Uncharacterized protein LmxM_30_0440_1

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein

Species:

Leishmania mexicana

UniProt:

E8NHG6_LEIMU

TriTrypDb:

LmxM.30.0440

Length:

724

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 1
Forrest at al. (metacyclic)	no	yes: 3
Forrest at al. (procyclic)	no	yes: 4
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 36

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 16

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 20

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 96
NetGPI	no	yes: 0, no: 97

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	5
GO:0005737	cytoplasm	2	3
GO:0005930	axoneme	2	1
GO:0005815	microtubule organizing center	2	1
GO:0005856	cytoskeleton	5	1
GO:0020016	ciliary pocket	2	1
GO:0020038	subpellicular network	2	1
GO:0030863	cortical cytoskeleton	6	1
GO:0036064	ciliary basal body	3	1
GO:0043226	organelle	2	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1

Expansion

Sequence features

E8NHG6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E8NHG6

Function

Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	98
GO:0006807	nitrogen compound metabolic process	2	98
GO:0008152	metabolic process	1	98
GO:0019538	protein metabolic process	3	98
GO:0043170	macromolecule metabolic process	3	98
GO:0044238	primary metabolic process	2	98
GO:0071704	organic substance metabolic process	2	98
GO:1901564	organonitrogen compound metabolic process	3	98

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	98
GO:0004175	endopeptidase activity	4	98
GO:0004197	cysteine-type endopeptidase activity	5	98
GO:0004198	calcium-dependent cysteine-type endopeptidase activity	6	98
GO:0008233	peptidase activity	3	98
GO:0008234	cysteine-type peptidase activity	4	98
GO:0016787	hydrolase activity	2	98
GO:0140096	catalytic activity, acting on a protein	2	98

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	368	372	PF00656	0.440
CLV_C14_Caspase3-7	498	502	PF00656	0.501
CLV_C14_Caspase3-7	536	540	PF00656	0.473
CLV_NRD_NRD_1	398	400	PF00675	0.201
CLV_NRD_NRD_1	581	583	PF00675	0.525
CLV_PCSK_KEX2_1	577	579	PF00082	0.462
CLV_PCSK_PC1ET2_1	577	579	PF00082	0.467
CLV_PCSK_SKI1_1	294	298	PF00082	0.304
CLV_PCSK_SKI1_1	546	550	PF00082	0.514
CLV_PCSK_SKI1_1	567	571	PF00082	0.472
CLV_PCSK_SKI1_1	650	654	PF00082	0.508
DEG_APCC_DBOX_1	125	133	PF00400	0.487
DEG_MDM2_SWIB_1	517	525	PF02201	0.486
DOC_ANK_TNKS_1	657	664	PF00023	0.294
DOC_CKS1_1	420	425	PF01111	0.497
DOC_CYCLIN_yCln2_LP_2	588	594	PF00134	0.495
DOC_MAPK_DCC_7	232	242	PF00069	0.395
DOC_MAPK_MEF2A_6	212	220	PF00069	0.315
DOC_MAPK_MEF2A_6	235	242	PF00069	0.569
DOC_PP1_RVXF_1	37	43	PF00149	0.478
DOC_PP1_RVXF_1	565	571	PF00149	0.450
DOC_PP2B_LxvP_1	588	591	PF13499	0.575
DOC_PP2B_LxvP_1	642	645	PF13499	0.377
DOC_PP4_FxxP_1	535	538	PF00568	0.417
DOC_USP7_MATH_1	117	121	PF00917	0.391
DOC_USP7_MATH_1	190	194	PF00917	0.532
DOC_USP7_MATH_1	436	440	PF00917	0.481
DOC_USP7_MATH_1	478	482	PF00917	0.551
DOC_USP7_MATH_1	562	566	PF00917	0.502
DOC_USP7_MATH_1	693	697	PF00917	0.477
DOC_USP7_UBL2_3	355	359	PF12436	0.502
DOC_WW_Pin1_4	210	215	PF00397	0.357
DOC_WW_Pin1_4	298	303	PF00397	0.465
DOC_WW_Pin1_4	379	384	PF00397	0.503
DOC_WW_Pin1_4	419	424	PF00397	0.511
LIG_14-3-3_CanoR_1	254	258	PF00244	0.513
LIG_14-3-3_CanoR_1	43	51	PF00244	0.745
LIG_14-3-3_CanoR_1	567	573	PF00244	0.404
LIG_BRCT_BRCA1_1	438	442	PF00533	0.579
LIG_BRCT_BRCA1_1	617	621	PF00533	0.464
LIG_BRCT_BRCA1_1	684	688	PF00533	0.492
LIG_FHA_1	146	152	PF00498	0.373
LIG_FHA_1	186	192	PF00498	0.497
LIG_FHA_1	211	217	PF00498	0.368
LIG_FHA_1	232	238	PF00498	0.520
LIG_FHA_1	244	250	PF00498	0.423
LIG_FHA_1	454	460	PF00498	0.502
LIG_FHA_1	51	57	PF00498	0.393
LIG_FHA_1	564	570	PF00498	0.425
LIG_FHA_1	638	644	PF00498	0.492
LIG_FHA_1	687	693	PF00498	0.382
LIG_FHA_2	125	131	PF00498	0.271
LIG_FHA_2	234	240	PF00498	0.526
LIG_FHA_2	366	372	PF00498	0.445
LIG_FHA_2	554	560	PF00498	0.415
LIG_HP1_1	263	267	PF01393	0.389
LIG_LIR_Apic_2	341	345	PF02991	0.525
LIG_LIR_Apic_2	654	659	PF02991	0.548
LIG_LIR_Gen_1	213	222	PF02991	0.254
LIG_LIR_Gen_1	331	339	PF02991	0.532
LIG_LIR_Gen_1	347	357	PF02991	0.478
LIG_LIR_Gen_1	363	372	PF02991	0.503
LIG_LIR_Gen_1	618	629	PF02991	0.438
LIG_LIR_Gen_1	638	649	PF02991	0.385
LIG_LIR_Nem_3	213	218	PF02991	0.281
LIG_LIR_Nem_3	347	352	PF02991	0.487
LIG_LIR_Nem_3	363	367	PF02991	0.496
LIG_LIR_Nem_3	618	624	PF02991	0.464
LIG_LIR_Nem_3	638	644	PF02991	0.369
LIG_LIR_Nem_3	685	691	PF02991	0.457
LIG_LIR_Nem_3	95	101	PF02991	0.325
LIG_MAD2	567	575	PF02301	0.440
LIG_Pex14_2	387	391	PF04695	0.487
LIG_Pex14_2	517	521	PF04695	0.494
LIG_SH2_CRK	310	314	PF00017	0.484
LIG_SH2_CRK	357	361	PF00017	0.493
LIG_SH2_CRK	364	368	PF00017	0.495
LIG_SH2_CRK	656	660	PF00017	0.518
LIG_SH2_GRB2like	83	86	PF00017	0.392
LIG_SH2_NCK_1	342	346	PF00017	0.519
LIG_SH2_NCK_1	364	368	PF00017	0.512
LIG_SH2_NCK_1	446	450	PF00017	0.501
LIG_SH2_NCK_1	656	660	PF00017	0.518
LIG_SH2_PTP2	215	218	PF00017	0.497
LIG_SH2_SRC	342	345	PF00017	0.544
LIG_SH2_SRC	446	449	PF00017	0.590
LIG_SH2_SRC	660	663	PF00017	0.381
LIG_SH2_STAP1	455	459	PF00017	0.510
LIG_SH2_STAT5	215	218	PF00017	0.515
LIG_SH2_STAT5	248	251	PF00017	0.485
LIG_SH2_STAT5	328	331	PF00017	0.506
LIG_SH2_STAT5	430	433	PF00017	0.492
LIG_SH2_STAT5	455	458	PF00017	0.477
LIG_SH2_STAT5	527	530	PF00017	0.501
LIG_SH2_STAT5	641	644	PF00017	0.362
LIG_SH2_STAT5	660	663	PF00017	0.355
LIG_SH2_STAT5	691	694	PF00017	0.521
LIG_SH2_STAT5	718	721	PF00017	0.490
LIG_SH2_STAT5	83	86	PF00017	0.356
LIG_SH2_STAT5	99	102	PF00017	0.380
LIG_SH3_3	17	23	PF00018	0.569
LIG_SH3_3	472	478	PF00018	0.467
LIG_SH3_3	611	617	PF00018	0.488
LIG_SH3_3	705	711	PF00018	0.394
LIG_SUMO_SIM_anti_2	460	467	PF11976	0.514
LIG_SUMO_SIM_par_1	263	268	PF11976	0.402
LIG_SUMO_SIM_par_1	321	327	PF11976	0.487
LIG_SUMO_SIM_par_1	460	467	PF11976	0.606
LIG_SUMO_SIM_par_1	555	561	PF11976	0.431
LIG_SUMO_SIM_par_1	590	595	PF11976	0.392
LIG_TRAF2_1	14	17	PF00917	0.784
LIG_TRAF2_1	301	304	PF00917	0.463
LIG_TRAF2_1	33	36	PF00917	0.668
LIG_TRAF2_1	617	620	PF00917	0.441
LIG_TRFH_1	641	645	PF08558	0.367
LIG_UBA3_1	569	577	PF00899	0.435
LIG_WRC_WIRS_1	329	334	PF05994	0.507
MOD_CDK_SPxxK_3	298	305	PF00069	0.460
MOD_CDK_SPxxK_3	379	386	PF00069	0.525
MOD_CK1_1	119	125	PF00069	0.324
MOD_CK1_1	193	199	PF00069	0.508
MOD_CK1_1	490	496	PF00069	0.473
MOD_CK1_1	563	569	PF00069	0.487
MOD_CK1_1	6	12	PF00069	0.587
MOD_CK2_1	124	130	PF00069	0.322
MOD_CK2_1	233	239	PF00069	0.507
MOD_CK2_1	298	304	PF00069	0.472
MOD_CK2_1	30	36	PF00069	0.746
MOD_CK2_1	43	49	PF00069	0.610
MOD_CK2_1	553	559	PF00069	0.395
MOD_CMANNOS	518	521	PF00535	0.297
MOD_GlcNHglycan	152	155	PF01048	0.318
MOD_GlcNHglycan	23	26	PF01048	0.736
MOD_GlcNHglycan	32	35	PF01048	0.705
MOD_GlcNHglycan	378	382	PF01048	0.308
MOD_GlcNHglycan	413	416	PF01048	0.276
MOD_GlcNHglycan	438	441	PF01048	0.323
MOD_GlcNHglycan	45	48	PF01048	0.533
MOD_GlcNHglycan	485	488	PF01048	0.357
MOD_GlcNHglycan	56	59	PF01048	0.402
MOD_GlcNHglycan	665	668	PF01048	0.464
MOD_GlcNHglycan	684	687	PF01048	0.434
MOD_GSK3_1	243	250	PF00069	0.462
MOD_GSK3_1	26	33	PF00069	0.698
MOD_GSK3_1	479	486	PF00069	0.514
MOD_GSK3_1	50	57	PF00069	0.485
MOD_GSK3_1	549	556	PF00069	0.446
MOD_GSK3_1	558	565	PF00069	0.470
MOD_GSK3_1	608	615	PF00069	0.471
MOD_GSK3_1	682	689	PF00069	0.425
MOD_GSK3_1	714	721	PF00069	0.389
MOD_N-GLC_1	101	106	PF02516	0.339
MOD_N-GLC_1	161	166	PF02516	0.361
MOD_N-GLC_1	180	185	PF02516	0.588
MOD_N-GLC_1	608	613	PF02516	0.446
MOD_N-GLC_2	71	73	PF02516	0.445
MOD_NEK2_1	274	279	PF00069	0.511
MOD_NEK2_1	292	297	PF00069	0.444
MOD_NEK2_1	411	416	PF00069	0.513
MOD_NEK2_1	549	554	PF00069	0.479
MOD_NEK2_1	558	563	PF00069	0.418
MOD_NEK2_1	570	575	PF00069	0.396
MOD_NEK2_2	145	150	PF00069	0.325
MOD_NMyristoyl	1	7	PF02799	0.521
MOD_PIKK_1	243	249	PF00454	0.560
MOD_PIKK_1	570	576	PF00454	0.399
MOD_PKA_2	231	237	PF00069	0.482
MOD_PKA_2	243	249	PF00069	0.427
MOD_PKA_2	253	259	PF00069	0.433
MOD_PKA_2	436	442	PF00069	0.536
MOD_PKA_2	479	485	PF00069	0.489
MOD_PKA_2	54	60	PF00069	0.398
MOD_Plk_1	101	107	PF00069	0.352
MOD_Plk_1	161	167	PF00069	0.371
MOD_Plk_1	563	569	PF00069	0.422
MOD_Plk_1	608	614	PF00069	0.410
MOD_Plk_1	637	643	PF00069	0.437
MOD_Plk_2-3	233	239	PF00069	0.503
MOD_Plk_2-3	698	704	PF00069	0.394
MOD_Plk_4	274	280	PF00069	0.507
MOD_Plk_4	348	354	PF00069	0.470
MOD_Plk_4	426	432	PF00069	0.536
MOD_Plk_4	467	473	PF00069	0.560
MOD_Plk_4	513	519	PF00069	0.513
MOD_Plk_4	553	559	PF00069	0.407
MOD_Plk_4	637	643	PF00069	0.501
MOD_Plk_4	714	720	PF00069	0.450
MOD_Plk_4	79	85	PF00069	0.308
MOD_Plk_4	94	100	PF00069	0.358
MOD_ProDKin_1	210	216	PF00069	0.350
MOD_ProDKin_1	298	304	PF00069	0.465
MOD_ProDKin_1	379	385	PF00069	0.503
MOD_ProDKin_1	419	425	PF00069	0.511
MOD_SPalmitoyl_4	1	7	PF01529	0.546
MOD_SUMO_for_1	38	41	PF00179	0.468
MOD_SUMO_rev_2	301	307	PF00179	0.431
MOD_SUMO_rev_2	33	40	PF00179	0.649
MOD_SUMO_rev_2	6	12	PF00179	0.598
MOD_SUMO_rev_2	671	681	PF00179	0.339
TRG_DiLeu_BaEn_1	147	152	PF01217	0.431
TRG_DiLeu_BaEn_1	467	472	PF01217	0.465
TRG_DiLeu_BaEn_1	638	643	PF01217	0.481
TRG_DiLeu_BaEn_2	618	624	PF01217	0.424
TRG_ENDOCYTIC_2	215	218	PF00928	0.507
TRG_ENDOCYTIC_2	310	313	PF00928	0.497
TRG_ENDOCYTIC_2	357	360	PF00928	0.502
TRG_ENDOCYTIC_2	364	367	PF00928	0.506
TRG_ENDOCYTIC_2	641	644	PF00928	0.353
TRG_ER_diArg_1	442	445	PF00400	0.541
TRG_NES_CRM1_1	259	270	PF08389	0.401
TRG_Pf-PMV_PEXEL_1	192	197	PF00026	0.607
TRG_Pf-PMV_PEXEL_1	235	239	PF00026	0.357

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8T6	Leptomonas seymouri	32%	100%
A0A0N1I8N2	Leptomonas seymouri	28%	74%
A0A0N1IGQ2	Leptomonas seymouri	32%	100%
A0A0N1ILF1	Leptomonas seymouri	34%	100%
A0A0N1IMH1	Leptomonas seymouri	32%	92%
A0A0N1P9P1	Leptomonas seymouri	34%	85%
A0A0N1PCA9	Leptomonas seymouri	30%	98%
A0A0N1PE91	Leptomonas seymouri	25%	81%
A0A0N1PFI4	Leptomonas seymouri	57%	93%
A0A0S4JS70	Bodo saltans	25%	94%
A0A0S4KGT2	Bodo saltans	37%	96%
A0A1X0NJ61	Trypanosomatidae	32%	100%
A0A1X0NJK2	Trypanosomatidae	31%	95%
A0A1X0NJX8	Trypanosomatidae	31%	93%
A0A1X0NKT7	Trypanosomatidae	29%	91%
A0A1X0NKX8	Trypanosomatidae	40%	89%
A0A1X0NMT3	Trypanosomatidae	32%	85%
A0A1X0NW84	Trypanosomatidae	32%	100%
A0A1X0NW85	Trypanosomatidae	36%	100%
A0A1X0NW89	Trypanosomatidae	32%	84%
A0A1X0NWA6	Trypanosomatidae	27%	83%
A0A1X0NWW1	Trypanosomatidae	36%	100%
A0A3Q8IBS3	Leishmania donovani	34%	80%
A0A3Q8IDD4	Leishmania donovani	31%	100%
A0A3Q8IJT4	Leishmania donovani	28%	96%
A0A3S5H5A5	Leishmania donovani	32%	85%
A0A3S5ISG2	Trypanosoma rangeli	39%	94%
A0A3S7WW18	Leishmania donovani	34%	88%
A0A3S7WW41	Leishmania donovani	29%	97%
A0A3S7WW71	Leishmania donovani	33%	100%
A0A3S7X430	Leishmania donovani	30%	92%
A0A3S7X438	Leishmania donovani	32%	77%
A0A3S7X460	Leishmania donovani	33%	93%
A0A3S7X463	Leishmania donovani	28%	77%
A0A3S7X470	Leishmania donovani	85%	100%
A0A422MYU1	Trypanosoma rangeli	34%	79%
A0A422MYX0	Trypanosoma rangeli	35%	100%
A4H3W4	Leishmania braziliensis	31%	100%
A4HE81	Leishmania braziliensis	31%	100%
A4HJ14	Leishmania braziliensis	31%	100%
A4HJ21	Leishmania braziliensis	26%	100%
A4HJ22	Leishmania braziliensis	30%	100%
A4HJ23	Leishmania braziliensis	68%	100%
A4HJ24	Leishmania braziliensis	32%	100%
A4HS39	Leishmania infantum	32%	85%
A4HYN0	Leishmania infantum	35%	88%
A4HYW1	Leishmania infantum	35%	71%
A4HYW2	Leishmania infantum	32%	100%
A4HYW3	Leishmania infantum	29%	97%
A4HYW4	Leishmania infantum	27%	72%
A4I1J4	Leishmania infantum	31%	100%
A4I6E4	Leishmania infantum	85%	100%
A4I6E6	Leishmania infantum	33%	93%
A4I6F0	Leishmania infantum	32%	77%
A4I6K4	Leishmania infantum	30%	92%
A4I6K5	Leishmania infantum	28%	77%
A4I6K6	Leishmania infantum	28%	96%
C9ZIE7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	35%	67%
C9ZIE8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	100%
C9ZIE9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	99%
C9ZN52	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	91%
C9ZN53	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	37%	85%
C9ZWY4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	37%	90%
C9ZY36	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	85%
E8NHF1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	34%	100%
E8NHG7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	32%	77%
E8NHG8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	33%	92%
E8NHM2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	33%	100%
E8NHM4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	33%	100%
E8NHM8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	36%	100%
E9AIH1	Leishmania braziliensis	34%	100%
E9AIH3	Leishmania braziliensis	32%	100%
E9AIH4	Leishmania braziliensis	30%	100%
E9AIH6	Leishmania braziliensis	29%	100%
E9AK26	Leishmania mexicana (strain MHOM/GT/2001/U1103)	32%	91%
E9AUQ7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	34%	78%
E9AUQ9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	32%	100%
E9AUR0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	28%	97%
E9AUR1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	28%	100%
E9AXM9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	31%	100%
E9B1J0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	30%	92%
E9B1J1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	27%	77%
E9B1J2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	26%	96%
E9B1J6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	34%	100%
P16259	Rattus norvegicus	27%	88%
P20807	Homo sapiens	26%	88%
P43368	Sus scrofa	26%	88%
P51186	Bos taurus	26%	88%
Q22036	Caenorhabditis elegans	25%	100%
Q4Q6L7	Leishmania major	32%	100%
Q4Q6L9	Leishmania major	84%	100%
Q4Q6M0	Leishmania major	31%	100%
Q4Q6M2	Leishmania major	27%	100%
Q4Q6M3	Leishmania major	27%	100%
Q4Q6M4	Leishmania major	30%	100%
Q4Q9U3	Leishmania major	31%	100%
Q4QCS6	Leishmania major	29%	100%
Q4QCS7	Leishmania major	32%	100%
Q4QCS8	Leishmania major	35%	100%
Q4QCS9	Leishmania major	35%	100%
Q64691	Mus musculus	27%	88%
Q9GLG7	Macaca fascicularis	27%	89%
Q9TTH8	Ovis aries	27%	88%
Q9U0T9	Leishmania major	33%	100%
V5AYJ1	Trypanosoma cruzi	31%	100%
V5B5I4	Trypanosoma cruzi	32%	86%
V5BA05	Trypanosoma cruzi	35%	100%
V5BEL3	Trypanosoma cruzi	33%	100%
V5BN20	Trypanosoma cruzi	33%	94%
V5D5V8	Trypanosoma cruzi	29%	98%
V5D9Y2	Trypanosoma cruzi	32%	85%
V5DES7	Trypanosoma cruzi	38%	91%