Uncharacterized protein LmxM_30_0440a_1

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein

Species:

Leishmania mexicana

UniProt:

E8NHG3_LEIMU

TriTrypDb:

LmxM.30.0440a

Length:

169

Annotations

LeishMANIAdb interaction annotations

by homology
Contact email: avilan@ula.ve
Publication title: Plasminogen binding proteins in secreted membrane vesicles of Leishmania mexicana
Publication 1st author(s): Figuera
Publication Identifier(s): 23178693
Host organism: -1
Interaction detection method(s): enzymatic linked imunosorbent assay
Interaction type: direct interaction
Identification method participant A: identification by antibody
Identification method participant B: identification by antibody
ID(s) interactor A: E9AUS1
ID(s) interactor B: P00747
Taxid interactor A: Leishmania mexicana
Taxid interactor B: Homo sapiens
Biological role(s) interactor A: unspecified role
Biological role(s) interactor B: unspecified role
Experimental role(s) interactor A: bait

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 2
Forrest at al. (procyclic)	no	yes: 2
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 21

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 10

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 5

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0031090	organelle membrane	3	1
GO:0031253	cell projection membrane	4	1
GO:0060170	ciliary membrane	5	1
GO:0098588	bounding membrane of organelle	4	1
GO:0098590	plasma membrane region	3	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E8NHG3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E8NHG3

PDB structure(s): 2fe0_A

Function

Biological processes
Term	Name	Level	Count
GO:0006996	organelle organization	4	1
GO:0009987	cellular process	1	1
GO:0016043	cellular component organization	3	1
GO:0022607	cellular component assembly	4	1
GO:0030030	cell projection organization	4	1
GO:0030031	cell projection assembly	5	1
GO:0044000	movement in host	4	1
GO:0044403	biological process involved in symbiotic interaction	2	1
GO:0044409	entry into host	5	1
GO:0044419	biological process involved in interspecies interaction between organisms	1	1
GO:0044782	cilium organization	5	1
GO:0051701	biological process involved in interaction with host	3	1
GO:0060271	cilium assembly	6	1
GO:0070925	organelle assembly	5	1
GO:0071840	cellular component organization or biogenesis	2	1
GO:0120031	plasma membrane bounded cell projection assembly	6	1
GO:0120036	plasma membrane bounded cell projection organization	5	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
DEG_APCC_DBOX_1	125	133	PF00400	0.264
DOC_PP1_RVXF_1	37	43	PF00149	0.476
DOC_USP7_MATH_1	117	121	PF00917	0.264
LIG_14-3-3_CanoR_1	43	51	PF00244	0.431
LIG_FHA_1	146	152	PF00498	0.264
LIG_FHA_1	51	57	PF00498	0.379
LIG_FHA_2	125	131	PF00498	0.402
LIG_LIR_Nem_3	95	101	PF02991	0.299
LIG_PDZ_Class_2	164	169	PF00595	0.507
LIG_SH2_CRK	164	168	PF00017	0.503
LIG_SH2_GRB2like	83	86	PF00017	0.289
LIG_SH2_STAT5	83	86	PF00017	0.340
LIG_SH2_STAT5	99	102	PF00017	0.264
LIG_SH3_3	17	23	PF00018	0.566
LIG_TRAF2_1	14	17	PF00917	0.563
LIG_TRAF2_1	33	36	PF00917	0.492
MOD_CK1_1	119	125	PF00069	0.287
MOD_CK1_1	6	12	PF00069	0.699
MOD_CK2_1	124	130	PF00069	0.383
MOD_CK2_1	30	36	PF00069	0.525
MOD_CK2_1	43	49	PF00069	0.423
MOD_GlcNHglycan	152	155	PF01048	0.318
MOD_GlcNHglycan	23	26	PF01048	0.555
MOD_GlcNHglycan	32	35	PF01048	0.514
MOD_GlcNHglycan	45	48	PF01048	0.418
MOD_GlcNHglycan	56	59	PF01048	0.403
MOD_GSK3_1	150	157	PF00069	0.264
MOD_GSK3_1	26	33	PF00069	0.547
MOD_GSK3_1	50	57	PF00069	0.381
MOD_N-GLC_1	101	106	PF02516	0.514
MOD_N-GLC_2	71	73	PF02516	0.349
MOD_NEK2_2	145	150	PF00069	0.275
MOD_NMyristoyl	1	7	PF02799	0.747
MOD_PKA_2	54	60	PF00069	0.381
MOD_Plk_1	101	107	PF00069	0.421
MOD_Plk_4	79	85	PF00069	0.322
MOD_Plk_4	94	100	PF00069	0.264
MOD_SPalmitoyl_4	1	7	PF01529	0.650
MOD_SUMO_for_1	38	41	PF00179	0.471
MOD_SUMO_rev_2	33	40	PF00179	0.492
MOD_SUMO_rev_2	6	12	PF00179	0.533
TRG_DiLeu_BaEn_1	147	152	PF01217	0.264
TRG_ENDOCYTIC_2	164	167	PF00928	0.523

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IKN9	Leishmania donovani	34%	100%
A4HYX4	Leishmania infantum	34%	100%
E9AII6	Leishmania braziliensis	34%	100%
E9AUS1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	35%	100%
Q4QCS4	Leishmania major	36%	100%
Q5SDH5	Leishmania major	35%	100%