PSP1 C-terminal domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

E8NHD4_LEIBR

TriTrypDb:

LbrM.02.0740 , LBRM2903_020005900 , LBRM2903_020006000

Length:

933

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 4
NetGPI	no	yes: 0, no: 4

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E8NHD4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E8NHD4

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	5
GO:0043167	ion binding	2	5
GO:0043169	cation binding	3	5
GO:0046872	metal ion binding	4	5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	35	39	PF00656	0.599
CLV_C14_Caspase3-7	454	458	PF00656	0.631
CLV_NRD_NRD_1	116	118	PF00675	0.573
CLV_NRD_NRD_1	316	318	PF00675	0.831
CLV_NRD_NRD_1	472	474	PF00675	0.589
CLV_NRD_NRD_1	485	487	PF00675	0.593
CLV_NRD_NRD_1	552	554	PF00675	0.369
CLV_NRD_NRD_1	919	921	PF00675	0.536
CLV_NRD_NRD_1	927	929	PF00675	0.621
CLV_PCSK_KEX2_1	116	118	PF00082	0.573
CLV_PCSK_KEX2_1	315	317	PF00082	0.676
CLV_PCSK_KEX2_1	472	474	PF00082	0.575
CLV_PCSK_KEX2_1	552	554	PF00082	0.369
CLV_PCSK_KEX2_1	712	714	PF00082	0.409
CLV_PCSK_KEX2_1	919	921	PF00082	0.536
CLV_PCSK_KEX2_1	927	929	PF00082	0.621
CLV_PCSK_KEX2_1	931	933	PF00082	0.614
CLV_PCSK_PC1ET2_1	712	714	PF00082	0.409
CLV_PCSK_PC7_1	927	933	PF00082	0.545
DEG_COP1_1	442	452	PF00400	0.588
DEG_Nend_UBRbox_3	1	3	PF02207	0.614
DEG_ODPH_VHL_1	846	857	PF01847	0.499
DEG_SPOP_SBC_1	101	105	PF00917	0.681
DEG_SPOP_SBC_1	124	128	PF00917	0.603
DEG_SPOP_SBC_1	254	258	PF00917	0.528
DEG_SPOP_SBC_1	278	282	PF00917	0.636
DEG_SPOP_SBC_1	424	428	PF00917	0.582
DOC_CKS1_1	459	464	PF01111	0.627
DOC_CYCLIN_yCln2_LP_2	812	815	PF00134	0.568
DOC_CYCLIN_yCln2_LP_2	820	826	PF00134	0.586
DOC_MAPK_gen_1	786	796	PF00069	0.515
DOC_PP2B_LxvP_1	144	147	PF13499	0.644
DOC_PP2B_LxvP_1	460	463	PF13499	0.574
DOC_PP2B_LxvP_1	812	815	PF13499	0.594
DOC_PP4_FxxP_1	205	208	PF00568	0.570
DOC_USP7_MATH_1	137	141	PF00917	0.667
DOC_USP7_MATH_1	171	175	PF00917	0.607
DOC_USP7_MATH_1	181	185	PF00917	0.643
DOC_USP7_MATH_1	193	197	PF00917	0.578
DOC_USP7_MATH_1	254	258	PF00917	0.528
DOC_USP7_MATH_1	278	282	PF00917	0.663
DOC_USP7_MATH_1	285	289	PF00917	0.601
DOC_USP7_MATH_1	320	324	PF00917	0.690
DOC_USP7_MATH_1	374	378	PF00917	0.640
DOC_USP7_MATH_1	388	392	PF00917	0.565
DOC_USP7_MATH_1	400	404	PF00917	0.594
DOC_USP7_MATH_1	424	428	PF00917	0.616
DOC_USP7_MATH_1	443	447	PF00917	0.611
DOC_USP7_MATH_1	539	543	PF00917	0.469
DOC_USP7_MATH_1	56	60	PF00917	0.616
DOC_USP7_MATH_1	787	791	PF00917	0.514
DOC_USP7_MATH_1	89	93	PF00917	0.590
DOC_WW_Pin1_4	127	132	PF00397	0.605
DOC_WW_Pin1_4	139	144	PF00397	0.565
DOC_WW_Pin1_4	159	164	PF00397	0.492
DOC_WW_Pin1_4	191	196	PF00397	0.614
DOC_WW_Pin1_4	204	209	PF00397	0.616
DOC_WW_Pin1_4	321	326	PF00397	0.685
DOC_WW_Pin1_4	356	361	PF00397	0.579
DOC_WW_Pin1_4	384	389	PF00397	0.587
DOC_WW_Pin1_4	458	463	PF00397	0.623
DOC_WW_Pin1_4	488	493	PF00397	0.596
DOC_WW_Pin1_4	501	506	PF00397	0.424
DOC_WW_Pin1_4	647	652	PF00397	0.374
DOC_WW_Pin1_4	70	75	PF00397	0.595
DOC_WW_Pin1_4	807	812	PF00397	0.525
LIG_14-3-3_CanoR_1	122	131	PF00244	0.685
LIG_14-3-3_CanoR_1	178	188	PF00244	0.594
LIG_14-3-3_CanoR_1	219	227	PF00244	0.595
LIG_14-3-3_CanoR_1	237	245	PF00244	0.647
LIG_14-3-3_CanoR_1	286	296	PF00244	0.606
LIG_14-3-3_CanoR_1	366	372	PF00244	0.544
LIG_14-3-3_CanoR_1	375	379	PF00244	0.518
LIG_14-3-3_CanoR_1	596	605	PF00244	0.422
LIG_14-3-3_CanoR_1	641	645	PF00244	0.475
LIG_14-3-3_CanoR_1	722	728	PF00244	0.304
LIG_14-3-3_CanoR_1	786	796	PF00244	0.515
LIG_BIR_III_4	38	42	PF00653	0.598
LIG_BRCT_BRCA1_1	363	367	PF00533	0.548
LIG_BRCT_BRCA1_1	719	723	PF00533	0.416
LIG_BRCT_BRCA1_1	759	763	PF00533	0.508
LIG_deltaCOP1_diTrp_1	17	22	PF00928	0.579
LIG_deltaCOP1_diTrp_1	433	438	PF00928	0.574
LIG_EH1_1	626	634	PF00400	0.439
LIG_FHA_1	108	114	PF00498	0.633
LIG_FHA_1	240	246	PF00498	0.641
LIG_FHA_1	511	517	PF00498	0.473
LIG_FHA_1	624	630	PF00498	0.519
LIG_FHA_1	648	654	PF00498	0.429
LIG_FHA_1	896	902	PF00498	0.561
LIG_FHA_1	911	917	PF00498	0.500
LIG_FHA_1	921	927	PF00498	0.505
LIG_FHA_2	288	294	PF00498	0.557
LIG_FHA_2	459	465	PF00498	0.581
LIG_FHA_2	801	807	PF00498	0.572
LIG_IBAR_NPY_1	119	121	PF08397	0.665
LIG_Integrin_isoDGR_2	766	768	PF01839	0.498
LIG_LIR_Apic_2	17	23	PF02991	0.577
LIG_LIR_Apic_2	204	208	PF02991	0.573
LIG_LIR_Gen_1	288	296	PF02991	0.557
LIG_LIR_Gen_1	364	374	PF02991	0.503
LIG_LIR_Nem_3	288	292	PF02991	0.557
LIG_LIR_Nem_3	364	370	PF02991	0.504
LIG_LIR_Nem_3	542	547	PF02991	0.344
LIG_LIR_Nem_3	643	649	PF02991	0.439
LIG_LIR_Nem_3	665	669	PF02991	0.334
LIG_LYPXL_S_1	867	871	PF13949	0.593
LIG_LYPXL_yS_3	646	649	PF13949	0.410
LIG_LYPXL_yS_3	868	871	PF13949	0.593
LIG_MYND_1	811	815	PF01753	0.516
LIG_NRBOX	511	517	PF00104	0.389
LIG_NRP_CendR_1	931	933	PF00754	0.553
LIG_PTB_Apo_2	5	12	PF02174	0.577
LIG_SH2_CRK	571	575	PF00017	0.419
LIG_SH2_GRB2like	854	857	PF00017	0.520
LIG_SH2_NCK_1	289	293	PF00017	0.642
LIG_SH2_PTP2	854	857	PF00017	0.492
LIG_SH2_SRC	592	595	PF00017	0.375
LIG_SH2_SRC	605	608	PF00017	0.343
LIG_SH2_SRC	854	857	PF00017	0.520
LIG_SH2_STAT3	188	191	PF00017	0.689
LIG_SH2_STAT3	578	581	PF00017	0.386
LIG_SH2_STAT5	289	292	PF00017	0.558
LIG_SH2_STAT5	555	558	PF00017	0.354
LIG_SH2_STAT5	592	595	PF00017	0.430
LIG_SH2_STAT5	605	608	PF00017	0.288
LIG_SH2_STAT5	854	857	PF00017	0.520
LIG_SH3_1	189	195	PF00018	0.593
LIG_SH3_2	192	197	PF14604	0.587
LIG_SH3_2	415	420	PF14604	0.600
LIG_SH3_3	157	163	PF00018	0.564
LIG_SH3_3	165	171	PF00018	0.553
LIG_SH3_3	189	195	PF00018	0.593
LIG_SH3_3	373	379	PF00018	0.548
LIG_SH3_3	409	415	PF00018	0.657
LIG_SH3_3	447	453	PF00018	0.669
LIG_SH3_3	460	466	PF00018	0.563
LIG_SH3_3	489	495	PF00018	0.595
LIG_SH3_3	533	539	PF00018	0.482
LIG_SH3_3	654	660	PF00018	0.393
LIG_SH3_3	732	738	PF00018	0.506
LIG_SH3_3	779	785	PF00018	0.559
LIG_SH3_3	792	798	PF00018	0.548
LIG_SH3_3	808	814	PF00018	0.482
LIG_SH3_3	863	869	PF00018	0.495
LIG_SH3_3	882	888	PF00018	0.489
LIG_SUMO_SIM_anti_2	255	265	PF11976	0.607
LIG_SUMO_SIM_anti_2	882	888	PF11976	0.542
LIG_SUMO_SIM_anti_2	912	918	PF11976	0.537
LIG_SUMO_SIM_par_1	872	878	PF11976	0.513
LIG_TRAF2_1	803	806	PF00917	0.603
LIG_TRFH_1	188	192	PF08558	0.602
LIG_TYR_ITIM	569	574	PF00017	0.427
LIG_TYR_ITIM	644	649	PF00017	0.429
LIG_WW_2	738	741	PF00397	0.498
MOD_CDC14_SPxK_1	194	197	PF00782	0.585
MOD_CDK_SPK_2	131	136	PF00069	0.676
MOD_CDK_SPK_2	204	209	PF00069	0.662
MOD_CDK_SPxK_1	191	197	PF00069	0.588
MOD_CDK_SPxxK_3	70	77	PF00069	0.589
MOD_CK1_1	104	110	PF00069	0.681
MOD_CK1_1	125	131	PF00069	0.684
MOD_CK1_1	155	161	PF00069	0.574
MOD_CK1_1	174	180	PF00069	0.605
MOD_CK1_1	218	224	PF00069	0.685
MOD_CK1_1	225	231	PF00069	0.579
MOD_CK1_1	239	245	PF00069	0.539
MOD_CK1_1	258	264	PF00069	0.489
MOD_CK1_1	281	287	PF00069	0.660
MOD_CK1_1	288	294	PF00069	0.589
MOD_CK1_1	318	324	PF00069	0.687
MOD_CK1_1	32	38	PF00069	0.600
MOD_CK1_1	334	340	PF00069	0.587
MOD_CK1_1	343	349	PF00069	0.527
MOD_CK1_1	423	429	PF00069	0.679
MOD_CK1_1	458	464	PF00069	0.581
MOD_CK1_1	501	507	PF00069	0.452
MOD_CK1_1	510	516	PF00069	0.354
MOD_CK1_1	542	548	PF00069	0.427
MOD_CK1_1	59	65	PF00069	0.618
MOD_CK1_1	612	618	PF00069	0.432
MOD_CK2_1	179	185	PF00069	0.678
MOD_CK2_1	423	429	PF00069	0.679
MOD_CK2_1	570	576	PF00069	0.432
MOD_CK2_1	59	65	PF00069	0.620
MOD_CK2_1	596	602	PF00069	0.351
MOD_CK2_1	800	806	PF00069	0.570
MOD_GlcNHglycan	139	142	PF01048	0.663
MOD_GlcNHglycan	155	158	PF01048	0.534
MOD_GlcNHglycan	197	200	PF01048	0.596
MOD_GlcNHglycan	221	224	PF01048	0.626
MOD_GlcNHglycan	257	260	PF01048	0.618
MOD_GlcNHglycan	274	278	PF01048	0.673
MOD_GlcNHglycan	281	284	PF01048	0.665
MOD_GlcNHglycan	31	34	PF01048	0.603
MOD_GlcNHglycan	317	320	PF01048	0.709
MOD_GlcNHglycan	333	336	PF01048	0.745
MOD_GlcNHglycan	342	345	PF01048	0.585
MOD_GlcNHglycan	394	397	PF01048	0.595
MOD_GlcNHglycan	409	412	PF01048	0.569
MOD_GlcNHglycan	422	425	PF01048	0.571
MOD_GlcNHglycan	439	442	PF01048	0.629
MOD_GlcNHglycan	50	53	PF01048	0.517
MOD_GlcNHglycan	500	503	PF01048	0.589
MOD_GlcNHglycan	548	551	PF01048	0.365
MOD_GlcNHglycan	58	61	PF01048	0.557
MOD_GlcNHglycan	598	601	PF01048	0.436
MOD_GlcNHglycan	688	691	PF01048	0.509
MOD_GlcNHglycan	749	752	PF01048	0.502
MOD_GlcNHglycan	759	762	PF01048	0.512
MOD_GlcNHglycan	816	819	PF01048	0.590
MOD_GlcNHglycan	82	85	PF01048	0.591
MOD_GlcNHglycan	92	95	PF01048	0.586
MOD_GSK3_1	100	107	PF00069	0.681
MOD_GSK3_1	120	127	PF00069	0.528
MOD_GSK3_1	155	162	PF00069	0.601
MOD_GSK3_1	191	198	PF00069	0.672
MOD_GSK3_1	213	220	PF00069	0.608
MOD_GSK3_1	222	229	PF00069	0.518
MOD_GSK3_1	249	256	PF00069	0.637
MOD_GSK3_1	25	32	PF00069	0.604
MOD_GSK3_1	258	265	PF00069	0.580
MOD_GSK3_1	269	276	PF00069	0.506
MOD_GSK3_1	277	284	PF00069	0.581
MOD_GSK3_1	336	343	PF00069	0.580
MOD_GSK3_1	347	354	PF00069	0.531
MOD_GSK3_1	361	368	PF00069	0.544
MOD_GSK3_1	384	391	PF00069	0.611
MOD_GSK3_1	400	407	PF00069	0.584
MOD_GSK3_1	416	423	PF00069	0.580
MOD_GSK3_1	451	458	PF00069	0.613
MOD_GSK3_1	493	500	PF00069	0.619
MOD_GSK3_1	501	508	PF00069	0.490
MOD_GSK3_1	542	549	PF00069	0.433
MOD_GSK3_1	605	612	PF00069	0.415
MOD_GSK3_1	682	689	PF00069	0.374
MOD_GSK3_1	814	821	PF00069	0.518
MOD_LATS_1	594	600	PF00433	0.360
MOD_N-GLC_1	101	106	PF02516	0.654
MOD_N-GLC_1	351	356	PF02516	0.595
MOD_N-GLC_1	443	448	PF02516	0.588
MOD_N-GLC_1	488	493	PF02516	0.596
MOD_N-GLC_1	855	860	PF02516	0.538
MOD_N-GLC_1	910	915	PF02516	0.500
MOD_NEK2_1	217	222	PF00069	0.721
MOD_NEK2_1	262	267	PF00069	0.566
MOD_NEK2_1	296	301	PF00069	0.623
MOD_NEK2_1	351	356	PF00069	0.620
MOD_NEK2_1	365	370	PF00069	0.580
MOD_NEK2_1	507	512	PF00069	0.454
MOD_NEK2_1	609	614	PF00069	0.450
MOD_NEK2_1	717	722	PF00069	0.407
MOD_NEK2_1	723	728	PF00069	0.332
MOD_NEK2_1	903	908	PF00069	0.542
MOD_NEK2_2	361	366	PF00069	0.559
MOD_NEK2_2	605	610	PF00069	0.327
MOD_OFUCOSY	226	233	PF10250	0.549
MOD_OFUCOSY	715	721	PF10250	0.396
MOD_PIKK_1	507	513	PF00454	0.456
MOD_PIKK_1	539	545	PF00454	0.456
MOD_PIKK_1	577	583	PF00454	0.384
MOD_PIKK_1	612	618	PF00454	0.432
MOD_PIKK_1	682	688	PF00454	0.391
MOD_PIKK_1	787	793	PF00454	0.515
MOD_PIKK_1	841	847	PF00454	0.625
MOD_PK_1	366	372	PF00069	0.544
MOD_PKA_1	315	321	PF00069	0.680
MOD_PKA_2	153	159	PF00069	0.615
MOD_PKA_2	174	180	PF00069	0.672
MOD_PKA_2	213	219	PF00069	0.627
MOD_PKA_2	236	242	PF00069	0.647
MOD_PKA_2	285	291	PF00069	0.565
MOD_PKA_2	315	321	PF00069	0.680
MOD_PKA_2	365	371	PF00069	0.543
MOD_PKA_2	374	380	PF00069	0.520
MOD_PKA_2	416	422	PF00069	0.686
MOD_PKA_2	595	601	PF00069	0.439
MOD_PKA_2	640	646	PF00069	0.471
MOD_Plk_1	400	406	PF00069	0.594
MOD_Plk_1	696	702	PF00069	0.438
MOD_Plk_1	910	916	PF00069	0.504
MOD_Plk_4	201	207	PF00069	0.667
MOD_Plk_4	258	264	PF00069	0.556
MOD_Plk_4	336	342	PF00069	0.581
MOD_Plk_4	451	457	PF00069	0.589
MOD_Plk_4	605	611	PF00069	0.415
MOD_Plk_4	696	702	PF00069	0.438
MOD_Plk_4	723	729	PF00069	0.379
MOD_Plk_4	880	886	PF00069	0.538
MOD_ProDKin_1	127	133	PF00069	0.605
MOD_ProDKin_1	139	145	PF00069	0.563
MOD_ProDKin_1	159	165	PF00069	0.495
MOD_ProDKin_1	191	197	PF00069	0.617
MOD_ProDKin_1	204	210	PF00069	0.616
MOD_ProDKin_1	321	327	PF00069	0.685
MOD_ProDKin_1	356	362	PF00069	0.577
MOD_ProDKin_1	384	390	PF00069	0.589
MOD_ProDKin_1	458	464	PF00069	0.627
MOD_ProDKin_1	488	494	PF00069	0.595
MOD_ProDKin_1	501	507	PF00069	0.406
MOD_ProDKin_1	647	653	PF00069	0.370
MOD_ProDKin_1	70	76	PF00069	0.592
MOD_ProDKin_1	807	813	PF00069	0.526
TRG_DiLeu_BaLyEn_6	808	813	PF01217	0.526
TRG_ENDOCYTIC_2	289	292	PF00928	0.558
TRG_ENDOCYTIC_2	571	574	PF00928	0.420
TRG_ENDOCYTIC_2	646	649	PF00928	0.410
TRG_ENDOCYTIC_2	854	857	PF00928	0.526
TRG_ENDOCYTIC_2	868	871	PF00928	0.573
TRG_ER_diArg_1	115	117	PF00400	0.574
TRG_ER_diArg_1	315	317	PF00400	0.676
TRG_ER_diArg_1	551	553	PF00400	0.376
TRG_ER_diArg_1	701	704	PF00400	0.443
TRG_ER_diArg_1	919	921	PF00400	0.528
TRG_ER_diArg_1	926	928	PF00400	0.620
TRG_ER_diArg_1	931	933	PF00400	0.609

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S5H4Y2	Leishmania donovani	56%	96%
A4HRL3	Leishmania infantum	57%	100%
E9AI19	Leishmania braziliensis	98%	100%