WGS CADB00000000 data, contig 104

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein

Species:

Leishmania mexicana

UniProt:

E8NHE4_LEIMU

TriTrypDb:

LmxM.22.1690c

Length:

654

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 3
NetGPI	no	yes: 0, no: 3

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	3
GO:0110165	cellular anatomical entity	1	3

Expansion

Sequence features

E8NHE4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E8NHE4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	233	237	PF00656	0.724
CLV_C14_Caspase3-7	609	613	PF00656	0.719
CLV_NRD_NRD_1	243	245	PF00675	0.557
CLV_NRD_NRD_1	268	270	PF00675	0.669
CLV_NRD_NRD_1	271	273	PF00675	0.640
CLV_PCSK_FUR_1	226	230	PF00082	0.521
CLV_PCSK_KEX2_1	228	230	PF00082	0.570
CLV_PCSK_KEX2_1	242	244	PF00082	0.514
CLV_PCSK_KEX2_1	268	270	PF00082	0.669
CLV_PCSK_PC1ET2_1	228	230	PF00082	0.593
DEG_APCC_DBOX_1	294	302	PF00400	0.847
DEG_APCC_DBOX_1	374	382	PF00400	0.697
DEG_APCC_DBOX_1	454	462	PF00400	0.698
DEG_APCC_DBOX_1	534	542	PF00400	0.699
DOC_CKS1_1	108	113	PF01111	0.667
DOC_CKS1_1	642	647	PF01111	0.724
DOC_MAPK_gen_1	336	346	PF00069	0.840
DOC_MAPK_gen_1	38	48	PF00069	0.730
DOC_MAPK_gen_1	416	426	PF00069	0.696
DOC_MAPK_gen_1	496	506	PF00069	0.695
DOC_MAPK_gen_1	576	586	PF00069	0.695
DOC_MAPK_MEF2A_6	336	344	PF00069	0.696
DOC_MAPK_MEF2A_6	41	50	PF00069	0.500
DOC_MAPK_MEF2A_6	416	424	PF00069	0.694
DOC_MAPK_MEF2A_6	496	504	PF00069	0.692
DOC_MAPK_MEF2A_6	576	584	PF00069	0.694
DOC_MAPK_NFAT4_5	339	347	PF00069	0.704
DOC_MAPK_NFAT4_5	419	427	PF00069	0.704
DOC_MAPK_NFAT4_5	499	507	PF00069	0.701
DOC_MAPK_NFAT4_5	579	587	PF00069	0.700
DOC_MAPK_RevD_3	256	269	PF00069	0.713
DOC_PP2B_LxvP_1	342	345	PF13499	0.704
DOC_PP2B_LxvP_1	422	425	PF13499	0.704
DOC_PP2B_LxvP_1	502	505	PF13499	0.700
DOC_PP2B_LxvP_1	582	585	PF13499	0.701
DOC_USP7_MATH_1	139	143	PF00917	0.732
DOC_USP7_MATH_1	189	193	PF00917	0.730
DOC_USP7_MATH_1	234	238	PF00917	0.777
DOC_USP7_MATH_1	280	284	PF00917	0.720
DOC_USP7_MATH_1	313	317	PF00917	0.820
DOC_USP7_MATH_1	353	357	PF00917	0.809
DOC_USP7_MATH_1	360	364	PF00917	0.814
DOC_USP7_MATH_1	393	397	PF00917	0.687
DOC_USP7_MATH_1	433	437	PF00917	0.719
DOC_USP7_MATH_1	440	444	PF00917	0.668
DOC_USP7_MATH_1	473	477	PF00917	0.689
DOC_USP7_MATH_1	513	517	PF00917	0.713
DOC_USP7_MATH_1	520	524	PF00917	0.664
DOC_USP7_MATH_1	553	557	PF00917	0.695
DOC_USP7_MATH_1	593	597	PF00917	0.724
DOC_USP7_MATH_1	600	604	PF00917	0.675
DOC_USP7_MATH_1	627	631	PF00917	0.726
DOC_USP7_MATH_2	645	651	PF00917	0.730
DOC_WW_Pin1_4	107	112	PF00397	0.786
DOC_WW_Pin1_4	128	133	PF00397	0.723
DOC_WW_Pin1_4	194	199	PF00397	0.803
DOC_WW_Pin1_4	252	257	PF00397	0.722
DOC_WW_Pin1_4	311	316	PF00397	0.698
DOC_WW_Pin1_4	391	396	PF00397	0.693
DOC_WW_Pin1_4	471	476	PF00397	0.694
DOC_WW_Pin1_4	551	556	PF00397	0.698
DOC_WW_Pin1_4	641	646	PF00397	0.724
LIG_14-3-3_CanoR_1	272	280	PF00244	0.727
LIG_14-3-3_CanoR_1	354	362	PF00244	0.706
LIG_14-3-3_CanoR_1	434	442	PF00244	0.714
LIG_14-3-3_CanoR_1	514	522	PF00244	0.706
LIG_14-3-3_CanoR_1	635	643	PF00244	0.734
LIG_BIR_II_1	1	5	PF00653	0.300
LIG_BIR_III_2	206	210	PF00653	0.729
LIG_BIR_III_2	357	361	PF00653	0.857
LIG_BIR_III_2	437	441	PF00653	0.713
LIG_BIR_III_2	517	521	PF00653	0.706
LIG_BIR_III_2	597	601	PF00653	0.723
LIG_BIR_III_2	612	616	PF00653	0.631
LIG_BIR_III_2	624	628	PF00653	0.662
LIG_FHA_1	108	114	PF00498	0.820
LIG_FHA_1	161	167	PF00498	0.859
LIG_FHA_1	318	324	PF00498	0.676
LIG_FHA_1	329	335	PF00498	0.611
LIG_FHA_1	398	404	PF00498	0.674
LIG_FHA_1	409	415	PF00498	0.605
LIG_FHA_1	478	484	PF00498	0.678
LIG_FHA_1	489	495	PF00498	0.605
LIG_FHA_1	558	564	PF00498	0.680
LIG_FHA_1	569	575	PF00498	0.612
LIG_FHA_2	150	156	PF00498	0.742
LIG_FHA_2	17	23	PF00498	0.526
LIG_FHA_2	197	203	PF00498	0.802
LIG_FHA_2	228	234	PF00498	0.717
LIG_FHA_2	346	352	PF00498	0.707
LIG_FHA_2	426	432	PF00498	0.709
LIG_FHA_2	506	512	PF00498	0.704
LIG_FHA_2	586	592	PF00498	0.709
LIG_FHA_2	615	621	PF00498	0.708
LIG_FHA_2	642	648	PF00498	0.725
LIG_LIR_Gen_1	131	139	PF02991	0.843
LIG_LIR_Nem_3	131	137	PF02991	0.714
LIG_SH2_CRK	61	65	PF00017	0.497
LIG_SH2_CRK	66	70	PF00017	0.515
LIG_SH2_GRB2like	134	137	PF00017	0.712
LIG_SH2_STAP1	203	207	PF00017	0.736
LIG_SH2_STAP1	66	70	PF00017	0.549
LIG_SH2_STAT5	61	64	PF00017	0.588
LIG_SH2_STAT5	66	69	PF00017	0.515
LIG_SH3_3	244	250	PF00018	0.734
LIG_SH3_3	253	259	PF00018	0.673
LIG_SH3_3	337	343	PF00018	0.696
LIG_SH3_3	417	423	PF00018	0.694
LIG_SH3_3	497	503	PF00018	0.692
LIG_SH3_3	577	583	PF00018	0.693
LIG_SH3_3	639	645	PF00018	0.727
LIG_SH3_3	90	96	PF00018	0.711
LIG_SUMO_SIM_par_1	319	324	PF11976	0.671
LIG_SUMO_SIM_par_1	399	404	PF11976	0.669
LIG_SUMO_SIM_par_1	479	484	PF11976	0.674
LIG_SUMO_SIM_par_1	559	564	PF11976	0.676
LIG_TYR_ITIM	64	69	PF00017	0.549
LIG_WRC_WIRS_1	329	334	PF05994	0.666
LIG_WRC_WIRS_1	409	414	PF05994	0.660
LIG_WRC_WIRS_1	489	494	PF05994	0.660
LIG_WRC_WIRS_1	569	574	PF05994	0.666
LIG_WW_3	336	340	PF00397	0.688
LIG_WW_3	416	420	PF00397	0.685
LIG_WW_3	496	500	PF00397	0.685
LIG_WW_3	576	580	PF00397	0.690
MOD_CDK_SPxxK_3	311	318	PF00069	0.697
MOD_CDK_SPxxK_3	391	398	PF00069	0.692
MOD_CDK_SPxxK_3	471	478	PF00069	0.694
MOD_CDK_SPxxK_3	551	558	PF00069	0.698
MOD_CK1_1	124	130	PF00069	0.744
MOD_CK1_1	148	154	PF00069	0.705
MOD_CK1_1	160	166	PF00069	0.638
MOD_CK1_1	2	8	PF00069	0.339
MOD_CK1_1	235	241	PF00069	0.875
MOD_CK1_1	274	280	PF00069	0.876
MOD_CK2_1	132	138	PF00069	0.732
MOD_CK2_1	196	202	PF00069	0.801
MOD_CK2_1	345	351	PF00069	0.706
MOD_CK2_1	425	431	PF00069	0.707
MOD_CK2_1	505	511	PF00069	0.702
MOD_CK2_1	585	591	PF00069	0.708
MOD_CK2_1	614	620	PF00069	0.707
MOD_CK2_1	641	647	PF00069	0.726
MOD_DYRK1A_RPxSP_1	641	645	PF00069	0.723
MOD_GlcNHglycan	123	126	PF01048	0.615
MOD_GlcNHglycan	141	144	PF01048	0.530
MOD_GlcNHglycan	159	162	PF01048	0.501
MOD_GlcNHglycan	186	189	PF01048	0.522
MOD_GlcNHglycan	191	194	PF01048	0.512
MOD_GlcNHglycan	247	250	PF01048	0.533
MOD_GlcNHglycan	315	318	PF01048	0.621
MOD_GlcNHglycan	395	398	PF01048	0.490
MOD_GlcNHglycan	475	478	PF01048	0.490
MOD_GlcNHglycan	555	558	PF01048	0.495
MOD_GlcNHglycan	608	611	PF01048	0.525
MOD_GlcNHglycan	631	634	PF01048	0.526
MOD_GSK3_1	124	131	PF00069	0.723
MOD_GSK3_1	145	152	PF00069	0.798
MOD_GSK3_1	184	191	PF00069	0.869
MOD_GSK3_1	313	320	PF00069	0.731
MOD_GSK3_1	393	400	PF00069	0.763
MOD_GSK3_1	473	480	PF00069	0.690
MOD_GSK3_1	553	560	PF00069	0.695
MOD_GSK3_1	600	607	PF00069	0.713
MOD_GSK3_1	629	636	PF00069	0.731
MOD_GSK3_1	637	644	PF00069	0.691
MOD_GSK3_1	81	88	PF00069	0.442
MOD_LATS_1	270	276	PF00433	0.725
MOD_NEK2_1	3	8	PF00069	0.549
MOD_NEK2_1	629	634	PF00069	0.728
MOD_NEK2_1	64	69	PF00069	0.339
MOD_NEK2_1	83	88	PF00069	0.316
MOD_PIKK_1	137	143	PF00454	0.697
MOD_PKA_1	272	278	PF00069	0.729
MOD_PKA_2	245	251	PF00069	0.735
MOD_PKA_2	271	277	PF00069	0.728
MOD_PKA_2	317	323	PF00069	0.781
MOD_PKA_2	353	359	PF00069	0.823
MOD_PKA_2	397	403	PF00069	0.678
MOD_PKA_2	433	439	PF00069	0.719
MOD_PKA_2	477	483	PF00069	0.681
MOD_PKA_2	513	519	PF00069	0.711
MOD_PKA_2	557	563	PF00069	0.685
MOD_PKA_2	94	100	PF00069	0.776
MOD_PKB_1	635	643	PF00069	0.734
MOD_Plk_1	235	241	PF00069	0.875
MOD_Plk_4	64	70	PF00069	0.549
MOD_ProDKin_1	107	113	PF00069	0.792
MOD_ProDKin_1	128	134	PF00069	0.723
MOD_ProDKin_1	194	200	PF00069	0.800
MOD_ProDKin_1	252	258	PF00069	0.721
MOD_ProDKin_1	311	317	PF00069	0.696
MOD_ProDKin_1	391	397	PF00069	0.691
MOD_ProDKin_1	471	477	PF00069	0.692
MOD_ProDKin_1	551	557	PF00069	0.697
MOD_ProDKin_1	641	647	PF00069	0.726
MOD_SUMO_for_1	125	128	PF00179	0.870
TRG_DiLeu_BaLyEn_6	109	114	PF01217	0.820
TRG_DiLeu_BaLyEn_6	342	347	PF01217	0.857
TRG_DiLeu_BaLyEn_6	422	427	PF01217	0.707
TRG_DiLeu_BaLyEn_6	502	507	PF01217	0.704
TRG_DiLeu_BaLyEn_6	582	587	PF01217	0.703
TRG_ENDOCYTIC_2	134	137	PF00928	0.862
TRG_ENDOCYTIC_2	61	64	PF00928	0.588
TRG_ENDOCYTIC_2	66	69	PF00928	0.515
TRG_ER_diArg_1	241	244	PF00400	0.734
TRG_ER_diArg_1	267	269	PF00400	0.715
TRG_ER_diArg_1	634	637	PF00400	0.737

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A4HRS0	Leishmania infantum	50%	100%
E9AH09	Leishmania infantum	51%	100%