WGS CADB00000000 data, contig 100

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

amastin-like surface protein, putative

Species:

Leishmania mexicana

UniProt:

E8NHD6_LEIMU

TriTrypDb:

LmxM.33.1920

Length:

130

Annotations

LeishMANIAdb annotations

Publication identifier(s): 26641088 15760660
Amastin, Kinetoplastid host adhesion protein. A host adhesion protein family greatly expanded in Leishmaniids.. Localization: Cell surface (experimental)

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 6, no: 84
NetGPI	no	yes: 0, no: 90

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	82
GO:0110165	cellular anatomical entity	1	82

Expansion

Sequence features

E8NHD6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E8NHD6

Function

Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0016485	protein processing	5	1
GO:0016540	protein autoprocessing	6	1
GO:0019538	protein metabolic process	3	1
GO:0043170	macromolecule metabolic process	3	1
GO:0044238	primary metabolic process	2	1
GO:0051604	protein maturation	4	1
GO:0071704	organic substance metabolic process	2	1
GO:1901564	organonitrogen compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	1
GO:0004175	endopeptidase activity	4	1
GO:0004197	cysteine-type endopeptidase activity	5	1
GO:0008233	peptidase activity	3	1
GO:0008234	cysteine-type peptidase activity	4	1
GO:0016787	hydrolase activity	2	1
GO:0140096	catalytic activity, acting on a protein	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
DEG_Nend_Nbox_1	1	3	PF02207	0.551
DOC_MAPK_gen_1	80	89	PF00069	0.411
DOC_MAPK_HePTP_8	81	93	PF00069	0.408
DOC_MAPK_MEF2A_6	45	53	PF00069	0.398
DOC_MAPK_MEF2A_6	82	91	PF00069	0.468
DOC_PP2B_LxvP_1	108	111	PF13499	0.525
DOC_SPAK_OSR1_1	12	16	PF12202	0.414
DOC_USP7_MATH_1	76	80	PF00917	0.485
LIG_Actin_WH2_2	31	47	PF00022	0.398
LIG_FHA_1	30	36	PF00498	0.293
LIG_FHA_1	56	62	PF00498	0.428
LIG_FHA_1	84	90	PF00498	0.491
LIG_LIR_Gen_1	42	51	PF02991	0.267
LIG_LIR_Gen_1	69	76	PF02991	0.419
LIG_LIR_Nem_3	42	46	PF02991	0.334
LIG_LIR_Nem_3	69	73	PF02991	0.424
LIG_Pex14_2	39	43	PF04695	0.490
LIG_PTB_Apo_2	101	108	PF02174	0.296
LIG_SH2_NCK_1	70	74	PF00017	0.492
LIG_SH2_STAT3	126	129	PF00017	0.351
LIG_SH2_STAT5	126	129	PF00017	0.359
LIG_SH2_STAT5	27	30	PF00017	0.478
LIG_SH3_3	70	76	PF00018	0.538
LIG_TRAF2_1	127	130	PF00917	0.414
LIG_TRFH_1	107	111	PF08558	0.316
LIG_TYR_ITIM	68	73	PF00017	0.210
MOD_CK1_1	117	123	PF00069	0.598
MOD_CK1_1	8	14	PF00069	0.326
MOD_CK2_1	124	130	PF00069	0.489
MOD_GSK3_1	120	127	PF00069	0.647
MOD_GSK3_1	29	36	PF00069	0.319
MOD_NEK2_1	2	7	PF00069	0.454
MOD_NEK2_1	39	44	PF00069	0.494
MOD_NEK2_1	66	71	PF00069	0.364
MOD_PIKK_1	109	115	PF00454	0.356
MOD_PKA_2	114	120	PF00069	0.385
MOD_PKA_2	8	14	PF00069	0.278
MOD_PKA_2	83	89	PF00069	0.227
MOD_Plk_4	33	39	PF00069	0.436
TRG_ENDOCYTIC_2	70	73	PF00928	0.268
TRG_NES_CRM1_1	101	113	PF08389	0.278

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P547	Leptomonas seymouri	38%	84%
A0A0N1HWY5	Leptomonas seymouri	27%	67%
A0A1X0P988	Trypanosomatidae	37%	75%
A0A381MTA7	Leishmania infantum	53%	68%
A0A381MTB8	Leishmania infantum	53%	67%
A0A381MTN2	Leishmania infantum	50%	67%
A0A381MVY0	Leishmania infantum	54%	68%
A0A3Q8IEC2	Leishmania donovani	54%	67%
A0A3Q8IEI1	Leishmania donovani	54%	68%
A0A3Q8IH65	Leishmania donovani	54%	67%
A0A3Q8IHN2	Leishmania donovani	53%	68%
A0A3Q8IHW7	Leishmania donovani	60%	71%
A0A3Q8IIH1	Leishmania donovani	54%	67%
A0A3Q8IL03	Leishmania donovani	48%	68%
A0A3Q8IUK8	Leishmania donovani	55%	68%
A0A3Q8IUR5	Leishmania donovani	50%	67%
A0A3R7ND49	Trypanosoma rangeli	37%	100%
A0A3S5H666	Leishmania donovani	46%	67%
A0A3S7WQA8	Leishmania donovani	54%	74%
A0A3S7WQC1	Leishmania donovani	49%	67%
A0A3S7X2E6	Leishmania donovani	54%	67%
A0A3S7X7Y0	Leishmania donovani	47%	67%
A4H5D1	Leishmania braziliensis	52%	67%
A4H5D2	Leishmania braziliensis	36%	70%
A4H5G0	Leishmania braziliensis	53%	70%
A4H5G9	Leishmania braziliensis	52%	70%
A4H5H0	Leishmania braziliensis	53%	69%
A4H5H1	Leishmania braziliensis	51%	70%
A4H5H2	Leishmania braziliensis	50%	100%
A4H7D7	Leishmania braziliensis	51%	67%
A4H9E9	Leishmania braziliensis	48%	67%
A4HAL1	Leishmania braziliensis	52%	100%
A4HAL2	Leishmania braziliensis	31%	67%
A4HAM2	Leishmania braziliensis	46%	68%
A4HAM4	Leishmania braziliensis	45%	68%
A4HAR1	Leishmania braziliensis	46%	68%
A4HAZ8	Leishmania braziliensis	50%	69%
A4HB00	Leishmania braziliensis	45%	68%
A4HB02	Leishmania braziliensis	47%	100%
A4HBJ0	Leishmania braziliensis	52%	68%
A4HBJ1	Leishmania braziliensis	46%	68%
A4HTM3	Leishmania infantum	47%	67%
A4HTM4	Leishmania infantum	54%	74%
A4HTM5	Leishmania infantum	49%	67%
A4I9Q4	Leishmania infantum	49%	77%
A4IAL7	Leishmania infantum	61%	71%
A4IAM1	Leishmania infantum	53%	68%
A4IAM2	Leishmania infantum	52%	68%
E8NHD9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	53%	71%
E8NHF5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	100%	68%
E8NHF7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	51%	67%
E8NHG1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	52%	100%
E8NHI3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	45%	67%
E8NHI5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	57%	68%
E8NHK9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	55%	67%
E8NHL7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	58%	67%
E8NHL9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	55%	67%
E8NHM0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	100%	69%
E8NHM1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	51%	67%
E8NHM6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	50%	68%
E8NHM7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	51%	93%
E8NHQ1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	50%	67%
E8NHR7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	50%	67%
E8NHR8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	53%	67%
E9AHI9	Leishmania infantum	55%	67%
E9AME9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	50%	74%
E9AMF0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	52%	71%
E9AMF2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	49%	67%
E9AMF3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	46%	67%
E9AMF7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	46%	79%
E9AMF8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	47%	67%
E9AMF9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	41%	68%
E9B1J3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	46%	67%
E9B4R8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	44%	66%
Q4Q1U9	Leishmania major	56%	100%
Q4Q305	Leishmania major	55%	100%
Q4Q313	Leishmania major	55%	100%
Q4Q327	Leishmania major	52%	100%
Q4Q329	Leishmania major	56%	100%
Q4Q333	Leishmania major	55%	100%
Q4Q335	Leishmania major	55%	100%
Q4Q337	Leishmania major	61%	100%
Q4Q339	Leishmania major	55%	100%
Q4Q341	Leishmania major	65%	74%
Q4QI84	Leishmania major	53%	74%
Q4QI85	Leishmania major	48%	100%
Q4QI86	Leishmania major	51%	74%
Q4QI87	Leishmania major	49%	100%
Q4QI88	Leishmania major	49%	70%