LeishMANIAdb
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Sodium stibogluconate resistance protein, putative

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Sodium stibogluconate resistance protein, putative
Gene product:
sodium stibogluconate resistance protein - putative
Species:
Leishmania infantum
UniProt:
E8NHD2_LEIIN
TriTrypDb:
LINF_310015600
Length:
459

Annotations

LeishMANIAdb annotations

Although predicted to have a multi-helical architecture, the protein is not hydrophobic enough for a membrane protein.. Unique to kinetoplastids, fast-evolving and duplicated multiple times.

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 2
Forrest at al. (procyclic) no yes: 2
Silverman et al. no yes: 0
Pissara et al. no yes: 15
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 5
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 19
NetGPI no yes: 0, no: 19
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E8NHD2
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E8NHD2

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 144 146 PF00675 0.661
CLV_NRD_NRD_1 378 380 PF00675 0.751
CLV_NRD_NRD_1 415 417 PF00675 0.528
CLV_NRD_NRD_1 453 455 PF00675 0.551
CLV_PCSK_KEX2_1 363 365 PF00082 0.733
CLV_PCSK_KEX2_1 377 379 PF00082 0.522
CLV_PCSK_PC1ET2_1 363 365 PF00082 0.754
CLV_PCSK_PC1ET2_1 377 379 PF00082 0.522
CLV_PCSK_PC7_1 374 380 PF00082 0.684
CLV_PCSK_SKI1_1 163 167 PF00082 0.607
CLV_PCSK_SKI1_1 364 368 PF00082 0.698
CLV_PCSK_SKI1_1 53 57 PF00082 0.545
CLV_PCSK_SKI1_1 70 74 PF00082 0.617
DEG_APCC_DBOX_1 192 200 PF00400 0.713
DEG_Nend_UBRbox_2 1 3 PF02207 0.376
DOC_MAPK_MEF2A_6 391 398 PF00069 0.626
DOC_PP1_RVXF_1 207 214 PF00149 0.727
DOC_PP1_SILK_1 450 455 PF00149 0.484
DOC_PP2B_LxvP_1 317 320 PF13499 0.743
DOC_USP7_MATH_1 186 190 PF00917 0.686
DOC_USP7_MATH_1 230 234 PF00917 0.758
DOC_USP7_MATH_1 284 288 PF00917 0.616
DOC_USP7_MATH_1 300 304 PF00917 0.530
DOC_USP7_MATH_1 441 445 PF00917 0.532
DOC_USP7_MATH_2 173 179 PF00917 0.675
DOC_USP7_MATH_2 263 269 PF00917 0.669
DOC_USP7_UBL2_3 94 98 PF12436 0.585
DOC_WW_Pin1_4 226 231 PF00397 0.783
DOC_WW_Pin1_4 259 264 PF00397 0.776
LIG_14-3-3_CanoR_1 104 109 PF00244 0.688
LIG_14-3-3_CanoR_1 140 147 PF00244 0.452
LIG_14-3-3_CanoR_1 254 260 PF00244 0.719
LIG_14-3-3_CanoR_1 266 270 PF00244 0.540
LIG_Actin_WH2_2 276 294 PF00022 0.685
LIG_BRCT_BRCA1_1 106 110 PF00533 0.650
LIG_CSL_BTD_1 227 230 PF09270 0.769
LIG_EH1_1 446 454 PF00400 0.523
LIG_eIF4E_1 122 128 PF01652 0.373
LIG_FHA_1 103 109 PF00498 0.682
LIG_FHA_1 276 282 PF00498 0.544
LIG_FHA_1 40 46 PF00498 0.580
LIG_FHA_2 308 314 PF00498 0.730
LIG_GBD_Chelix_1 449 457 PF00786 0.488
LIG_LIR_Gen_1 13 22 PF02991 0.591
LIG_LIR_Gen_1 137 143 PF02991 0.599
LIG_LIR_Gen_1 443 453 PF02991 0.562
LIG_LIR_Gen_1 65 74 PF02991 0.681
LIG_LIR_Nem_3 13 17 PF02991 0.440
LIG_LIR_Nem_3 137 141 PF02991 0.597
LIG_LIR_Nem_3 2 7 PF02991 0.429
LIG_LIR_Nem_3 303 308 PF02991 0.691
LIG_LIR_Nem_3 443 449 PF02991 0.491
LIG_LIR_Nem_3 65 69 PF02991 0.665
LIG_PCNA_yPIPBox_3 140 151 PF02747 0.423
LIG_PTB_Apo_2 270 277 PF02174 0.457
LIG_SH2_CRK 122 126 PF00017 0.554
LIG_SH2_CRK 130 134 PF00017 0.496
LIG_SH2_CRK 138 142 PF00017 0.443
LIG_SH2_CRK 4 8 PF00017 0.604
LIG_SH2_CRK 66 70 PF00017 0.648
LIG_SH2_GRB2like 151 154 PF00017 0.428
LIG_SH2_GRB2like 271 274 PF00017 0.463
LIG_SH2_GRB2like 380 383 PF00017 0.605
LIG_SH2_SRC 151 154 PF00017 0.422
LIG_SH2_SRC 380 383 PF00017 0.563
LIG_SH2_STAP1 151 155 PF00017 0.414
LIG_SH2_STAP1 308 312 PF00017 0.688
LIG_SH2_STAT5 122 125 PF00017 0.569
LIG_SH2_STAT5 130 133 PF00017 0.463
LIG_SH2_STAT5 14 17 PF00017 0.611
LIG_SH2_STAT5 176 179 PF00017 0.671
LIG_SH2_STAT5 271 274 PF00017 0.694
LIG_SH2_STAT5 34 37 PF00017 0.301
LIG_SH2_STAT5 380 383 PF00017 0.605
LIG_SH3_3 224 230 PF00018 0.778
LIG_SH3_3 278 284 PF00018 0.700
LIG_SH3_3 332 338 PF00018 0.793
LIG_SH3_3 435 441 PF00018 0.352
LIG_SUMO_SIM_anti_2 278 284 PF11976 0.686
LIG_TYR_ITIM 128 133 PF00017 0.409
LIG_TYR_ITIM 64 69 PF00017 0.630
LIG_UBA3_1 181 187 PF00899 0.660
LIG_UBA3_1 448 455 PF00899 0.549
LIG_UBA3_1 45 53 PF00899 0.618
LIG_WRC_WIRS_1 210 215 PF05994 0.723
MOD_CDK_SPxxK_3 259 266 PF00069 0.763
MOD_CK1_1 139 145 PF00069 0.645
MOD_CK1_1 203 209 PF00069 0.642
MOD_CK1_1 253 259 PF00069 0.742
MOD_CK1_1 355 361 PF00069 0.730
MOD_CK1_1 89 95 PF00069 0.626
MOD_CK2_1 226 232 PF00069 0.563
MOD_CK2_1 259 265 PF00069 0.652
MOD_CK2_1 307 313 PF00069 0.698
MOD_CK2_1 420 426 PF00069 0.377
MOD_GlcNHglycan 223 226 PF01048 0.789
MOD_GlcNHglycan 232 235 PF01048 0.530
MOD_GlcNHglycan 331 334 PF01048 0.766
MOD_GlcNHglycan 356 360 PF01048 0.773
MOD_GlcNHglycan 418 421 PF01048 0.585
MOD_GlcNHglycan 75 78 PF01048 0.658
MOD_GlcNHglycan 80 84 PF01048 0.639
MOD_GSK3_1 195 202 PF00069 0.775
MOD_GSK3_1 226 233 PF00069 0.772
MOD_GSK3_1 265 272 PF00069 0.646
MOD_GSK3_1 35 42 PF00069 0.588
MOD_GSK3_1 385 392 PF00069 0.692
MOD_GSK3_1 416 423 PF00069 0.446
MOD_GSK3_1 98 105 PF00069 0.685
MOD_N-GLC_1 250 255 PF02516 0.731
MOD_N-GLC_2 129 131 PF02516 0.511
MOD_NEK2_1 108 113 PF00069 0.595
MOD_NEK2_1 134 139 PF00069 0.624
MOD_NEK2_1 199 204 PF00069 0.715
MOD_NEK2_1 221 226 PF00069 0.797
MOD_NEK2_1 291 296 PF00069 0.675
MOD_NEK2_1 37 42 PF00069 0.585
MOD_NEK2_1 410 415 PF00069 0.516
MOD_NEK2_2 284 289 PF00069 0.603
MOD_PIKK_1 204 210 PF00454 0.724
MOD_PIKK_1 253 259 PF00454 0.742
MOD_PIKK_1 39 45 PF00454 0.579
MOD_PKA_1 416 422 PF00069 0.562
MOD_PKA_2 139 145 PF00069 0.457
MOD_PKA_2 253 259 PF00069 0.719
MOD_PKA_2 265 271 PF00069 0.546
MOD_PKA_2 329 335 PF00069 0.759
MOD_Plk_1 389 395 PF00069 0.644
MOD_Plk_4 10 16 PF00069 0.587
MOD_Plk_4 104 110 PF00069 0.680
MOD_Plk_4 284 290 PF00069 0.600
MOD_Plk_4 410 416 PF00069 0.496
MOD_Plk_4 448 454 PF00069 0.561
MOD_Plk_4 47 53 PF00069 0.437
MOD_ProDKin_1 226 232 PF00069 0.778
MOD_ProDKin_1 259 265 PF00069 0.772
TRG_DiLeu_BaLyEn_6 176 181 PF01217 0.611
TRG_DiLeu_BaLyEn_6 2 7 PF01217 0.630
TRG_DiLeu_BaLyEn_6 234 239 PF01217 0.751
TRG_ENDOCYTIC_2 121 124 PF00928 0.576
TRG_ENDOCYTIC_2 130 133 PF00928 0.455
TRG_ENDOCYTIC_2 138 141 PF00928 0.402
TRG_ENDOCYTIC_2 14 17 PF00928 0.442
TRG_ENDOCYTIC_2 3 6 PF00928 0.602
TRG_ENDOCYTIC_2 308 311 PF00928 0.678
TRG_ENDOCYTIC_2 34 37 PF00928 0.295
TRG_ENDOCYTIC_2 66 69 PF00928 0.651
TRG_ER_diArg_1 378 380 PF00400 0.604
TRG_NLS_Bipartite_1 363 381 PF00514 0.725
TRG_NLS_MonoCore_2 375 380 PF00514 0.688
TRG_NLS_MonoExtN_4 374 381 PF00514 0.700
TRG_Pf-PMV_PEXEL_1 455 459 PF00026 0.478
TRG_Pf-PMV_PEXEL_1 5 9 PF00026 0.604

Homologs

Protein Taxonomy Sequence identity Coverage
A0A3Q8IFG5 Leishmania donovani 93% 74%
A0A3Q8ISI8 Leishmania donovani 98% 74%
A0A3S7X4A3 Leishmania donovani 93% 74%
A4HJ70 Leishmania braziliensis 63% 100%
A4HJ71 Leishmania braziliensis 69% 100%
A4HJ73 Leishmania braziliensis 69% 93%
A4HJ75 Leishmania braziliensis 27% 100%
A4HJW7 Leishmania braziliensis 60% 100%
A4I6I2 Leishmania infantum 94% 100%
A4I6L8 Leishmania infantum 95% 100%
E8NHD1 Leishmania infantum 100% 100%
E8NHE7 Leishmania mexicana (strain MHOM/GT/2001/U1103) 84% 100%
E8NHE8 Leishmania mexicana (strain MHOM/GT/2001/U1103) 85% 100%
E9B1P3 Leishmania mexicana (strain MHOM/GT/2001/U1103) 86% 100%
Q4Q6G7 Leishmania major 86% 100%
Q4Q6G8 Leishmania major 86% 100%
Q4Q6H0 Leishmania major 86% 100%
Q9BHE5 Leishmania major 86% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS