Uncharacterized protein LmxM_27_1560a_1

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein

Species:

Leishmania mexicana

UniProt:

E8NHG0_LEIMU

TriTrypDb:

LmxM.27.1560a

Length:

298

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	5
GO:0110165	cellular anatomical entity	1	5
GO:0005789	endoplasmic reticulum membrane	4	3
GO:0031090	organelle membrane	3	3

Expansion

Sequence features

E8NHG0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E8NHG0

Function

Biological processes
Term	Name	Level	Count
GO:0006629	lipid metabolic process	3	1
GO:0006638	neutral lipid metabolic process	4	1
GO:0006639	acylglycerol metabolic process	5	1
GO:0006641	triglyceride metabolic process	6	1
GO:0008152	metabolic process	1	1
GO:0008610	lipid biosynthetic process	4	1
GO:0009058	biosynthetic process	2	1
GO:0009987	cellular process	1	1
GO:0019432	triglyceride biosynthetic process	6	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044249	cellular biosynthetic process	3	1
GO:0044255	cellular lipid metabolic process	3	1
GO:0045017	glycerolipid biosynthetic process	4	1
GO:0046460	neutral lipid biosynthetic process	4	1
GO:0046463	acylglycerol biosynthetic process	5	1
GO:0046486	glycerolipid metabolic process	4	1
GO:0071704	organic substance metabolic process	2	1
GO:1901576	organic substance biosynthetic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	6
GO:0008374	O-acyltransferase activity	5	6
GO:0016740	transferase activity	2	6
GO:0016746	acyltransferase activity	3	6
GO:0016747	acyltransferase activity, transferring groups other than amino-acyl groups	4	6
GO:0004144	diacylglycerol O-acyltransferase activity	7	1
GO:0016411	acylglycerol O-acyltransferase activity	6	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	218	220	PF00675	0.381
CLV_NRD_NRD_1	9	11	PF00675	0.368
CLV_PCSK_KEX2_1	218	220	PF00082	0.381
CLV_PCSK_KEX2_1	226	228	PF00082	0.290
CLV_PCSK_KEX2_1	9	11	PF00082	0.368
CLV_PCSK_PC1ET2_1	226	228	PF00082	0.290
CLV_PCSK_SKI1_1	250	254	PF00082	0.381
CLV_PCSK_SKI1_1	67	71	PF00082	0.315
CLV_Separin_Metazoa	240	244	PF03568	0.581
DEG_APCC_DBOX_1	267	275	PF00400	0.581
DEG_Nend_Nbox_1	1	2	PF02207	0.581
DOC_MAPK_DCC_7	268	277	PF00069	0.521
DOC_MAPK_gen_1	226	234	PF00069	0.490
DOC_MAPK_gen_1	290	298	PF00069	0.664
DOC_MAPK_gen_1	46	56	PF00069	0.222
DOC_MAPK_HePTP_8	265	277	PF00069	0.581
DOC_MAPK_MEF2A_6	268	277	PF00069	0.521
DOC_MAPK_MEF2A_6	290	298	PF00069	0.664
DOC_MAPK_MEF2A_6	49	56	PF00069	0.246
DOC_MAPK_NFAT4_5	49	57	PF00069	0.249
DOC_PP1_RVXF_1	113	120	PF00149	0.381
DOC_PP4_FxxP_1	199	202	PF00568	0.484
DOC_USP7_MATH_1	25	29	PF00917	0.533
DOC_USP7_MATH_1	264	268	PF00917	0.581
LIG_14-3-3_CanoR_1	118	126	PF00244	0.324
LIG_14-3-3_CanoR_1	188	198	PF00244	0.581
LIG_14-3-3_CanoR_1	218	222	PF00244	0.581
LIG_14-3-3_CanoR_1	227	232	PF00244	0.479
LIG_14-3-3_CanoR_1	243	253	PF00244	0.554
LIG_14-3-3_CanoR_1	26	31	PF00244	0.569
LIG_14-3-3_CanoR_1	293	297	PF00244	0.661
LIG_14-3-3_CanoR_1	3	7	PF00244	0.722
LIG_Actin_WH2_2	167	183	PF00022	0.472
LIG_Actin_WH2_2	194	212	PF00022	0.484
LIG_Actin_WH2_2	33	51	PF00022	0.217
LIG_APCC_ABBAyCdc20_2	124	130	PF00400	0.381
LIG_BRCT_BRCA1_1	115	119	PF00533	0.381
LIG_BRCT_BRCA1_1	195	199	PF00533	0.490
LIG_BRCT_BRCA1_1	27	31	PF00533	0.459
LIG_FHA_1	256	262	PF00498	0.531
LIG_FHA_1	45	51	PF00498	0.349
LIG_GBD_Chelix_1	80	88	PF00786	0.217
LIG_LIR_Apic_2	196	202	PF02991	0.490
LIG_LIR_Gen_1	116	127	PF02991	0.381
LIG_LIR_Gen_1	168	179	PF02991	0.472
LIG_LIR_Gen_1	258	266	PF02991	0.581
LIG_LIR_Nem_3	116	122	PF02991	0.379
LIG_LIR_Nem_3	168	174	PF02991	0.485
LIG_LIR_Nem_3	258	263	PF02991	0.563
LIG_PDZ_Class_2	293	298	PF00595	0.488
LIG_SH2_CRK	57	61	PF00017	0.249
LIG_SH2_GRB2like	134	137	PF00017	0.315
LIG_SH2_NCK_1	57	61	PF00017	0.249
LIG_SH2_STAT5	100	103	PF00017	0.550
LIG_SH2_STAT5	126	129	PF00017	0.310
LIG_SH2_STAT5	134	137	PF00017	0.278
LIG_SH2_STAT5	155	158	PF00017	0.279
LIG_SH2_STAT5	189	192	PF00017	0.581
LIG_SH2_STAT5	62	65	PF00017	0.428
LIG_SH3_3	138	144	PF00018	0.381
LIG_SH3_3	19	25	PF00018	0.556
LIG_SH3_3	267	273	PF00018	0.515
LIG_SUMO_SIM_anti_2	230	235	PF11976	0.515
LIG_SUMO_SIM_par_1	230	235	PF11976	0.581
LIG_SUMO_SIM_par_1	250	255	PF11976	0.554
LIG_TYR_ITIM	98	103	PF00017	0.472
LIG_WRC_WIRS_1	156	161	PF05994	0.472
MOD_CK1_1	113	119	PF00069	0.380
MOD_CK1_1	217	223	PF00069	0.472
MOD_GlcNHglycan	104	107	PF01048	0.478
MOD_GlcNHglycan	247	250	PF01048	0.217
MOD_GlcNHglycan	31	34	PF01048	0.332
MOD_GSK3_1	113	120	PF00069	0.472
MOD_GSK3_1	189	196	PF00069	0.472
MOD_GSK3_1	217	224	PF00069	0.384
MOD_GSK3_1	241	248	PF00069	0.345
MOD_GSK3_1	25	32	PF00069	0.472
MOD_NEK2_1	170	175	PF00069	0.485
MOD_NEK2_1	214	219	PF00069	0.485
MOD_NEK2_1	232	237	PF00069	0.207
MOD_NEK2_1	241	246	PF00069	0.279
MOD_NEK2_2	155	160	PF00069	0.472
MOD_PIKK_1	110	116	PF00454	0.472
MOD_PIKK_1	150	156	PF00454	0.472
MOD_PIKK_1	241	247	PF00454	0.402
MOD_PIKK_1	252	258	PF00454	0.367
MOD_PK_1	227	233	PF00069	0.472
MOD_PKA_2	117	123	PF00069	0.472
MOD_PKA_2	2	8	PF00069	0.670
MOD_PKA_2	217	223	PF00069	0.472
MOD_PKA_2	25	31	PF00069	0.458
MOD_PKA_2	292	298	PF00069	0.586
MOD_Plk_1	150	156	PF00069	0.494
MOD_Plk_1	221	227	PF00069	0.380
MOD_Plk_4	193	199	PF00069	0.397
MOD_Plk_4	227	233	PF00069	0.321
MOD_Plk_4	26	32	PF00069	0.217
MOD_Plk_4	74	80	PF00069	0.293
TRG_DiLeu_BaLyEn_6	199	204	PF01217	0.472
TRG_DiLeu_BaLyEn_6	270	275	PF01217	0.472
TRG_ENDOCYTIC_2	100	103	PF00928	0.452
TRG_ENDOCYTIC_2	134	137	PF00928	0.321
TRG_ENDOCYTIC_2	57	60	PF00928	0.356
TRG_ER_diArg_1	8	10	PF00400	0.456
TRG_Pf-PMV_PEXEL_1	138	142	PF00026	0.472

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0S4JRA5	Bodo saltans	42%	100%
A0A3S7X0T2	Leishmania donovani	96%	90%
A4I2V0	Leishmania infantum	96%	90%
E9ADD8	Leishmania major	95%	100%
O74850	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	30%	86%
Q2KHS5	Xenopus laevis	28%	89%
Q54GC1	Dictyostelium discoideum	28%	90%
Q6ZPD8	Homo sapiens	26%	88%
Q70VZ7	Bos taurus	28%	89%
Q91ZV4	Mus musculus	28%	89%
Q96PD6	Homo sapiens	26%	89%