Uncharacterized protein LmxM_08_1040_1

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein

Species:

Leishmania mexicana

UniProt:

E8NHJ1_LEIMU

TriTrypDb:

LmxM.08.1040

Length:

503

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 125

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 21

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 33, no: 5
NetGPI	no	yes: 0, no: 38

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	9
GO:0000323	lytic vacuole	6	8
GO:0005615	extracellular space	2	8
GO:0005764	lysosome	7	8
GO:0005773	vacuole	5	8
GO:0043226	organelle	2	8
GO:0043227	membrane-bounded organelle	3	8
GO:0043229	intracellular organelle	3	8
GO:0043231	intracellular membrane-bounded organelle	4	8

Expansion

Sequence features

E8NHJ1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E8NHJ1

Function

Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	39
GO:0006807	nitrogen compound metabolic process	2	39
GO:0008152	metabolic process	1	39
GO:0019538	protein metabolic process	3	39
GO:0043170	macromolecule metabolic process	3	39
GO:0044238	primary metabolic process	2	39
GO:0071704	organic substance metabolic process	2	39
GO:1901564	organonitrogen compound metabolic process	3	39
GO:0051603	proteolysis involved in protein catabolic process	5	8

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	39
GO:0004175	endopeptidase activity	4	29
GO:0004197	cysteine-type endopeptidase activity	5	29
GO:0008233	peptidase activity	3	39
GO:0008234	cysteine-type peptidase activity	4	39
GO:0016787	hydrolase activity	2	39
GO:0140096	catalytic activity, acting on a protein	2	39

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	243	247	PF00656	0.389
CLV_C14_Caspase3-7	482	486	PF00656	0.492
CLV_NRD_NRD_1	176	178	PF00675	0.663
CLV_NRD_NRD_1	436	438	PF00675	0.467
CLV_NRD_NRD_1	9	11	PF00675	0.477
CLV_PCSK_KEX2_1	102	104	PF00082	0.631
CLV_PCSK_KEX2_1	169	171	PF00082	0.573
CLV_PCSK_KEX2_1	9	11	PF00082	0.390
CLV_PCSK_PC1ET2_1	102	104	PF00082	0.631
CLV_PCSK_PC1ET2_1	169	171	PF00082	0.568
CLV_PCSK_SKI1_1	65	69	PF00082	0.407
CLV_Separin_Metazoa	127	131	PF03568	0.386
DEG_APCC_DBOX_1	179	187	PF00400	0.472
DEG_APCC_DBOX_1	64	72	PF00400	0.612
DEG_SPOP_SBC_1	16	20	PF00917	0.600
DEG_SPOP_SBC_1	406	410	PF00917	0.301
DOC_CKS1_1	481	486	PF01111	0.309
DOC_CKS1_1	90	95	PF01111	0.541
DOC_CYCLIN_RxL_1	118	131	PF00134	0.386
DOC_MAPK_MEF2A_6	317	325	PF00069	0.413
DOC_PP4_FxxP_1	481	484	PF00568	0.261
DOC_USP7_MATH_1	17	21	PF00917	0.754
DOC_USP7_MATH_1	206	210	PF00917	0.448
DOC_USP7_MATH_1	275	279	PF00917	0.329
DOC_USP7_MATH_1	284	288	PF00917	0.329
DOC_USP7_MATH_1	34	38	PF00917	0.579
DOC_USP7_MATH_1	406	410	PF00917	0.317
DOC_USP7_UBL2_3	438	442	PF12436	0.276
DOC_WW_Pin1_4	19	24	PF00397	0.595
DOC_WW_Pin1_4	196	201	PF00397	0.368
DOC_WW_Pin1_4	40	45	PF00397	0.583
DOC_WW_Pin1_4	411	416	PF00397	0.302
DOC_WW_Pin1_4	457	462	PF00397	0.223
DOC_WW_Pin1_4	480	485	PF00397	0.441
DOC_WW_Pin1_4	89	94	PF00397	0.518
LIG_14-3-3_CanoR_1	10	16	PF00244	0.594
LIG_14-3-3_CanoR_1	27	33	PF00244	0.584
LIG_14-3-3_CanoR_1	437	441	PF00244	0.371
LIG_BRCT_BRCA1_1	469	473	PF00533	0.222
LIG_FHA_1	337	343	PF00498	0.347
LIG_FHA_1	356	362	PF00498	0.447
LIG_FHA_2	1	7	PF00498	0.586
LIG_FHA_2	109	115	PF00498	0.393
LIG_FHA_2	408	414	PF00498	0.308
LIG_LIR_Gen_1	37	47	PF02991	0.772
LIG_LIR_Gen_1	376	386	PF02991	0.365
LIG_LIR_LC3C_4	289	294	PF02991	0.244
LIG_LIR_Nem_3	144	149	PF02991	0.392
LIG_LIR_Nem_3	271	277	PF02991	0.369
LIG_LIR_Nem_3	328	333	PF02991	0.321
LIG_LIR_Nem_3	360	366	PF02991	0.342
LIG_LIR_Nem_3	37	42	PF02991	0.777
LIG_LIR_Nem_3	376	382	PF02991	0.304
LIG_LYPXL_yS_3	274	277	PF13949	0.296
LIG_PCNA_PIPBox_1	140	149	PF02747	0.244
LIG_PCNA_yPIPBox_3	135	147	PF02747	0.244
LIG_SH2_GRB2like	158	161	PF00017	0.407
LIG_SH2_GRB2like	469	472	PF00017	0.379
LIG_SH2_PTP2	379	382	PF00017	0.321
LIG_SH2_SRC	158	161	PF00017	0.438
LIG_SH2_STAP1	109	113	PF00017	0.341
LIG_SH2_STAP1	469	473	PF00017	0.222
LIG_SH2_STAT5	158	161	PF00017	0.399
LIG_SH2_STAT5	164	167	PF00017	0.395
LIG_SH2_STAT5	224	227	PF00017	0.265
LIG_SH2_STAT5	25	28	PF00017	0.595
LIG_SH2_STAT5	269	272	PF00017	0.318
LIG_SH2_STAT5	276	279	PF00017	0.317
LIG_SH2_STAT5	282	285	PF00017	0.317
LIG_SH2_STAT5	379	382	PF00017	0.321
LIG_SH2_STAT5	491	494	PF00017	0.403
LIG_SH3_3	51	57	PF00018	0.663
LIG_SH3_3	87	93	PF00018	0.503
LIG_SUMO_SIM_par_1	229	235	PF11976	0.327
LIG_SUMO_SIM_par_1	418	423	PF11976	0.241
LIG_TRFH_1	50	54	PF08558	0.578
LIG_TYR_ITIM	361	366	PF00017	0.391
MOD_CDC14_SPxK_1	460	463	PF00782	0.222
MOD_CDK_SPK_2	40	45	PF00069	0.583
MOD_CDK_SPxK_1	196	202	PF00069	0.368
MOD_CDK_SPxK_1	457	463	PF00069	0.222
MOD_CDK_SPxxK_3	411	418	PF00069	0.316
MOD_CDK_SPxxK_3	480	487	PF00069	0.323
MOD_CK1_1	287	293	PF00069	0.370
MOD_CK1_1	329	335	PF00069	0.329
MOD_CK1_1	409	415	PF00069	0.317
MOD_CK1_1	43	49	PF00069	0.578
MOD_CK2_1	108	114	PF00069	0.375
MOD_CK2_1	147	153	PF00069	0.321
MOD_CK2_1	229	235	PF00069	0.309
MOD_CK2_1	407	413	PF00069	0.295
MOD_GlcNHglycan	182	186	PF01048	0.727
MOD_GlcNHglycan	213	216	PF01048	0.620
MOD_GlcNHglycan	277	280	PF01048	0.529
MOD_GlcNHglycan	334	337	PF01048	0.589
MOD_GlcNHglycan	36	39	PF01048	0.389
MOD_GlcNHglycan	396	399	PF01048	0.555
MOD_GlcNHglycan	402	405	PF01048	0.509
MOD_GlcNHglycan	58	61	PF01048	0.463
MOD_GSK3_1	11	18	PF00069	0.765
MOD_GSK3_1	19	26	PF00069	0.659
MOD_GSK3_1	325	332	PF00069	0.340
MOD_GSK3_1	405	412	PF00069	0.359
MOD_GSK3_1	492	499	PF00069	0.393
MOD_GSK3_1	52	59	PF00069	0.574
MOD_N-GLC_1	287	292	PF02516	0.598
MOD_N-GLC_1	430	435	PF02516	0.478
MOD_N-GLC_2	387	389	PF02516	0.540
MOD_N-GLC_2	444	446	PF02516	0.542
MOD_N-GLC_2	498	500	PF02516	0.529
MOD_NEK2_1	101	106	PF00069	0.427
MOD_NEK2_1	141	146	PF00069	0.419
MOD_NEK2_1	15	20	PF00069	0.722
MOD_NEK2_1	261	266	PF00069	0.298
MOD_NEK2_1	325	330	PF00069	0.392
MOD_NEK2_1	492	497	PF00069	0.391
MOD_NEK2_1	61	66	PF00069	0.749
MOD_PIKK_1	430	436	PF00454	0.257
MOD_PKA_2	400	406	PF00069	0.238
MOD_PKA_2	436	442	PF00069	0.234
MOD_Plk_1	181	187	PF00069	0.531
MOD_Plk_1	270	276	PF00069	0.315
MOD_Plk_1	325	331	PF00069	0.296
MOD_Plk_2-3	229	235	PF00069	0.244
MOD_Plk_4	11	17	PF00069	0.592
MOD_Plk_4	326	332	PF00069	0.309
MOD_Plk_4	436	442	PF00069	0.376
MOD_Plk_4	452	458	PF00069	0.245
MOD_Plk_4	492	498	PF00069	0.355
MOD_ProDKin_1	19	25	PF00069	0.597
MOD_ProDKin_1	196	202	PF00069	0.368
MOD_ProDKin_1	40	46	PF00069	0.582
MOD_ProDKin_1	411	417	PF00069	0.308
MOD_ProDKin_1	457	463	PF00069	0.223
MOD_ProDKin_1	480	486	PF00069	0.442
MOD_ProDKin_1	89	95	PF00069	0.513
MOD_SUMO_rev_2	482	489	PF00179	0.329
MOD_SUMO_rev_2	99	104	PF00179	0.434
TRG_DiLeu_BaEn_4	114	120	PF01217	0.373
TRG_ENDOCYTIC_2	109	112	PF00928	0.382
TRG_ENDOCYTIC_2	274	277	PF00928	0.311
TRG_ENDOCYTIC_2	363	366	PF00928	0.321
TRG_ENDOCYTIC_2	379	382	PF00928	0.321
TRG_ER_diArg_1	9	11	PF00400	0.590
TRG_NES_CRM1_1	117	131	PF08389	0.386
TRG_NLS_MonoExtC_3	176	182	PF00514	0.495

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8D1	Leptomonas seymouri	26%	100%
A0A0N1PA65	Leptomonas seymouri	44%	100%
A0A0S4ISD8	Bodo saltans	41%	94%
A0A0S4J628	Bodo saltans	45%	92%
A0A0S4JXJ3	Bodo saltans	31%	100%
A0A0S4KJA5	Bodo saltans	42%	100%
A0A1X0NXC8	Trypanosomatidae	32%	100%
A0A3R7L7E7	Trypanosoma rangeli	47%	95%
A0A3S5H682	Leishmania donovani	80%	100%
A0A3S5H683	Leishmania donovani	80%	100%
A0A3S5H684	Leishmania donovani	80%	100%
A0A3S5H685	Leishmania donovani	80%	100%
A0A3S7WQD0	Leishmania donovani	80%	100%
A0A6L0WJ22	Leishmania infantum	81%	100%
A4H5E4	Leishmania braziliensis	67%	100%
A4H5E5	Leishmania braziliensis	65%	100%
A4H5E6	Leishmania braziliensis	65%	100%
A4HA92	Leishmania braziliensis	44%	100%
A4HTP0	Leishmania infantum	78%	100%
A4HYH2	Leishmania infantum	45%	100%
A4I4D6	Leishmania infantum	32%	100%
A5HII1	Actinidia deliciosa	30%	100%
C9ZQB3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	46%	100%
C9ZQB5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	46%	100%
C9ZQB6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	47%	100%
E8NHD8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	98%	100%
E8NHH6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	99%	100%
E8NHL3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	100%	94%
E8NHS3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	99%	100%
E9ADT5	Leishmania major	30%	100%
E9ALZ5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	29%	100%
E9AMH5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	98%	100%
E9AMH6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	98%	100%
E9AMH7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	98%	100%
E9AS96	Leishmania mexicana (strain MHOM/GT/2001/U1103)	46%	100%
F4JNL3	Arabidopsis thaliana	31%	100%
O65493	Arabidopsis thaliana	36%	100%
P00785	Actinidia chinensis var. chinensis	31%	100%
P04988	Dictyostelium discoideum	36%	100%
P14658	Trypanosoma brucei brucei	46%	100%
P25775	Leishmania mexicana	46%	100%
P25779	Trypanosoma cruzi	47%	100%
P25805	Plasmodium falciparum	28%	88%
P35591	Leishmania pifanoi	46%	100%
P36400	Leishmania mexicana	100%	100%
P42666	Plasmodium vivax (strain Salvador I)	28%	86%
P43156	Hemerocallis sp.	37%	100%
P46102	Plasmodium vinckei	30%	99%
P54640	Dictyostelium discoideum	34%	100%
P56202	Homo sapiens	32%	100%
Q05094	Leishmania pifanoi	100%	100%
Q23894	Dictyostelium discoideum	34%	100%
Q4QD68	Leishmania major	48%	100%
Q4QI61	Leishmania major	74%	100%
Q4QI62	Leishmania major	85%	100%
Q4QI64	Leishmania major	85%	100%
Q4QI65	Leishmania major	85%	100%
Q4QI66	Leishmania major	74%	100%
Q4QI67	Leishmania major	85%	100%
Q4QI68	Leishmania major	84%	100%
Q7GDU7	Oryza sativa subsp. japonica	36%	100%
Q8QLK1	Mamestra configurata nucleopolyhedrovirus	35%	100%
Q9BIE1	Leishmania donovani	45%	100%
Q9GQM5	Leishmania donovani	32%	100%
Q9LT78	Arabidopsis thaliana	36%	100%
Q9QZE3	Rattus norvegicus	33%	100%
Q9SUT0	Arabidopsis thaliana	34%	100%