WGS CADB00000000 data, contig 26

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein (fragment)

Species:

Leishmania mexicana

UniProt:

E8NHH1_LEIMU

TriTrypDb:

LmxM.15.0440c

Length:

703

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E8NHH1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E8NHH1

Function

Biological processes
Term	Name	Level	Count
GO:0006996	organelle organization	4	2
GO:0009987	cellular process	1	2
GO:0016043	cellular component organization	3	2
GO:0071840	cellular component organization or biogenesis	2	2

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	530	534	PF00656	0.590
CLV_C14_Caspase3-7	536	540	PF00656	0.533
CLV_NRD_NRD_1	104	106	PF00675	0.638
CLV_NRD_NRD_1	110	112	PF00675	0.753
CLV_NRD_NRD_1	137	139	PF00675	0.576
CLV_NRD_NRD_1	142	144	PF00675	0.609
CLV_NRD_NRD_1	375	377	PF00675	0.466
CLV_NRD_NRD_1	434	436	PF00675	0.534
CLV_NRD_NRD_1	583	585	PF00675	0.389
CLV_PCSK_FUR_1	108	112	PF00082	0.681
CLV_PCSK_FUR_1	140	144	PF00082	0.633
CLV_PCSK_KEX2_1	104	106	PF00082	0.638
CLV_PCSK_KEX2_1	108	110	PF00082	0.731
CLV_PCSK_KEX2_1	137	139	PF00082	0.576
CLV_PCSK_KEX2_1	142	144	PF00082	0.609
CLV_PCSK_KEX2_1	375	377	PF00082	0.463
CLV_PCSK_KEX2_1	434	436	PF00082	0.534
CLV_PCSK_KEX2_1	46	48	PF00082	0.425
CLV_PCSK_KEX2_1	478	480	PF00082	0.415
CLV_PCSK_KEX2_1	583	585	PF00082	0.389
CLV_PCSK_PC1ET2_1	46	48	PF00082	0.450
CLV_PCSK_PC1ET2_1	478	480	PF00082	0.504
CLV_PCSK_PC7_1	104	110	PF00082	0.572
CLV_PCSK_PC7_1	138	144	PF00082	0.551
CLV_PCSK_PC7_1	579	585	PF00082	0.324
CLV_PCSK_SKI1_1	285	289	PF00082	0.635
CLV_PCSK_SKI1_1	341	345	PF00082	0.614
CLV_PCSK_SKI1_1	53	57	PF00082	0.611
CLV_PCSK_SKI1_1	583	587	PF00082	0.462
DEG_APCC_DBOX_1	284	292	PF00400	0.427
DEG_APCC_DBOX_1	313	321	PF00400	0.491
DEG_APCC_DBOX_1	82	90	PF00400	0.380
DEG_Nend_Nbox_1	1	2	PF02207	0.494
DOC_CKS1_1	281	286	PF01111	0.457
DOC_CYCLIN_RxL_1	562	574	PF00134	0.534
DOC_MAPK_gen_1	137	146	PF00069	0.479
DOC_MAPK_gen_1	478	485	PF00069	0.479
DOC_PP4_FxxP_1	246	249	PF00568	0.385
DOC_USP7_MATH_1	125	129	PF00917	0.563
DOC_USP7_MATH_1	297	301	PF00917	0.404
DOC_USP7_MATH_1	408	412	PF00917	0.370
DOC_WW_Pin1_4	277	282	PF00397	0.500
DOC_WW_Pin1_4	506	511	PF00397	0.480
LIG_14-3-3_CanoR_1	180	184	PF00244	0.447
LIG_14-3-3_CanoR_1	193	197	PF00244	0.313
LIG_Actin_WH2_2	263	280	PF00022	0.406
LIG_Actin_WH2_2	451	466	PF00022	0.311
LIG_APCC_ABBA_1	555	560	PF00400	0.440
LIG_BIR_III_4	391	395	PF00653	0.377
LIG_EH_1	552	556	PF12763	0.408
LIG_FHA_1	440	446	PF00498	0.412
LIG_FHA_1	54	60	PF00498	0.394
LIG_FHA_2	326	332	PF00498	0.343
LIG_FHA_2	597	603	PF00498	0.516
LIG_LIR_Gen_1	183	194	PF02991	0.365
LIG_LIR_Gen_1	493	504	PF02991	0.401
LIG_LIR_Gen_1	574	585	PF02991	0.445
LIG_LIR_Gen_1	62	73	PF02991	0.356
LIG_LIR_Nem_3	183	189	PF02991	0.356
LIG_LIR_Nem_3	241	247	PF02991	0.393
LIG_LIR_Nem_3	264	270	PF02991	0.380
LIG_LIR_Nem_3	397	402	PF02991	0.389
LIG_LIR_Nem_3	420	426	PF02991	0.447
LIG_LIR_Nem_3	493	499	PF02991	0.392
LIG_LIR_Nem_3	574	580	PF02991	0.391
LIG_LIR_Nem_3	62	68	PF02991	0.355
LIG_LYPXL_yS_3	244	247	PF13949	0.471
LIG_LYPXL_yS_3	473	476	PF13949	0.431
LIG_LYPXL_yS_3	627	630	PF13949	0.462
LIG_MAD2	145	153	PF02301	0.505
LIG_MYND_1	245	249	PF01753	0.452
LIG_Rb_LxCxE_1	206	224	PF01857	0.405
LIG_Rb_LxCxE_1	283	305	PF01857	0.412
LIG_SH2_CRK	577	581	PF00017	0.380
LIG_SH2_SRC	447	450	PF00017	0.328
LIG_SH2_STAP1	577	581	PF00017	0.389
LIG_SH3_1	109	115	PF00018	0.655
LIG_SH3_1	278	284	PF00018	0.449
LIG_SH3_2	112	117	PF14604	0.597
LIG_SH3_3	109	115	PF00018	0.637
LIG_SH3_3	278	284	PF00018	0.449
LIG_SH3_3	397	403	PF00018	0.393
LIG_SH3_3	504	510	PF00018	0.353
LIG_SH3_3	551	557	PF00018	0.538
LIG_SUMO_SIM_par_1	145	151	PF11976	0.504
LIG_TRAF2_1	32	35	PF00917	0.430
LIG_TRAF2_1	438	441	PF00917	0.449
LIG_TRAF2_1	465	468	PF00917	0.472
LIG_TRAF2_1	691	694	PF00917	0.446
LIG_UBA3_1	343	352	PF00899	0.491
LIG_WW_3	114	118	PF00397	0.582
LIG_WW_3	169	173	PF00397	0.506
MOD_CDK_SPK_2	280	285	PF00069	0.452
MOD_CDK_SPK_2	506	511	PF00069	0.480
MOD_CK1_1	509	515	PF00069	0.496
MOD_CK2_1	29	35	PF00069	0.522
MOD_CK2_1	325	331	PF00069	0.478
MOD_CK2_1	408	414	PF00069	0.331
MOD_CK2_1	435	441	PF00069	0.468
MOD_CK2_1	447	453	PF00069	0.316
MOD_CK2_1	596	602	PF00069	0.477
MOD_CK2_1	637	643	PF00069	0.337
MOD_CK2_1	688	694	PF00069	0.377
MOD_Cter_Amidation	102	105	PF01082	0.511
MOD_GlcNHglycan	127	130	PF01048	0.570
MOD_GlcNHglycan	28	34	PF01048	0.524
MOD_GlcNHglycan	436	440	PF01048	0.371
MOD_GlcNHglycan	459	462	PF01048	0.382
MOD_GlcNHglycan	687	693	PF01048	0.375
MOD_GSK3_1	269	276	PF00069	0.410
MOD_GSK3_1	435	442	PF00069	0.431
MOD_GSK3_1	638	645	PF00069	0.548
MOD_NEK2_1	192	197	PF00069	0.446
MOD_NEK2_1	64	69	PF00069	0.347
MOD_NEK2_2	325	330	PF00069	0.345
MOD_PKA_2	179	185	PF00069	0.439
MOD_PKA_2	192	198	PF00069	0.318
MOD_PKA_2	297	303	PF00069	0.400
MOD_PKA_2	463	469	PF00069	0.535
MOD_PKA_2	607	613	PF00069	0.377
MOD_Plk_1	596	602	PF00069	0.412
MOD_Plk_1	642	648	PF00069	0.365
MOD_Plk_4	192	198	PF00069	0.580
MOD_ProDKin_1	277	283	PF00069	0.494
MOD_ProDKin_1	506	512	PF00069	0.484
MOD_SUMO_rev_2	162	170	PF00179	0.587
MOD_SUMO_rev_2	333	343	PF00179	0.421
MOD_SUMO_rev_2	530	536	PF00179	0.334
MOD_SUMO_rev_2	611	618	PF00179	0.395
TRG_AP2beta_CARGO_1	493	503	PF09066	0.397
TRG_DiLeu_BaEn_1	576	581	PF01217	0.391
TRG_DiLeu_BaEn_2	314	320	PF01217	0.493
TRG_DiLeu_BaEn_2	396	402	PF01217	0.419
TRG_DiLeu_BaLyEn_6	114	119	PF01217	0.573
TRG_DiLeu_BaLyEn_6	339	344	PF01217	0.413
TRG_ENDOCYTIC_2	186	189	PF00928	0.398
TRG_ENDOCYTIC_2	244	247	PF00928	0.471
TRG_ENDOCYTIC_2	473	476	PF00928	0.431
TRG_ENDOCYTIC_2	577	580	PF00928	0.385
TRG_ENDOCYTIC_2	627	630	PF00928	0.403
TRG_ER_diArg_1	108	111	PF00400	0.635
TRG_ER_diArg_1	137	140	PF00400	0.597
TRG_ER_diArg_1	142	145	PF00400	0.634
TRG_ER_diArg_1	171	174	PF00400	0.569
TRG_ER_diArg_1	295	298	PF00400	0.457
TRG_ER_diArg_1	433	435	PF00400	0.514
TRG_ER_diArg_1	549	552	PF00400	0.355
TRG_ER_diArg_1	583	585	PF00400	0.522
TRG_ER_diArg_1	93	96	PF00400	0.509
TRG_Pf-PMV_PEXEL_1	145	150	PF00026	0.573
TRG_Pf-PMV_PEXEL_1	529	533	PF00026	0.398

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A1X0NYQ1	Trypanosomatidae	31%	74%
A0A3R7KIM7	Trypanosoma rangeli	34%	100%
A4H817	Leishmania braziliensis	83%	79%
E8NHP1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	50%	83%
E8NHS4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	56%	100%
V5BG02	Trypanosoma cruzi	44%	100%