0.470
MOD_Plk_2-3	104	110	PF00069	0.517
MOD_Plk_4	104	110	PF00069	0.574
MOD_Plk_4	140	146	PF00069	0.492
MOD_Plk_4	177	183	PF00069	0.459
MOD_Plk_4	195	201	PF00069	0.348
MOD_ProDKin_1	185	191	PF00069	0.512
MOD_ProDKin_1	70	76	PF00069	0.460
MOD_SUMO_for_1	7	10	PF00179	0.534
MOD_SUMO_rev_2	160	168	PF00179	0.484
MOD_SUMO_rev_2	71	79	PF00179	0.483
TRG_DiLeu_BaEn_1	84	89	PF01217	0.571
TRG_DiLeu_BaEn_4	84	90	PF01217	0.496
TRG_ENDOCYTIC_2	191	194	PF00928	0.350
TRG_ENDOCYTIC_2	22	25	PF00928	0.467
TRG_ENDOCYTIC_2	86	89	PF00928	0.591
TRG_ER_diArg_1	41	43	PF00400	0.459
TRG_Pf-PMV_PEXEL_1	220	224	PF00026	0.414
TRG_Pf-PMV_PEXEL_1	272	276	PF00026	0.371

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2F2	Leptomonas seymouri	81%	100%
A0A1X0P470	Trypanosomatidae	70%	100%
A0A1X0P504	Trypanosomatidae	70%	100%
A0A3Q8IDC2	Leishmania donovani	96%	100%
A0A3S7X0P4	Leishmania donovani	96%	100%
A0A3S7XBL0	Leishmania donovani	24%	100%
A0A422NFR1	Trypanosoma rangeli	71%	99%
A3DNI2	Staphylothermus marinus (strain ATCC 43588 / DSM 3639 / JCM 9404 / F1)	25%	95%
A4FZS8	Methanococcus maripaludis (strain C5 / ATCC BAA-1333)	27%	96%
A4HFR5	Leishmania braziliensis	88%	100%
A4HFR6	Leishmania braziliensis	88%	100%
A4I2U1	Leishmania infantum	96%	100%
A4IDP3	Leishmania infantum	24%	100%
A5UKU8	Methanobrevibacter smithii (strain ATCC 35061 / DSM 861 / OCM 144 / PS)	26%	96%
A6UTF8	Methanococcus aeolicus (strain ATCC BAA-1280 / DSM 17508 / OCM 812 / Nankai-3)	27%	95%
A6VIP9	Methanococcus maripaludis (strain C7 / ATCC BAA-1331)	29%	96%
A8ABQ7	Ignicoccus hospitalis (strain KIN4/I / DSM 18386 / JCM 14125)	24%	93%
A9A838	Methanococcus maripaludis (strain C6 / ATCC BAA-1332)	29%	96%
B0R4W1	Halobacterium salinarum (strain ATCC 29341 / DSM 671 / R1)	29%	91%
B6YSX9	Thermococcus onnurineus (strain NA1)	27%	95%
C3MR85	Sulfolobus islandicus (strain L.S.2.15 / Lassen #1)	24%	95%
C3MXH4	Sulfolobus islandicus (strain M.14.25 / Kamchatka #1)	24%	95%
C3MZC0	Sulfolobus islandicus (strain M.16.27)	24%	95%
C3N7E1	Sulfolobus islandicus (strain Y.G.57.14 / Yellowstone #1)	24%	95%
C3NG93	Sulfolobus islandicus (strain Y.N.15.51 / Yellowstone #2)	24%	95%
C4KIJ9	Sulfolobus islandicus (strain M.16.4 / Kamchatka #3)	24%	95%
C5A428	Thermococcus gammatolerans (strain DSM 15229 / JCM 11827 / EJ3)	26%	95%
C6A1F5	Thermococcus sibiricus (strain DSM 12597 / MM 739)	28%	95%
D0A606	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	68%	99%
D0A607	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	68%	99%
E9ADB9	Leishmania major	93%	100%
E9ATP9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	23%	100%
G0S616	Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)	25%	100%
O04204	Arabidopsis thaliana	42%	100%
O24573	Zea mays	42%	100%
O27717	Methanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H)	25%	96%
O28781	Archaeoglobus fulgidus (strain ATCC 49558 / DSM 4304 / JCM 9628 / NBRC 100126 / VC-16)	22%	95%
O52705	Methanothermococcus thermolithotrophicus	27%	95%
O74109	Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3)	27%	94%
O74864	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	44%	100%
P05317	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	42%	100%
P05388	Homo sapiens	41%	100%
P13553	Halobacterium salinarum (strain ATCC 700922 / JCM 11081 / NRC-1)	29%	91%
P14869	Mus musculus	41%	100%
P15825	Haloarcula marismortui (strain ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809)	26%	93%
P15826	Methanococcus vannielii (strain ATCC 35089 / DSM 1224 / JCM 13029 / OCM 148 / SB)	30%	96%
P19889	Drosophila melanogaster	40%	100%
P19945	Rattus norvegicus	41%	100%
P22685	Dictyostelium discoideum	40%	100%
P26796	Trypanosoma cruzi	69%	100%
P29764	Oxybasis rubra	41%	100%
P35023	Sulfolobus acidocaldarius (strain ATCC 33909 / DSM 639 / JCM 8929 / NBRC 15157 / NCIMB 11770)	27%	96%
P39096	Leishmania chagasi	95%	100%
P39097	Leishmania infantum	94%	100%
P41095	Oryza sativa subsp. japonica	40%	100%
P41198	Haloferax volcanii (strain ATCC 29605 / DSM 3757 / JCM 8879 / NBRC 14742 / NCIMB 2012 / VKM B-1768 / DS2)	28%	93%
P47826	Gallus gallus	42%	100%
P50345	Lupinus luteus	42%	100%
P50346	Glycine max	43%	100%
P54049	Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440)	26%	95%
P57691	Arabidopsis thaliana	42%	100%
P57692	Thermoplasma acidophilum (strain ATCC 25905 / DSM 1728 / JCM 9062 / NBRC 15155 / AMRC-C165)	23%	100%
P96039	Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)	25%	95%
Q12UP8	Methanococcoides burtonii (strain DSM 6242 / NBRC 107633 / OCM 468 / ACE-M)	23%	96%
Q29214	Sus scrofa	41%	100%
Q2NEW2	Methanosphaera stadtmanae (strain ATCC 43021 / DSM 3091 / JCM 11832 / MCB-3)	25%	97%
Q3INI7	Natronomonas pharaonis (strain ATCC 35678 / DSM 2160 / CIP 103997 / JCM 8858 / NBRC 14720 / NCIMB 2260 / Gabara)	26%	91%
Q42112	Arabidopsis thaliana	42%	100%
Q46EU9	Methanosarcina barkeri (strain Fusaro / DSM 804)	26%	93%
Q4Q0U9	Leishmania major	24%	100%
Q5JH36	Thermococcus kodakarensis (strain ATCC BAA-918 / JCM 12380 / KOD1)	26%	95%
Q6L1X8	Picrophilus torridus (strain ATCC 700027 / DSM 9790 / JCM 10055 / NBRC 100828)	20%	100%
Q6M0L1	Methanococcus maripaludis (strain S2 / LL)	29%	96%
Q7S302	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	26%	100%
Q8NHW5	Homo sapiens	40%	100%
Q8PY51	Methanosarcina mazei (strain ATCC BAA-159 / DSM 3647 / Goe1 / Go1 / JCM 11833 / OCM 88)	23%	93%
Q8SRJ7	Encephalitozoon cuniculi (strain GB-M1)	37%	100%
Q8TI80	Methanosarcina acetivorans (strain ATCC 35395 / DSM 2834 / JCM 12185 / C2A)	24%	93%
Q8TX50	Methanopyrus kandleri (strain AV19 / DSM 6324 / JCM 9639 / NBRC 100938)	28%	90%
Q8TZJ8	Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1)	27%	95%
Q8ZTT3	Pyrobaculum aerophilum (strain ATCC 51768 / DSM 7523 / JCM 9630 / CIP 104966 / NBRC 100827 / IM2)	27%	93%
Q90YX1	Ictalurus punctatus	41%	100%
Q93572	Caenorhabditis elegans	39%	100%
Q94660	Plasmodium falciparum (isolate 7G8)	40%	100%
Q95140	Bos taurus	41%	100%
Q967Y7	Eimeria tenella	35%	100%
Q96TJ5	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	41%	100%
Q971J2	Sulfurisphaera tokodaii (strain DSM 16993 / JCM 10545 / NBRC 100140 / 7)	26%	96%
Q97BN3	Thermoplasma volcanium (strain ATCC 51530 / DSM 4299 / JCM 9571 / NBRC 15438 / GSS1)	24%	100%
Q9C3Z6	Podospora anserina	41%	100%
Q9DG68	Lithobates sylvaticus	41%	100%
Q9PV90	Danio rerio	39%	100%
Q9U3U0	Ceratitis capitata	39%	100%
Q9UXS5	Pyrococcus abyssi (strain GE5 / Orsay)	27%	94%
Q9Y8J3	Methanococcus voltae	28%	100%
V5BL26	Trypanosoma cruzi	69%	99%