Uncharacterized protein LmxM_20_1365_1

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein

Species:

Leishmania mexicana

UniProt:

E8NHJ3_LEIMU

TriTrypDb:

LmxM.20.1365

Length:

453

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 18
NetGPI	no	yes: 0, no: 18

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

E8NHJ3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E8NHJ3

Function

Biological processes
Term	Name	Level	Count
GO:0010468	regulation of gene expression	5	2
GO:0010608	post-transcriptional regulation of gene expression	6	2
GO:0019222	regulation of metabolic process	3	2
GO:0050789	regulation of biological process	2	2
GO:0060255	regulation of macromolecule metabolic process	4	2
GO:0065007	biological regulation	1	2

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	19
GO:0003723	RNA binding	4	19
GO:0005488	binding	1	19
GO:0097159	organic cyclic compound binding	2	19
GO:1901363	heterocyclic compound binding	2	19
GO:0003729	mRNA binding	5	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	41	45	PF00656	0.396
CLV_C14_Caspase3-7	420	424	PF00656	0.526
CLV_NRD_NRD_1	102	104	PF00675	0.434
CLV_NRD_NRD_1	111	113	PF00675	0.491
CLV_NRD_NRD_1	227	229	PF00675	0.328
CLV_NRD_NRD_1	435	437	PF00675	0.629
CLV_PCSK_KEX2_1	102	104	PF00082	0.434
CLV_PCSK_KEX2_1	111	113	PF00082	0.491
CLV_PCSK_KEX2_1	227	229	PF00082	0.328
CLV_PCSK_KEX2_1	268	270	PF00082	0.497
CLV_PCSK_KEX2_1	294	296	PF00082	0.571
CLV_PCSK_KEX2_1	435	437	PF00082	0.652
CLV_PCSK_PC1ET2_1	268	270	PF00082	0.497
CLV_PCSK_PC1ET2_1	294	296	PF00082	0.605
CLV_PCSK_SKI1_1	157	161	PF00082	0.458
CLV_PCSK_SKI1_1	227	231	PF00082	0.389
CLV_PCSK_SKI1_1	275	279	PF00082	0.410
CLV_PCSK_SKI1_1	28	32	PF00082	0.409
CLV_Separin_Metazoa	154	158	PF03568	0.368
DEG_APCC_DBOX_1	101	109	PF00400	0.397
DEG_APCC_DBOX_1	156	164	PF00400	0.368
DEG_APCC_DBOX_1	227	235	PF00400	0.479
DEG_APCC_DBOX_1	366	374	PF00400	0.498
DOC_CYCLIN_RxL_1	224	233	PF00134	0.413
DOC_MAPK_FxFP_2	399	402	PF00069	0.558
DOC_MAPK_gen_1	53	61	PF00069	0.337
DOC_MAPK_MEF2A_6	53	61	PF00069	0.493
DOC_PP4_FxxP_1	399	402	PF00568	0.757
DOC_PP4_FxxP_1	445	448	PF00568	0.581
DOC_USP7_MATH_1	293	297	PF00917	0.558
DOC_USP7_MATH_1	346	350	PF00917	0.740
DOC_USP7_UBL2_3	286	290	PF12436	0.452
DOC_WW_Pin1_4	21	26	PF00397	0.472
DOC_WW_Pin1_4	365	370	PF00397	0.532
DOC_WW_Pin1_4	409	414	PF00397	0.791
DOC_WW_Pin1_4	428	433	PF00397	0.618
LIG_14-3-3_CanoR_1	102	106	PF00244	0.452
LIG_14-3-3_CanoR_1	11	18	PF00244	0.455
LIG_14-3-3_CanoR_1	185	193	PF00244	0.463
LIG_14-3-3_CanoR_1	36	46	PF00244	0.553
LIG_14-3-3_CanoR_1	407	415	PF00244	0.568
LIG_Actin_WH2_1	227	244	PF00022	0.414
LIG_Actin_WH2_1	39	57	PF00022	0.430
LIG_Actin_WH2_2	40	57	PF00022	0.428
LIG_EH1_1	251	259	PF00400	0.431
LIG_FHA_1	195	201	PF00498	0.494
LIG_FHA_1	337	343	PF00498	0.711
LIG_FHA_1	77	83	PF00498	0.379
LIG_FHA_2	322	328	PF00498	0.571
LIG_FHA_2	67	73	PF00498	0.402
LIG_LIR_Apic_2	397	402	PF02991	0.663
LIG_LIR_Nem_3	169	174	PF02991	0.401
LIG_LIR_Nem_3	247	252	PF02991	0.365
LIG_LIR_Nem_3	266	270	PF02991	0.415
LIG_PDZ_Class_2	448	453	PF00595	0.508
LIG_Pex14_2	445	449	PF04695	0.646
LIG_SH2_STAT3	174	177	PF00017	0.320
LIG_SH2_STAT5	100	103	PF00017	0.517
LIG_SH2_STAT5	129	132	PF00017	0.417
LIG_SH2_STAT5	191	194	PF00017	0.401
LIG_SH2_STAT5	360	363	PF00017	0.791
LIG_SH3_3	232	238	PF00018	0.419
LIG_SH3_3	258	264	PF00018	0.434
LIG_SH3_3	328	334	PF00018	0.737
LIG_SH3_3	335	341	PF00018	0.727
LIG_SH3_3	424	430	PF00018	0.704
LIG_SUMO_SIM_par_1	256	262	PF11976	0.226
LIG_UBA3_1	200	207	PF00899	0.371
MOD_CDK_SPxxK_3	21	28	PF00069	0.467
MOD_CDK_SPxxK_3	428	435	PF00069	0.669
MOD_CK1_1	183	189	PF00069	0.355
MOD_CK1_1	259	265	PF00069	0.426
MOD_CK1_1	409	415	PF00069	0.518
MOD_CK1_1	45	51	PF00069	0.508
MOD_CK1_1	98	104	PF00069	0.427
MOD_CK2_1	104	110	PF00069	0.407
MOD_CK2_1	346	352	PF00069	0.735
MOD_CK2_1	66	72	PF00069	0.408
MOD_GlcNHglycan	115	119	PF01048	0.555
MOD_GlcNHglycan	295	298	PF01048	0.588
MOD_GlcNHglycan	319	322	PF01048	0.526
MOD_GlcNHglycan	389	392	PF01048	0.694
MOD_GlcNHglycan	408	411	PF01048	0.751
MOD_GlcNHglycan	423	426	PF01048	0.761
MOD_GSK3_1	180	187	PF00069	0.382
MOD_GSK3_1	317	324	PF00069	0.648
MOD_GSK3_1	332	339	PF00069	0.704
MOD_GSK3_1	405	412	PF00069	0.523
MOD_GSK3_1	72	79	PF00069	0.388
MOD_GSK3_1	94	101	PF00069	0.397
MOD_N-GLC_2	93	95	PF02516	0.409
MOD_NEK2_1	130	135	PF00069	0.375
MOD_NEK2_1	201	206	PF00069	0.373
MOD_NEK2_1	86	91	PF00069	0.399
MOD_NEK2_1	94	99	PF00069	0.388
MOD_PIKK_1	130	136	PF00454	0.384
MOD_PIKK_1	34	40	PF00454	0.463
MOD_PIKK_1	340	346	PF00454	0.533
MOD_PIKK_1	354	360	PF00454	0.751
MOD_PIKK_1	95	101	PF00454	0.393
MOD_PKA_2	10	16	PF00069	0.496
MOD_PKA_2	101	107	PF00069	0.490
MOD_PKA_2	184	190	PF00069	0.448
MOD_PKA_2	336	342	PF00069	0.612
MOD_PKA_2	406	412	PF00069	0.566
MOD_Plk_1	114	120	PF00069	0.429
MOD_Plk_4	104	110	PF00069	0.240
MOD_Plk_4	26	32	PF00069	0.313
MOD_Plk_4	42	48	PF00069	0.446
MOD_Plk_4	86	92	PF00069	0.400
MOD_ProDKin_1	21	27	PF00069	0.467
MOD_ProDKin_1	365	371	PF00069	0.534
MOD_ProDKin_1	409	415	PF00069	0.792
MOD_ProDKin_1	428	434	PF00069	0.613
MOD_SUMO_for_1	285	288	PF00179	0.466
TRG_ENDOCYTIC_2	249	252	PF00928	0.481
TRG_ER_diArg_1	226	228	PF00400	0.372
TRG_ER_diArg_1	273	276	PF00400	0.430
TRG_ER_diArg_1	52	55	PF00400	0.441
TRG_NES_CRM1_1	158	169	PF08389	0.368
TRG_NES_CRM1_1	49	60	PF08389	0.375
TRG_Pf-PMV_PEXEL_1	227	232	PF00026	0.361
TRG_Pf-PMV_PEXEL_1	436	440	PF00026	0.637
TRG_Pf-PMV_PEXEL_1	68	72	PF00026	0.334

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1ILR0	Leptomonas seymouri	60%	69%
A0A1X0NJM4	Trypanosomatidae	39%	100%
A0A1X0P8D8	Trypanosomatidae	22%	79%
A0A3Q8IA47	Leishmania donovani	94%	77%
A0A3R7NFN9	Trypanosoma rangeli	52%	84%
A0A3R7NHA6	Trypanosoma rangeli	26%	79%
A0A3S5IQY1	Trypanosoma rangeli	36%	100%
A0A3S7WW64	Leishmania donovani	96%	83%
A4HYX9	Leishmania infantum	94%	77%
A4HYY0	Leishmania infantum	96%	83%
C9ZII7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	42%	67%
D0A2G7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	25%	79%
E9AIJ1	Leishmania braziliensis	83%	100%
E9ASC2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	23%	82%
E9AUS6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	98%	100%
Q4QCQ8	Leishmania major	74%	96%
Q4QCQ9	Leishmania major	92%	100%