Uncharacterized protein LmxM_08_1030_1

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Protein of unknown function (DUF2946), putative

Species:

Leishmania mexicana

UniProt:

E8NHH7_LEIMU

TriTrypDb:

Length:

236

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 5

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 1
NetGPI	no	yes: 0, no: 2

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E8NHH7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E8NHH7

Function

Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	3
GO:0006807	nitrogen compound metabolic process	2	3
GO:0008152	metabolic process	1	3
GO:0019538	protein metabolic process	3	3
GO:0043170	macromolecule metabolic process	3	3
GO:0044238	primary metabolic process	2	3
GO:0071704	organic substance metabolic process	2	3
GO:1901564	organonitrogen compound metabolic process	3	3

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	3
GO:0004175	endopeptidase activity	4	3
GO:0004197	cysteine-type endopeptidase activity	5	3
GO:0008233	peptidase activity	3	3
GO:0008234	cysteine-type peptidase activity	4	3
GO:0016787	hydrolase activity	2	3
GO:0140096	catalytic activity, acting on a protein	2	3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	166	168	PF00675	0.253
CLV_NRD_NRD_1	169	171	PF00675	0.245
CLV_PCSK_KEX2_1	166	168	PF00082	0.253
DEG_APCC_DBOX_1	169	177	PF00400	0.253
DEG_Nend_Nbox_1	1	3	PF02207	0.383
DEG_SPOP_SBC_1	139	143	PF00917	0.335
DOC_MAPK_gen_1	166	176	PF00069	0.253
DOC_MAPK_MEF2A_6	50	58	PF00069	0.523
DOC_USP7_MATH_1	139	143	PF00917	0.246
DOC_USP7_MATH_1	8	12	PF00917	0.523
DOC_USP7_UBL2_3	171	175	PF12436	0.253
DOC_WW_Pin1_4	144	149	PF00397	0.286
DOC_WW_Pin1_4	190	195	PF00397	0.253
DOC_WW_Pin1_4	219	224	PF00397	0.329
LIG_14-3-3_CanoR_1	170	174	PF00244	0.271
LIG_BRCT_BRCA1_1	202	206	PF00533	0.253
LIG_BRCT_BRCA1_1	221	225	PF00533	0.282
LIG_FHA_1	70	76	PF00498	0.345
LIG_FHA_1	89	95	PF00498	0.202
LIG_FHA_2	141	147	PF00498	0.350
LIG_LIR_Gen_1	109	119	PF02991	0.523
LIG_LIR_LC3C_4	22	27	PF02991	0.253
LIG_LIR_Nem_3	109	115	PF02991	0.355
LIG_LIR_Nem_3	4	10	PF02991	0.253
LIG_LIR_Nem_3	61	66	PF02991	0.523
LIG_LIR_Nem_3	93	99	PF02991	0.412
LIG_LYPXL_yS_3	7	10	PF13949	0.253
LIG_MLH1_MIPbox_1	221	225	PF16413	0.336
LIG_SH2_GRB2like	202	205	PF00017	0.253
LIG_SH2_NCK_1	202	206	PF00017	0.253
LIG_SH2_PTP2	112	115	PF00017	0.368
LIG_SH2_STAP1	202	206	PF00017	0.253
LIG_SH2_STAT5	112	115	PF00017	0.368
LIG_SH2_STAT5	15	18	PF00017	0.305
LIG_SH2_STAT5	2	5	PF00017	0.356
LIG_SH2_STAT5	224	227	PF00017	0.346
LIG_SH2_STAT5	9	12	PF00017	0.467
LIG_SUMO_SIM_par_1	151	156	PF11976	0.253
LIG_TYR_ITIM	94	99	PF00017	0.253
MOD_CDC14_SPxK_1	193	196	PF00782	0.253
MOD_CDK_SPxK_1	190	196	PF00069	0.253
MOD_CDK_SPxxK_3	144	151	PF00069	0.253
MOD_CK1_1	142	148	PF00069	0.337
MOD_CK1_1	20	26	PF00069	0.253
MOD_CK1_1	62	68	PF00069	0.253
MOD_CK2_1	140	146	PF00069	0.253
MOD_GlcNHglycan	10	13	PF01048	0.523
MOD_GlcNHglycan	129	132	PF01048	0.336
MOD_GlcNHglycan	135	138	PF01048	0.265
MOD_GlcNHglycan	67	70	PF01048	0.253
MOD_GSK3_1	138	145	PF00069	0.330
MOD_GSK3_1	225	232	PF00069	0.308
MOD_GSK3_1	58	65	PF00069	0.288
MOD_N-GLC_1	20	25	PF02516	0.356
MOD_N-GLC_2	120	122	PF02516	0.368
MOD_N-GLC_2	177	179	PF02516	0.253
MOD_N-GLC_2	231	233	PF02516	0.323
MOD_NEK2_1	17	22	PF00069	0.253
MOD_NEK2_1	225	230	PF00069	0.310
MOD_NEK2_1	58	63	PF00069	0.292
MOD_PKA_2	133	139	PF00069	0.253
MOD_PKA_2	169	175	PF00069	0.253
MOD_Plk_1	3	9	PF00069	0.523
MOD_Plk_1	58	64	PF00069	0.523
MOD_Plk_4	169	175	PF00069	0.463
MOD_Plk_4	185	191	PF00069	0.216
MOD_Plk_4	225	231	PF00069	0.315
MOD_Plk_4	59	65	PF00069	0.253
MOD_ProDKin_1	144	150	PF00069	0.286
MOD_ProDKin_1	190	196	PF00069	0.253
MOD_ProDKin_1	219	225	PF00069	0.336
MOD_SUMO_rev_2	215	222	PF00179	0.317
TRG_ENDOCYTIC_2	112	115	PF00928	0.368
TRG_ENDOCYTIC_2	7	10	PF00928	0.253
TRG_ENDOCYTIC_2	96	99	PF00928	0.368

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S5IRW0	Trypanosoma rangeli	35%	96%