WGS CADB00000000 data, contig 34

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein

Species:

Leishmania mexicana

UniProt:

E8NHI2_LEIMU

TriTrypDb:

LmxM.34.2810b

Length:

705

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 12
NetGPI	no	yes: 0, no: 12

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	13
GO:0110165	cellular anatomical entity	1	13

Expansion

Sequence features

E8NHI2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E8NHI2

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005215	transporter activity	1	13
GO:0022857	transmembrane transporter activity	2	13

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	297	301	PF00656	0.654
CLV_C14_Caspase3-7	367	371	PF00656	0.644
CLV_C14_Caspase3-7	397	401	PF00656	0.605
CLV_NRD_NRD_1	109	111	PF00675	0.298
CLV_NRD_NRD_1	212	214	PF00675	0.548
CLV_NRD_NRD_1	27	29	PF00675	0.462
CLV_NRD_NRD_1	31	33	PF00675	0.431
CLV_NRD_NRD_1	359	361	PF00675	0.436
CLV_PCSK_KEX2_1	109	111	PF00082	0.276
CLV_PCSK_KEX2_1	31	33	PF00082	0.447
CLV_PCSK_KEX2_1	359	361	PF00082	0.436
CLV_PCSK_KEX2_1	461	463	PF00082	0.363
CLV_PCSK_PC1ET2_1	31	33	PF00082	0.457
CLV_PCSK_PC1ET2_1	461	463	PF00082	0.363
CLV_PCSK_SKI1_1	214	218	PF00082	0.494
CLV_PCSK_SKI1_1	32	36	PF00082	0.391
CLV_PCSK_SKI1_1	338	342	PF00082	0.430
CLV_PCSK_SKI1_1	364	368	PF00082	0.424
CLV_PCSK_SKI1_1	466	470	PF00082	0.356
CLV_PCSK_SKI1_1	471	475	PF00082	0.341
CLV_PCSK_SKI1_1	584	588	PF00082	0.280
DEG_MDM2_SWIB_1	586	594	PF02201	0.326
DOC_CKS1_1	629	634	PF01111	0.326
DOC_MAPK_DCC_7	213	223	PF00069	0.288
DOC_MAPK_FxFP_2	572	575	PF00069	0.284
DOC_MAPK_gen_1	511	520	PF00069	0.323
DOC_MAPK_MEF2A_6	214	223	PF00069	0.288
DOC_MAPK_MEF2A_6	475	484	PF00069	0.533
DOC_MAPK_NFAT4_5	475	483	PF00069	0.459
DOC_PP4_FxxP_1	266	269	PF00568	0.556
DOC_PP4_FxxP_1	385	388	PF00568	0.657
DOC_PP4_FxxP_1	469	472	PF00568	0.586
DOC_PP4_FxxP_1	572	575	PF00568	0.312
DOC_PP4_FxxP_1	629	632	PF00568	0.263
DOC_USP7_MATH_1	171	175	PF00917	0.310
DOC_USP7_MATH_1	194	198	PF00917	0.265
DOC_USP7_MATH_1	562	566	PF00917	0.353
DOC_USP7_UBL2_3	29	33	PF12436	0.694
DOC_WW_Pin1_4	32	37	PF00397	0.586
DOC_WW_Pin1_4	324	329	PF00397	0.693
DOC_WW_Pin1_4	384	389	PF00397	0.629
DOC_WW_Pin1_4	440	445	PF00397	0.651
DOC_WW_Pin1_4	628	633	PF00397	0.326
LIG_14-3-3_CanoR_1	359	366	PF00244	0.644
LIG_14-3-3_CanoR_1	548	553	PF00244	0.279
LIG_Actin_WH2_2	388	406	PF00022	0.618
LIG_Actin_WH2_2	58	73	PF00022	0.326
LIG_BIR_II_1	1	5	PF00653	0.645
LIG_BRCT_BRCA1_1	114	118	PF00533	0.322
LIG_BRCT_BRCA1_1	361	365	PF00533	0.650
LIG_BRCT_BRCA1_1	405	409	PF00533	0.633
LIG_BRCT_BRCA1_1	568	572	PF00533	0.428
LIG_deltaCOP1_diTrp_1	681	686	PF00928	0.592
LIG_DLG_GKlike_1	548	556	PF00625	0.279
LIG_EH1_1	176	184	PF00400	0.310
LIG_eIF4E_1	177	183	PF01652	0.310
LIG_eIF4E_1	80	86	PF01652	0.343
LIG_FHA_1	233	239	PF00498	0.386
LIG_FHA_1	272	278	PF00498	0.672
LIG_FHA_1	420	426	PF00498	0.688
LIG_FHA_1	44	50	PF00498	0.332
LIG_FHA_1	474	480	PF00498	0.522
LIG_FHA_1	55	61	PF00498	0.351
LIG_FHA_1	562	568	PF00498	0.415
LIG_FHA_2	315	321	PF00498	0.627
LIG_FHA_2	365	371	PF00498	0.687
LIG_FHA_2	488	494	PF00498	0.294
LIG_FHA_2	669	675	PF00498	0.533
LIG_IRF3_LxIS_1	113	120	PF10401	0.207
LIG_LIR_Apic_2	569	575	PF02991	0.325
LIG_LIR_Apic_2	639	645	PF02991	0.272
LIG_LIR_Gen_1	333	341	PF02991	0.664
LIG_LIR_Gen_1	46	54	PF02991	0.362
LIG_LIR_Nem_3	333	339	PF02991	0.664
LIG_LIR_Nem_3	46	50	PF02991	0.294
LIG_LIR_Nem_3	551	556	PF02991	0.489
LIG_LIR_Nem_3	569	574	PF02991	0.272
LIG_LIR_Nem_3	589	595	PF02991	0.316
LIG_LIR_Nem_3	97	103	PF02991	0.429
LIG_LYPXL_S_1	255	259	PF13949	0.315
LIG_MLH1_MIPbox_1	568	572	PF16413	0.346
LIG_MYND_1	215	219	PF01753	0.364
LIG_MYND_1	269	273	PF01753	0.583
LIG_NRBOX	479	485	PF00104	0.255
LIG_NRBOX	649	655	PF00104	0.294
LIG_Pex14_1	134	138	PF04695	0.265
LIG_Pex14_2	586	590	PF04695	0.343
LIG_REV1ctd_RIR_1	136	144	PF16727	0.294
LIG_SH2_CRK	226	230	PF00017	0.288
LIG_SH2_CRK	592	596	PF00017	0.455
LIG_SH2_CRK	698	702	PF00017	0.522
LIG_SH2_GRB2like	226	229	PF00017	0.288
LIG_SH2_GRB2like	540	543	PF00017	0.548
LIG_SH2_NCK_1	192	196	PF00017	0.248
LIG_SH2_NCK_1	226	230	PF00017	0.245
LIG_SH2_PTP2	254	257	PF00017	0.535
LIG_SH2_PTP2	481	484	PF00017	0.255
LIG_SH2_SRC	192	195	PF00017	0.248
LIG_SH2_SRC	254	257	PF00017	0.535
LIG_SH2_SRC	663	666	PF00017	0.294
LIG_SH2_STAP1	665	669	PF00017	0.340
LIG_SH2_STAT5	226	229	PF00017	0.288
LIG_SH2_STAT5	254	257	PF00017	0.511
LIG_SH2_STAT5	481	484	PF00017	0.272
LIG_SH2_STAT5	517	520	PF00017	0.315
LIG_SH2_STAT5	540	543	PF00017	0.542
LIG_SH2_STAT5	566	569	PF00017	0.358
LIG_SH2_STAT5	571	574	PF00017	0.346
LIG_SH2_STAT5	663	666	PF00017	0.326
LIG_SH3_3	13	19	PF00018	0.668
LIG_SH3_3	322	328	PF00018	0.655
LIG_SH3_3	6	12	PF00018	0.730
LIG_SUMO_SIM_anti_2	391	400	PF11976	0.642
LIG_SUMO_SIM_anti_2	557	562	PF11976	0.288
LIG_SUMO_SIM_par_1	391	400	PF11976	0.642
LIG_TRAF2_1	490	493	PF00917	0.379
LIG_TRAF2_1	671	674	PF00917	0.527
LIG_TRFH_1	571	575	PF08558	0.321
LIG_TYR_ITIM	479	484	PF00017	0.461
LIG_UBA3_1	156	163	PF00899	0.437
LIG_WRC_WIRS_1	233	238	PF05994	0.365
MOD_CDK_SPxxK_3	440	447	PF00069	0.638
MOD_CK1_1	206	212	PF00069	0.366
MOD_CK1_1	346	352	PF00069	0.766
MOD_CK1_1	53	59	PF00069	0.347
MOD_CK1_1	596	602	PF00069	0.426
MOD_CK2_1	289	295	PF00069	0.713
MOD_CK2_1	314	320	PF00069	0.638
MOD_CK2_1	368	374	PF00069	0.638
MOD_CK2_1	487	493	PF00069	0.294
MOD_CK2_1	668	674	PF00069	0.532
MOD_CK2_1	71	77	PF00069	0.288
MOD_Cter_Amidation	107	110	PF01082	0.300
MOD_GlcNHglycan	114	117	PF01048	0.288
MOD_GlcNHglycan	119	122	PF01048	0.288
MOD_GlcNHglycan	197	200	PF01048	0.568
MOD_GlcNHglycan	312	315	PF01048	0.494
MOD_GlcNHglycan	601	604	PF01048	0.335
MOD_GlcNHglycan	654	657	PF01048	0.400
MOD_GlcNHglycan	660	663	PF01048	0.288
MOD_GlcNHglycan	81	84	PF01048	0.343
MOD_GSK3_1	267	274	PF00069	0.681
MOD_GSK3_1	276	283	PF00069	0.678
MOD_GSK3_1	310	317	PF00069	0.647
MOD_GSK3_1	324	331	PF00069	0.683
MOD_GSK3_1	339	346	PF00069	0.644
MOD_GSK3_1	360	367	PF00069	0.704
MOD_GSK3_1	50	57	PF00069	0.399
MOD_GSK3_1	562	569	PF00069	0.380
MOD_GSK3_1	599	606	PF00069	0.572
MOD_LATS_1	358	364	PF00433	0.633
MOD_LATS_1	69	75	PF00433	0.288
MOD_N-GLC_1	195	200	PF02516	0.554
MOD_N-GLC_1	289	294	PF02516	0.495
MOD_N-GLC_1	346	351	PF02516	0.471
MOD_N-GLC_1	50	55	PF02516	0.288
MOD_NEK2_1	117	122	PF00069	0.298
MOD_NEK2_1	127	132	PF00069	0.332
MOD_NEK2_1	224	229	PF00069	0.422
MOD_NEK2_1	232	237	PF00069	0.477
MOD_NEK2_1	277	282	PF00069	0.696
MOD_NEK2_1	341	346	PF00069	0.677
MOD_NEK2_1	403	408	PF00069	0.686
MOD_NEK2_1	50	55	PF00069	0.329
MOD_NEK2_1	520	525	PF00069	0.400
MOD_NEK2_1	578	583	PF00069	0.352
MOD_NEK2_1	586	591	PF00069	0.480
MOD_NEK2_1	612	617	PF00069	0.505
MOD_NEK2_1	634	639	PF00069	0.384
MOD_NEK2_1	652	657	PF00069	0.341
MOD_NEK2_1	690	695	PF00069	0.516
MOD_NEK2_2	321	326	PF00069	0.641
MOD_NEK2_2	419	424	PF00069	0.645
MOD_PIKK_1	314	320	PF00454	0.676
MOD_PIKK_1	612	618	PF00454	0.480
MOD_PK_1	368	374	PF00069	0.613
MOD_PK_1	71	77	PF00069	0.288
MOD_PKA_1	359	365	PF00069	0.631
MOD_PKA_2	271	277	PF00069	0.687
MOD_PKA_2	359	365	PF00069	0.670
MOD_PKA_2	403	409	PF00069	0.697
MOD_Plk_1	195	201	PF00069	0.359
MOD_Plk_1	319	325	PF00069	0.624
MOD_Plk_1	487	493	PF00069	0.294
MOD_Plk_1	50	56	PF00069	0.288
MOD_Plk_1	680	686	PF00069	0.584
MOD_Plk_2-3	413	419	PF00069	0.644
MOD_Plk_4	10	16	PF00069	0.649
MOD_Plk_4	129	135	PF00069	0.361
MOD_Plk_4	152	158	PF00069	0.501
MOD_Plk_4	206	212	PF00069	0.380
MOD_Plk_4	217	223	PF00069	0.243
MOD_Plk_4	232	238	PF00069	0.348
MOD_Plk_4	419	425	PF00069	0.643
MOD_Plk_4	43	49	PF00069	0.312
MOD_Plk_4	54	60	PF00069	0.359
MOD_Plk_4	542	548	PF00069	0.554
MOD_Plk_4	562	568	PF00069	0.426
MOD_Plk_4	593	599	PF00069	0.341
MOD_Plk_4	607	613	PF00069	0.499
MOD_ProDKin_1	32	38	PF00069	0.576
MOD_ProDKin_1	324	330	PF00069	0.693
MOD_ProDKin_1	384	390	PF00069	0.629
MOD_ProDKin_1	440	446	PF00069	0.649
MOD_ProDKin_1	628	634	PF00069	0.326
MOD_SUMO_rev_2	456	463	PF00179	0.609
MOD_SUMO_rev_2	683	693	PF00179	0.526
TRG_DiLeu_BaEn_2	261	267	PF01217	0.560
TRG_DiLeu_BaLyEn_6	325	330	PF01217	0.676
TRG_DiLeu_BaLyEn_6	385	390	PF01217	0.659
TRG_ENDOCYTIC_2	226	229	PF00928	0.304
TRG_ENDOCYTIC_2	256	259	PF00928	0.512
TRG_ENDOCYTIC_2	481	484	PF00928	0.388
TRG_ENDOCYTIC_2	517	520	PF00928	0.311
TRG_ENDOCYTIC_2	571	574	PF00928	0.311
TRG_ENDOCYTIC_2	592	595	PF00928	0.489
TRG_ENDOCYTIC_2	698	701	PF00928	0.574
TRG_ER_diArg_1	109	111	PF00400	0.461
TRG_NES_CRM1_1	41	52	PF08389	0.488
TRG_NLS_MonoExtC_3	27	32	PF00514	0.673
TRG_NLS_MonoExtN_4	28	35	PF00514	0.644

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IMM8	Leptomonas seymouri	44%	100%
A0A3Q8II42	Leishmania donovani	31%	98%
A0A3Q8IPN7	Leishmania donovani	82%	100%
A4HMU7	Leishmania braziliensis	64%	100%
A4HMU9	Leishmania braziliensis	30%	99%
A4IBH0	Leishmania infantum	82%	100%
A4IBH1	Leishmania infantum	29%	96%
E9AFA5	Leishmania major	79%	100%
E9AFA6	Leishmania major	30%	94%
E9B6G0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	97%	100%
E9B6G1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	31%	100%