WGS CADB00000000 data, contig 22

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein

Species:

Leishmania mexicana

UniProt:

E8NHG5_LEIMU

TriTrypDb:

LmxM.30.1440c

Length:

444

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 75

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 7

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 30, no: 0
NetGPI	no	yes: 0, no: 30

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	31
GO:0042995	cell projection	2	31
GO:0043226	organelle	2	31
GO:0043227	membrane-bounded organelle	3	31
GO:0110165	cellular anatomical entity	1	31
GO:0120025	plasma membrane bounded cell projection	3	31
GO:0016020	membrane	2	8

Expansion

Sequence features

E8NHG5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E8NHG5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	246	248	PF00675	0.478
CLV_NRD_NRD_1	3	5	PF00675	0.651
CLV_PCSK_KEX2_1	246	248	PF00082	0.477
CLV_PCSK_KEX2_1	264	266	PF00082	0.501
CLV_PCSK_KEX2_1	3	5	PF00082	0.651
CLV_PCSK_KEX2_1	413	415	PF00082	0.541
CLV_PCSK_PC1ET2_1	264	266	PF00082	0.499
CLV_PCSK_PC1ET2_1	413	415	PF00082	0.541
CLV_PCSK_SKI1_1	171	175	PF00082	0.530
CLV_PCSK_SKI1_1	42	46	PF00082	0.601
DEG_Nend_Nbox_1	1	3	PF02207	0.462
DEG_SPOP_SBC_1	154	158	PF00917	0.235
DEG_SPOP_SBC_1	288	292	PF00917	0.462
DEG_SPOP_SBC_1	296	300	PF00917	0.463
DEG_SPOP_SBC_1	304	308	PF00917	0.443
DEG_SPOP_SBC_1	312	316	PF00917	0.441
DEG_SPOP_SBC_1	320	324	PF00917	0.435
DEG_SPOP_SBC_1	328	332	PF00917	0.437
DEG_SPOP_SBC_1	336	340	PF00917	0.486
DEG_SPOP_SBC_1	344	348	PF00917	0.469
DEG_SPOP_SBC_1	352	356	PF00917	0.463
DEG_SPOP_SBC_1	360	364	PF00917	0.461
DEG_SPOP_SBC_1	368	372	PF00917	0.452
DOC_MAPK_gen_1	264	272	PF00069	0.344
DOC_MAPK_MEF2A_6	145	154	PF00069	0.251
DOC_PP1_RVXF_1	169	176	PF00149	0.254
DOC_USP7_MATH_1	274	278	PF00917	0.371
DOC_USP7_MATH_1	430	434	PF00917	0.318
DOC_USP7_MATH_1	72	76	PF00917	0.265
DOC_USP7_MATH_2	212	218	PF00917	0.268
DOC_WW_Pin1_4	419	424	PF00397	0.442
LIG_14-3-3_CanoR_1	171	176	PF00244	0.260
LIG_14-3-3_CanoR_1	246	251	PF00244	0.347
LIG_14-3-3_CanoR_1	265	269	PF00244	0.286
LIG_14-3-3_CanoR_1	51	60	PF00244	0.326
LIG_Actin_WH2_2	156	173	PF00022	0.250
LIG_BIR_III_2	71	75	PF00653	0.313
LIG_BRCT_BRCA1_1	424	428	PF00533	0.207
LIG_deltaCOP1_diTrp_1	261	268	PF00928	0.289
LIG_FHA_1	149	155	PF00498	0.260
LIG_FHA_1	197	203	PF00498	0.252
LIG_FHA_1	60	66	PF00498	0.387
LIG_FHA_1	9	15	PF00498	0.465
LIG_FHA_1	93	99	PF00498	0.254
LIG_FHA_2	106	112	PF00498	0.348
LIG_FHA_2	370	376	PF00498	0.451
LIG_FHA_2	392	398	PF00498	0.299
LIG_FHA_2	77	83	PF00498	0.300
LIG_FXI_DFP_1	109	113	PF00024	0.453
LIG_LIR_Gen_1	115	126	PF02991	0.290
LIG_LIR_Gen_1	174	183	PF02991	0.340
LIG_LIR_Gen_1	214	223	PF02991	0.294
LIG_LIR_Gen_1	237	245	PF02991	0.372
LIG_LIR_Nem_3	115	121	PF02991	0.334
LIG_LIR_Nem_3	141	146	PF02991	0.309
LIG_LIR_Nem_3	166	170	PF02991	0.310
LIG_LIR_Nem_3	174	178	PF02991	0.320
LIG_NRBOX	16	22	PF00104	0.444
LIG_Pex14_2	231	235	PF04695	0.263
LIG_SH2_CRK	118	122	PF00017	0.261
LIG_SH2_GRB2like	118	121	PF00017	0.258
LIG_SH2_STAP1	118	122	PF00017	0.269
LIG_SH2_STAP1	203	207	PF00017	0.262
LIG_SH2_STAT3	203	206	PF00017	0.286
LIG_SH2_STAT5	148	151	PF00017	0.320
LIG_SH3_3	107	113	PF00018	0.337
LIG_SH3_3	283	289	PF00018	0.332
LIG_SH3_3	29	35	PF00018	0.455
LIG_SUMO_SIM_par_1	17	24	PF11976	0.455
LIG_SUMO_SIM_par_1	198	205	PF11976	0.249
LIG_SUMO_SIM_par_1	94	101	PF11976	0.246
LIG_TYR_ITIM	116	121	PF00017	0.372
MOD_CK1_1	101	107	PF00069	0.338
MOD_CK1_1	133	139	PF00069	0.289
MOD_CK1_1	166	172	PF00069	0.384
MOD_CK1_1	177	183	PF00069	0.279
MOD_CK1_1	192	198	PF00069	0.376
MOD_CK1_1	217	223	PF00069	0.432
MOD_CK1_1	421	427	PF00069	0.416
MOD_CK1_1	53	59	PF00069	0.354
MOD_CK1_1	87	93	PF00069	0.405
MOD_CK2_1	231	237	PF00069	0.326
MOD_CK2_1	369	375	PF00069	0.469
MOD_GlcNHglycan	100	103	PF01048	0.559
MOD_GlcNHglycan	135	138	PF01048	0.550
MOD_GlcNHglycan	159	162	PF01048	0.518
MOD_GlcNHglycan	183	186	PF01048	0.539
MOD_GlcNHglycan	207	210	PF01048	0.634
MOD_GlcNHglycan	276	279	PF01048	0.553
MOD_GlcNHglycan	400	403	PF01048	0.546
MOD_GlcNHglycan	415	418	PF01048	0.601
MOD_GlcNHglycan	55	58	PF01048	0.597
MOD_GSK3_1	101	108	PF00069	0.354
MOD_GSK3_1	131	138	PF00069	0.368
MOD_GSK3_1	153	160	PF00069	0.351
MOD_GSK3_1	174	181	PF00069	0.314
MOD_GSK3_1	189	196	PF00069	0.428
MOD_GSK3_1	213	220	PF00069	0.374
MOD_GSK3_1	231	238	PF00069	0.307
MOD_GSK3_1	264	271	PF00069	0.328
MOD_GSK3_1	287	294	PF00069	0.441
MOD_GSK3_1	295	302	PF00069	0.467
MOD_GSK3_1	303	310	PF00069	0.474
MOD_GSK3_1	311	318	PF00069	0.458
MOD_GSK3_1	319	326	PF00069	0.431
MOD_GSK3_1	327	334	PF00069	0.428
MOD_GSK3_1	335	342	PF00069	0.450
MOD_GSK3_1	343	350	PF00069	0.452
MOD_GSK3_1	351	358	PF00069	0.447
MOD_GSK3_1	359	366	PF00069	0.462
MOD_GSK3_1	367	374	PF00069	0.473
MOD_GSK3_1	418	425	PF00069	0.417
MOD_GSK3_1	72	79	PF00069	0.272
MOD_GSK3_1	87	94	PF00069	0.360
MOD_N-GLC_2	254	256	PF02516	0.522
MOD_NEK2_1	178	183	PF00069	0.341
MOD_NEK2_1	190	195	PF00069	0.392
MOD_NEK2_1	202	207	PF00069	0.330
MOD_NEK2_1	231	236	PF00069	0.382
MOD_NEK2_1	76	81	PF00069	0.335
MOD_NEK2_1	98	103	PF00069	0.297
MOD_OFUCOSY	84	91	PF10250	0.490
MOD_PIKK_1	202	208	PF00454	0.282
MOD_PK_1	246	252	PF00069	0.250
MOD_PK_1	85	91	PF00069	0.297
MOD_PKA_1	246	252	PF00069	0.269
MOD_PKA_1	264	270	PF00069	0.283
MOD_PKA_1	413	419	PF00069	0.372
MOD_PKA_2	246	252	PF00069	0.348
MOD_PKA_2	264	270	PF00069	0.284
MOD_PKA_2	413	419	PF00069	0.372
MOD_PKA_2	50	56	PF00069	0.301
MOD_Plk_1	213	219	PF00069	0.285
MOD_Plk_2-3	375	381	PF00069	0.383
MOD_Plk_4	171	177	PF00069	0.312
MOD_Plk_4	196	202	PF00069	0.330
MOD_Plk_4	246	252	PF00069	0.306
MOD_Plk_4	92	98	PF00069	0.290
MOD_ProDKin_1	419	425	PF00069	0.444
MOD_SUMO_rev_2	267	277	PF00179	0.336
TRG_ENDOCYTIC_2	118	121	PF00928	0.420
TRG_ER_diArg_1	2	4	PF00400	0.543
TRG_ER_diArg_1	245	247	PF00400	0.376

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I121	Leptomonas seymouri	26%	89%
A0A3Q8I9A6	Leishmania donovani	41%	100%
A0A3Q8IFC2	Leishmania donovani	85%	100%
A0A3Q8IIJ9	Leishmania donovani	33%	100%
A0A3S5H6L9	Leishmania donovani	37%	77%
A0A3S7X4J4	Leishmania donovani	33%	100%
A4HJC8	Leishmania braziliensis	37%	100%
A4HVB0	Leishmania infantum	36%	100%
A4I6S4	Leishmania infantum	34%	100%
E8NHP8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	32%	100%
E9AEF4	Leishmania major	83%	100%
E9AGG5	Leishmania infantum	38%	100%
E9AGH0	Leishmania infantum	39%	100%
E9AP02	Leishmania mexicana (strain MHOM/GT/2001/U1103)	44%	100%
E9AP03	Leishmania mexicana (strain MHOM/GT/2001/U1103)	40%	100%
E9AP07	Leishmania mexicana (strain MHOM/GT/2001/U1103)	44%	100%
E9AP08	Leishmania mexicana (strain MHOM/GT/2001/U1103)	41%	100%
E9B1U5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
E9B1U6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	32%	100%
Q25331	Leishmania major	40%	100%
Q4Q6B6	Leishmania major	34%	100%
Q4Q6B7	Leishmania major	32%	100%
Q4QGJ4	Leishmania major	40%	100%
Q4QGJ6	Leishmania major	35%	78%
Q4QGJ7	Leishmania major	40%	100%
Q4QGK0	Leishmania major	38%	78%
Q4QGK6	Leishmania major	40%	100%
Q4QGL4	Leishmania major	37%	100%
Q4QGL5	Leishmania major	33%	81%