Uncharacterized protein LmxM_30_0470b_1

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein

Species:

Leishmania mexicana

UniProt:

E8NHF0_LEIMU

TriTrypDb:

LmxM.30.0470b

Length:

242

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0032991	protein-containing complex	1	1
GO:0097196	Shu complex	2	1

Expansion

Sequence features

E8NHF0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E8NHF0

Function

Biological processes
Term	Name	Level	Count
GO:0000724	double-strand break repair via homologous recombination	7	1
GO:0000725	recombinational repair	6	1
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006259	DNA metabolic process	4	1
GO:0006281	DNA repair	5	1
GO:0006302	double-strand break repair	6	1
GO:0006310	DNA recombination	5	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0006950	response to stress	2	1
GO:0006974	DNA damage response	4	1
GO:0008152	metabolic process	1	1
GO:0009987	cellular process	1	1
GO:0033554	cellular response to stress	3	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0043170	macromolecule metabolic process	3	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044260	obsolete cellular macromolecule metabolic process	3	1
GO:0046483	heterocycle metabolic process	3	1
GO:0050896	response to stimulus	1	1
GO:0051716	cellular response to stimulus	2	1
GO:0071704	organic substance metabolic process	2	1
GO:0090304	nucleic acid metabolic process	4	1
GO:1901360	organic cyclic compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	1
GO:0003677	DNA binding	4	1
GO:0003697	single-stranded DNA binding	5	1
GO:0005488	binding	1	1
GO:0097159	organic cyclic compound binding	2	1
GO:1901363	heterocyclic compound binding	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	138	140	PF00675	0.528
CLV_PCSK_FUR_1	139	143	PF00082	0.746
CLV_PCSK_KEX2_1	138	140	PF00082	0.640
CLV_PCSK_KEX2_1	141	143	PF00082	0.669
CLV_PCSK_PC1ET2_1	141	143	PF00082	0.747
CLV_PCSK_SKI1_1	174	178	PF00082	0.613
DEG_COP1_1	115	122	PF00400	0.511
DEG_SCF_FBW7_1	80	86	PF00400	0.628
DOC_CKS1_1	80	85	PF01111	0.550
DOC_MAPK_gen_1	171	181	PF00069	0.573
DOC_MAPK_MEF2A_6	11	20	PF00069	0.491
DOC_MAPK_MEF2A_6	117	124	PF00069	0.681
DOC_MAPK_MEF2A_6	142	151	PF00069	0.686
DOC_PP1_RVXF_1	92	98	PF00149	0.428
DOC_PP2B_LxvP_1	192	195	PF13499	0.691
DOC_USP7_MATH_1	10	14	PF00917	0.616
DOC_USP7_MATH_1	154	158	PF00917	0.663
DOC_USP7_MATH_1	2	6	PF00917	0.649
DOC_USP7_MATH_1	206	210	PF00917	0.485
DOC_USP7_MATH_1	21	25	PF00917	0.611
DOC_USP7_MATH_1	83	87	PF00917	0.612
DOC_WW_Pin1_4	224	229	PF00397	0.697
DOC_WW_Pin1_4	79	84	PF00397	0.553
LIG_BIR_II_1	1	5	PF00653	0.728
LIG_BIR_III_1	1	5	PF00653	0.682
LIG_BIR_III_3	1	5	PF00653	0.682
LIG_BRCT_BRCA1_1	46	50	PF00533	0.493
LIG_Clathr_ClatBox_1	122	126	PF01394	0.507
LIG_eIF4E_1	196	202	PF01652	0.671
LIG_eIF4E_1	31	37	PF01652	0.455
LIG_FHA_1	102	108	PF00498	0.587
LIG_FHA_1	114	120	PF00498	0.542
LIG_FHA_1	180	186	PF00498	0.639
LIG_FHA_1	196	202	PF00498	0.512
LIG_FHA_1	209	215	PF00498	0.575
LIG_FHA_2	168	174	PF00498	0.609
LIG_KLC1_Yacidic_2	96	101	PF13176	0.503
LIG_LIR_Gen_1	96	105	PF02991	0.484
LIG_LIR_Nem_3	101	106	PF02991	0.485
LIG_LIR_Nem_3	173	179	PF02991	0.633
LIG_LIR_Nem_3	198	202	PF02991	0.563
LIG_LIR_Nem_3	96	100	PF02991	0.473
LIG_MYND_1	12	16	PF01753	0.491
LIG_SH2_NCK_1	74	78	PF00017	0.663
LIG_SH2_PTP2	178	181	PF00017	0.532
LIG_SH2_SRC	99	102	PF00017	0.500
LIG_SH2_STAT5	161	164	PF00017	0.643
LIG_SH2_STAT5	178	181	PF00017	0.542
LIG_SH2_STAT5	231	234	PF00017	0.668
LIG_SH2_STAT5	99	102	PF00017	0.481
LIG_SH3_3	222	228	PF00018	0.687
LIG_SH3_3	23	29	PF00018	0.666
LIG_SH3_3	77	83	PF00018	0.551
LIG_SUMO_SIM_anti_2	121	128	PF11976	0.473
LIG_SUMO_SIM_anti_2	63	68	PF11976	0.507
LIG_SUMO_SIM_par_1	120	128	PF11976	0.505
LIG_WW_1	228	231	PF00397	0.606
MOD_CK1_1	157	163	PF00069	0.694
MOD_CK1_1	85	91	PF00069	0.615
MOD_CK2_1	157	163	PF00069	0.548
MOD_CK2_1	83	89	PF00069	0.582
MOD_Cter_Amidation	139	142	PF01082	0.746
MOD_GlcNHglycan	142	145	PF01048	0.691
MOD_GlcNHglycan	208	211	PF01048	0.586
MOD_GlcNHglycan	60	63	PF01048	0.543
MOD_GlcNHglycan	89	92	PF01048	0.676
MOD_GSK3_1	150	157	PF00069	0.696
MOD_GSK3_1	208	215	PF00069	0.616
MOD_GSK3_1	53	60	PF00069	0.598
MOD_GSK3_1	79	86	PF00069	0.618
MOD_NEK2_1	113	118	PF00069	0.692
MOD_NEK2_1	130	135	PF00069	0.444
MOD_NEK2_1	150	155	PF00069	0.381
MOD_NEK2_1	87	92	PF00069	0.544
MOD_PIKK_1	187	193	PF00454	0.686
MOD_PIKK_1	214	220	PF00454	0.694
MOD_PKA_2	10	16	PF00069	0.660
MOD_PKA_2	58	64	PF00069	0.394
MOD_Plk_1	130	136	PF00069	0.625
MOD_Plk_1	69	75	PF00069	0.709
MOD_Plk_4	118	124	PF00069	0.648
MOD_Plk_4	157	163	PF00069	0.606
MOD_Plk_4	60	66	PF00069	0.616
MOD_Plk_4	69	75	PF00069	0.698
MOD_ProDKin_1	224	230	PF00069	0.693
MOD_ProDKin_1	79	85	PF00069	0.554
TRG_ENDOCYTIC_2	178	181	PF00928	0.542
TRG_ENDOCYTIC_2	196	199	PF00928	0.659
TRG_ER_diArg_1	238	241	PF00400	0.722

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I3G7	Leptomonas seymouri	69%	100%
A0A1X0NJ44	Trypanosomatidae	40%	100%
A0A3Q8IIC3	Leishmania donovani	89%	100%
A0A422P024	Trypanosoma rangeli	42%	100%
A4HJ25	Leishmania braziliensis	81%	100%
A4I6E7	Leishmania infantum	89%	100%
C9ZN54	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	40%	100%
E9B1J7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	99%	100%
Q4Q6L6	Leishmania major	87%	100%
V5BN46	Trypanosoma cruzi	46%	100%