WGS CADB00000000 data, contig 105

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

tuzin-like protein

Species:

Leishmania mexicana

UniProt:

E8NHE5_LEIMU

TriTrypDb:

LmxM.33.1830

Length:

631

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 33
NetGPI	no	yes: 0, no: 33

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	15
GO:0110165	cellular anatomical entity	1	15

Expansion

Sequence features

E8NHE5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E8NHE5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	128	130	PF00675	0.620
CLV_NRD_NRD_1	2	4	PF00675	0.503
CLV_NRD_NRD_1	284	286	PF00675	0.440
CLV_NRD_NRD_1	325	327	PF00675	0.648
CLV_NRD_NRD_1	363	365	PF00675	0.645
CLV_NRD_NRD_1	509	511	PF00675	0.570
CLV_NRD_NRD_1	578	580	PF00675	0.653
CLV_NRD_NRD_1	68	70	PF00675	0.412
CLV_PCSK_KEX2_1	127	129	PF00082	0.449
CLV_PCSK_KEX2_1	2	4	PF00082	0.507
CLV_PCSK_KEX2_1	284	286	PF00082	0.407
CLV_PCSK_KEX2_1	325	327	PF00082	0.676
CLV_PCSK_KEX2_1	363	365	PF00082	0.645
CLV_PCSK_KEX2_1	509	511	PF00082	0.570
CLV_PCSK_KEX2_1	578	580	PF00082	0.675
CLV_PCSK_KEX2_1	70	72	PF00082	0.408
CLV_PCSK_PC1ET2_1	70	72	PF00082	0.404
CLV_PCSK_SKI1_1	202	206	PF00082	0.472
CLV_PCSK_SKI1_1	294	298	PF00082	0.382
CLV_PCSK_SKI1_1	450	454	PF00082	0.638
CLV_PCSK_SKI1_1	499	503	PF00082	0.655
DEG_Nend_UBRbox_1	1	4	PF02207	0.597
DOC_ANK_TNKS_1	607	614	PF00023	0.328
DOC_CYCLIN_RxL_1	199	207	PF00134	0.608
DOC_CYCLIN_yClb5_NLxxxL_5	288	297	PF00134	0.487
DOC_CYCLIN_yCln2_LP_2	494	500	PF00134	0.340
DOC_MAPK_DCC_7	455	465	PF00069	0.366
DOC_MAPK_MEF2A_6	225	234	PF00069	0.539
DOC_PP1_RVXF_1	267	273	PF00149	0.493
DOC_PP2B_LxvP_1	198	201	PF13499	0.628
DOC_PP2B_LxvP_1	494	497	PF13499	0.406
DOC_PP2B_LxvP_1	584	587	PF13499	0.499
DOC_USP7_MATH_1	344	348	PF00917	0.426
DOC_USP7_MATH_1	35	39	PF00917	0.706
DOC_USP7_MATH_1	389	393	PF00917	0.477
DOC_USP7_MATH_1	567	571	PF00917	0.334
DOC_WW_Pin1_4	499	504	PF00397	0.389
DOC_WW_Pin1_4	58	63	PF00397	0.697
DOC_WW_Pin1_4	586	591	PF00397	0.408
DOC_WW_Pin1_4	64	69	PF00397	0.715
LIG_14-3-3_CanoR_1	142	146	PF00244	0.609
LIG_14-3-3_CanoR_1	26	30	PF00244	0.781
LIG_14-3-3_CanoR_1	326	335	PF00244	0.439
LIG_14-3-3_CanoR_1	345	353	PF00244	0.603
LIG_14-3-3_CanoR_1	450	455	PF00244	0.418
LIG_14-3-3_CanoR_1	547	554	PF00244	0.489
LIG_14-3-3_CanoR_1	596	602	PF00244	0.409
LIG_14-3-3_CanoR_1	71	76	PF00244	0.755
LIG_Actin_WH2_2	409	426	PF00022	0.376
LIG_APCC_ABBAyCdc20_2	401	407	PF00400	0.416
LIG_BIR_III_4	610	614	PF00653	0.436
LIG_Clathr_ClatBox_1	134	138	PF01394	0.631
LIG_Clathr_ClatBox_1	411	415	PF01394	0.362
LIG_DLG_GKlike_1	71	78	PF00625	0.592
LIG_EH1_1	162	170	PF00400	0.501
LIG_eIF4E_1	568	574	PF01652	0.320
LIG_FHA_1	152	158	PF00498	0.712
LIG_FHA_1	174	180	PF00498	0.578
LIG_FHA_1	316	322	PF00498	0.538
LIG_FHA_1	602	608	PF00498	0.446
LIG_FHA_2	337	343	PF00498	0.431
LIG_Integrin_RGD_1	364	366	PF01839	0.487
LIG_LIR_Gen_1	174	181	PF02991	0.565
LIG_LIR_Nem_3	174	180	PF02991	0.557
LIG_NRBOX	74	80	PF00104	0.667
LIG_Pex14_2	235	239	PF04695	0.564
LIG_SH2_CRK	568	572	PF00017	0.464
LIG_SH2_PTP2	177	180	PF00017	0.537
LIG_SH2_STAP1	110	114	PF00017	0.629
LIG_SH2_STAP1	527	531	PF00017	0.304
LIG_SH2_STAP1	568	572	PF00017	0.351
LIG_SH2_STAT3	324	327	PF00017	0.370
LIG_SH2_STAT5	110	113	PF00017	0.664
LIG_SH2_STAT5	177	180	PF00017	0.623
LIG_SH2_STAT5	245	248	PF00017	0.548
LIG_SH2_STAT5	315	318	PF00017	0.431
LIG_SH2_STAT5	514	517	PF00017	0.385
LIG_SH2_STAT5	527	530	PF00017	0.373
LIG_SH2_STAT5	539	542	PF00017	0.329
LIG_SH2_STAT5	568	571	PF00017	0.363
LIG_SH2_STAT5	603	606	PF00017	0.462
LIG_SH3_2	587	592	PF14604	0.403
LIG_SH3_3	218	224	PF00018	0.642
LIG_SH3_3	580	586	PF00018	0.377
LIG_SH3_3	81	87	PF00018	0.710
LIG_SH3_CIN85_PxpxPR_1	64	69	PF14604	0.605
LIG_SUMO_SIM_anti_2	176	183	PF11976	0.686
LIG_SUMO_SIM_anti_2	228	234	PF11976	0.537
LIG_SUMO_SIM_anti_2	479	486	PF11976	0.408
LIG_SUMO_SIM_anti_2	533	539	PF11976	0.424
LIG_SUMO_SIM_anti_2	569	575	PF11976	0.261
LIG_SUMO_SIM_par_1	133	138	PF11976	0.683
LIG_SUMO_SIM_par_1	479	486	PF11976	0.332
LIG_TYR_ITIM	566	571	PF00017	0.439
LIG_UBA3_1	164	170	PF00899	0.525
LIG_UBA3_1	252	260	PF00899	0.452
MOD_CDC14_SPxK_1	589	592	PF00782	0.388
MOD_CDC14_SPxK_1	67	70	PF00782	0.703
MOD_CDK_SPK_2	64	69	PF00069	0.704
MOD_CDK_SPxK_1	586	592	PF00069	0.406
MOD_CDK_SPxK_1	64	70	PF00069	0.704
MOD_CDK_SPxxK_3	64	71	PF00069	0.614
MOD_CK1_1	103	109	PF00069	0.744
MOD_CK1_1	25	31	PF00069	0.675
MOD_CK1_1	482	488	PF00069	0.409
MOD_CK1_1	504	510	PF00069	0.430
MOD_CK2_1	256	262	PF00069	0.570
MOD_CK2_1	336	342	PF00069	0.421
MOD_CK2_1	344	350	PF00069	0.531
MOD_CK2_1	414	420	PF00069	0.292
MOD_CK2_1	422	428	PF00069	0.307
MOD_GlcNHglycan	159	162	PF01048	0.537
MOD_GlcNHglycan	182	185	PF01048	0.303
MOD_GlcNHglycan	206	209	PF01048	0.467
MOD_GlcNHglycan	235	238	PF01048	0.385
MOD_GlcNHglycan	37	40	PF01048	0.499
MOD_GlcNHglycan	415	419	PF01048	0.574
MOD_GlcNHglycan	456	459	PF01048	0.517
MOD_GSK3_1	316	323	PF00069	0.480
MOD_GSK3_1	450	457	PF00069	0.467
MOD_GSK3_1	597	604	PF00069	0.514
MOD_GSK3_1	82	89	PF00069	0.723
MOD_N-GLC_1	504	509	PF02516	0.602
MOD_NEK2_1	164	169	PF00069	0.652
MOD_NEK2_1	204	209	PF00069	0.711
MOD_NEK2_1	378	383	PF00069	0.434
MOD_PIKK_1	373	379	PF00454	0.452
MOD_PKA_2	141	147	PF00069	0.664
MOD_PKA_2	25	31	PF00069	0.662
MOD_PKA_2	344	350	PF00069	0.582
MOD_PKA_2	546	552	PF00069	0.497
MOD_PKB_1	466	474	PF00069	0.373
MOD_PKB_1	69	77	PF00069	0.595
MOD_Plk_1	106	112	PF00069	0.621
MOD_Plk_1	173	179	PF00069	0.635
MOD_Plk_1	186	192	PF00069	0.610
MOD_Plk_1	419	425	PF00069	0.427
MOD_Plk_1	504	510	PF00069	0.312
MOD_Plk_2-3	262	268	PF00069	0.544
MOD_Plk_4	164	170	PF00069	0.568
MOD_Plk_4	173	179	PF00069	0.628
MOD_Plk_4	25	31	PF00069	0.646
MOD_Plk_4	262	268	PF00069	0.491
MOD_Plk_4	479	485	PF00069	0.348
MOD_Plk_4	567	573	PF00069	0.488
MOD_Plk_4	86	92	PF00069	0.683
MOD_ProDKin_1	499	505	PF00069	0.383
MOD_ProDKin_1	58	64	PF00069	0.697
MOD_ProDKin_1	586	592	PF00069	0.406
TRG_DiLeu_BaEn_1	228	233	PF01217	0.628
TRG_DiLeu_BaEn_1	242	247	PF01217	0.543
TRG_DiLeu_BaEn_1	479	484	PF01217	0.370
TRG_ENDOCYTIC_2	177	180	PF00928	0.606
TRG_ENDOCYTIC_2	277	280	PF00928	0.671
TRG_ENDOCYTIC_2	477	480	PF00928	0.369
TRG_ENDOCYTIC_2	568	571	PF00928	0.464
TRG_ER_diArg_1	1	3	PF00400	0.721
TRG_ER_diArg_1	127	129	PF00400	0.586
TRG_ER_diArg_1	283	285	PF00400	0.645
TRG_ER_diArg_1	324	326	PF00400	0.473
TRG_ER_diArg_1	362	364	PF00400	0.460
TRG_ER_diArg_1	465	468	PF00400	0.372
TRG_ER_diArg_1	508	510	PF00400	0.373
TRG_ER_diArg_1	558	561	PF00400	0.485
TRG_ER_diArg_1	577	579	PF00400	0.487
TRG_ER_diArg_1	68	71	PF00400	0.671
TRG_NES_CRM1_1	251	264	PF08389	0.622
TRG_NES_CRM1_1	421	436	PF08389	0.371
TRG_NLS_MonoExtN_4	66	73	PF00514	0.598
TRG_Pf-PMV_PEXEL_1	281	286	PF00026	0.382

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PAN2	Leptomonas seymouri	60%	96%
A0A0N1PB02	Leptomonas seymouri	39%	96%
A0A0S4J6C6	Bodo saltans	34%	98%
A0A1X0P9A6	Trypanosomatidae	37%	93%
A0A3Q8IHH1	Leishmania donovani	78%	86%
A0A3R7K2Y9	Trypanosoma rangeli	38%	92%
A0A3S5H668	Leishmania donovani	35%	100%
A0A3S5H669	Leishmania donovani	36%	99%
A0A3S7X835	Leishmania donovani	39%	100%
A4H5C9	Leishmania braziliensis	35%	100%
A4H5D0	Leishmania braziliensis	37%	100%
A4HAZ7	Leishmania braziliensis	39%	100%
A4HAZ9	Leishmania braziliensis	41%	100%
A4HB01	Leishmania braziliensis	41%	100%
A4HTM0	Leishmania infantum	35%	100%
A4HTM1	Leishmania infantum	35%	99%
A4IA57	Leishmania infantum	39%	100%
C6K3V8	Leptomonas seymouri	34%	100%
C6K3V9	Leptomonas seymouri	33%	96%
C9ZMY5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	37%	93%
E8NHF8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
E9AME6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	36%	100%
E9AME7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	36%	99%
E9B571	Leishmania mexicana (strain MHOM/GT/2001/U1103)	38%	100%
Q4Q1U8	Leishmania major	80%	100%
Q4Q2R4	Leishmania major	38%	100%
Q4Q310	Leishmania major	77%	100%
Q4Q312	Leishmania major	77%	100%
Q4Q340	Leishmania major	77%	100%
Q4Q342	Leishmania major	77%	100%
Q4QI90	Leishmania major	35%	100%
Q4QI91	Leishmania major	35%	100%