WGS CADB00000000 data, contig 28

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein

Species:

Leishmania mexicana

UniProt:

E8NHH3_LEIMU

TriTrypDb:

LmxM.11.1220a

Length:

359

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	6
GO:0110165	cellular anatomical entity	1	6

Expansion

Sequence features

E8NHH3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E8NHH3

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	6
GO:0005215	transporter activity	1	6
GO:0005488	binding	1	6
GO:0005524	ATP binding	5	6
GO:0015399	primary active transmembrane transporter activity	4	6
GO:0017076	purine nucleotide binding	4	6
GO:0022804	active transmembrane transporter activity	3	6
GO:0022857	transmembrane transporter activity	2	6
GO:0030554	adenyl nucleotide binding	5	6
GO:0032553	ribonucleotide binding	3	6
GO:0032555	purine ribonucleotide binding	4	6
GO:0032559	adenyl ribonucleotide binding	5	6
GO:0035639	purine ribonucleoside triphosphate binding	4	6
GO:0036094	small molecule binding	2	6
GO:0042626	ATPase-coupled transmembrane transporter activity	2	6
GO:0043167	ion binding	2	6
GO:0043168	anion binding	3	6
GO:0097159	organic cyclic compound binding	2	6
GO:0097367	carbohydrate derivative binding	2	6
GO:0140359	ABC-type transporter activity	3	6
GO:0140657	ATP-dependent activity	1	6
GO:1901265	nucleoside phosphate binding	3	6
GO:1901363	heterocyclic compound binding	2	6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	11	13	PF00675	0.299
CLV_NRD_NRD_1	132	134	PF00675	0.179
CLV_NRD_NRD_1	162	164	PF00675	0.120
CLV_NRD_NRD_1	192	194	PF00675	0.216
CLV_NRD_NRD_1	286	288	PF00675	0.223
CLV_PCSK_FUR_1	284	288	PF00082	0.246
CLV_PCSK_KEX2_1	11	13	PF00082	0.296
CLV_PCSK_KEX2_1	134	136	PF00082	0.286
CLV_PCSK_KEX2_1	162	164	PF00082	0.120
CLV_PCSK_KEX2_1	192	194	PF00082	0.216
CLV_PCSK_KEX2_1	286	288	PF00082	0.223
CLV_PCSK_PC1ET2_1	134	136	PF00082	0.286
CLV_PCSK_SKI1_1	12	16	PF00082	0.329
CLV_PCSK_SKI1_1	176	180	PF00082	0.212
CLV_PCSK_SKI1_1	268	272	PF00082	0.451
CLV_PCSK_SKI1_1	286	290	PF00082	0.261
CLV_PCSK_SKI1_1	300	304	PF00082	0.275
CLV_PCSK_SKI1_1	42	46	PF00082	0.331
CLV_PCSK_SKI1_1	94	98	PF00082	0.165
DEG_APCC_DBOX_1	93	101	PF00400	0.129
DEG_Nend_UBRbox_3	1	2	PF02207	0.458
DOC_CYCLIN_RxL_1	281	291	PF00134	0.229
DOC_MAPK_gen_1	162	171	PF00069	0.260
DOC_MAPK_gen_1	20	27	PF00069	0.197
DOC_MAPK_gen_1	281	290	PF00069	0.232
DOC_MAPK_MEF2A_6	162	171	PF00069	0.120
DOC_PP1_RVXF_1	174	180	PF00149	0.212
DOC_PP1_RVXF_1	284	291	PF00149	0.223
DOC_PP1_RVXF_1	40	47	PF00149	0.122
DOC_PP4_FxxP_1	290	293	PF00568	0.247
DOC_USP7_MATH_1	203	207	PF00917	0.277
DOC_USP7_MATH_1	276	280	PF00917	0.235
DOC_USP7_UBL2_3	239	243	PF12436	0.231
LIG_14-3-3_CanoR_1	11	15	PF00244	0.230
LIG_14-3-3_CanoR_1	126	131	PF00244	0.187
LIG_14-3-3_CanoR_1	162	168	PF00244	0.128
LIG_14-3-3_CanoR_1	193	202	PF00244	0.201
LIG_14-3-3_CanoR_1	255	263	PF00244	0.265
LIG_14-3-3_CanoR_1	286	291	PF00244	0.238
LIG_14-3-3_CanoR_1	42	47	PF00244	0.176
LIG_Actin_WH2_2	218	236	PF00022	0.229
LIG_BRCT_BRCA1_1	298	302	PF00533	0.251
LIG_Clathr_ClatBox_1	112	116	PF01394	0.176
LIG_Clathr_ClatBox_1	24	28	PF01394	0.174
LIG_EH1_1	222	230	PF00400	0.187
LIG_FHA_1	210	216	PF00498	0.201
LIG_FHA_1	287	293	PF00498	0.196
LIG_FHA_1	299	305	PF00498	0.224
LIG_FHA_1	43	49	PF00498	0.301
LIG_FHA_1	63	69	PF00498	0.239
LIG_FHA_2	112	118	PF00498	0.127
LIG_FHA_2	195	201	PF00498	0.199
LIG_FHA_2	246	252	PF00498	0.327
LIG_FHA_2	320	326	PF00498	0.232
LIG_LIR_Apic_2	289	293	PF02991	0.198
LIG_LIR_Gen_1	325	335	PF02991	0.253
LIG_LIR_Nem_3	120	125	PF02991	0.122
LIG_LIR_Nem_3	325	331	PF02991	0.250
LIG_LIR_Nem_3	52	57	PF02991	0.311
LIG_Pex14_2	246	250	PF04695	0.235
LIG_Pex14_2	271	275	PF04695	0.214
LIG_PTB_Apo_2	40	47	PF02174	0.122
LIG_Rb_LxCxE_1	65	88	PF01857	0.176
LIG_REV1ctd_RIR_1	268	275	PF16727	0.214
LIG_SH2_CRK	122	126	PF00017	0.127
LIG_SH2_GRB2like	34	37	PF00017	0.286
LIG_SH2_STAT3	102	105	PF00017	0.120
LIG_SH2_STAT5	102	105	PF00017	0.121
LIG_SUMO_SIM_anti_2	65	72	PF11976	0.322
LIG_SUMO_SIM_par_1	111	117	PF11976	0.151
LIG_SUMO_SIM_par_1	138	145	PF11976	0.122
LIG_TRAF2_1	114	117	PF00917	0.141
LIG_TRAF2_1	258	261	PF00917	0.276
LIG_WRC_WIRS_1	267	272	PF05994	0.211
MOD_CK1_1	320	326	PF00069	0.260
MOD_CK1_1	348	354	PF00069	0.291
MOD_CK2_1	10	16	PF00069	0.305
MOD_CK2_1	111	117	PF00069	0.120
MOD_CK2_1	194	200	PF00069	0.195
MOD_CK2_1	245	251	PF00069	0.241
MOD_CK2_1	255	261	PF00069	0.260
MOD_CK2_1	276	282	PF00069	0.293
MOD_CK2_1	319	325	PF00069	0.226
MOD_GlcNHglycan	157	160	PF01048	0.130
MOD_GlcNHglycan	181	186	PF01048	0.141
MOD_GSK3_1	10	17	PF00069	0.232
MOD_GSK3_1	163	170	PF00069	0.351
MOD_GSK3_1	204	211	PF00069	0.334
MOD_GSK3_1	28	35	PF00069	0.171
MOD_GSK3_1	315	322	PF00069	0.246
MOD_GSK3_1	62	69	PF00069	0.368
MOD_N-GLC_1	204	209	PF02516	0.194
MOD_N-GLC_1	28	33	PF02516	0.319
MOD_N-GLC_1	42	47	PF02516	0.176
MOD_NEK2_1	298	303	PF00069	0.256
MOD_NEK2_1	56	61	PF00069	0.176
MOD_NEK2_2	276	281	PF00069	0.239
MOD_PIKK_1	317	323	PF00454	0.226
MOD_PK_1	163	169	PF00069	0.141
MOD_PKA_1	163	169	PF00069	0.127
MOD_PKA_1	286	292	PF00069	0.201
MOD_PKA_2	10	16	PF00069	0.232
MOD_PKA_2	286	292	PF00069	0.220
MOD_PKA_2	348	354	PF00069	0.526
MOD_PKA_2	80	86	PF00069	0.176
MOD_PKB_1	284	292	PF00069	0.218
MOD_Plk_1	203	209	PF00069	0.248
MOD_Plk_1	237	243	PF00069	0.221
MOD_Plk_1	315	321	PF00069	0.250
MOD_Plk_1	42	48	PF00069	0.141
MOD_Plk_2-3	10	16	PF00069	0.232
MOD_Plk_2-3	111	117	PF00069	0.141
MOD_Plk_4	204	210	PF00069	0.348
TRG_DiLeu_BaEn_2	51	57	PF01217	0.176
TRG_DiLeu_BaEn_4	116	122	PF01217	0.176
TRG_DiLeu_BaEn_4	216	222	PF01217	0.211
TRG_DiLeu_BaEn_4	342	348	PF01217	0.289
TRG_ENDOCYTIC_2	122	125	PF00928	0.127
TRG_ER_diArg_1	133	136	PF00400	0.122
TRG_ER_diArg_1	254	257	PF00400	0.221
TRG_ER_diArg_1	283	286	PF00400	0.260
TRG_NLS_MonoExtC_3	132	138	PF00514	0.122
TRG_Pf-PMV_PEXEL_1	234	238	PF00026	0.186
TRG_Pf-PMV_PEXEL_1	286	291	PF00026	0.205

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0S4KRK8	Bodo saltans	35%	100%
A0A1X0NDR4	Trypanosomatidae	66%	100%
A0A3Q8ICA0	Leishmania donovani	25%	100%
A4H9V4	Leishmania braziliensis	25%	100%
A4HUR6	Leishmania infantum	25%	100%
E0SCY1	Dickeya dadantii (strain 3937)	25%	90%
E9ANF0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	25%	100%
O32169	Bacillus subtilis (strain 168)	24%	100%
O34641	Bacillus subtilis (strain 168)	26%	100%
P14175	Escherichia coli (strain K12)	27%	90%
P17328	Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)	26%	90%
P19844	Pseudonocardia sediminis	27%	100%
P22040	Synechocystis sp. (strain PCC 6803 / Kazusa)	31%	100%
P32010	Streptomyces peucetius	30%	100%
P33360	Escherichia coli (strain K12)	26%	100%
P42332	Bacillus licheniformis	26%	100%
P46920	Bacillus subtilis (strain 168)	28%	86%
P74548	Synechocystis sp. (strain PCC 6803 / Kazusa)	28%	100%
P94374	Bacillus subtilis (strain 168)	30%	100%
P94440	Bacillus subtilis (strain 168)	30%	100%
P9WQL8	Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)	32%	100%
P9WQL9	Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)	32%	100%
Q0I5E9	Haemophilus somnus (strain 129Pt)	27%	100%
Q0KDG3	Cupriavidus necator (strain ATCC 17699 / DSM 428 / KCTC 22496 / NCIMB 10442 / H16 / Stanier 337)	25%	100%
Q12B04	Polaromonas sp. (strain JS666 / ATCC BAA-500)	25%	100%
Q1AS06	Rubrobacter xylanophilus (strain DSM 9941 / NBRC 16129 / PRD-1)	25%	95%
Q1LQF6	Cupriavidus metallidurans (strain ATCC 43123 / DSM 2839 / NBRC 102507 / CH34)	25%	100%
Q1R0Z6	Chromohalobacter salexigens (strain ATCC BAA-138 / DSM 3043 / CIP 106854 / NCIMB 13768 / 1H11)	27%	100%
Q24QI5	Desulfitobacterium hafniense (strain Y51)	26%	100%
Q3KJQ7	Pseudomonas fluorescens (strain Pf0-1)	25%	100%
Q46Y69	Cupriavidus pinatubonensis (strain JMP 134 / LMG 1197)	25%	100%
Q48PN3	Pseudomonas savastanoi pv. phaseolicola (strain 1448A / Race 6)	27%	95%
Q4K681	Pseudomonas fluorescens (strain ATCC BAA-477 / NRRL B-23932 / Pf-5)	28%	97%
Q4QH76	Leishmania major	24%	100%
Q4ZZK0	Pseudomonas syringae pv. syringae (strain B728a)	27%	95%
Q5E715	Aliivibrio fischeri (strain ATCC 700601 / ES114)	27%	100%
Q631Y4	Bacillus cereus (strain ZK / E33L)	26%	100%
Q63GR8	Bacillus cereus (strain ZK / E33L)	28%	100%
Q65F80	Bacillus licheniformis (strain ATCC 14580 / DSM 13 / JCM 2505 / CCUG 7422 / NBRC 12200 / NCIMB 9375 / NCTC 10341 / NRRL NRS-1264 / Gibson 46)	27%	100%
Q65VG9	Mannheimia succiniciproducens (strain MBEL55E)	27%	100%
Q6HBS0	Bacillus thuringiensis subsp. konkukian (strain 97-27)	26%	100%
Q6HP89	Bacillus thuringiensis subsp. konkukian (strain 97-27)	28%	100%
Q6LN52	Photobacterium profundum (strain SS9)	30%	100%
Q6WB63	Alcaligenes faecalis	31%	100%
Q72Y96	Bacillus cereus (strain ATCC 10987 / NRS 248)	26%	100%
Q73EL7	Bacillus cereus (strain ATCC 10987 / NRS 248)	28%	100%
Q73P71	Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)	24%	100%
Q7NIW1	Gloeobacter violaceus (strain ATCC 29082 / PCC 7421)	27%	100%
Q815Y7	Bacillus cereus (strain ATCC 14579 / DSM 31 / CCUG 7414 / JCM 2152 / NBRC 15305 / NCIMB 9373 / NCTC 2599 / NRRL B-3711)	25%	100%
Q81IN8	Bacillus cereus (strain ATCC 14579 / DSM 31 / CCUG 7414 / JCM 2152 / NBRC 15305 / NCIMB 9373 / NCTC 2599 / NRRL B-3711)	28%	100%
Q81XL3	Bacillus anthracis	26%	100%
Q827Y0	Streptomyces avermitilis (strain ATCC 31267 / DSM 46492 / JCM 5070 / NBRC 14893 / NCIMB 12804 / NRRL 8165 / MA-4680)	27%	100%
Q87RS1	Vibrio parahaemolyticus serotype O3:K6 (strain RIMD 2210633)	26%	100%
Q8NSN2	Corynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / BCRC 11384 / JCM 1318 / LMG 3730 / NCIMB 10025)	28%	100%
Q97KD5	Clostridium acetobutylicum (strain ATCC 824 / DSM 792 / JCM 1419 / LMG 5710 / VKM B-1787)	25%	100%
Q9I6L0	Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)	26%	100%
Q9KTJ5	Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)	28%	100%
Q9MUN1	Mesostigma viride	26%	100%
Q9RR46	Listeria monocytogenes serotype 1/2a (strain 10403S)	23%	90%
V5B4W5	Trypanosoma cruzi	39%	100%
V5BHJ6	Trypanosoma cruzi	64%	93%