WGS CADB00000000 data, contig 3

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

amastin-like surface protein, putative

Species:

Leishmania mexicana

UniProt:

E8NHH8_LEIMU

TriTrypDb:

LmxM.33.1680

Length:

Annotations

LeishMANIAdb annotations

Publication identifier(s): 26641088 15760660
Amastin, Kinetoplastid host adhesion protein. A host adhesion protein family greatly expanded in Leishmaniids.. Localization: Cell surface (experimental)

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 4
NetGPI	no	yes: 0, no: 4

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	5
GO:0110165	cellular anatomical entity	1	5

Expansion

Sequence features

E8NHH8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E8NHH8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
DOC_MAPK_gen_1	67	75	PF00069	0.525
DOC_PP4_FxxP_1	37	40	PF00568	0.325
DOC_WW_Pin1_4	22	27	PF00397	0.390
DOC_WW_Pin1_4	31	36	PF00397	0.328
LIG_Actin_WH2_2	37	52	PF00022	0.325
LIG_BIR_II_1	1	5	PF00653	0.671
LIG_BRCT_BRCA1_1	26	30	PF00533	0.325
LIG_BRCT_BRCA1_1	33	37	PF00533	0.272
LIG_LIR_Apic_2	34	40	PF02991	0.325
LIG_Pex14_2	37	41	PF04695	0.325
LIG_REV1ctd_RIR_1	62	71	PF16727	0.525
LIG_SH2_CRK	3	7	PF00017	0.512
LIG_SH2_PTP2	10	13	PF00017	0.454
LIG_SH2_SRC	10	13	PF00017	0.385
LIG_SH2_STAT5	10	13	PF00017	0.394
LIG_SH3_3	32	38	PF00018	0.368
LIG_TYR_ITIM	8	13	PF00017	0.390
MOD_DYRK1A_RPxSP_1	31	35	PF00069	0.325
MOD_GlcNHglycan	26	29	PF01048	0.546
MOD_GlcNHglycan	31	34	PF01048	0.507
MOD_GSK3_1	29	36	PF00069	0.328
MOD_N-GLC_1	58	63	PF02516	0.365
MOD_NEK2_1	1	6	PF00069	0.636
MOD_NEK2_1	29	34	PF00069	0.379
MOD_NEK2_1	49	54	PF00069	0.430
MOD_NEK2_2	58	63	PF00069	0.525
MOD_Plk_1	58	64	PF00069	0.565
MOD_ProDKin_1	22	28	PF00069	0.390
MOD_ProDKin_1	31	37	PF00069	0.328
TRG_DiLeu_BaLyEn_6	3	8	PF01217	0.525
TRG_ENDOCYTIC_2	10	13	PF00928	0.390
TRG_ER_diArg_1	70	73	PF00400	0.533

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4Q6	Leptomonas seymouri	36%	100%
A0A3Q8IE85	Leishmania donovani	49%	69%
E8NHH9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	97%	67%