WGS CADB00000000 data, contig 19

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein

Species:

Leishmania mexicana

UniProt:

E8NHG1_LEIMU

TriTrypDb:

LmxM.30.1450partial

Length:

119

Annotations

LeishMANIAdb annotations

Publication identifier(s): 26641088 15760660
Amastin, Kinetoplastid host adhesion protein. A host adhesion protein family greatly expanded in Leishmaniids.. Localization: Cell surface (experimental)

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 2, no: 11
NetGPI	no	yes: 0, no: 13

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	13
GO:0110165	cellular anatomical entity	1	13

Expansion

Sequence features

E8NHG1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E8NHG1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
DEG_Nend_Nbox_1	1	2	PF02207	0.203
DOC_CYCLIN_yCln2_LP_2	81	87	PF00134	0.566
DOC_MAPK_MEF2A_6	19	27	PF00069	0.424
DOC_PP2B_LxvP_1	81	84	PF13499	0.576
LIG_eIF4E_1	1	7	PF01652	0.214
LIG_FHA_1	30	36	PF00498	0.447
LIG_FHA_1	41	47	PF00498	0.513
LIG_LIR_Gen_1	77	87	PF02991	0.421
LIG_LIR_Nem_3	16	21	PF02991	0.347
LIG_LIR_Nem_3	62	67	PF02991	0.343
LIG_LIR_Nem_3	77	83	PF02991	0.337
LIG_Pex14_2	3	7	PF04695	0.408
LIG_Pex14_2	60	64	PF04695	0.404
LIG_SH2_STAT3	44	47	PF00017	0.214
LIG_SH2_STAT5	13	16	PF00017	0.220
LIG_SH3_3	43	49	PF00018	0.270
LIG_SUMO_SIM_anti_2	74	80	PF11976	0.249
LIG_SUMO_SIM_par_1	37	43	PF11976	0.203
LIG_SUMO_SIM_par_1	71	77	PF11976	0.246
LIG_TRAF2_1	110	113	PF00917	0.553
MOD_CK1_1	90	96	PF00069	0.554
MOD_CK2_1	105	111	PF00069	0.596
MOD_GlcNHglycan	15	18	PF01048	0.220
MOD_GlcNHglycan	89	92	PF01048	0.494
MOD_GSK3_1	93	100	PF00069	0.575
MOD_NEK2_1	40	45	PF00069	0.339
MOD_NEK2_1	54	59	PF00069	0.382
MOD_Plk_1	52	58	PF00069	0.216
MOD_SUMO_rev_2	101	110	PF00179	0.504
MOD_SUMO_rev_2	111	118	PF00179	0.511
TRG_ENDOCYTIC_2	115	118	PF00928	0.510
TRG_NES_CRM1_1	74	86	PF08389	0.295

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P547	Leptomonas seymouri	38%	77%
A0A3S7WQA8	Leishmania donovani	52%	68%
A4HAL1	Leishmania braziliensis	46%	88%
A4HTM4	Leishmania infantum	52%	68%
A4I9Q4	Leishmania infantum	47%	70%
E8NHD6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	52%	92%
E8NHM7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	40%	85%
E9AME9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	48%	68%
E9AMF7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	44%	73%
Q4Q341	Leishmania major	56%	68%
Q4QI84	Leishmania major	48%	68%
Q4QI86	Leishmania major	48%	68%