WGS CADB00000000 data, contig 76

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

amastin-like surface protein, putative

Species:

Leishmania mexicana

UniProt:

E8NHF5_LEIMU

TriTrypDb:

LmxM.33.1560 , LmxM.33.1920a , LmxM.33.1920b , LmxM.33.1920d , LmxM.33.1920e

Length:

191

Annotations

LeishMANIAdb annotations

Publication identifier(s): 26641088 15760660
Part of the greater amastin family, a cell adhesion protein critical for intracellular parasitism. Localization: Cell surface (experimental)

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 9
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 16

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 10, no: 191
NetGPI	no	yes: 0, no: 201

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	179
GO:0110165	cellular anatomical entity	1	179

Expansion

Sequence features

E8NHF5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E8NHF5

Function

Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0016485	protein processing	5	1
GO:0016540	protein autoprocessing	6	1
GO:0019538	protein metabolic process	3	1
GO:0043170	macromolecule metabolic process	3	1
GO:0044238	primary metabolic process	2	1
GO:0051604	protein maturation	4	1
GO:0071704	organic substance metabolic process	2	1
GO:1901564	organonitrogen compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	1
GO:0004175	endopeptidase activity	4	1
GO:0004197	cysteine-type endopeptidase activity	5	1
GO:0008233	peptidase activity	3	1
GO:0008234	cysteine-type peptidase activity	4	1
GO:0016787	hydrolase activity	2	1
GO:0140096	catalytic activity, acting on a protein	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
DOC_CKS1_1	23	28	PF01111	0.371
DOC_MAPK_gen_1	141	150	PF00069	0.304
DOC_MAPK_HePTP_8	142	154	PF00069	0.199
DOC_MAPK_MEF2A_6	106	114	PF00069	0.567
DOC_MAPK_MEF2A_6	143	152	PF00069	0.269
DOC_PP2B_LxvP_1	169	172	PF13499	0.669
DOC_SPAK_OSR1_1	73	77	PF12202	0.210
DOC_USP7_MATH_1	137	141	PF00917	0.401
DOC_WW_Pin1_4	22	27	PF00397	0.368
DOC_WW_Pin1_4	44	49	PF00397	0.268
LIG_14-3-3_CanoR_1	52	60	PF00244	0.297
LIG_Actin_WH2_2	92	108	PF00022	0.400
LIG_BIR_II_1	1	5	PF00653	0.711
LIG_Clathr_ClatBox_1	57	61	PF01394	0.198
LIG_FHA_1	117	123	PF00498	0.382
LIG_FHA_1	145	151	PF00498	0.303
LIG_FHA_1	91	97	PF00498	0.295
LIG_FHA_2	23	29	PF00498	0.391
LIG_LIR_Apic_2	43	48	PF02991	0.201
LIG_LIR_Gen_1	103	112	PF02991	0.615
LIG_LIR_Gen_1	130	137	PF02991	0.353
LIG_LIR_Nem_3	103	107	PF02991	0.636
LIG_LIR_Nem_3	130	134	PF02991	0.298
LIG_LIR_Nem_3	53	59	PF02991	0.294
LIG_NRBOX	14	20	PF00104	0.206
LIG_Pex14_1	45	49	PF04695	0.433
LIG_Pex14_2	100	104	PF04695	0.486
LIG_PTB_Apo_2	162	169	PF02174	0.429
LIG_SH2_CRK	3	7	PF00017	0.556
LIG_SH2_NCK_1	131	135	PF00017	0.204
LIG_SH2_PTP2	10	13	PF00017	0.359
LIG_SH2_SRC	10	13	PF00017	0.226
LIG_SH2_STAT3	187	190	PF00017	0.580
LIG_SH2_STAT5	10	13	PF00017	0.469
LIG_SH2_STAT5	187	190	PF00017	0.719
LIG_SH2_STAT5	49	52	PF00017	0.367
LIG_SH2_STAT5	56	59	PF00017	0.417
LIG_SH2_STAT5	88	91	PF00017	0.468
LIG_SH3_3	131	137	PF00018	0.349
LIG_SH3_3	20	26	PF00018	0.375
LIG_SH3_3	29	35	PF00018	0.327
LIG_SUMO_SIM_par_1	19	25	PF11976	0.441
LIG_TRAF2_1	188	191	PF00917	0.636
LIG_TRFH_1	168	172	PF08558	0.270
LIG_TYR_ITIM	129	134	PF00017	0.202
LIG_TYR_ITIM	8	13	PF00017	0.460
MOD_CK1_1	178	184	PF00069	0.507
MOD_CK1_1	47	53	PF00069	0.446
MOD_CK1_1	69	75	PF00069	0.287
MOD_CK2_1	185	191	PF00069	0.539
MOD_CK2_1	22	28	PF00069	0.317
MOD_GSK3_1	181	188	PF00069	0.531
MOD_GSK3_1	40	47	PF00069	0.303
MOD_GSK3_1	90	97	PF00069	0.319
MOD_NEK2_1	1	6	PF00069	0.454
MOD_NEK2_1	100	105	PF00069	0.356
MOD_NEK2_1	127	132	PF00069	0.496
MOD_NEK2_1	63	68	PF00069	0.313
MOD_PIKK_1	170	176	PF00454	0.403
MOD_PKA_2	144	150	PF00069	0.213
MOD_PKA_2	175	181	PF00069	0.447
MOD_PKA_2	51	57	PF00069	0.396
MOD_PKA_2	69	75	PF00069	0.367
MOD_Plk_4	94	100	PF00069	0.404
MOD_ProDKin_1	22	28	PF00069	0.368
MOD_ProDKin_1	44	50	PF00069	0.297
TRG_DiLeu_BaLyEn_6	3	8	PF01217	0.217
TRG_ENDOCYTIC_2	10	13	PF00928	0.462
TRG_ENDOCYTIC_2	131	134	PF00928	0.323
TRG_ENDOCYTIC_2	59	62	PF00928	0.328
TRG_NES_CRM1_1	162	174	PF08389	0.458

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2C4	Leptomonas seymouri	29%	100%
A0A0N0P547	Leptomonas seymouri	37%	100%
A0A0N0P6P9	Leptomonas seymouri	28%	83%
A0A0N1HWY5	Leptomonas seymouri	27%	98%
A0A0N1PDH0	Leptomonas seymouri	37%	95%
A0A0N1PFN2	Leptomonas seymouri	22%	100%
A0A1X0NQ58	Trypanosomatidae	28%	100%
A0A1X0NUH1	Trypanosomatidae	27%	84%
A0A1X0P2R3	Trypanosomatidae	27%	91%
A0A1X0P988	Trypanosomatidae	39%	100%
A0A381MTA7	Leishmania infantum	52%	99%
A0A381MTB8	Leishmania infantum	48%	99%
A0A381MTC7	Leishmania infantum	58%	93%
A0A381MTN2	Leishmania infantum	46%	98%
A0A381MVY0	Leishmania infantum	50%	99%
A0A3Q8ID16	Leishmania donovani	28%	100%
A0A3Q8IE85	Leishmania donovani	46%	100%
A0A3Q8IEC2	Leishmania donovani	53%	99%
A0A3Q8IEI1	Leishmania donovani	48%	99%
A0A3Q8IF65	Leishmania donovani	43%	97%
A0A3Q8IFB9	Leishmania donovani	31%	94%
A0A3Q8IFH7	Leishmania donovani	58%	93%
A0A3Q8IH65	Leishmania donovani	49%	99%
A0A3Q8IHN2	Leishmania donovani	47%	99%
A0A3Q8IHW7	Leishmania donovani	52%	100%
A0A3Q8IHZ6	Leishmania donovani	44%	91%
A0A3Q8IIH1	Leishmania donovani	49%	98%
A0A3Q8IL03	Leishmania donovani	45%	99%
A0A3Q8IMR4	Leishmania donovani	24%	100%
A0A3Q8IUK8	Leishmania donovani	56%	100%
A0A3Q8IUR5	Leishmania donovani	46%	98%
A0A3S5H662	Leishmania donovani	43%	95%
A0A3S5H663	Leishmania donovani	43%	95%
A0A3S5H665	Leishmania donovani	43%	95%
A0A3S5H666	Leishmania donovani	46%	99%
A0A3S5H667	Leishmania donovani	44%	94%
A0A3S5H7D2	Leishmania donovani	30%	100%
A0A3S5H7L2	Leishmania donovani	48%	93%
A0A3S5H7V9	Leishmania donovani	42%	96%
A0A3S5H7W2	Leishmania donovani	32%	99%
A0A3S5H7W6	Leishmania donovani	55%	96%
A0A3S7WQA0	Leishmania donovani	43%	94%
A0A3S7WQA8	Leishmania donovani	48%	100%
A0A3S7WQC1	Leishmania donovani	48%	99%
A0A3S7X2E6	Leishmania donovani	48%	99%
A0A3S7X357	Leishmania donovani	25%	86%
A0A3S7X453	Leishmania donovani	42%	97%
A0A3S7X472	Leishmania donovani	43%	96%
A0A3S7X7E5	Leishmania donovani	48%	76%
A0A3S7X7M4	Leishmania donovani	44%	91%
A0A3S7X7U1	Leishmania donovani	51%	91%
A0A3S7X7U4	Leishmania donovani	52%	74%
A0A3S7X7W2	Leishmania donovani	49%	91%
A0A3S7X7Y0	Leishmania donovani	48%	98%
A4H595	Leishmania braziliensis	40%	100%
A4H596	Leishmania braziliensis	42%	100%
A4H597	Leishmania braziliensis	42%	100%
A4H5D1	Leishmania braziliensis	47%	98%
A4H5D2	Leishmania braziliensis	34%	100%
A4H5G0	Leishmania braziliensis	50%	99%
A4H5G4	Leishmania braziliensis	42%	100%
A4H5G6	Leishmania braziliensis	41%	100%
A4H5G7	Leishmania braziliensis	44%	100%
A4H5G9	Leishmania braziliensis	48%	99%
A4H5H0	Leishmania braziliensis	49%	99%
A4H5H1	Leishmania braziliensis	47%	99%
A4H5H2	Leishmania braziliensis	46%	97%
A4H5H3	Leishmania braziliensis	40%	100%
A4H6C8	Leishmania braziliensis	40%	100%
A4H7D7	Leishmania braziliensis	46%	100%
A4H9E8	Leishmania braziliensis	51%	100%
A4H9E9	Leishmania braziliensis	43%	100%
A4HAJ4	Leishmania braziliensis	46%	100%
A4HAJ5	Leishmania braziliensis	40%	100%
A4HAJ6	Leishmania braziliensis	41%	100%
A4HAL1	Leishmania braziliensis	50%	100%
A4HAL2	Leishmania braziliensis	31%	100%
A4HAM2	Leishmania braziliensis	43%	100%
A4HAM4	Leishmania braziliensis	43%	100%
A4HAR1	Leishmania braziliensis	42%	100%
A4HAZ8	Leishmania braziliensis	44%	99%
A4HB00	Leishmania braziliensis	41%	100%
A4HB02	Leishmania braziliensis	43%	98%
A4HB47	Leishmania braziliensis	34%	100%
A4HBJ0	Leishmania braziliensis	46%	100%
A4HBJ1	Leishmania braziliensis	43%	100%
A4HBJ2	Leishmania braziliensis	47%	100%
A4HDI4	Leishmania braziliensis	29%	99%
A4HDL3	Leishmania braziliensis	31%	100%
A4HDL4	Leishmania braziliensis	29%	99%
A4HTM3	Leishmania infantum	47%	99%
A4HTM4	Leishmania infantum	47%	100%
A4HTM5	Leishmania infantum	47%	99%
A4I0W3	Leishmania infantum	24%	100%
A4I0W5	Leishmania infantum	28%	100%
A4I4J2	Leishmania infantum	44%	93%
A4I4J3	Leishmania infantum	48%	74%
A4I5B9	Leishmania infantum	25%	86%
A4I6E5	Leishmania infantum	43%	96%
A4I9Q4	Leishmania infantum	46%	100%
A4I9R4	Leishmania infantum	32%	99%
A4I9R5	Leishmania infantum	31%	94%
A4I9R7	Leishmania infantum	48%	97%
A4I9W8	Leishmania infantum	52%	74%
A4I9X0	Leishmania infantum	48%	91%
A4IA59	Leishmania infantum	46%	73%
A4IAL7	Leishmania infantum	52%	100%
A4IAM1	Leishmania infantum	48%	99%
A4IAM2	Leishmania infantum	47%	99%
E8NHC3	Leishmania infantum	45%	95%
E8NHD3	Leishmania infantum	44%	93%
E8NHD6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	100%	100%
E8NHD9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	55%	100%
E8NHE0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	52%	100%
E8NHF4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	45%	100%
E8NHF7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	48%	99%
E8NHG2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	44%	91%
E8NHH5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	44%	91%
E8NHH9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	59%	100%
E8NHI3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	40%	98%
E8NHI5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	55%	99%
E8NHK7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	44%	91%
E8NHK9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	52%	98%
E8NHL7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	53%	99%
E8NHL9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	53%	99%
E8NHM0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	100%	100%
E8NHM1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	44%	98%
E8NHM3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	45%	91%
E8NHM5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	45%	91%
E8NHM6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	50%	100%
E8NHM7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	48%	100%
E8NHP0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	50%	93%
E8NHQ0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	44%	91%
E8NHQ1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	43%	98%
E8NHR7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	54%	98%
E8NHR8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	56%	98%
E8NHS2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	44%	91%
E9AG81	Leishmania infantum	43%	94%
E9AG82	Leishmania infantum	43%	94%
E9AG83	Leishmania infantum	42%	96%
E9AG85	Leishmania infantum	45%	94%
E9AHI9	Leishmania infantum	49%	99%
E9AHT2	Leishmania infantum	45%	91%
E9AME9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	45%	100%
E9AMF0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	47%	100%
E9AMF1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	43%	92%
E9AMF2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	43%	98%
E9AMF3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	42%	98%
E9AMF4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	44%	74%
E9AMF5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	44%	92%
E9AMF7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	44%	100%
E9AMF8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	45%	99%
E9AMF9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	41%	99%
E9ASP7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	49%	91%
E9AWW8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	34%	100%
E9AWW9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	28%	100%
E9B0L6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	26%	86%
E9B1J3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	41%	98%
E9B1J4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	43%	92%
E9B1J5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	45%	91%
E9B4L9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	41%	96%
E9B4R7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	40%	96%
E9B4R8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	42%	97%
E9B4R9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	29%	94%
E9B4S0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	31%	100%
E9B4Y3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	51%	93%
Q4Q1U9	Leishmania major	53%	100%
Q4Q305	Leishmania major	51%	100%
Q4Q309	Leishmania major	58%	100%
Q4Q313	Leishmania major	51%	100%
Q4Q317	Leishmania major	47%	100%
Q4Q325	Leishmania major	56%	100%
Q4Q327	Leishmania major	53%	100%
Q4Q329	Leishmania major	52%	100%
Q4Q333	Leishmania major	52%	100%
Q4Q335	Leishmania major	51%	100%
Q4Q337	Leishmania major	56%	99%
Q4Q339	Leishmania major	51%	100%
Q4Q341	Leishmania major	56%	100%
Q4Q397	Leishmania major	47%	100%
Q4Q3A7	Leishmania major	29%	100%
Q4Q3A8	Leishmania major	31%	100%
Q4Q3A9	Leishmania major	47%	100%
Q4Q3F7	Leishmania major	48%	100%
Q4Q6L8	Leishmania major	42%	100%
Q4Q7L6	Leishmania major	29%	100%
Q4QAK4	Leishmania major	25%	99%
Q4QAK5	Leishmania major	29%	100%
Q4QAK7	Leishmania major	26%	99%
Q4QI84	Leishmania major	48%	100%
Q4QI85	Leishmania major	47%	100%
Q4QI86	Leishmania major	48%	100%
Q4QI87	Leishmania major	47%	100%
Q4QI88	Leishmania major	48%	99%
Q4QI92	Leishmania major	46%	100%
Q4QI93	Leishmania major	46%	100%
Q4QI95	Leishmania major	46%	100%
Q4QI97	Leishmania major	46%	100%
Q4QIA0	Leishmania major	46%	100%
Q4QIA1	Leishmania major	46%	100%