Although predicted to have a multi-helical architecture, the protein is not hydrophobic enough for a membrane protein.. Unique to kinetoplastids, fast-evolving and duplicated multiple times.
Source | Evidence on protein | Close homologs |
---|---|---|
Cuervo et al. | no | yes: 0 |
Hassani et al. | no | yes: 0 |
Forrest at al. (metacyclic) | no | yes: 2 |
Forrest at al. (procyclic) | no | yes: 2 |
Silverman et al. | no | yes: 0 |
Pissara et al. | yes | yes: 15 |
Source | Evidence on protein | Close homologs |
---|---|---|
Pires et al. | no | yes: 0 |
Source | Evidence on protein | Close homologs |
---|---|---|
Silverman et al. | no | yes: 5 |
Source | Evidence on protein | Close homologs |
---|---|---|
Jamdhade et al. | no | yes: 0 |
Source | Evidence on protein | Close homologs |
---|---|---|
DeepLoc | ||
SignalP6 | no | yes: 0, no: 18 |
NetGPI | no | yes: 0, no: 18 |
Related structures:
AlphaFold database: E8NHE7
Leishmania | From | To | Domain/Motif | Score |
---|---|---|---|---|
CLV_C14_Caspase3-7 | 124 | 128 | PF00656 | 0.836 |
CLV_C14_Caspase3-7 | 523 | 527 | PF00656 | 0.627 |
CLV_C14_Caspase3-7 | 81 | 85 | PF00656 | 0.730 |
CLV_NRD_NRD_1 | 305 | 307 | PF00675 | 0.703 |
CLV_NRD_NRD_1 | 514 | 516 | PF00675 | 0.717 |
CLV_NRD_NRD_1 | 540 | 542 | PF00675 | 0.758 |
CLV_NRD_NRD_1 | 63 | 65 | PF00675 | 0.590 |
CLV_PCSK_KEX2_1 | 514 | 516 | PF00082 | 0.744 |
CLV_PCSK_KEX2_1 | 524 | 526 | PF00082 | 0.786 |
CLV_PCSK_KEX2_1 | 539 | 541 | PF00082 | 0.498 |
CLV_PCSK_KEX2_1 | 63 | 65 | PF00082 | 0.590 |
CLV_PCSK_PC1ET2_1 | 524 | 526 | PF00082 | 0.807 |
CLV_PCSK_PC1ET2_1 | 539 | 541 | PF00082 | 0.498 |
CLV_PCSK_PC7_1 | 535 | 541 | PF00082 | 0.689 |
CLV_PCSK_SKI1_1 | 102 | 106 | PF00082 | 0.605 |
CLV_PCSK_SKI1_1 | 21 | 25 | PF00082 | 0.600 |
CLV_PCSK_SKI1_1 | 214 | 218 | PF00082 | 0.524 |
CLV_PCSK_SKI1_1 | 324 | 328 | PF00082 | 0.634 |
CLV_PCSK_SKI1_1 | 525 | 529 | PF00082 | 0.745 |
CLV_PCSK_SKI1_1 | 535 | 539 | PF00082 | 0.565 |
CLV_PCSK_SKI1_1 | 56 | 60 | PF00082 | 0.628 |
DEG_APCC_DBOX_1 | 353 | 361 | PF00400 | 0.741 |
DOC_CYCLIN_RxL_1 | 228 | 237 | PF00134 | 0.550 |
DOC_MAPK_MEF2A_6 | 146 | 154 | PF00069 | 0.655 |
DOC_MAPK_MEF2A_6 | 553 | 560 | PF00069 | 0.654 |
DOC_MAPK_MEF2A_6 | 591 | 600 | PF00069 | 0.370 |
DOC_PP1_RVXF_1 | 368 | 375 | PF00149 | 0.726 |
DOC_PP2B_LxvP_1 | 478 | 481 | PF13499 | 0.782 |
DOC_SPAK_OSR1_1 | 30 | 34 | PF12202 | 0.595 |
DOC_USP7_MATH_1 | 347 | 351 | PF00917 | 0.697 |
DOC_USP7_MATH_1 | 391 | 395 | PF00917 | 0.674 |
DOC_USP7_MATH_1 | 445 | 449 | PF00917 | 0.626 |
DOC_USP7_MATH_1 | 461 | 465 | PF00917 | 0.556 |
DOC_USP7_MATH_1 | 494 | 498 | PF00917 | 0.602 |
DOC_USP7_MATH_1 | 513 | 517 | PF00917 | 0.751 |
DOC_USP7_MATH_1 | 567 | 571 | PF00917 | 0.526 |
DOC_USP7_MATH_1 | 603 | 607 | PF00917 | 0.596 |
DOC_USP7_MATH_2 | 334 | 340 | PF00917 | 0.700 |
DOC_USP7_MATH_2 | 424 | 430 | PF00917 | 0.636 |
DOC_WW_Pin1_4 | 387 | 392 | PF00397 | 0.707 |
DOC_WW_Pin1_4 | 420 | 425 | PF00397 | 0.711 |
LIG_14-3-3_CanoR_1 | 108 | 116 | PF00244 | 0.577 |
LIG_14-3-3_CanoR_1 | 265 | 270 | PF00244 | 0.669 |
LIG_14-3-3_CanoR_1 | 30 | 39 | PF00244 | 0.636 |
LIG_14-3-3_CanoR_1 | 340 | 349 | PF00244 | 0.435 |
LIG_14-3-3_CanoR_1 | 4 | 9 | PF00244 | 0.741 |
LIG_14-3-3_CanoR_1 | 415 | 421 | PF00244 | 0.670 |
LIG_14-3-3_CanoR_1 | 427 | 431 | PF00244 | 0.525 |
LIG_14-3-3_CanoR_1 | 541 | 549 | PF00244 | 0.651 |
LIG_Actin_WH2_2 | 437 | 455 | PF00022 | 0.682 |
LIG_AP2alpha_1 | 50 | 54 | PF02296 | 0.634 |
LIG_BIR_III_2 | 84 | 88 | PF00653 | 0.699 |
LIG_BRCT_BRCA1_1 | 267 | 271 | PF00533 | 0.651 |
LIG_CSL_BTD_1 | 388 | 391 | PF09270 | 0.698 |
LIG_EH1_1 | 608 | 616 | PF00400 | 0.576 |
LIG_eIF4E_1 | 283 | 289 | PF01652 | 0.406 |
LIG_FHA_1 | 143 | 149 | PF00498 | 0.694 |
LIG_FHA_1 | 180 | 186 | PF00498 | 0.586 |
LIG_FHA_1 | 201 | 207 | PF00498 | 0.589 |
LIG_FHA_1 | 264 | 270 | PF00498 | 0.675 |
LIG_FHA_1 | 482 | 488 | PF00498 | 0.577 |
LIG_FHA_1 | 53 | 59 | PF00498 | 0.651 |
LIG_FHA_2 | 101 | 107 | PF00498 | 0.602 |
LIG_FHA_2 | 30 | 36 | PF00498 | 0.640 |
LIG_FHA_2 | 469 | 475 | PF00498 | 0.791 |
LIG_LIR_Gen_1 | 174 | 183 | PF02991 | 0.595 |
LIG_LIR_Gen_1 | 226 | 235 | PF02991 | 0.722 |
LIG_LIR_Gen_1 | 298 | 304 | PF02991 | 0.619 |
LIG_LIR_Gen_1 | 605 | 615 | PF02991 | 0.618 |
LIG_LIR_Nem_3 | 149 | 154 | PF02991 | 0.629 |
LIG_LIR_Nem_3 | 163 | 168 | PF02991 | 0.393 |
LIG_LIR_Nem_3 | 17 | 23 | PF02991 | 0.652 |
LIG_LIR_Nem_3 | 174 | 178 | PF02991 | 0.438 |
LIG_LIR_Nem_3 | 226 | 230 | PF02991 | 0.713 |
LIG_LIR_Nem_3 | 298 | 302 | PF02991 | 0.619 |
LIG_LIR_Nem_3 | 464 | 469 | PF02991 | 0.727 |
LIG_PCNA_PIPBox_1 | 594 | 603 | PF02747 | 0.410 |
LIG_Pex14_2 | 50 | 54 | PF04695 | 0.634 |
LIG_SH2_CRK | 165 | 169 | PF00017 | 0.588 |
LIG_SH2_CRK | 20 | 24 | PF00017 | 0.656 |
LIG_SH2_CRK | 227 | 231 | PF00017 | 0.693 |
LIG_SH2_CRK | 283 | 287 | PF00017 | 0.575 |
LIG_SH2_CRK | 291 | 295 | PF00017 | 0.431 |
LIG_SH2_CRK | 299 | 303 | PF00017 | 0.568 |
LIG_SH2_GRB2like | 542 | 545 | PF00017 | 0.613 |
LIG_SH2_STAP1 | 469 | 473 | PF00017 | 0.735 |
LIG_SH2_STAT3 | 37 | 40 | PF00017 | 0.636 |
LIG_SH2_STAT5 | 175 | 178 | PF00017 | 0.612 |
LIG_SH2_STAT5 | 184 | 187 | PF00017 | 0.553 |
LIG_SH2_STAT5 | 195 | 198 | PF00017 | 0.304 |
LIG_SH2_STAT5 | 283 | 286 | PF00017 | 0.615 |
LIG_SH2_STAT5 | 291 | 294 | PF00017 | 0.392 |
LIG_SH2_STAT5 | 337 | 340 | PF00017 | 0.666 |
LIG_SH2_STAT5 | 37 | 40 | PF00017 | 0.636 |
LIG_SH2_STAT5 | 432 | 435 | PF00017 | 0.648 |
LIG_SH2_STAT5 | 542 | 545 | PF00017 | 0.613 |
LIG_SH2_STAT5 | 589 | 592 | PF00017 | 0.425 |
LIG_SH3_3 | 147 | 153 | PF00018 | 0.607 |
LIG_SH3_3 | 385 | 391 | PF00018 | 0.732 |
LIG_SH3_3 | 439 | 445 | PF00018 | 0.704 |
LIG_SH3_3 | 493 | 499 | PF00018 | 0.846 |
LIG_SH3_3 | 86 | 92 | PF00018 | 0.780 |
LIG_SUMO_SIM_anti_2 | 439 | 445 | PF11976 | 0.696 |
LIG_SUMO_SIM_par_1 | 325 | 332 | PF11976 | 0.446 |
LIG_TRAF2_1 | 25 | 28 | PF00917 | 0.591 |
LIG_TYR_ITIM | 18 | 23 | PF00017 | 0.644 |
LIG_TYR_ITIM | 225 | 230 | PF00017 | 0.680 |
LIG_TYR_ITIM | 289 | 294 | PF00017 | 0.438 |
LIG_UBA3_1 | 206 | 214 | PF00899 | 0.617 |
LIG_UBA3_1 | 342 | 348 | PF00899 | 0.641 |
LIG_UBA3_1 | 572 | 579 | PF00899 | 0.493 |
LIG_UBA3_1 | 610 | 617 | PF00899 | 0.609 |
LIG_WRC_WIRS_1 | 371 | 376 | PF05994 | 0.712 |
MOD_CDK_SPxxK_3 | 420 | 427 | PF00069 | 0.708 |
MOD_CK1_1 | 247 | 253 | PF00069 | 0.645 |
MOD_CK1_1 | 300 | 306 | PF00069 | 0.668 |
MOD_CK1_1 | 364 | 370 | PF00069 | 0.667 |
MOD_CK1_1 | 373 | 379 | PF00069 | 0.566 |
MOD_CK1_1 | 414 | 420 | PF00069 | 0.694 |
MOD_CK1_1 | 516 | 522 | PF00069 | 0.784 |
MOD_CK2_1 | 100 | 106 | PF00069 | 0.603 |
MOD_CK2_1 | 29 | 35 | PF00069 | 0.635 |
MOD_CK2_1 | 420 | 426 | PF00069 | 0.594 |
MOD_CK2_1 | 468 | 474 | PF00069 | 0.762 |
MOD_GlcNHglycan | 118 | 121 | PF01048 | 0.811 |
MOD_GlcNHglycan | 127 | 130 | PF01048 | 0.793 |
MOD_GlcNHglycan | 241 | 245 | PF01048 | 0.678 |
MOD_GlcNHglycan | 384 | 387 | PF01048 | 0.790 |
MOD_GlcNHglycan | 393 | 396 | PF01048 | 0.470 |
MOD_GlcNHglycan | 438 | 441 | PF01048 | 0.510 |
MOD_GlcNHglycan | 492 | 495 | PF01048 | 0.819 |
MOD_GlcNHglycan | 517 | 521 | PF01048 | 0.830 |
MOD_GSK3_1 | 196 | 203 | PF00069 | 0.589 |
MOD_GSK3_1 | 240 | 247 | PF00069 | 0.564 |
MOD_GSK3_1 | 259 | 266 | PF00069 | 0.693 |
MOD_GSK3_1 | 356 | 363 | PF00069 | 0.815 |
MOD_GSK3_1 | 387 | 394 | PF00069 | 0.704 |
MOD_GSK3_1 | 426 | 433 | PF00069 | 0.626 |
MOD_GSK3_1 | 490 | 497 | PF00069 | 0.595 |
MOD_GSK3_1 | 547 | 554 | PF00069 | 0.724 |
MOD_N-GLC_1 | 411 | 416 | PF02516 | 0.695 |
MOD_N-GLC_2 | 290 | 292 | PF02516 | 0.536 |
MOD_NEK2_1 | 198 | 203 | PF00069 | 0.615 |
MOD_NEK2_1 | 269 | 274 | PF00069 | 0.619 |
MOD_NEK2_1 | 295 | 300 | PF00069 | 0.646 |
MOD_NEK2_1 | 341 | 346 | PF00069 | 0.422 |
MOD_NEK2_1 | 360 | 365 | PF00069 | 0.792 |
MOD_NEK2_1 | 382 | 387 | PF00069 | 0.758 |
MOD_NEK2_1 | 452 | 457 | PF00069 | 0.668 |
MOD_NEK2_1 | 50 | 55 | PF00069 | 0.633 |
MOD_NEK2_2 | 445 | 450 | PF00069 | 0.619 |
MOD_NMyristoyl | 1 | 7 | PF02799 | 0.819 |
MOD_PIKK_1 | 200 | 206 | PF00454 | 0.587 |
MOD_PIKK_1 | 365 | 371 | PF00454 | 0.748 |
MOD_PIKK_1 | 389 | 395 | PF00454 | 0.569 |
MOD_PIKK_1 | 414 | 420 | PF00454 | 0.694 |
MOD_PK_1 | 4 | 10 | PF00069 | 0.790 |
MOD_PKA_2 | 107 | 113 | PF00069 | 0.572 |
MOD_PKA_2 | 29 | 35 | PF00069 | 0.635 |
MOD_PKA_2 | 3 | 9 | PF00069 | 0.749 |
MOD_PKA_2 | 414 | 420 | PF00069 | 0.677 |
MOD_PKA_2 | 426 | 432 | PF00069 | 0.527 |
MOD_PKA_2 | 490 | 496 | PF00069 | 0.807 |
MOD_PKA_2 | 513 | 519 | PF00069 | 0.728 |
MOD_Plk_1 | 551 | 557 | PF00069 | 0.681 |
MOD_Plk_4 | 100 | 106 | PF00069 | 0.701 |
MOD_Plk_4 | 171 | 177 | PF00069 | 0.589 |
MOD_Plk_4 | 265 | 271 | PF00069 | 0.668 |
MOD_Plk_4 | 445 | 451 | PF00069 | 0.615 |
MOD_Plk_4 | 567 | 573 | PF00069 | 0.562 |
MOD_Plk_4 | 592 | 598 | PF00069 | 0.414 |
MOD_Plk_4 | 610 | 616 | PF00069 | 0.619 |
MOD_ProDKin_1 | 387 | 393 | PF00069 | 0.703 |
MOD_ProDKin_1 | 420 | 426 | PF00069 | 0.715 |
TRG_DiLeu_BaLyEn_6 | 163 | 168 | PF01217 | 0.594 |
TRG_DiLeu_BaLyEn_6 | 337 | 342 | PF01217 | 0.636 |
TRG_DiLeu_BaLyEn_6 | 395 | 400 | PF01217 | 0.702 |
TRG_DiLeu_BaLyEn_6 | 532 | 537 | PF01217 | 0.669 |
TRG_ENDOCYTIC_2 | 164 | 167 | PF00928 | 0.565 |
TRG_ENDOCYTIC_2 | 175 | 178 | PF00928 | 0.442 |
TRG_ENDOCYTIC_2 | 195 | 198 | PF00928 | 0.298 |
TRG_ENDOCYTIC_2 | 20 | 23 | PF00928 | 0.651 |
TRG_ENDOCYTIC_2 | 227 | 230 | PF00928 | 0.698 |
TRG_ENDOCYTIC_2 | 282 | 285 | PF00928 | 0.612 |
TRG_ENDOCYTIC_2 | 291 | 294 | PF00928 | 0.378 |
TRG_ENDOCYTIC_2 | 299 | 302 | PF00928 | 0.570 |
TRG_ENDOCYTIC_2 | 469 | 472 | PF00928 | 0.727 |
TRG_ER_diArg_1 | 513 | 515 | PF00400 | 0.613 |
TRG_ER_diArg_1 | 540 | 542 | PF00400 | 0.610 |
TRG_NES_CRM1_1 | 317 | 331 | PF08389 | 0.497 |
TRG_NLS_Bipartite_1 | 524 | 543 | PF00514 | 0.748 |
TRG_NLS_MonoCore_2 | 537 | 542 | PF00514 | 0.707 |
TRG_NLS_MonoExtN_4 | 535 | 542 | PF00514 | 0.709 |
TRG_Pf-PMV_PEXEL_1 | 166 | 170 | PF00026 | 0.583 |
TRG_Pf-PMV_PEXEL_1 | 617 | 621 | PF00026 | 0.549 |
Protein | Taxonomy | Sequence identity | Coverage |
---|---|---|---|
A0A3Q8IFG5 | Leishmania donovani | 85% | 100% |
A0A3Q8ISI8 | Leishmania donovani | 85% | 100% |
A0A3S7X4A3 | Leishmania donovani | 85% | 100% |
A4HJ70 | Leishmania braziliensis | 61% | 99% |
A4HJ71 | Leishmania braziliensis | 64% | 99% |
A4HJ73 | Leishmania braziliensis | 65% | 100% |
A4HJW7 | Leishmania braziliensis | 57% | 100% |
A4I6I2 | Leishmania infantum | 85% | 94% |
A4I6L8 | Leishmania infantum | 85% | 100% |
E8NHD1 | Leishmania infantum | 86% | 100% |
E8NHD2 | Leishmania infantum | 84% | 100% |
E8NHE8 | Leishmania mexicana (strain MHOM/GT/2001/U1103) | 95% | 100% |
E9B1P3 | Leishmania mexicana (strain MHOM/GT/2001/U1103) | 95% | 100% |
Q4Q6G7 | Leishmania major | 85% | 100% |
Q4Q6G8 | Leishmania major | 83% | 100% |
Q4Q6H0 | Leishmania major | 85% | 100% |
Q9BHE5 | Leishmania major | 84% | 100% |