Uncharacterized protein LmxM_23_0870_1

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein

Species:

Leishmania mexicana

UniProt:

E8NHF2_LEIMU

TriTrypDb:

LmxM.23.0870

Length:

525

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 19
NetGPI	no	yes: 0, no: 19

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	12
GO:0110165	cellular anatomical entity	1	12

Expansion

Sequence features

E8NHF2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E8NHF2

Function

Biological processes
Term	Name	Level	Count
GO:0005975	carbohydrate metabolic process	3	20
GO:0008152	metabolic process	1	20
GO:0044238	primary metabolic process	2	20
GO:0071704	organic substance metabolic process	2	20

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	20
GO:0004553	hydrolase activity, hydrolyzing O-glycosyl compounds	4	20
GO:0016787	hydrolase activity	2	20
GO:0016798	hydrolase activity, acting on glycosyl bonds	3	20
GO:0004564	beta-fructofuranosidase activity	5	17

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	271	273	PF00675	0.265
CLV_NRD_NRD_1	354	356	PF00675	0.315
CLV_PCSK_KEX2_1	354	356	PF00082	0.315
CLV_PCSK_KEX2_1	465	467	PF00082	0.332
CLV_PCSK_PC1ET2_1	465	467	PF00082	0.319
CLV_PCSK_SKI1_1	211	215	PF00082	0.348
CLV_PCSK_SKI1_1	245	249	PF00082	0.348
CLV_PCSK_SKI1_1	400	404	PF00082	0.473
CLV_PCSK_SKI1_1	466	470	PF00082	0.369
DEG_Nend_UBRbox_3	1	3	PF02207	0.506
DOC_CYCLIN_RxL_1	380	391	PF00134	0.291
DOC_MAPK_MEF2A_6	257	265	PF00069	0.298
DOC_MAPK_MEF2A_6	500	507	PF00069	0.261
DOC_PP2B_LxvP_1	379	382	PF13499	0.322
DOC_PP4_FxxP_1	192	195	PF00568	0.322
DOC_PP4_FxxP_1	342	345	PF00568	0.280
DOC_PP4_MxPP_1	396	399	PF00568	0.313
DOC_USP7_MATH_1	12	16	PF00917	0.543
DOC_USP7_MATH_1	168	172	PF00917	0.382
DOC_USP7_MATH_1	33	37	PF00917	0.267
DOC_WW_Pin1_4	22	27	PF00397	0.372
DOC_WW_Pin1_4	264	269	PF00397	0.291
DOC_WW_Pin1_4	304	309	PF00397	0.252
DOC_WW_Pin1_4	363	368	PF00397	0.348
LIG_14-3-3_CanoR_1	322	328	PF00244	0.265
LIG_14-3-3_CanoR_1	500	504	PF00244	0.193
LIG_AP2alpha_2	388	390	PF02296	0.244
LIG_APCC_ABBA_1	494	499	PF00400	0.284
LIG_BRCT_BRCA1_1	329	333	PF00533	0.198
LIG_BRCT_BRCA1_1	515	519	PF00533	0.337
LIG_Clathr_ClatBox_1	255	259	PF01394	0.219
LIG_deltaCOP1_diTrp_1	85	92	PF00928	0.294
LIG_EH_1	80	84	PF12763	0.296
LIG_eIF4E_1	343	349	PF01652	0.219
LIG_FHA_1	212	218	PF00498	0.374
LIG_FHA_1	223	229	PF00498	0.285
LIG_FHA_1	295	301	PF00498	0.341
LIG_FHA_1	38	44	PF00498	0.269
LIG_FHA_1	389	395	PF00498	0.403
LIG_FHA_1	419	425	PF00498	0.305
LIG_FHA_1	486	492	PF00498	0.250
LIG_FHA_2	142	148	PF00498	0.263
LIG_FHA_2	222	228	PF00498	0.291
LIG_FHA_2	428	434	PF00498	0.302
LIG_FHA_2	94	100	PF00498	0.308
LIG_KLC1_Yacidic_2	457	461	PF13176	0.425
LIG_LIR_Apic_2	341	345	PF02991	0.283
LIG_LIR_Apic_2	362	367	PF02991	0.265
LIG_LIR_Gen_1	233	241	PF02991	0.322
LIG_LIR_Gen_1	40	49	PF02991	0.251
LIG_LIR_Nem_3	201	207	PF02991	0.349
LIG_LIR_Nem_3	233	239	PF02991	0.328
LIG_LIR_Nem_3	330	336	PF02991	0.332
LIG_LIR_Nem_3	40	44	PF02991	0.356
LIG_LIR_Nem_3	89	95	PF02991	0.219
LIG_NRBOX	216	222	PF00104	0.348
LIG_Pex14_1	323	327	PF04695	0.265
LIG_Pex14_1	48	52	PF04695	0.364
LIG_Pex14_2	83	87	PF04695	0.256
LIG_PTB_Apo_2	128	135	PF02174	0.276
LIG_PTB_Apo_2	467	474	PF02174	0.319
LIG_PTB_Phospho_1	128	134	PF10480	0.276
LIG_PTB_Phospho_1	467	473	PF10480	0.319
LIG_RPA_C_Fungi	276	288	PF08784	0.265
LIG_SH2_SRC	459	462	PF00017	0.439
LIG_SH2_STAP1	432	436	PF00017	0.315
LIG_SH2_STAT3	162	165	PF00017	0.302
LIG_SH2_STAT3	266	269	PF00017	0.265
LIG_SH2_STAT3	343	346	PF00017	0.322
LIG_SH2_STAT5	134	137	PF00017	0.329
LIG_SH2_STAT5	189	192	PF00017	0.349
LIG_SH2_STAT5	286	289	PF00017	0.348
LIG_SH2_STAT5	459	462	PF00017	0.469
LIG_SH3_3	179	185	PF00018	0.322
LIG_SUMO_SIM_anti_2	419	428	PF11976	0.244
LIG_SUMO_SIM_par_1	419	428	PF11976	0.269
LIG_TRAF2_1	25	28	PF00917	0.391
LIG_WRC_WIRS_1	324	329	PF05994	0.291
LIG_WRC_WIRS_1	54	59	PF05994	0.219
LIG_WW_1	186	189	PF00397	0.348
MOD_CDK_SPK_2	304	309	PF00069	0.244
MOD_CDK_SPxxK_3	22	29	PF00069	0.346
MOD_CK1_1	123	129	PF00069	0.277
MOD_CK1_1	294	300	PF00069	0.256
MOD_CK2_1	141	147	PF00069	0.260
MOD_CK2_1	22	28	PF00069	0.488
MOD_CK2_1	298	304	PF00069	0.258
MOD_CK2_1	427	433	PF00069	0.317
MOD_CK2_1	440	446	PF00069	0.319
MOD_CK2_1	451	457	PF00069	0.319
MOD_CK2_1	498	504	PF00069	0.319
MOD_Cter_Amidation	352	355	PF01082	0.282
MOD_GlcNHglycan	122	125	PF01048	0.312
MOD_GlcNHglycan	14	17	PF01048	0.512
MOD_GlcNHglycan	283	286	PF01048	0.265
MOD_GlcNHglycan	312	315	PF01048	0.301
MOD_GlcNHglycan	35	38	PF01048	0.276
MOD_GlcNHglycan	375	378	PF01048	0.367
MOD_GlcNHglycan	412	415	PF01048	0.333
MOD_GlcNHglycan	453	456	PF01048	0.337
MOD_GlcNHglycan	478	481	PF01048	0.319
MOD_GSK3_1	2	9	PF00069	0.504
MOD_GSK3_1	287	294	PF00069	0.304
MOD_GSK3_1	304	311	PF00069	0.268
MOD_GSK3_1	323	330	PF00069	0.197
MOD_GSK3_1	33	40	PF00069	0.315
MOD_GSK3_1	363	370	PF00069	0.318
MOD_GSK3_1	373	380	PF00069	0.331
MOD_GSK3_1	476	483	PF00069	0.320
MOD_N-GLC_1	291	296	PF02516	0.257
MOD_N-GLC_1	33	38	PF02516	0.351
MOD_NEK2_1	122	127	PF00069	0.337
MOD_NEK2_1	287	292	PF00069	0.244
MOD_NEK2_1	327	332	PF00069	0.295
MOD_NEK2_1	390	395	PF00069	0.350
MOD_NEK2_1	440	445	PF00069	0.377
MOD_PIKK_1	298	304	PF00454	0.193
MOD_PIKK_1	327	333	PF00454	0.265
MOD_PK_1	39	45	PF00069	0.302
MOD_PKA_2	499	505	PF00069	0.284
MOD_PKB_1	279	287	PF00069	0.291
MOD_Plk_1	291	297	PF00069	0.277
MOD_Plk_1	427	433	PF00069	0.348
MOD_Plk_1	498	504	PF00069	0.319
MOD_Plk_1	510	516	PF00069	0.323
MOD_Plk_2-3	499	505	PF00069	0.319
MOD_Plk_4	157	163	PF00069	0.276
MOD_Plk_4	291	297	PF00069	0.266
MOD_Plk_4	344	350	PF00069	0.384
MOD_ProDKin_1	22	28	PF00069	0.367
MOD_ProDKin_1	264	270	PF00069	0.291
MOD_ProDKin_1	304	310	PF00069	0.252
MOD_ProDKin_1	363	369	PF00069	0.348
MOD_SUMO_for_1	20	23	PF00179	0.468
TRG_DiLeu_BaLyEn_6	352	357	PF01217	0.254
TRG_ENDOCYTIC_2	189	192	PF00928	0.356
TRG_ENDOCYTIC_2	74	77	PF00928	0.322
TRG_ENDOCYTIC_2	80	83	PF00928	0.322
TRG_ER_diArg_1	278	281	PF00400	0.322
TRG_ER_diArg_1	354	356	PF00400	0.315
TRG_NES_CRM1_1	485	499	PF08389	0.391
TRG_Pf-PMV_PEXEL_1	215	219	PF00026	0.203
TRG_Pf-PMV_PEXEL_1	383	388	PF00026	0.291

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8F7	Leptomonas seymouri	50%	100%
A0A0N1PBT6	Leptomonas seymouri	26%	82%
A0A1X0NFY9	Trypanosomatidae	24%	100%
A0A1X0NTL0	Trypanosomatidae	24%	83%
A0A1X0NTM3	Trypanosomatidae	25%	83%
A0A1X0NY19	Trypanosomatidae	24%	83%
A0A1X0P322	Trypanosomatidae	23%	83%
A0A1X0P5Y7	Trypanosomatidae	24%	82%
A0A3Q8IB13	Leishmania donovani	93%	95%
A0A3Q8IFU7	Leishmania donovani	76%	100%
A0A3S5H595	Leishmania donovani	25%	82%
A0A3S5H7I4	Leishmania donovani	50%	100%
A0A3S7WXQ4	Leishmania donovani	65%	100%
A0A3S7WXS2	Leishmania donovani	76%	100%
A1STJ9	Psychromonas ingrahamii (strain 37)	33%	96%
A2R0E0	Aspergillus niger (strain CBS 513.88 / FGSC A1513)	27%	98%
A2X5P7	Oryza sativa subsp. indica	25%	91%
A2YZ01	Oryza sativa subsp. indica	24%	88%
A4H3V1	Leishmania braziliensis	26%	82%
A4HCV9	Leishmania braziliensis	81%	100%
A4HCW0	Leishmania braziliensis	64%	98%
A4HG14	Leishmania braziliensis	48%	98%
A4HS26	Leishmania infantum	25%	82%
A4I0D9	Leishmania infantum	93%	95%
A4I0E0	Leishmania infantum	65%	100%
A4I336	Leishmania infantum	49%	100%
A4IAW1	Leishmania infantum	26%	75%
A5ABL2	Aspergillus niger (strain CBS 513.88 / FGSC A1513)	26%	100%
A5DHM6	Meyerozyma guilliermondii (strain ATCC 6260 / CBS 566 / DSM 6381 / JCM 1539 / NBRC 10279 / NRRL Y-324)	25%	100%
A5EZZ8	Vibrio cholerae serotype O1 (strain ATCC 39541 / Classical Ogawa 395 / O395)	32%	96%
A8W7I5	Meyerozyma guilliermondii	25%	100%
B6DXP5	Leymus chinensis	25%	88%
B6DZC8	Triticum aestivum	24%	88%
B6DZD0	Triticum urartu	25%	88%
B6DZD1	Aegilops speltoides	25%	88%
B6DZD2	Aegilops tauschii	25%	88%
D2IGW7	Bromus pictus	25%	87%
E1ABX2	Aspergillus ficuum	27%	98%
E8NHF3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	100%	100%
E9ACV4	Leishmania major	50%	98%
E9AK13	Leishmania mexicana (strain MHOM/GT/2001/U1103)	26%	83%
E9AWA3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	60%	100%
E9AZE3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	49%	98%
F8DVG5	Zymomonas mobilis subsp. mobilis (strain ATCC 10988 / DSM 424 / LMG 404 / NCIMB 8938 / NRRL B-806 / ZM1)	38%	100%
H2DF87	Rosa hybrid cultivar	26%	89%
H2DF88	Rosa hybrid cultivar	24%	82%
K0E681	Aspergillus rugulosus	26%	100%
O07003	Bacillus subtilis (strain 168)	25%	100%
O24509	Phaseolus vulgaris	26%	81%
O33833	Thermotoga maritima (strain ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826 / MSB8)	31%	100%
O42878	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	29%	100%
O59852	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	22%	90%
O74641	Aspergillus niger	26%	100%
O74642	Aspergillus niger	26%	100%
O94220	Aspergillus ficuum	26%	100%
P00724	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	28%	99%
P05656	Bacillus subtilis (strain 168)	29%	78%
P07819	Bacillus subtilis (strain 168)	36%	100%
P0DJA7	Zymomonas mobilis subsp. mobilis (strain ATCC 31821 / ZM4 / CP4)	39%	100%
P10594	Saccharomyces cerevisiae	28%	99%
P10596	Saccharomyces cerevisiae	26%	99%
P13394	Vibrio alginolyticus	30%	100%
P13522	Streptococcus mutans serotype c (strain ATCC 700610 / UA159)	27%	100%
P16553	Escherichia coli	44%	100%
P24133	Schwanniomyces occidentalis	22%	98%
P26792	Daucus carota	25%	89%
P27217	Klebsiella pneumoniae	34%	100%
P28999	Kluyveromyces marxianus	27%	95%
P29000	Solanum lycopersicum	27%	83%
P29001	Vigna radiata var. radiata	26%	81%
P37075	Salmonella typhimurium	33%	100%
P40714	Escherichia coli	46%	100%
P40912	Wickerhamomyces anomalus	23%	95%
P43471	Pediococcus pentosaceus	25%	100%
P49174	Zea mays	24%	89%
P49175	Zea mays	26%	78%
P80065	Daucus carota	25%	79%
P92916	Allium cepa	23%	86%
P93761	Capsicum annuum	25%	82%
P94469	Geobacillus stearothermophilus	25%	100%
Q01IS7	Oryza sativa subsp. indica	24%	88%
Q01IS8	Oryza sativa subsp. indica	24%	90%
Q04937	Lactococcus lactis subsp. lactis	25%	100%
Q05936	Staphylococcus xylosus	29%	100%
Q0E0P0	Oryza sativa subsp. japonica	25%	91%
Q0J360	Oryza sativa subsp. japonica	24%	88%
Q0JDC5	Oryza sativa subsp. japonica	24%	88%
Q0JDC6	Oryza sativa subsp. japonica	24%	90%
Q1PEF8	Arabidopsis thaliana	25%	89%
Q2UXF7	Triticum aestivum	28%	88%
Q39041	Arabidopsis thaliana	26%	79%
Q39692	Daucus carota	28%	89%
Q39693	Daucus carota	27%	90%
Q43089	Pisum sativum	23%	95%
Q43348	Arabidopsis thaliana	26%	81%
Q43857	Vicia faba	25%	82%
Q43866	Arabidopsis thaliana	26%	90%
Q4QB75	Leishmania major	63%	100%
Q4QB76	Leishmania major	91%	100%
Q56660	Vibrio cholerae	32%	96%
Q56UD0	Oryza sativa subsp. japonica	26%	88%
Q56UD1	Oryza sativa subsp. japonica	23%	97%
Q5FC15	Asparagus officinalis	25%	86%
Q5JJV0	Oryza sativa subsp. japonica	24%	89%
Q67XZ3	Arabidopsis thaliana	27%	88%
Q70AT7	Hordeum vulgare	25%	88%
Q70XE6	Beta vulgaris	26%	87%
Q76HP6	Aspergillus niger	27%	98%
Q84LA1	Triticum aestivum	25%	88%
Q84PN8	Triticum aestivum	25%	88%
Q8W413	Arabidopsis thaliana	25%	89%
Q8W4S6	Arabidopsis thaliana	24%	95%
Q96TU3	Aspergillus awamori	26%	98%
Q9FSV7	Festuca arundinacea	24%	80%
Q9KLT6	Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)	30%	96%
Q9LIB9	Arabidopsis thaliana	24%	92%
Q9XTP3	Leishmania major	25%	82%
Q9Y746	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)	22%	86%