Uncharacterized protein LmxM_33_1590_1

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

tuzin-like protein

Species:

Leishmania mexicana

UniProt:

E8NHF8_LEIMU

TriTrypDb:

LmxM.33.1590

Length:

609

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 34
NetGPI	no	yes: 0, no: 34

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	15
GO:0110165	cellular anatomical entity	1	15

Expansion

Sequence features

E8NHF8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E8NHF8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	128	130	PF00675	0.636
CLV_NRD_NRD_1	2	4	PF00675	0.512
CLV_NRD_NRD_1	284	286	PF00675	0.455
CLV_NRD_NRD_1	325	327	PF00675	0.650
CLV_NRD_NRD_1	466	468	PF00675	0.589
CLV_NRD_NRD_1	535	537	PF00675	0.614
CLV_NRD_NRD_1	68	70	PF00675	0.430
CLV_PCSK_KEX2_1	127	129	PF00082	0.468
CLV_PCSK_KEX2_1	2	4	PF00082	0.512
CLV_PCSK_KEX2_1	284	286	PF00082	0.415
CLV_PCSK_KEX2_1	325	327	PF00082	0.683
CLV_PCSK_KEX2_1	466	468	PF00082	0.589
CLV_PCSK_KEX2_1	535	537	PF00082	0.639
CLV_PCSK_KEX2_1	70	72	PF00082	0.426
CLV_PCSK_PC1ET2_1	70	72	PF00082	0.422
CLV_PCSK_SKI1_1	202	206	PF00082	0.467
CLV_PCSK_SKI1_1	294	298	PF00082	0.378
CLV_PCSK_SKI1_1	407	411	PF00082	0.636
CLV_PCSK_SKI1_1	416	420	PF00082	0.637
CLV_PCSK_SKI1_1	456	460	PF00082	0.645
CLV_PCSK_SKI1_1	605	609	PF00082	0.664
DEG_Nend_UBRbox_1	1	4	PF02207	0.619
DOC_ANK_TNKS_1	564	571	PF00023	0.313
DOC_CYCLIN_RxL_1	199	207	PF00134	0.614
DOC_CYCLIN_yClb5_NLxxxL_5	288	297	PF00134	0.503
DOC_CYCLIN_yCln2_LP_2	451	457	PF00134	0.347
DOC_MAPK_DCC_7	362	371	PF00069	0.379
DOC_MAPK_MEF2A_6	225	234	PF00069	0.547
DOC_MAPK_MEF2A_6	362	371	PF00069	0.337
DOC_PP1_RVXF_1	267	273	PF00149	0.533
DOC_PP1_RVXF_1	414	420	PF00149	0.269
DOC_PP2B_LxvP_1	198	201	PF13499	0.606
DOC_PP2B_LxvP_1	451	454	PF13499	0.428
DOC_PP2B_LxvP_1	541	544	PF13499	0.474
DOC_PP4_FxxP_1	595	598	PF00568	0.238
DOC_USP7_MATH_1	346	350	PF00917	0.530
DOC_USP7_MATH_1	35	39	PF00917	0.683
DOC_USP7_MATH_1	524	528	PF00917	0.313
DOC_WW_Pin1_4	456	461	PF00397	0.378
DOC_WW_Pin1_4	543	548	PF00397	0.387
DOC_WW_Pin1_4	58	63	PF00397	0.700
DOC_WW_Pin1_4	64	69	PF00397	0.714
LIG_14-3-3_CanoR_1	26	30	PF00244	0.785
LIG_14-3-3_CanoR_1	407	412	PF00244	0.416
LIG_14-3-3_CanoR_1	504	511	PF00244	0.450
LIG_14-3-3_CanoR_1	553	559	PF00244	0.365
LIG_Actin_WH2_2	366	383	PF00022	0.375
LIG_BIR_III_4	567	571	PF00653	0.423
LIG_Clathr_ClatBox_1	134	138	PF01394	0.633
LIG_Clathr_ClatBox_1	368	372	PF01394	0.353
LIG_deltaCOP1_diTrp_1	591	595	PF00928	0.340
LIG_DLG_GKlike_1	71	78	PF00625	0.612
LIG_EH1_1	162	170	PF00400	0.512
LIG_eIF4E_1	525	531	PF01652	0.300
LIG_FHA_1	152	158	PF00498	0.743
LIG_FHA_1	174	180	PF00498	0.582
LIG_FHA_1	316	322	PF00498	0.542
LIG_FHA_1	559	565	PF00498	0.395
LIG_FHA_2	333	339	PF00498	0.405
LIG_LIR_Apic_2	592	598	PF02991	0.240
LIG_LIR_Gen_1	174	181	PF02991	0.565
LIG_LIR_Nem_3	174	180	PF02991	0.565
LIG_NRBOX	74	80	PF00104	0.699
LIG_PDZ_Class_2	604	609	PF00595	0.417
LIG_Pex14_2	235	239	PF04695	0.561
LIG_Rb_LxCxE_1	397	414	PF01857	0.251
LIG_SH2_CRK	525	529	PF00017	0.449
LIG_SH2_CRK	586	590	PF00017	0.386
LIG_SH2_PTP2	177	180	PF00017	0.546
LIG_SH2_STAP1	110	114	PF00017	0.637
LIG_SH2_STAP1	484	488	PF00017	0.286
LIG_SH2_STAP1	525	529	PF00017	0.330
LIG_SH2_STAT3	324	327	PF00017	0.368
LIG_SH2_STAT5	110	113	PF00017	0.694
LIG_SH2_STAT5	177	180	PF00017	0.625
LIG_SH2_STAT5	245	248	PF00017	0.548
LIG_SH2_STAT5	315	318	PF00017	0.454
LIG_SH2_STAT5	471	474	PF00017	0.427
LIG_SH2_STAT5	484	487	PF00017	0.348
LIG_SH2_STAT5	496	499	PF00017	0.302
LIG_SH2_STAT5	525	528	PF00017	0.348
LIG_SH2_STAT5	560	563	PF00017	0.410
LIG_SH3_2	544	549	PF14604	0.381
LIG_SH3_3	218	224	PF00018	0.641
LIG_SH3_3	537	543	PF00018	0.345
LIG_SH3_3	81	87	PF00018	0.753
LIG_SH3_CIN85_PxpxPR_1	64	69	PF14604	0.622
LIG_SUMO_SIM_anti_2	176	183	PF11976	0.691
LIG_SUMO_SIM_anti_2	228	234	PF11976	0.544
LIG_SUMO_SIM_anti_2	436	443	PF11976	0.430
LIG_SUMO_SIM_anti_2	490	496	PF11976	0.389
LIG_SUMO_SIM_anti_2	526	532	PF11976	0.246
LIG_SUMO_SIM_par_1	133	138	PF11976	0.673
LIG_SUMO_SIM_par_1	436	443	PF11976	0.348
LIG_TYR_ITIM	523	528	PF00017	0.420
LIG_TYR_ITIM	584	589	PF00017	0.356
LIG_UBA3_1	164	170	PF00899	0.533
LIG_UBA3_1	252	260	PF00899	0.471
MOD_CAAXbox	606	609	PF01239	0.423
MOD_CDC14_SPxK_1	546	549	PF00782	0.363
MOD_CDC14_SPxK_1	67	70	PF00782	0.712
MOD_CDK_SPK_2	64	69	PF00069	0.711
MOD_CDK_SPxK_1	543	549	PF00069	0.384
MOD_CDK_SPxK_1	64	70	PF00069	0.712
MOD_CDK_SPxxK_3	64	71	PF00069	0.625
MOD_CK1_1	103	109	PF00069	0.749
MOD_CK1_1	25	31	PF00069	0.624
MOD_CK1_1	439	445	PF00069	0.429
MOD_CK1_1	461	467	PF00069	0.356
MOD_CK2_1	256	262	PF00069	0.577
MOD_CK2_1	332	338	PF00069	0.411
MOD_CK2_1	379	385	PF00069	0.304
MOD_GlcNHglycan	159	162	PF01048	0.533
MOD_GlcNHglycan	182	185	PF01048	0.317
MOD_GlcNHglycan	206	209	PF01048	0.463
MOD_GlcNHglycan	235	238	PF01048	0.421
MOD_GlcNHglycan	37	40	PF01048	0.521
MOD_GlcNHglycan	413	416	PF01048	0.539
MOD_GSK3_1	316	323	PF00069	0.481
MOD_GSK3_1	332	339	PF00069	0.407
MOD_GSK3_1	407	414	PF00069	0.470
MOD_GSK3_1	554	561	PF00069	0.472
MOD_GSK3_1	82	89	PF00069	0.723
MOD_N-GLC_1	461	466	PF02516	0.623
MOD_NEK2_1	164	169	PF00069	0.649
MOD_NEK2_1	204	209	PF00069	0.712
MOD_PKA_2	25	31	PF00069	0.782
MOD_PKA_2	503	509	PF00069	0.452
MOD_PKB_1	423	431	PF00069	0.363
MOD_PKB_1	69	77	PF00069	0.616
MOD_Plk_1	106	112	PF00069	0.650
MOD_Plk_1	173	179	PF00069	0.633
MOD_Plk_1	186	192	PF00069	0.608
MOD_Plk_1	376	382	PF00069	0.442
MOD_Plk_1	461	467	PF00069	0.319
MOD_Plk_2-3	262	268	PF00069	0.551
MOD_Plk_4	164	170	PF00069	0.568
MOD_Plk_4	173	179	PF00069	0.624
MOD_Plk_4	25	31	PF00069	0.686
MOD_Plk_4	262	268	PF00069	0.504
MOD_Plk_4	436	442	PF00069	0.373
MOD_Plk_4	524	530	PF00069	0.474
MOD_Plk_4	86	92	PF00069	0.696
MOD_ProDKin_1	456	462	PF00069	0.373
MOD_ProDKin_1	543	549	PF00069	0.384
MOD_ProDKin_1	58	64	PF00069	0.700
TRG_DiLeu_BaEn_1	228	233	PF01217	0.643
TRG_DiLeu_BaEn_1	242	247	PF01217	0.559
TRG_DiLeu_BaEn_1	436	441	PF01217	0.390
TRG_DiLeu_BaLyEn_6	413	418	PF01217	0.336
TRG_ENDOCYTIC_2	177	180	PF00928	0.605
TRG_ENDOCYTIC_2	277	280	PF00928	0.677
TRG_ENDOCYTIC_2	434	437	PF00928	0.367
TRG_ENDOCYTIC_2	525	528	PF00928	0.450
TRG_ENDOCYTIC_2	586	589	PF00928	0.382
TRG_ER_diArg_1	1	3	PF00400	0.718
TRG_ER_diArg_1	127	129	PF00400	0.610
TRG_ER_diArg_1	283	285	PF00400	0.658
TRG_ER_diArg_1	324	326	PF00400	0.476
TRG_ER_diArg_1	422	425	PF00400	0.357
TRG_ER_diArg_1	465	467	PF00400	0.383
TRG_ER_diArg_1	515	518	PF00400	0.449
TRG_ER_diArg_1	534	536	PF00400	0.451
TRG_ER_diArg_1	68	71	PF00400	0.681
TRG_NES_CRM1_1	251	264	PF08389	0.622
TRG_NES_CRM1_1	378	393	PF08389	0.370
TRG_Pf-PMV_PEXEL_1	281	286	PF00026	0.380

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PAN2	Leptomonas seymouri	57%	93%
A0A0N1PB02	Leptomonas seymouri	36%	93%
A0A0S4J6C6	Bodo saltans	32%	94%
A0A1X0P9A6	Trypanosomatidae	37%	89%
A0A3Q8IHH1	Leishmania donovani	74%	83%
A0A3R7K2Y9	Trypanosoma rangeli	36%	89%
A0A3S5H668	Leishmania donovani	34%	100%
A0A3S5H669	Leishmania donovani	32%	96%
A0A3S7X835	Leishmania donovani	36%	100%
A4H5C9	Leishmania braziliensis	34%	99%
A4H5D0	Leishmania braziliensis	35%	100%
A4HAZ7	Leishmania braziliensis	37%	100%
A4HAZ9	Leishmania braziliensis	39%	100%
A4HB01	Leishmania braziliensis	40%	100%
A4HTM0	Leishmania infantum	34%	100%
A4HTM1	Leishmania infantum	31%	96%
A4IA57	Leishmania infantum	37%	100%
C6K3V8	Leptomonas seymouri	34%	100%
C9ZMY5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	90%
E8NHE5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
E8NHF6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	99%	100%
E8NHR9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	98%	100%
E8NHS6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	97%	100%
E9AME6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	35%	100%
E9B571	Leishmania mexicana (strain MHOM/GT/2001/U1103)	36%	100%
Q4Q1U8	Leishmania major	75%	100%
Q4Q2R4	Leishmania major	36%	100%
Q4Q310	Leishmania major	73%	100%
Q4Q312	Leishmania major	72%	100%
Q4Q340	Leishmania major	73%	100%
Q4Q342	Leishmania major	73%	100%
Q4QI90	Leishmania major	33%	100%
Q4QI91	Leishmania major	34%	98%