Uncharacterized protein LmxM_23_0880a_1

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein

Species:

Leishmania mexicana

UniProt:

E8NHF3_LEIMU

TriTrypDb:

LmxM.23.0880a

Length:

486

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 19
NetGPI	no	yes: 0, no: 19

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	12
GO:0110165	cellular anatomical entity	1	12

Expansion

Sequence features

E8NHF3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E8NHF3

Function

Biological processes
Term	Name	Level	Count
GO:0005975	carbohydrate metabolic process	3	20
GO:0008152	metabolic process	1	20
GO:0044238	primary metabolic process	2	20
GO:0071704	organic substance metabolic process	2	20

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	20
GO:0004553	hydrolase activity, hydrolyzing O-glycosyl compounds	4	20
GO:0016787	hydrolase activity	2	20
GO:0016798	hydrolase activity, acting on glycosyl bonds	3	20
GO:0004564	beta-fructofuranosidase activity	5	17

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	205	207	PF00675	0.286
CLV_NRD_NRD_1	288	290	PF00675	0.333
CLV_PCSK_KEX2_1	288	290	PF00082	0.333
CLV_PCSK_KEX2_1	399	401	PF00082	0.336
CLV_PCSK_PC1ET2_1	399	401	PF00082	0.336
CLV_PCSK_SKI1_1	145	149	PF00082	0.386
CLV_PCSK_SKI1_1	179	183	PF00082	0.387
CLV_PCSK_SKI1_1	334	338	PF00082	0.485
CLV_PCSK_SKI1_1	400	404	PF00082	0.373
DEG_Nend_Nbox_1	1	2	PF02207	0.204
DOC_CYCLIN_RxL_1	314	325	PF00134	0.308
DOC_MAPK_MEF2A_6	191	199	PF00069	0.325
DOC_MAPK_MEF2A_6	434	441	PF00069	0.275
DOC_PP2B_LxvP_1	313	316	PF13499	0.340
DOC_PP4_FxxP_1	126	129	PF00568	0.340
DOC_PP4_FxxP_1	276	279	PF00568	0.304
DOC_PP4_MxPP_1	330	333	PF00568	0.333
DOC_USP7_MATH_1	102	106	PF00917	0.428
DOC_WW_Pin1_4	198	203	PF00397	0.308
DOC_WW_Pin1_4	238	243	PF00397	0.270
DOC_WW_Pin1_4	297	302	PF00397	0.386
LIG_14-3-3_CanoR_1	256	262	PF00244	0.286
LIG_14-3-3_CanoR_1	434	438	PF00244	0.197
LIG_AP2alpha_2	322	324	PF02296	0.261
LIG_APCC_ABBA_1	428	433	PF00400	0.300
LIG_BRCT_BRCA1_1	263	267	PF00533	0.198
LIG_BRCT_BRCA1_1	449	453	PF00533	0.373
LIG_Clathr_ClatBox_1	189	193	PF01394	0.229
LIG_deltaCOP1_diTrp_1	19	26	PF00928	0.310
LIG_EH_1	14	18	PF12763	0.323
LIG_eIF4E_1	277	283	PF01652	0.229
LIG_FHA_1	146	152	PF00498	0.391
LIG_FHA_1	157	163	PF00498	0.301
LIG_FHA_1	229	235	PF00498	0.359
LIG_FHA_1	323	329	PF00498	0.418
LIG_FHA_1	353	359	PF00498	0.296
LIG_FHA_1	420	426	PF00498	0.267
LIG_FHA_2	156	162	PF00498	0.317
LIG_FHA_2	28	34	PF00498	0.325
LIG_FHA_2	362	368	PF00498	0.319
LIG_FHA_2	76	82	PF00498	0.273
LIG_KLC1_Yacidic_2	391	395	PF13176	0.479
LIG_LIR_Apic_2	275	279	PF02991	0.304
LIG_LIR_Apic_2	296	301	PF02991	0.286
LIG_LIR_Gen_1	167	175	PF02991	0.340
LIG_LIR_Nem_3	135	141	PF02991	0.367
LIG_LIR_Nem_3	167	173	PF02991	0.340
LIG_LIR_Nem_3	23	29	PF02991	0.233
LIG_LIR_Nem_3	264	270	PF02991	0.337
LIG_NRBOX	150	156	PF00104	0.386
LIG_Pex14_1	257	261	PF04695	0.286
LIG_Pex14_2	17	21	PF04695	0.270
LIG_PTB_Apo_2	401	408	PF02174	0.336
LIG_PTB_Apo_2	62	69	PF02174	0.298
LIG_PTB_Phospho_1	401	407	PF10480	0.336
LIG_PTB_Phospho_1	62	68	PF10480	0.298
LIG_RPA_C_Fungi	210	222	PF08784	0.286
LIG_SH2_SRC	393	396	PF00017	0.451
LIG_SH2_STAP1	366	370	PF00017	0.333
LIG_SH2_STAT3	200	203	PF00017	0.286
LIG_SH2_STAT3	277	280	PF00017	0.340
LIG_SH2_STAT3	96	99	PF00017	0.319
LIG_SH2_STAT5	123	126	PF00017	0.364
LIG_SH2_STAT5	220	223	PF00017	0.386
LIG_SH2_STAT5	393	396	PF00017	0.472
LIG_SH2_STAT5	68	71	PF00017	0.340
LIG_SH3_3	113	119	PF00018	0.340
LIG_SUMO_SIM_anti_2	353	362	PF11976	0.261
LIG_SUMO_SIM_par_1	353	362	PF11976	0.287
LIG_WRC_WIRS_1	258	263	PF05994	0.286
LIG_WW_1	120	123	PF00397	0.386
MOD_CDK_SPK_2	238	243	PF00069	0.261
MOD_CK1_1	228	234	PF00069	0.274
MOD_CK1_1	57	63	PF00069	0.293
MOD_CK2_1	232	238	PF00069	0.277
MOD_CK2_1	361	367	PF00069	0.333
MOD_CK2_1	374	380	PF00069	0.336
MOD_CK2_1	385	391	PF00069	0.336
MOD_CK2_1	432	438	PF00069	0.336
MOD_CK2_1	75	81	PF00069	0.273
MOD_Cter_Amidation	286	289	PF01082	0.298
MOD_GlcNHglycan	217	220	PF01048	0.286
MOD_GlcNHglycan	246	249	PF01048	0.264
MOD_GlcNHglycan	309	312	PF01048	0.409
MOD_GlcNHglycan	346	349	PF01048	0.308
MOD_GlcNHglycan	387	390	PF01048	0.373
MOD_GlcNHglycan	412	415	PF01048	0.336
MOD_GlcNHglycan	56	59	PF01048	0.329
MOD_GSK3_1	221	228	PF00069	0.321
MOD_GSK3_1	238	245	PF00069	0.282
MOD_GSK3_1	257	264	PF00069	0.202
MOD_GSK3_1	297	304	PF00069	0.336
MOD_GSK3_1	307	314	PF00069	0.348
MOD_GSK3_1	410	417	PF00069	0.336
MOD_GSK3_1	462	469	PF00069	0.317
MOD_N-GLC_1	225	230	PF02516	0.270
MOD_N-GLC_1	466	471	PF02516	0.423
MOD_NEK2_1	221	226	PF00069	0.261
MOD_NEK2_1	261	266	PF00069	0.308
MOD_NEK2_1	324	329	PF00069	0.361
MOD_NEK2_1	374	379	PF00069	0.359
MOD_NEK2_1	480	485	PF00069	0.550
MOD_NEK2_1	56	61	PF00069	0.340
MOD_PIKK_1	232	238	PF00454	0.198
MOD_PIKK_1	261	267	PF00454	0.286
MOD_PK_1	462	468	PF00069	0.308
MOD_PKA_2	433	439	PF00069	0.300
MOD_PKB_1	213	221	PF00069	0.308
MOD_Plk_1	225	231	PF00069	0.286
MOD_Plk_1	361	367	PF00069	0.363
MOD_Plk_1	432	438	PF00069	0.336
MOD_Plk_1	444	450	PF00069	0.336
MOD_Plk_2-3	433	439	PF00069	0.336
MOD_Plk_4	225	231	PF00069	0.286
MOD_Plk_4	278	284	PF00069	0.423
MOD_Plk_4	473	479	PF00069	0.410
MOD_Plk_4	91	97	PF00069	0.298
MOD_ProDKin_1	198	204	PF00069	0.308
MOD_ProDKin_1	238	244	PF00069	0.270
MOD_ProDKin_1	297	303	PF00069	0.386
TRG_DiLeu_BaLyEn_6	286	291	PF01217	0.272
TRG_ENDOCYTIC_2	123	126	PF00928	0.367
TRG_ENDOCYTIC_2	14	17	PF00928	0.340
TRG_ENDOCYTIC_2	8	11	PF00928	0.340
TRG_ER_diArg_1	212	215	PF00400	0.339
TRG_ER_diArg_1	288	290	PF00400	0.333
TRG_NES_CRM1_1	419	433	PF08389	0.438
TRG_Pf-PMV_PEXEL_1	149	153	PF00026	0.211
TRG_Pf-PMV_PEXEL_1	317	322	PF00026	0.308

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8F7	Leptomonas seymouri	50%	99%
A0A0N1PBT6	Leptomonas seymouri	26%	75%
A0A1X0NFY9	Trypanosomatidae	24%	100%
A0A1X0NTL0	Trypanosomatidae	24%	77%
A0A1X0NTM3	Trypanosomatidae	25%	77%
A0A1X0NY19	Trypanosomatidae	24%	77%
A0A1X0P322	Trypanosomatidae	23%	77%
A0A1X0P5Y7	Trypanosomatidae	24%	76%
A0A3Q8IB13	Leishmania donovani	94%	88%
A0A3Q8IFU7	Leishmania donovani	76%	92%
A0A3S5H595	Leishmania donovani	25%	76%
A0A3S5H7I4	Leishmania donovani	50%	99%
A0A3S7WXQ4	Leishmania donovani	67%	95%
A0A3S7WXS2	Leishmania donovani	75%	92%
A1STJ9	Psychromonas ingrahamii (strain 37)	34%	89%
A2R0E0	Aspergillus niger (strain CBS 513.88 / FGSC A1513)	26%	91%
A2X5P7	Oryza sativa subsp. indica	26%	84%
A2YZ01	Oryza sativa subsp. indica	23%	82%
A4H3V1	Leishmania braziliensis	26%	76%
A4HCV9	Leishmania braziliensis	83%	100%
A4HCW0	Leishmania braziliensis	65%	94%
A4HG14	Leishmania braziliensis	49%	100%
A4HS26	Leishmania infantum	25%	76%
A4I0D9	Leishmania infantum	94%	88%
A4I0E0	Leishmania infantum	67%	95%
A4I336	Leishmania infantum	50%	99%
A4IAW1	Leishmania infantum	26%	69%
A5ABL2	Aspergillus niger (strain CBS 513.88 / FGSC A1513)	25%	94%
A5DHM6	Meyerozyma guilliermondii (strain ATCC 6260 / CBS 566 / DSM 6381 / JCM 1539 / NBRC 10279 / NRRL Y-324)	25%	95%
A5EZZ8	Vibrio cholerae serotype O1 (strain ATCC 39541 / Classical Ogawa 395 / O395)	32%	89%
A8W7I5	Meyerozyma guilliermondii	25%	95%
B6DXP5	Leymus chinensis	25%	81%
B6DZC8	Triticum aestivum	24%	82%
B6DZD0	Triticum urartu	25%	81%
B6DZD1	Aegilops speltoides	25%	82%
B6DZD2	Aegilops tauschii	25%	82%
D2IGW7	Bromus pictus	25%	81%
E1ABX2	Aspergillus ficuum	27%	91%
E8NHF2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	100%	100%
E9ACV4	Leishmania major	50%	100%
E9AK13	Leishmania mexicana (strain MHOM/GT/2001/U1103)	26%	76%
E9AWA3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	60%	100%
E9AZE3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	49%	100%
F8DVG5	Zymomonas mobilis subsp. mobilis (strain ATCC 10988 / DSM 424 / LMG 404 / NCIMB 8938 / NRRL B-806 / ZM1)	38%	95%
H2DF87	Rosa hybrid cultivar	26%	83%
H2DF88	Rosa hybrid cultivar	24%	76%
K0E681	Aspergillus rugulosus	26%	96%
O07003	Bacillus subtilis (strain 168)	25%	94%
O24509	Phaseolus vulgaris	26%	75%
O33833	Thermotoga maritima (strain ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826 / MSB8)	31%	100%
O42878	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	29%	96%
O59852	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	22%	84%
O74641	Aspergillus niger	26%	94%
O74642	Aspergillus niger	25%	94%
O94220	Aspergillus ficuum	26%	94%
P00724	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	27%	91%
P05656	Bacillus subtilis (strain 168)	29%	72%
P07819	Bacillus subtilis (strain 168)	36%	100%
P0DJA7	Zymomonas mobilis subsp. mobilis (strain ATCC 31821 / ZM4 / CP4)	38%	95%
P10594	Saccharomyces cerevisiae	28%	91%
P10596	Saccharomyces cerevisiae	25%	91%
P13394	Vibrio alginolyticus	29%	100%
P13522	Streptococcus mutans serotype c (strain ATCC 700610 / UA159)	26%	100%
P16553	Escherichia coli	44%	100%
P24133	Schwanniomyces occidentalis	21%	91%
P26792	Daucus carota	24%	82%
P27217	Klebsiella pneumoniae	34%	100%
P28999	Kluyveromyces marxianus	26%	88%
P29000	Solanum lycopersicum	24%	76%
P29001	Vigna radiata var. radiata	25%	75%
P37075	Salmonella typhimurium	34%	100%
P40714	Escherichia coli	46%	100%
P40912	Wickerhamomyces anomalus	23%	88%
P43471	Pediococcus pentosaceus	24%	97%
P49174	Zea mays	25%	82%
P49175	Zea mays	26%	73%
P80065	Daucus carota	25%	74%
P92916	Allium cepa	23%	79%
P93761	Capsicum annuum	25%	76%
P94469	Geobacillus stearothermophilus	25%	100%
Q01IS7	Oryza sativa subsp. indica	24%	81%
Q01IS8	Oryza sativa subsp. indica	25%	83%
Q04937	Lactococcus lactis subsp. lactis	24%	100%
Q05936	Staphylococcus xylosus	30%	98%
Q0E0P0	Oryza sativa subsp. japonica	26%	84%
Q0J360	Oryza sativa subsp. japonica	23%	82%
Q0JDC5	Oryza sativa subsp. japonica	24%	81%
Q0JDC6	Oryza sativa subsp. japonica	25%	83%
Q1PEF8	Arabidopsis thaliana	26%	82%
Q2UXF7	Triticum aestivum	25%	81%
Q39041	Arabidopsis thaliana	26%	73%
Q39692	Daucus carota	27%	82%
Q39693	Daucus carota	27%	83%
Q43089	Pisum sativum	23%	88%
Q43348	Arabidopsis thaliana	27%	75%
Q43857	Vicia faba	24%	76%
Q43866	Arabidopsis thaliana	26%	83%
Q4QB75	Leishmania major	66%	100%
Q4QB76	Leishmania major	93%	100%
Q56660	Vibrio cholerae	33%	89%
Q56UD0	Oryza sativa subsp. japonica	25%	82%
Q56UD1	Oryza sativa subsp. japonica	24%	90%
Q5FC15	Asparagus officinalis	26%	80%
Q5JJV0	Oryza sativa subsp. japonica	24%	82%
Q67XZ3	Arabidopsis thaliana	26%	82%
Q6BJW6	Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968)	27%	91%
Q70AT7	Hordeum vulgare	25%	81%
Q70XE6	Beta vulgaris	26%	80%
Q76HP6	Aspergillus niger	27%	91%
Q84LA1	Triticum aestivum	25%	82%
Q84PN8	Triticum aestivum	25%	81%
Q8W413	Arabidopsis thaliana	25%	82%
Q8W4S6	Arabidopsis thaliana	24%	88%
Q96TU3	Aspergillus awamori	25%	91%
Q9FSV7	Festuca arundinacea	24%	74%
Q9KLT6	Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)	32%	89%
Q9LIB9	Arabidopsis thaliana	23%	85%
Q9XTP3	Leishmania major	25%	76%
Q9Y746	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)	22%	80%