Uncharacterized protein LmxM_30_0460b_1

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein

Species:

Leishmania mexicana

UniProt:

E8NHF1_LEIMU

TriTrypDb:

LmxM.30.0460b

Length:

508

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 1
Forrest at al. (metacyclic)	no	yes: 1
Forrest at al. (procyclic)	no	yes: 1
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 14

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 4

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 4

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 48
NetGPI	no	yes: 0, no: 49

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	3
GO:0110165	cellular anatomical entity	1	4
GO:0005815	microtubule organizing center	2	1
GO:0005856	cytoskeleton	5	1
GO:0020016	ciliary pocket	2	1
GO:0020038	subpellicular network	2	1
GO:0030863	cortical cytoskeleton	6	1
GO:0036064	ciliary basal body	3	1
GO:0043226	organelle	2	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0005930	axoneme	2	1

Expansion

Sequence features

E8NHF1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E8NHF1

Function

Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	50
GO:0006807	nitrogen compound metabolic process	2	50
GO:0008152	metabolic process	1	50
GO:0019538	protein metabolic process	3	50
GO:0043170	macromolecule metabolic process	3	50
GO:0044238	primary metabolic process	2	50
GO:0071704	organic substance metabolic process	2	50
GO:1901564	organonitrogen compound metabolic process	3	50

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	50
GO:0004175	endopeptidase activity	4	50
GO:0004197	cysteine-type endopeptidase activity	5	50
GO:0004198	calcium-dependent cysteine-type endopeptidase activity	6	50
GO:0008233	peptidase activity	3	50
GO:0008234	cysteine-type peptidase activity	4	50
GO:0016787	hydrolase activity	2	50
GO:0140096	catalytic activity, acting on a protein	2	50

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	288	292	PF00656	0.536
CLV_NRD_NRD_1	180	182	PF00675	0.386
CLV_NRD_NRD_1	272	274	PF00675	0.281
CLV_NRD_NRD_1	330	332	PF00675	0.427
CLV_NRD_NRD_1	345	347	PF00675	0.426
CLV_NRD_NRD_1	69	71	PF00675	0.239
CLV_NRD_NRD_1	7	9	PF00675	0.333
CLV_PCSK_KEX2_1	272	274	PF00082	0.260
CLV_PCSK_KEX2_1	345	347	PF00082	0.467
CLV_PCSK_KEX2_1	481	483	PF00082	0.505
CLV_PCSK_KEX2_1	69	71	PF00082	0.295
CLV_PCSK_KEX2_1	7	9	PF00082	0.280
CLV_PCSK_PC1ET2_1	481	483	PF00082	0.526
CLV_PCSK_SKI1_1	175	179	PF00082	0.268
CLV_PCSK_SKI1_1	240	244	PF00082	0.299
CLV_PCSK_SKI1_1	335	339	PF00082	0.419
CLV_PCSK_SKI1_1	358	362	PF00082	0.411
CLV_PCSK_SKI1_1	418	422	PF00082	0.465
CLV_PCSK_SKI1_1	428	432	PF00082	0.432
CLV_PCSK_SKI1_1	58	62	PF00082	0.256
DEG_APCC_DBOX_1	237	245	PF00400	0.531
DEG_MDM2_SWIB_1	285	293	PF02201	0.440
DEG_ODPH_VHL_1	435	447	PF01847	0.282
DEG_SPOP_SBC_1	51	55	PF00917	0.474
DOC_AGCK_PIF_1	151	156	PF00069	0.480
DOC_CKS1_1	189	194	PF01111	0.466
DOC_CYCLIN_RxL_1	331	341	PF00134	0.259
DOC_CYCLIN_RxL_1	355	365	PF00134	0.427
DOC_MAPK_DCC_7	232	241	PF00069	0.561
DOC_MAPK_gen_1	179	189	PF00069	0.446
DOC_MAPK_gen_1	331	338	PF00069	0.400
DOC_MAPK_gen_1	443	452	PF00069	0.454
DOC_MAPK_gen_1	487	494	PF00069	0.288
DOC_MAPK_HePTP_8	229	241	PF00069	0.470
DOC_MAPK_MEF2A_6	232	241	PF00069	0.477
DOC_MAPK_MEF2A_6	398	406	PF00069	0.406
DOC_MAPK_RevD_3	318	332	PF00069	0.456
DOC_PP1_RVXF_1	333	339	PF00149	0.410
DOC_PP1_RVXF_1	444	450	PF00149	0.377
DOC_PP4_FxxP_1	234	237	PF00568	0.470
DOC_PP4_FxxP_1	61	64	PF00568	0.431
DOC_USP7_MATH_1	168	172	PF00917	0.464
DOC_USP7_MATH_1	247	251	PF00917	0.500
DOC_USP7_MATH_1	437	441	PF00917	0.469
DOC_USP7_UBL2_3	124	128	PF12436	0.449
DOC_WW_Pin1_4	188	193	PF00397	0.467
LIG_14-3-3_CanoR_1	25	33	PF00244	0.477
LIG_14-3-3_CanoR_1	272	280	PF00244	0.572
LIG_14-3-3_CanoR_1	418	427	PF00244	0.415
LIG_14-3-3_CanoR_1	446	450	PF00244	0.386
LIG_14-3-3_CanoR_1	460	466	PF00244	0.416
LIG_BRCT_BRCA1_1	170	174	PF00533	0.497
LIG_deltaCOP1_diTrp_1	253	258	PF00928	0.442
LIG_deltaCOP1_diTrp_1	288	296	PF00928	0.463
LIG_FHA_1	215	221	PF00498	0.517
LIG_FHA_1	371	377	PF00498	0.397
LIG_FHA_1	52	58	PF00498	0.434
LIG_FHA_2	491	497	PF00498	0.483
LIG_IRF3_LxIS_1	356	363	PF10401	0.424
LIG_LIR_Apic_2	501	507	PF02991	0.618
LIG_LIR_Apic_2	59	64	PF02991	0.444
LIG_LIR_Gen_1	116	126	PF02991	0.424
LIG_LIR_Gen_1	132	141	PF02991	0.505
LIG_LIR_Gen_1	225	234	PF02991	0.513
LIG_LIR_Gen_1	390	400	PF02991	0.438
LIG_LIR_Gen_1	448	457	PF02991	0.359
LIG_LIR_Nem_3	100	104	PF02991	0.475
LIG_LIR_Nem_3	116	121	PF02991	0.440
LIG_LIR_Nem_3	123	129	PF02991	0.451
LIG_LIR_Nem_3	132	136	PF02991	0.468
LIG_LIR_Nem_3	149	154	PF02991	0.468
LIG_LIR_Nem_3	171	177	PF02991	0.417
LIG_LIR_Nem_3	225	229	PF02991	0.516
LIG_LIR_Nem_3	354	360	PF02991	0.390
LIG_LIR_Nem_3	390	395	PF02991	0.490
LIG_LIR_Nem_3	448	452	PF02991	0.360
LIG_LIR_Nem_3	458	462	PF02991	0.441
LIG_MLH1_MIPbox_1	170	174	PF16413	0.492
LIG_Pex14_2	156	160	PF04695	0.477
LIG_Pex14_2	285	289	PF04695	0.453
LIG_Pex14_2	313	317	PF04695	0.386
LIG_REV1ctd_RIR_1	171	179	PF16727	0.461
LIG_SH2_CRK	101	105	PF00017	0.567
LIG_SH2_CRK	126	130	PF00017	0.448
LIG_SH2_CRK	133	137	PF00017	0.454
LIG_SH2_CRK	226	230	PF00017	0.455
LIG_SH2_CRK	311	315	PF00017	0.376
LIG_SH2_CRK	357	361	PF00017	0.380
LIG_SH2_PTP2	414	417	PF00017	0.343
LIG_SH2_SRC	12	15	PF00017	0.484
LIG_SH2_SRC	185	188	PF00017	0.478
LIG_SH2_SRC	392	395	PF00017	0.470
LIG_SH2_SRC	414	417	PF00017	0.361
LIG_SH2_SRC	504	507	PF00017	0.419
LIG_SH2_STAP1	115	119	PF00017	0.492
LIG_SH2_STAP1	133	137	PF00017	0.449
LIG_SH2_STAP1	226	230	PF00017	0.519
LIG_SH2_STAP1	392	396	PF00017	0.468
LIG_SH2_STAT5	106	109	PF00017	0.460
LIG_SH2_STAT5	12	15	PF00017	0.423
LIG_SH2_STAT5	185	188	PF00017	0.465
LIG_SH2_STAT5	414	417	PF00017	0.333
LIG_SH2_STAT5	504	507	PF00017	0.629
LIG_SH2_STAT5	97	100	PF00017	0.460
LIG_SH3_3	347	353	PF00018	0.496
LIG_SH3_3	383	389	PF00018	0.561
LIG_SH3_3	447	453	PF00018	0.362
LIG_SH3_3	460	466	PF00018	0.410
LIG_SUMO_SIM_anti_2	46	55	PF11976	0.531
LIG_SUMO_SIM_par_1	185	191	PF11976	0.447
LIG_SUMO_SIM_par_1	360	365	PF11976	0.372
LIG_SUMO_SIM_par_1	375	382	PF11976	0.444
LIG_TRAF2_1	164	167	PF00917	0.368
LIG_TRAF2_1	17	20	PF00917	0.362
LIG_UBA3_1	336	343	PF00899	0.486
LIG_WRC_WIRS_1	153	158	PF05994	0.439
MOD_CK1_1	132	138	PF00069	0.464
MOD_CK1_1	188	194	PF00069	0.446
MOD_CK1_1	278	284	PF00069	0.496
MOD_CK2_1	117	123	PF00069	0.445
MOD_CK2_1	247	253	PF00069	0.499
MOD_CK2_1	65	71	PF00069	0.434
MOD_CMANNOS	286	289	PF00535	0.249
MOD_GlcNHglycan	195	199	PF01048	0.272
MOD_GlcNHglycan	202	205	PF01048	0.269
MOD_GlcNHglycan	249	252	PF01048	0.315
MOD_GlcNHglycan	28	31	PF01048	0.287
MOD_GSK3_1	152	159	PF00069	0.441
MOD_GSK3_1	187	194	PF00069	0.466
MOD_GSK3_1	214	221	PF00069	0.530
MOD_GSK3_1	271	278	PF00069	0.511
MOD_GSK3_1	93	100	PF00069	0.495
MOD_N-GLC_1	260	265	PF02516	0.255
MOD_N-GLC_1	437	442	PF02516	0.541
MOD_NEK2_1	107	112	PF00069	0.445
MOD_NEK2_1	117	122	PF00069	0.453
MOD_NEK2_1	129	134	PF00069	0.468
MOD_NEK2_1	156	161	PF00069	0.523
MOD_NEK2_1	336	341	PF00069	0.361
MOD_NEK2_1	360	365	PF00069	0.308
MOD_NEK2_1	43	48	PF00069	0.462
MOD_NEK2_1	445	450	PF00069	0.345
MOD_NEK2_1	495	500	PF00069	0.493
MOD_NEK2_2	490	495	PF00069	0.283
MOD_PIKK_1	168	174	PF00454	0.395
MOD_PIKK_1	338	344	PF00454	0.364
MOD_PIKK_1	370	376	PF00454	0.500
MOD_PIKK_1	63	69	PF00454	0.451
MOD_PKA_2	108	114	PF00069	0.492
MOD_PKA_2	271	277	PF00069	0.482
MOD_PKA_2	445	451	PF00069	0.379
MOD_Plk_1	194	200	PF00069	0.445
MOD_Plk_1	207	213	PF00069	0.489
MOD_Plk_1	260	266	PF00069	0.469
MOD_Plk_1	428	434	PF00069	0.430
MOD_Plk_1	495	501	PF00069	0.498
MOD_Plk_1	51	57	PF00069	0.458
MOD_Plk_4	117	123	PF00069	0.447
MOD_Plk_4	132	138	PF00069	0.464
MOD_Plk_4	224	230	PF00069	0.472
MOD_Plk_4	266	272	PF00069	0.496
MOD_Plk_4	281	287	PF00069	0.451
MOD_Plk_4	320	326	PF00069	0.383
MOD_Plk_4	445	451	PF00069	0.448
MOD_Plk_4	500	506	PF00069	0.565
MOD_Plk_4	52	58	PF00069	0.476
MOD_Plk_4	93	99	PF00069	0.486
MOD_ProDKin_1	188	194	PF00069	0.467
MOD_SUMO_for_1	326	329	PF00179	0.348
MOD_SUMO_rev_2	19	24	PF00179	0.362
TRG_ENDOCYTIC_2	101	104	PF00928	0.486
TRG_ENDOCYTIC_2	126	129	PF00928	0.457
TRG_ENDOCYTIC_2	133	136	PF00928	0.455
TRG_ENDOCYTIC_2	226	229	PF00928	0.482
TRG_ENDOCYTIC_2	357	360	PF00928	0.349
TRG_ENDOCYTIC_2	392	395	PF00928	0.434
TRG_ER_diArg_1	271	273	PF00400	0.495
TRG_ER_diArg_1	345	347	PF00400	0.527
TRG_ER_diArg_1	6	8	PF00400	0.523
TRG_NLS_MonoExtC_3	330	335	PF00514	0.395
TRG_NLS_MonoExtN_4	331	336	PF00514	0.393

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8T6	Leptomonas seymouri	69%	73%
A0A0N1IGQ2	Leptomonas seymouri	39%	72%
A0A0N1ILF1	Leptomonas seymouri	37%	74%
A0A0N1PCA9	Leptomonas seymouri	31%	69%
A0A0S4JS70	Bodo saltans	26%	66%
A0A0S4KGT2	Bodo saltans	43%	67%
A0A0S4KKP7	Bodo saltans	22%	68%
A0A1X0NJ61	Trypanosomatidae	45%	89%
A0A1X0NJK2	Trypanosomatidae	46%	67%
A0A1X0NW84	Trypanosomatidae	36%	73%
A0A1X0NW85	Trypanosomatidae	33%	75%
A0A1X0NWW1	Trypanosomatidae	35%	70%
A0A3Q8IDD4	Leishmania donovani	39%	72%
A0A3Q8IJT4	Leishmania donovani	25%	67%
A0A3S7WW41	Leishmania donovani	30%	68%
A0A3S7WW71	Leishmania donovani	37%	74%
A0A3S7X470	Leishmania donovani	34%	70%
A0A422MYX0	Trypanosoma rangeli	34%	70%
A4HE81	Leishmania braziliensis	41%	100%
A4HJ23	Leishmania braziliensis	33%	98%
A4HJ24	Leishmania braziliensis	81%	100%
A4HYW2	Leishmania infantum	37%	74%
A4HYW3	Leishmania infantum	30%	68%
A4I1J4	Leishmania infantum	39%	72%
A4I6E4	Leishmania infantum	34%	70%
A4I6K6	Leishmania infantum	26%	67%
C9ZIE8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	74%
C9ZIE9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	69%
E8NHG6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	34%	70%
E8NHM2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	98%	72%
E8NHM4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	99%	72%
E8NHM8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	98%	87%
E8NHQ2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	34%	100%
E9AIH3	Leishmania braziliensis	37%	100%
E9AIH4	Leishmania braziliensis	31%	100%
E9AIH6	Leishmania braziliensis	29%	100%
E9AUQ8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	35%	78%
E9AUQ9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	37%	74%
E9AUR0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	30%	68%
E9AUR1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	28%	93%
E9AXM9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	39%	72%
E9B1J2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	26%	67%
E9B1J6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	99%	72%
O08688	Mus musculus	27%	79%
O15484	Homo sapiens	27%	79%
Q3UW68	Mus musculus	27%	76%
Q4Q6L7	Leishmania major	87%	100%
Q4Q6L9	Leishmania major	34%	100%
Q4Q6M2	Leishmania major	25%	100%
Q4Q9U3	Leishmania major	40%	100%
Q4QCS5	Leishmania major	28%	100%
Q4QCS6	Leishmania major	32%	100%
Q4QCS7	Leishmania major	37%	100%
Q8R4C0	Rattus norvegicus	26%	79%
Q9D805	Mus musculus	26%	74%
V5AYJ1	Trypanosoma cruzi	40%	71%
V5BA05	Trypanosoma cruzi	36%	76%
V5BEL3	Trypanosoma cruzi	36%	73%
V5D5V8	Trypanosoma cruzi	30%	68%