Uncharacterized protein LmxM_08_1050_1

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein

Species:

Leishmania mexicana

UniProt:

E8NHJ0_LEIMU

TriTrypDb:

LmxM.08.1050

Length:

231

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 35

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 13, no: 0
NetGPI	no	yes: 0, no: 13

Cellular components
Term	Name	Level	Count
GO:0000323	lytic vacuole	6	5
GO:0005615	extracellular space	2	5
GO:0005764	lysosome	7	5
GO:0005773	vacuole	5	5
GO:0043226	organelle	2	5
GO:0043227	membrane-bounded organelle	3	5
GO:0043229	intracellular organelle	3	5
GO:0043231	intracellular membrane-bounded organelle	4	5
GO:0110165	cellular anatomical entity	1	5

Expansion

Sequence features

E8NHJ0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E8NHJ0

Function

Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	14
GO:0006807	nitrogen compound metabolic process	2	14
GO:0008152	metabolic process	1	14
GO:0019538	protein metabolic process	3	14
GO:0043170	macromolecule metabolic process	3	14
GO:0044238	primary metabolic process	2	14
GO:0071704	organic substance metabolic process	2	14
GO:1901564	organonitrogen compound metabolic process	3	14
GO:0051603	proteolysis involved in protein catabolic process	5	5

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	14
GO:0008233	peptidase activity	3	14
GO:0008234	cysteine-type peptidase activity	4	14
GO:0016787	hydrolase activity	2	14
GO:0140096	catalytic activity, acting on a protein	2	14
GO:0004175	endopeptidase activity	4	5
GO:0004197	cysteine-type endopeptidase activity	5	5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	183	187	PF00656	0.382
CLV_NRD_NRD_1	116	118	PF00675	0.577
CLV_PCSK_KEX2_1	109	111	PF00082	0.443
CLV_PCSK_KEX2_1	42	44	PF00082	0.483
CLV_PCSK_PC1ET2_1	109	111	PF00082	0.447
CLV_PCSK_PC1ET2_1	42	44	PF00082	0.480
CLV_PCSK_SKI1_1	5	9	PF00082	0.618
CLV_Separin_Metazoa	67	71	PF03568	0.390
DEG_APCC_DBOX_1	119	127	PF00400	0.653
DEG_APCC_DBOX_1	4	12	PF00400	0.718
DOC_CKS1_1	30	35	PF01111	0.516
DOC_CYCLIN_RxL_1	58	71	PF00134	0.390
DOC_USP7_MATH_1	146	150	PF00917	0.429
DOC_WW_Pin1_4	136	141	PF00397	0.374
DOC_WW_Pin1_4	29	34	PF00397	0.598
LIG_BIR_II_1	1	5	PF00653	0.613
LIG_FHA_2	49	55	PF00498	0.450
LIG_LIR_Gen_1	211	222	PF02991	0.462
LIG_LIR_Nem_3	211	217	PF02991	0.489
LIG_LIR_Nem_3	84	89	PF02991	0.457
LIG_PCNA_PIPBox_1	80	89	PF02747	0.231
LIG_PCNA_yPIPBox_3	75	87	PF02747	0.231
LIG_SH2_CRK	214	218	PF00017	0.204
LIG_SH2_GRB2like	98	101	PF00017	0.530
LIG_SH2_SRC	98	101	PF00017	0.509
LIG_SH2_STAP1	49	53	PF00017	0.346
LIG_SH2_STAT5	104	107	PF00017	0.405
LIG_SH2_STAT5	164	167	PF00017	0.231
LIG_SH2_STAT5	216	219	PF00017	0.363
LIG_SH2_STAT5	222	225	PF00017	0.367
LIG_SH2_STAT5	98	101	PF00017	0.494
LIG_SH3_3	27	33	PF00018	0.560
LIG_SUMO_SIM_par_1	169	174	PF11976	0.292
MOD_CDK_SPxK_1	136	142	PF00069	0.343
MOD_CK1_1	215	221	PF00069	0.314
MOD_CK2_1	48	54	PF00069	0.390
MOD_CK2_1	87	93	PF00069	0.310
MOD_GlcNHglycan	122	126	PF01048	0.614
MOD_GlcNHglycan	153	156	PF01048	0.466
MOD_GlcNHglycan	173	176	PF01048	0.196
MOD_GlcNHglycan	217	220	PF01048	0.325
MOD_NEK2_1	1	6	PF00069	0.606
MOD_NEK2_1	201	206	PF00069	0.437
MOD_NEK2_1	224	229	PF00069	0.328
MOD_NEK2_1	41	46	PF00069	0.456
MOD_NEK2_1	81	86	PF00069	0.397
MOD_Plk_1	121	127	PF00069	0.537
MOD_Plk_1	210	216	PF00069	0.320
MOD_Plk_4	212	218	PF00069	0.417
MOD_ProDKin_1	136	142	PF00069	0.374
MOD_ProDKin_1	29	35	PF00069	0.591
MOD_SUMO_rev_2	39	44	PF00179	0.487
TRG_DiLeu_BaEn_4	54	60	PF01217	0.450
TRG_ENDOCYTIC_2	214	217	PF00928	0.345
TRG_ENDOCYTIC_2	49	52	PF00928	0.413
TRG_NES_CRM1_1	57	71	PF08389	0.390
TRG_NLS_MonoExtC_3	116	122	PF00514	0.648

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0S4IWQ5	Bodo saltans	34%	72%
A0A0S4IY45	Bodo saltans	34%	70%
A0A0S4J328	Bodo saltans	49%	74%
A0A0S4J918	Bodo saltans	37%	71%
A0A0S4J9K9	Bodo saltans	46%	68%
A0A0S4JEN2	Bodo saltans	31%	100%
A0A0S4KGP4	Bodo saltans	45%	77%
A0A1X0NM52	Trypanosomatidae	48%	74%
A0E358	Paramecium tetraurelia	33%	74%
A1KXI0	Blomia tropicalis	30%	69%
A2XQE8	Oryza sativa subsp. indica	38%	68%
C9ZQB4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	49%	100%
C9ZQB7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	49%	100%
D3ZZ07	Rattus norvegicus	32%	70%
E8NHH6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	98%	100%
O10364	Orgyia pseudotsugata multicapsid polyhedrosis virus	34%	71%
O35186	Rattus norvegicus	35%	70%
O45734	Caenorhabditis elegans	36%	69%
O46427	Sus scrofa	35%	69%
O60911	Homo sapiens	39%	69%
O70370	Mus musculus	36%	68%
O91466	Cydia pomonella granulosis virus (isolate Mexico/1963)	33%	69%
O97397	Phaedon cochleariae	33%	71%
P00784	Carica papaya	35%	67%
P00786	Rattus norvegicus	34%	69%
P04988	Dictyostelium discoideum	34%	67%
P05994	Carica papaya	34%	66%
P06797	Mus musculus	41%	69%
P07154	Rattus norvegicus	41%	69%
P07711	Homo sapiens	36%	69%
P08176	Dermatophagoides pteronyssinus	28%	72%
P09668	Homo sapiens	36%	69%
P10056	Carica papaya	36%	66%
P13277	Homarus americanus	41%	72%
P15242	Rattus norvegicus	33%	69%
P16311	Dermatophagoides farinae	33%	72%
P25251	Brassica napus	40%	70%
P25326	Bos taurus	37%	70%
P25773	Felis catus	36%	70%
P25774	Homo sapiens	36%	70%
P25780	Euroglyphus maynei	29%	72%
P25782	Homarus americanus	36%	72%
P25783	Autographa californica nuclear polyhedrosis virus	33%	72%
P25784	Homarus americanus	41%	72%
P25975	Bos taurus	37%	69%
P36184	Entamoeba histolytica	31%	75%
P41715	Choristoneura fumiferana nuclear polyhedrosis virus	34%	71%
P41721	Bombyx mori nuclear polyhedrosis virus	33%	72%
P43234	Homo sapiens	36%	72%
P43235	Homo sapiens	34%	70%
P43236	Oryctolagus cuniculus	33%	70%
P49935	Mus musculus	35%	69%
P54640	Dictyostelium discoideum	34%	67%
P55097	Mus musculus	35%	70%
P61276	Macaca fascicularis	37%	70%
P61277	Macaca mulatta	37%	70%
P80884	Ananas comosus	34%	67%
Q02765	Rattus norvegicus	34%	70%
Q1EIQ3	Psoroptes ovis	32%	72%
Q23894	Dictyostelium discoideum	33%	69%
Q24940	Fasciola hepatica	39%	71%
Q26534	Schistosoma mansoni	38%	72%
Q26636	Sarcophaga peregrina	36%	68%
Q28944	Sus scrofa	40%	69%
Q3T0I2	Bos taurus	35%	69%
Q3ZKN1	Canis lupus familiaris	36%	70%
Q4QI62	Leishmania major	87%	66%
Q4QI64	Leishmania major	87%	66%
Q4QI65	Leishmania major	87%	66%
Q4QI67	Leishmania major	87%	66%
Q4QI68	Leishmania major	86%	66%
Q5E968	Bos taurus	37%	70%
Q5E998	Bos taurus	37%	69%
Q63088	Rattus norvegicus	36%	69%
Q6VTL7	Choristoneura fumiferana defective polyhedrosis virus	33%	71%
Q6YD92	Petrosia ficiformis	36%	68%
Q7XWK5	Oryza sativa subsp. japonica	38%	68%
Q80LP4	Adoxophyes honmai nucleopolyhedrovirus	36%	69%
Q80UB0	Mus musculus	32%	69%
Q86GF7	Pandalus borealis	39%	72%
Q8B9D5	Rachiplusia ou multiple nucleopolyhedrovirus (strain R1)	33%	72%
Q8BM88	Mus musculus	37%	74%
Q8HY81	Canis lupus familiaris	36%	70%
Q8HY82	Saimiri boliviensis boliviensis	35%	70%
Q8QLK1	Mamestra configurata nucleopolyhedrovirus	32%	69%
Q91BH1	Spodoptera litura multicapsid nucleopolyhedrovirus	33%	69%
Q91CL9	Antheraea pernyi nuclear polyhedrosis virus	34%	71%
Q91GE3	Epiphyas postvittana nucleopolyhedrovirus	34%	72%
Q91ZF2	Mus musculus	33%	70%
Q94714	Paramecium tetraurelia	34%	74%
Q94715	Paramecium tetraurelia	28%	75%
Q9FJ47	Arabidopsis thaliana	39%	67%
Q9GKL8	Chlorocebus aethiops	36%	69%
Q9GL24	Canis lupus familiaris	37%	69%
Q9GLE3	Sus scrofa	33%	70%
Q9J8B9	Spodoptera exigua nuclear polyhedrosis virus (strain US)	33%	69%
Q9JI81	Mus musculus	33%	69%
Q9JIA9	Mus musculus	33%	69%
Q9JL96	Mus musculus	32%	69%
Q9PYY5	Xestia c-nigrum granulosis virus	35%	67%
Q9QZE3	Rattus norvegicus	30%	67%
Q9R014	Mus musculus	36%	69%
Q9WGE0	Hyphantria cunea nuclear polyhedrosis virus	31%	71%
Q9YWK4	Buzura suppressaria nuclear polyhedrosis virus	32%	70%
V5BNL4	Trypanosoma cruzi	30%	82%