WGS CADB00000000 data, contig 32

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Protein of unknown function (DUF2946), putative

Species:

Leishmania mexicana

UniProt:

E8NHH9_LEIMU

TriTrypDb:

Length:

142

Annotations

LeishMANIAdb annotations

Publication identifier(s): 26641088 15760660
Amastin, Kinetoplastid host adhesion protein. A host adhesion protein family greatly expanded in Leishmaniids.. Localization: Cell surface (experimental)

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 3
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 12

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 11, no: 165
NetGPI	no	yes: 0, no: 176

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	156
GO:0110165	cellular anatomical entity	1	156

Expansion

Sequence features

E8NHH9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E8NHH9

Function

Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0016485	protein processing	5	1
GO:0016540	protein autoprocessing	6	1
GO:0019538	protein metabolic process	3	1
GO:0043170	macromolecule metabolic process	3	1
GO:0044238	primary metabolic process	2	1
GO:0051604	protein maturation	4	1
GO:0071704	organic substance metabolic process	2	1
GO:1901564	organonitrogen compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	1
GO:0004175	endopeptidase activity	4	1
GO:0004197	cysteine-type endopeptidase activity	5	1
GO:0008233	peptidase activity	3	1
GO:0008234	cysteine-type peptidase activity	4	1
GO:0016787	hydrolase activity	2	1
GO:0140096	catalytic activity, acting on a protein	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
DOC_MAPK_gen_1	67	75	PF00069	0.289
DOC_MAPK_MEF2A_6	108	116	PF00069	0.549
DOC_PP4_FxxP_1	37	40	PF00568	0.327
DOC_WW_Pin1_4	22	27	PF00397	0.365
DOC_WW_Pin1_4	31	36	PF00397	0.310
LIG_Actin_WH2_2	37	52	PF00022	0.203
LIG_Actin_WH2_2	92	110	PF00022	0.367
LIG_BIR_II_1	1	5	PF00653	0.694
LIG_BRCT_BRCA1_1	26	30	PF00533	0.215
LIG_BRCT_BRCA1_1	33	37	PF00533	0.209
LIG_FHA_1	119	125	PF00498	0.423
LIG_FHA_1	84	90	PF00498	0.327
LIG_LIR_Apic_2	34	40	PF02991	0.366
LIG_Pex14_2	37	41	PF04695	0.209
LIG_REV1ctd_RIR_1	62	71	PF16727	0.202
LIG_SH2_PTP2	10	13	PF00017	0.375
LIG_SH2_SRC	10	13	PF00017	0.223
LIG_SH2_STAT5	10	13	PF00017	0.449
LIG_SH3_3	32	38	PF00018	0.309
LIG_TYR_ITIM	8	13	PF00017	0.438
MOD_DYRK1A_RPxSP_1	31	35	PF00069	0.199
MOD_GlcNHglycan	26	29	PF01048	0.350
MOD_GlcNHglycan	31	34	PF01048	0.485
MOD_GSK3_1	29	36	PF00069	0.282
MOD_N-GLC_1	133	138	PF02516	0.562
MOD_N-GLC_1	58	63	PF02516	0.614
MOD_NEK2_1	1	6	PF00069	0.693
MOD_NEK2_1	29	34	PF00069	0.343
MOD_NEK2_1	49	54	PF00069	0.383
MOD_NEK2_2	58	63	PF00069	0.214
MOD_NEK2_2	83	88	PF00069	0.446
MOD_Plk_1	58	64	PF00069	0.276
MOD_Plk_4	102	108	PF00069	0.369
MOD_Plk_4	83	89	PF00069	0.310
MOD_ProDKin_1	22	28	PF00069	0.365
MOD_ProDKin_1	31	37	PF00069	0.310
TRG_DiLeu_BaLyEn_6	3	8	PF01217	0.414
TRG_ENDOCYTIC_2	10	13	PF00928	0.424
TRG_ER_diArg_1	70	73	PF00400	0.269

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2C4	Leptomonas seymouri	29%	80%
A0A0N0P547	Leptomonas seymouri	42%	92%
A0A0N1HWY5	Leptomonas seymouri	26%	73%
A0A0N1PDH0	Leptomonas seymouri	39%	70%
A0A1X0NQ58	Trypanosomatidae	30%	79%
A0A1X0P988	Trypanosomatidae	43%	82%
A0A381MTA7	Leishmania infantum	55%	74%
A0A381MTB8	Leishmania infantum	52%	74%
A0A381MTC7	Leishmania infantum	57%	69%
A0A381MTN2	Leishmania infantum	41%	73%
A0A381MVY0	Leishmania infantum	59%	74%
A0A3Q8ID16	Leishmania donovani	31%	82%
A0A3Q8IE85	Leishmania donovani	54%	100%
A0A3Q8IEC2	Leishmania donovani	58%	74%
A0A3Q8IEI1	Leishmania donovani	46%	74%
A0A3Q8IF65	Leishmania donovani	46%	72%
A0A3Q8IFB9	Leishmania donovani	34%	70%
A0A3Q8IFH7	Leishmania donovani	57%	69%
A0A3Q8IH65	Leishmania donovani	53%	74%
A0A3Q8IHN2	Leishmania donovani	48%	74%
A0A3Q8IHW7	Leishmania donovani	50%	77%
A0A3Q8IHZ6	Leishmania donovani	49%	67%
A0A3Q8IIH1	Leishmania donovani	51%	73%
A0A3Q8IL03	Leishmania donovani	51%	74%
A0A3Q8IMR4	Leishmania donovani	26%	76%
A0A3Q8IUK8	Leishmania donovani	58%	74%
A0A3Q8IUR5	Leishmania donovani	41%	73%
A0A3S5H662	Leishmania donovani	45%	70%
A0A3S5H663	Leishmania donovani	45%	70%
A0A3S5H665	Leishmania donovani	45%	70%
A0A3S5H666	Leishmania donovani	44%	74%
A0A3S5H667	Leishmania donovani	45%	70%
A0A3S5H7L2	Leishmania donovani	41%	69%
A0A3S5H7V9	Leishmania donovani	44%	72%
A0A3S5H7W2	Leishmania donovani	28%	74%
A0A3S5H7W6	Leishmania donovani	52%	71%
A0A3S7WQA0	Leishmania donovani	45%	70%
A0A3S7WQA8	Leishmania donovani	50%	81%
A0A3S7WQC1	Leishmania donovani	50%	74%
A0A3S7X2E6	Leishmania donovani	41%	74%
A0A3S7X453	Leishmania donovani	45%	72%
A0A3S7X472	Leishmania donovani	44%	71%
A0A3S7X7M4	Leishmania donovani	49%	67%
A0A3S7X7U1	Leishmania donovani	56%	68%
A0A3S7X7W2	Leishmania donovani	45%	68%
A0A3S7X7Y0	Leishmania donovani	52%	73%
A4H5D1	Leishmania braziliensis	51%	100%
A4H5D2	Leishmania braziliensis	34%	100%
A4H5G0	Leishmania braziliensis	44%	100%
A4H5G4	Leishmania braziliensis	40%	100%
A4H5G9	Leishmania braziliensis	52%	100%
A4H5H0	Leishmania braziliensis	52%	100%
A4H5H1	Leishmania braziliensis	49%	100%
A4H5H2	Leishmania braziliensis	45%	100%
A4H5H3	Leishmania braziliensis	40%	100%
A4H6C8	Leishmania braziliensis	43%	100%
A4H7D7	Leishmania braziliensis	47%	100%
A4H9E8	Leishmania braziliensis	55%	68%
A4H9E9	Leishmania braziliensis	46%	100%
A4HAJ4	Leishmania braziliensis	48%	100%
A4HAL2	Leishmania braziliensis	27%	100%
A4HAM2	Leishmania braziliensis	48%	100%
A4HAM4	Leishmania braziliensis	48%	100%
A4HAR1	Leishmania braziliensis	48%	100%
A4HAZ8	Leishmania braziliensis	46%	100%
A4HB00	Leishmania braziliensis	45%	100%
A4HB02	Leishmania braziliensis	46%	100%
A4HB47	Leishmania braziliensis	35%	70%
A4HBJ0	Leishmania braziliensis	46%	100%
A4HBJ1	Leishmania braziliensis	48%	100%
A4HBJ2	Leishmania braziliensis	51%	100%
A4HDI4	Leishmania braziliensis	28%	100%
A4HDL3	Leishmania braziliensis	29%	100%
A4HDL4	Leishmania braziliensis	28%	100%
A4HTM3	Leishmania infantum	50%	74%
A4HTM4	Leishmania infantum	48%	81%
A4HTM5	Leishmania infantum	52%	74%
A4I0W3	Leishmania infantum	26%	100%
A4I0W5	Leishmania infantum	31%	82%
A4I4J2	Leishmania infantum	41%	69%
A4I6E5	Leishmania infantum	44%	71%
A4I9Q4	Leishmania infantum	49%	84%
A4I9R4	Leishmania infantum	28%	74%
A4I9R5	Leishmania infantum	34%	70%
A4I9R7	Leishmania infantum	48%	72%
A4I9X0	Leishmania infantum	47%	68%
A4IAL7	Leishmania infantum	49%	77%
A4IAM1	Leishmania infantum	43%	74%
A4IAM2	Leishmania infantum	46%	74%
C6K3X9	Leptomonas seymouri	25%	74%
E8NHC3	Leishmania infantum	46%	71%
E8NHD3	Leishmania infantum	41%	69%
E8NHD9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	97%	100%
E8NHE0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	61%	100%
E8NHF4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	43%	100%
E8NHF5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	59%	100%
E8NHF7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	51%	100%
E8NHG2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	45%	100%
E8NHH5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	43%	100%
E8NHH8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	97%	100%
E8NHI3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	38%	73%
E8NHI5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	65%	74%
E8NHK7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	44%	67%
E8NHK9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	60%	73%
E8NHL7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	60%	74%
E8NHL9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	59%	74%
E8NHM0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	59%	76%
E8NHM1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	42%	73%
E8NHM3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	44%	67%
E8NHM5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	44%	67%
E8NHM6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	55%	75%
E8NHP0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	56%	69%
E8NHQ0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	41%	68%
E8NHQ1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	42%	73%
E8NHR7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	99%	73%
E8NHR8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	73%
E8NHS2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	42%	67%
E9AG81	Leishmania infantum	45%	70%
E9AG82	Leishmania infantum	45%	70%
E9AG83	Leishmania infantum	44%	71%
E9AG85	Leishmania infantum	45%	70%
E9AHI9	Leishmania infantum	41%	74%
E9AHT2	Leishmania infantum	50%	67%
E9AME9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	46%	81%
E9AMF0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	48%	77%
E9AMF1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	44%	68%
E9AMF2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	45%	73%
E9AMF3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	42%	73%
E9AMF5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	44%	68%
E9AMF8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	48%	74%
E9AMF9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	50%	74%
E9ASP7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	55%	68%
E9AWW7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	28%	100%
E9AWW9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	29%	82%
E9AWX0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	28%	100%
E9B1J3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	39%	73%
E9B1J4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	45%	68%
E9B1J5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	45%	67%
E9B4L9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	42%	72%
E9B4R7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	43%	72%
E9B4R8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	45%	72%
E9B4R9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	32%	70%
E9B4Y3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	55%	69%
Q4Q1U9	Leishmania major	58%	100%
Q4Q305	Leishmania major	55%	100%
Q4Q309	Leishmania major	56%	100%
Q4Q313	Leishmania major	55%	100%
Q4Q317	Leishmania major	49%	100%
Q4Q325	Leishmania major	56%	100%
Q4Q327	Leishmania major	57%	100%
Q4Q329	Leishmania major	56%	100%
Q4Q333	Leishmania major	56%	100%
Q4Q335	Leishmania major	55%	100%
Q4Q337	Leishmania major	59%	100%
Q4Q339	Leishmania major	55%	100%
Q4Q341	Leishmania major	56%	100%
Q4Q3A7	Leishmania major	28%	74%
Q4Q3A8	Leishmania major	32%	100%
Q4Q3A9	Leishmania major	52%	100%
Q4Q3F7	Leishmania major	50%	67%
Q4Q6L8	Leishmania major	46%	100%
Q4QAK4	Leishmania major	27%	100%
Q4QAK5	Leishmania major	31%	100%
Q4QAK7	Leishmania major	28%	100%
Q4QI84	Leishmania major	52%	100%
Q4QI85	Leishmania major	54%	100%
Q4QI86	Leishmania major	54%	100%
Q4QI87	Leishmania major	51%	100%
Q4QI88	Leishmania major	51%	100%
Q4QI92	Leishmania major	45%	100%
Q4QI93	Leishmania major	45%	100%
Q4QI95	Leishmania major	45%	100%
Q4QI97	Leishmania major	45%	100%
Q4QIA0	Leishmania major	45%	100%
Q4QIA1	Leishmania major	45%	100%