Uncharacterized protein LmxM_33_1610_1

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

tuzin-like protein

Species:

Leishmania mexicana

UniProt:

E8NHF6_LEIMU

TriTrypDb:

LmxM.33.1610

Length:

414

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	5
GO:0110165	cellular anatomical entity	1	5

Expansion

Sequence features

E8NHF6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E8NHF6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	128	130	PF00675	0.579
CLV_NRD_NRD_1	2	4	PF00675	0.549
CLV_NRD_NRD_1	284	286	PF00675	0.468
CLV_NRD_NRD_1	326	328	PF00675	0.661
CLV_NRD_NRD_1	380	382	PF00675	0.608
CLV_NRD_NRD_1	396	398	PF00675	0.687
CLV_NRD_NRD_1	407	409	PF00675	0.658
CLV_NRD_NRD_1	68	70	PF00675	0.467
CLV_PCSK_KEX2_1	127	129	PF00082	0.525
CLV_PCSK_KEX2_1	2	4	PF00082	0.549
CLV_PCSK_KEX2_1	284	286	PF00082	0.468
CLV_PCSK_KEX2_1	325	327	PF00082	0.673
CLV_PCSK_KEX2_1	380	382	PF00082	0.611
CLV_PCSK_KEX2_1	396	398	PF00082	0.572
CLV_PCSK_KEX2_1	407	409	PF00082	0.682
CLV_PCSK_KEX2_1	70	72	PF00082	0.459
CLV_PCSK_PC1ET2_1	70	72	PF00082	0.442
CLV_PCSK_PC7_1	322	328	PF00082	0.479
CLV_PCSK_SKI1_1	202	206	PF00082	0.520
CLV_PCSK_SKI1_1	294	298	PF00082	0.446
CLV_PCSK_SKI1_1	371	375	PF00082	0.644
DEG_Nend_UBRbox_1	1	4	PF02207	0.613
DOC_CYCLIN_RxL_1	199	207	PF00134	0.699
DOC_CYCLIN_yClb5_NLxxxL_5	288	297	PF00134	0.516
DOC_MAPK_MEF2A_6	225	234	PF00069	0.638
DOC_PP1_RVXF_1	267	273	PF00149	0.475
DOC_PP2B_LxvP_1	198	201	PF13499	0.570
DOC_USP7_MATH_1	344	348	PF00917	0.402
DOC_USP7_MATH_1	35	39	PF00917	0.685
DOC_WW_Pin1_4	379	384	PF00397	0.378
DOC_WW_Pin1_4	58	63	PF00397	0.756
DOC_WW_Pin1_4	64	69	PF00397	0.783
LIG_14-3-3_CanoR_1	142	146	PF00244	0.686
LIG_14-3-3_CanoR_1	26	30	PF00244	0.746
LIG_14-3-3_CanoR_1	345	353	PF00244	0.374
LIG_14-3-3_CanoR_1	371	376	PF00244	0.458
LIG_14-3-3_CanoR_1	397	406	PF00244	0.351
LIG_14-3-3_CanoR_1	71	76	PF00244	0.696
LIG_Clathr_ClatBox_1	134	138	PF01394	0.714
LIG_DLG_GKlike_1	71	78	PF00625	0.632
LIG_EH1_1	162	170	PF00400	0.531
LIG_FHA_1	152	158	PF00498	0.626
LIG_FHA_1	174	180	PF00498	0.587
LIG_FHA_1	316	322	PF00498	0.544
LIG_FHA_2	333	339	PF00498	0.415
LIG_LIR_Gen_1	174	181	PF02991	0.638
LIG_LIR_Nem_3	174	180	PF02991	0.651
LIG_NRBOX	74	80	PF00104	0.637
LIG_Pex14_2	235	239	PF04695	0.660
LIG_Pex14_2	373	377	PF04695	0.357
LIG_SH2_PTP2	177	180	PF00017	0.632
LIG_SH2_STAP1	110	114	PF00017	0.623
LIG_SH2_STAT5	110	113	PF00017	0.616
LIG_SH2_STAT5	177	180	PF00017	0.632
LIG_SH2_STAT5	245	248	PF00017	0.599
LIG_SH2_STAT5	315	318	PF00017	0.465
LIG_SH3_3	218	224	PF00018	0.657
LIG_SH3_3	81	87	PF00018	0.643
LIG_SH3_CIN85_PxpxPR_1	64	69	PF14604	0.646
LIG_SUMO_SIM_anti_2	176	183	PF11976	0.676
LIG_SUMO_SIM_anti_2	228	234	PF11976	0.634
LIG_SUMO_SIM_par_1	133	138	PF11976	0.654
LIG_UBA3_1	164	170	PF00899	0.554
LIG_UBA3_1	252	260	PF00899	0.493
MOD_CDC14_SPxK_1	67	70	PF00782	0.787
MOD_CDK_SPK_2	64	69	PF00069	0.788
MOD_CDK_SPxK_1	64	70	PF00069	0.788
MOD_CDK_SPxxK_3	64	71	PF00069	0.646
MOD_CK1_1	103	109	PF00069	0.756
MOD_CK1_1	25	31	PF00069	0.717
MOD_CK2_1	256	262	PF00069	0.664
MOD_CK2_1	332	338	PF00069	0.471
MOD_CK2_1	344	350	PF00069	0.437
MOD_CMANNOS	372	375	PF00535	0.559
MOD_CMANNOS	403	406	PF00535	0.556
MOD_GlcNHglycan	159	162	PF01048	0.426
MOD_GlcNHglycan	182	185	PF01048	0.346
MOD_GlcNHglycan	206	209	PF01048	0.488
MOD_GlcNHglycan	235	238	PF01048	0.311
MOD_GlcNHglycan	37	40	PF01048	0.487
MOD_GSK3_1	316	323	PF00069	0.538
MOD_GSK3_1	332	339	PF00069	0.399
MOD_GSK3_1	82	89	PF00069	0.772
MOD_NEK2_1	164	169	PF00069	0.677
MOD_NEK2_1	204	209	PF00069	0.687
MOD_NEK2_1	373	378	PF00069	0.487
MOD_PKA_2	141	147	PF00069	0.688
MOD_PKA_2	25	31	PF00069	0.743
MOD_PKA_2	344	350	PF00069	0.390
MOD_PKB_1	325	333	PF00069	0.286
MOD_PKB_1	69	77	PF00069	0.636
MOD_Plk_1	106	112	PF00069	0.616
MOD_Plk_1	173	179	PF00069	0.629
MOD_Plk_1	186	192	PF00069	0.553
MOD_Plk_2-3	262	268	PF00069	0.634
MOD_Plk_4	164	170	PF00069	0.594
MOD_Plk_4	173	179	PF00069	0.653
MOD_Plk_4	25	31	PF00069	0.612
MOD_Plk_4	262	268	PF00069	0.499
MOD_Plk_4	86	92	PF00069	0.771
MOD_ProDKin_1	379	385	PF00069	0.379
MOD_ProDKin_1	58	64	PF00069	0.756
TRG_DiLeu_BaEn_1	228	233	PF01217	0.642
TRG_DiLeu_BaEn_1	242	247	PF01217	0.527
TRG_ENDOCYTIC_2	177	180	PF00928	0.632
TRG_ENDOCYTIC_2	277	280	PF00928	0.499
TRG_ER_diArg_1	1	3	PF00400	0.744
TRG_ER_diArg_1	127	129	PF00400	0.636
TRG_ER_diArg_1	283	285	PF00400	0.669
TRG_ER_diArg_1	324	327	PF00400	0.462
TRG_ER_diArg_1	395	397	PF00400	0.357
TRG_ER_diArg_1	406	408	PF00400	0.355
TRG_ER_diArg_1	68	71	PF00400	0.755
TRG_NES_CRM1_1	251	264	PF08389	0.568
TRG_NLS_MonoExtN_4	66	73	PF00514	0.634
TRG_Pf-PMV_PEXEL_1	281	286	PF00026	0.311

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A4H5D0	Leishmania braziliensis	31%	69%
A4HB03	Leishmania braziliensis	61%	100%
C6K3V8	Leptomonas seymouri	26%	68%
E8NHF8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	99%	68%
E8NHI6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	98%	100%
E8NHR9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	98%	100%
E8NHS6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	98%	100%
E9AMF6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	32%	100%
Q4Q1U8	Leishmania major	76%	70%