Uncharacterized protein LmxM_08_1030_1

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Protein of unknown function (DUF2946), putative

Species:

Leishmania mexicana

UniProt:

E8NHH7_LEIMU

TriTrypDb:

Length:

236

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 5

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 1
NetGPI	no	yes: 0, no: 2

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E8NHH7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E8NHH7

Function

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Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	3
GO:0006807	nitrogen compound metabolic process	2	3
GO:0008152	metabolic process	1	3
GO:0019538	protein metabolic process	3	3
GO:0043170	macromolecule metabolic process	3	3
GO:0044238	primary metabolic process	2	3
GO:0071704	organic substance metabolic process	2	3
GO:1901564	organonitrogen compound metabolic process	3	3

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Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	3
GO:0004175	endopeptidase activity	4	3
GO:0004197	cysteine-type endopeptidase activity	5	3
GO:0008233	peptidase activity	3	3
GO:0008234	cysteine-type peptidase activity	4	3
GO:0016787	hydrolase activity	2	3
GO:0140096	catalytic activity, acting on a protein	2	3

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	166	168	PF00675	0.253
CLV_NRD_NRD_1	169	171	PF00675	0.245
CLV_PCSK_KEX2_1	166	168	PF00082	0.253
DEG_APCC_DBOX_1	169	177	PF00400	0.253
DEG_Nend_Nbox_1	1	3	PF02207	0.383
DEG_SPOP_SBC_1	139	143	PF00917	0.335
DOC_MAPK_gen_1	166	176	PF00069	0.253
DOC_MAPK_MEF2A_6	50	58	PF00069	0.523
DOC_USP7_MATH_1	139	143	PF00917	0.246
DOC_USP7_MATH_1	8	12	PF00917	0.523

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A3S5IRW0	Trypanosoma rangeli	35%	96%

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