Uncharacterized protein LmxM_11_1130a_1

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

60S ribosomal protein L28, putative

Species:

Leishmania mexicana

UniProt:

E8NHE3_LEIMU

TriTrypDb:

LmxM.11.1130 , LmxM.11.1130partial

Length:

147

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 4
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 16

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 6

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 13
NetGPI	no	yes: 0, no: 13

Cellular components
Term	Name	Level	Count
GO:0005840	ribosome	5	13
GO:0032991	protein-containing complex	1	11
GO:0043226	organelle	2	13
GO:0043228	non-membrane-bounded organelle	3	13
GO:0043229	intracellular organelle	3	13
GO:0043232	intracellular non-membrane-bounded organelle	4	13
GO:0110165	cellular anatomical entity	1	14
GO:1990904	ribonucleoprotein complex	2	11
GO:0005737	cytoplasm	2	1
GO:0015934	large ribosomal subunit	4	1
GO:0022625	cytosolic large ribosomal subunit	5	1
GO:0044391	ribosomal subunit	3	1

Expansion

Sequence features

E8NHE3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E8NHE3

PDB structure(s): 6az3_Z

Function

Biological processes
Term	Name	Level	Count
GO:0006412	translation	4	11
GO:0006518	peptide metabolic process	4	11
GO:0006807	nitrogen compound metabolic process	2	11
GO:0008152	metabolic process	1	11
GO:0009058	biosynthetic process	2	11
GO:0009059	macromolecule biosynthetic process	4	11
GO:0009987	cellular process	1	11
GO:0019538	protein metabolic process	3	11
GO:0034641	cellular nitrogen compound metabolic process	3	11
GO:0034645	obsolete cellular macromolecule biosynthetic process	4	11
GO:0043043	peptide biosynthetic process	5	11
GO:0043170	macromolecule metabolic process	3	11
GO:0043603	amide metabolic process	3	11
GO:0043604	amide biosynthetic process	4	11
GO:0044237	cellular metabolic process	2	11
GO:0044238	primary metabolic process	2	11
GO:0044249	cellular biosynthetic process	3	11
GO:0044260	obsolete cellular macromolecule metabolic process	3	11
GO:0044271	cellular nitrogen compound biosynthetic process	4	11
GO:0071704	organic substance metabolic process	2	11
GO:1901564	organonitrogen compound metabolic process	3	11
GO:1901566	organonitrogen compound biosynthetic process	4	11
GO:1901576	organic substance biosynthetic process	3	11

Molecular functions
Term	Name	Level	Count
GO:0003735	structural constituent of ribosome	2	11
GO:0005198	structural molecule activity	1	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	64	68	PF00656	0.465
CLV_NRD_NRD_1	109	111	PF00675	0.351
CLV_NRD_NRD_1	112	114	PF00675	0.351
CLV_NRD_NRD_1	127	129	PF00675	0.362
CLV_NRD_NRD_1	138	140	PF00675	0.593
CLV_NRD_NRD_1	78	80	PF00675	0.332
CLV_PCSK_FUR_1	110	114	PF00082	0.471
CLV_PCSK_FUR_1	143	147	PF00082	0.617
CLV_PCSK_KEX2_1	109	111	PF00082	0.351
CLV_PCSK_KEX2_1	112	114	PF00082	0.351
CLV_PCSK_KEX2_1	145	147	PF00082	0.628
CLV_PCSK_KEX2_1	21	23	PF00082	0.340
CLV_PCSK_KEX2_1	40	42	PF00082	0.342
CLV_PCSK_PC1ET2_1	145	147	PF00082	0.628
CLV_PCSK_PC1ET2_1	21	23	PF00082	0.360
CLV_PCSK_PC1ET2_1	40	42	PF00082	0.351
CLV_PCSK_PC7_1	17	23	PF00082	0.469
CLV_PCSK_SKI1_1	120	124	PF00082	0.571
CLV_PCSK_SKI1_1	131	135	PF00082	0.577
CLV_PCSK_SKI1_1	54	58	PF00082	0.446
DEG_APCC_DBOX_1	99	107	PF00400	0.351
DOC_MAPK_gen_1	128	137	PF00069	0.582
DOC_MAPK_gen_1	54	63	PF00069	0.366
DOC_MAPK_MEF2A_6	57	65	PF00069	0.471
DOC_MAPK_RevD_3	97	110	PF00069	0.366
DOC_PP1_RVXF_1	132	138	PF00149	0.608
DOC_USP7_MATH_1	104	108	PF00917	0.497
DOC_USP7_MATH_1	31	35	PF00917	0.201
LIG_14-3-3_CanoR_1	128	137	PF00244	0.641
LIG_14-3-3_CanoR_1	139	143	PF00244	0.577
LIG_14-3-3_CanoR_1	79	83	PF00244	0.367
LIG_14-3-3_CanoR_1	88	96	PF00244	0.259
LIG_AP2alpha_2	30	32	PF02296	0.366
LIG_BIR_II_1	1	5	PF00653	0.667
LIG_FHA_1	119	125	PF00498	0.619
LIG_FHA_2	62	68	PF00498	0.385
LIG_LIR_Nem_3	6	12	PF02991	0.360
LIG_PTB_Apo_2	26	33	PF02174	0.469
LIG_RPA_C_Fungi	134	146	PF08784	0.735
LIG_SH3_3	49	55	PF00018	0.470
MOD_CK1_1	138	144	PF00069	0.710
MOD_CK1_1	90	96	PF00069	0.366
MOD_GlcNHglycan	131	134	PF01048	0.568
MOD_GlcNHglycan	3	6	PF01048	0.504
MOD_GSK3_1	129	136	PF00069	0.508
MOD_N-GLC_1	36	41	PF02516	0.350
MOD_NEK2_2	104	109	PF00069	0.457
MOD_NEK2_2	78	83	PF00069	0.468
MOD_PKA_2	138	144	PF00069	0.661
MOD_PKA_2	25	31	PF00069	0.341
MOD_PKA_2	78	84	PF00069	0.367
MOD_PKA_2	87	93	PF00069	0.259
MOD_Plk_1	104	110	PF00069	0.457
TRG_ER_diArg_1	108	110	PF00400	0.351
TRG_ER_diArg_1	112	114	PF00400	0.351
TRG_NLS_Bipartite_1	112	132	PF00514	0.622

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HQW7	Leptomonas seymouri	83%	100%
A0A0S4IQT0	Bodo saltans	59%	100%
A0A1X0NUX0	Trypanosomatidae	70%	100%
A0A3Q8I930	Leishmania donovani	95%	100%
A0A3Q8I959	Leishmania donovani	95%	100%
A0A3R7M2X2	Trypanosoma rangeli	67%	100%
A0A422NRH0	Trypanosoma rangeli	68%	100%
A4H6N5	Leishmania braziliensis	86%	100%
A4H6N7	Leishmania braziliensis	83%	100%
A4HV19	Leishmania infantum	95%	100%
D0A7C8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	63%	100%
O00822	Trypanosoma cruzi	66%	100%
P41105	Mus musculus	35%	100%
P46779	Homo sapiens	35%	100%
Q3T0L7	Bos taurus	35%	100%
Q4QGW7	Leishmania major	94%	100%