LeishMANIAdb
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Sodium stibogluconate resistance protein, putative

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Sodium stibogluconate resistance protein, putative
Gene product:
sodium stibogluconate resistance protein - putative
Species:
Leishmania infantum
UniProt:
E8NHD1_LEIIN
TriTrypDb:
LINF_310015600 *
Length:
595

Annotations

LeishMANIAdb annotations

Although predicted to have a multi-helical architecture, the protein is not hydrophobic enough for a membrane protein.. Unique to kinetoplastids, fast-evolving and duplicated multiple times.

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) yes yes: 2
Forrest at al. (procyclic) yes yes: 2
Silverman et al. no yes: 0
Pissara et al. no yes: 15
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 5
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 18
NetGPI no yes: 0, no: 18
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E8NHD1
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E8NHD1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 121 125 PF00656 0.862
CLV_C14_Caspase3-7 130 134 PF00656 0.758
CLV_C14_Caspase3-7 81 85 PF00656 0.756
CLV_NRD_NRD_1 305 307 PF00675 0.701
CLV_NRD_NRD_1 539 541 PF00675 0.609
CLV_NRD_NRD_1 576 578 PF00675 0.617
CLV_PCSK_KEX2_1 524 526 PF00082 0.737
CLV_PCSK_KEX2_1 538 540 PF00082 0.526
CLV_PCSK_PC1ET2_1 524 526 PF00082 0.788
CLV_PCSK_PC1ET2_1 538 540 PF00082 0.537
CLV_PCSK_PC7_1 535 541 PF00082 0.687
CLV_PCSK_SKI1_1 21 25 PF00082 0.603
CLV_PCSK_SKI1_1 214 218 PF00082 0.619
CLV_PCSK_SKI1_1 231 235 PF00082 0.769
CLV_PCSK_SKI1_1 324 328 PF00082 0.610
CLV_PCSK_SKI1_1 525 529 PF00082 0.727
CLV_PCSK_SKI1_1 56 60 PF00082 0.630
DEG_APCC_DBOX_1 353 361 PF00400 0.764
DOC_MAPK_MEF2A_6 146 154 PF00069 0.654
DOC_MAPK_MEF2A_6 552 559 PF00069 0.616
DOC_PP1_RVXF_1 368 375 PF00149 0.758
DOC_PP2B_LxvP_1 478 481 PF13499 0.792
DOC_SPAK_OSR1_1 30 34 PF12202 0.601
DOC_USP7_MATH_1 347 351 PF00917 0.639
DOC_USP7_MATH_1 391 395 PF00917 0.646
DOC_USP7_MATH_1 445 449 PF00917 0.603
DOC_USP7_MATH_1 461 465 PF00917 0.499
DOC_USP7_MATH_2 334 340 PF00917 0.664
DOC_USP7_MATH_2 424 430 PF00917 0.613
DOC_USP7_UBL2_3 255 259 PF12436 0.572
DOC_WW_Pin1_4 387 392 PF00397 0.533
DOC_WW_Pin1_4 420 425 PF00397 0.549
LIG_14-3-3_CanoR_1 265 270 PF00244 0.653
LIG_14-3-3_CanoR_1 30 39 PF00244 0.646
LIG_14-3-3_CanoR_1 301 308 PF00244 0.499
LIG_14-3-3_CanoR_1 4 9 PF00244 0.689
LIG_14-3-3_CanoR_1 415 421 PF00244 0.640
LIG_14-3-3_CanoR_1 427 431 PF00244 0.513
LIG_Actin_WH2_2 437 455 PF00022 0.676
LIG_AP2alpha_1 50 54 PF02296 0.649
LIG_BIR_III_2 84 88 PF00653 0.721
LIG_BRCT_BRCA1_1 267 271 PF00533 0.632
LIG_BRCT_BRCA1_1 63 67 PF00533 0.615
LIG_CSL_BTD_1 388 391 PF09270 0.672
LIG_eIF4E_1 283 289 PF01652 0.386
LIG_FHA_1 143 149 PF00498 0.690
LIG_FHA_1 201 207 PF00498 0.531
LIG_FHA_1 264 270 PF00498 0.662
LIG_FHA_1 437 443 PF00498 0.540
LIG_FHA_1 53 59 PF00498 0.659
LIG_FHA_2 30 36 PF00498 0.647
LIG_FHA_2 469 475 PF00498 0.758
LIG_Integrin_RGD_1 122 124 PF01839 0.792
LIG_LIR_Gen_1 174 183 PF02991 0.614
LIG_LIR_Gen_1 226 235 PF02991 0.609
LIG_LIR_Gen_1 298 304 PF02991 0.617
LIG_LIR_Nem_3 149 154 PF02991 0.633
LIG_LIR_Nem_3 163 168 PF02991 0.386
LIG_LIR_Nem_3 17 23 PF02991 0.657
LIG_LIR_Nem_3 174 178 PF02991 0.446
LIG_LIR_Nem_3 226 230 PF02991 0.685
LIG_LIR_Nem_3 298 302 PF02991 0.603
LIG_LIR_Nem_3 464 469 PF02991 0.689
LIG_PCNA_yPIPBox_3 301 312 PF02747 0.437
LIG_Pex14_2 50 54 PF04695 0.649
LIG_PTB_Apo_2 431 438 PF02174 0.425
LIG_SH2_CRK 165 169 PF00017 0.589
LIG_SH2_CRK 20 24 PF00017 0.661
LIG_SH2_CRK 227 231 PF00017 0.689
LIG_SH2_CRK 283 287 PF00017 0.428
LIG_SH2_CRK 291 295 PF00017 0.457
LIG_SH2_CRK 299 303 PF00017 0.484
LIG_SH2_GRB2like 312 315 PF00017 0.437
LIG_SH2_GRB2like 432 435 PF00017 0.410
LIG_SH2_GRB2like 541 544 PF00017 0.549
LIG_SH2_SRC 312 315 PF00017 0.437
LIG_SH2_SRC 541 544 PF00017 0.530
LIG_SH2_STAP1 312 316 PF00017 0.435
LIG_SH2_STAP1 469 473 PF00017 0.717
LIG_SH2_STAP1 589 593 PF00017 0.443
LIG_SH2_STAT3 37 40 PF00017 0.649
LIG_SH2_STAT5 175 178 PF00017 0.626
LIG_SH2_STAT5 195 198 PF00017 0.568
LIG_SH2_STAT5 283 286 PF00017 0.587
LIG_SH2_STAT5 291 294 PF00017 0.475
LIG_SH2_STAT5 337 340 PF00017 0.640
LIG_SH2_STAT5 37 40 PF00017 0.649
LIG_SH2_STAT5 432 435 PF00017 0.651
LIG_SH2_STAT5 541 544 PF00017 0.549
LIG_SH3_3 147 153 PF00018 0.605
LIG_SH3_3 385 391 PF00018 0.721
LIG_SH3_3 439 445 PF00018 0.692
LIG_SH3_3 493 499 PF00018 0.844
LIG_SH3_3 89 95 PF00018 0.804
LIG_SUMO_SIM_anti_2 439 445 PF11976 0.687
LIG_TRAF2_1 25 28 PF00917 0.595
LIG_TYR_ITIM 18 23 PF00017 0.650
LIG_TYR_ITIM 225 230 PF00017 0.676
LIG_TYR_ITIM 289 294 PF00017 0.426
LIG_UBA3_1 206 214 PF00899 0.610
LIG_UBA3_1 342 348 PF00899 0.616
LIG_WRC_WIRS_1 371 376 PF05994 0.739
MOD_CDK_SPxxK_3 420 427 PF00069 0.676
MOD_CK1_1 250 256 PF00069 0.641
MOD_CK1_1 300 306 PF00069 0.666
MOD_CK1_1 364 370 PF00069 0.689
MOD_CK1_1 414 420 PF00069 0.665
MOD_CK1_1 516 522 PF00069 0.681
MOD_CK2_1 29 35 PF00069 0.642
MOD_CK2_1 387 393 PF00069 0.491
MOD_CK2_1 420 426 PF00069 0.553
MOD_CK2_1 468 474 PF00069 0.721
MOD_CK2_1 581 587 PF00069 0.480
MOD_GlcNHglycan 118 121 PF01048 0.822
MOD_GlcNHglycan 127 130 PF01048 0.801
MOD_GlcNHglycan 236 239 PF01048 0.722
MOD_GlcNHglycan 241 245 PF01048 0.697
MOD_GlcNHglycan 384 387 PF01048 0.782
MOD_GlcNHglycan 393 396 PF01048 0.433
MOD_GlcNHglycan 492 495 PF01048 0.808
MOD_GlcNHglycan 517 521 PF01048 0.700
MOD_GlcNHglycan 579 582 PF01048 0.678
MOD_GlcNHglycan 62 66 PF01048 0.632
MOD_GSK3_1 138 145 PF00069 0.637
MOD_GSK3_1 196 203 PF00069 0.588
MOD_GSK3_1 259 266 PF00069 0.675
MOD_GSK3_1 356 363 PF00069 0.834
MOD_GSK3_1 387 394 PF00069 0.540
MOD_GSK3_1 426 433 PF00069 0.613
MOD_GSK3_1 546 553 PF00069 0.655
MOD_GSK3_1 577 584 PF00069 0.541
MOD_N-GLC_1 411 416 PF02516 0.676
MOD_N-GLC_2 290 292 PF02516 0.526
MOD_NEK2_1 105 110 PF00069 0.702
MOD_NEK2_1 198 203 PF00069 0.600
MOD_NEK2_1 269 274 PF00069 0.611
MOD_NEK2_1 295 300 PF00069 0.590
MOD_NEK2_1 360 365 PF00069 0.783
MOD_NEK2_1 382 387 PF00069 0.764
MOD_NEK2_1 452 457 PF00069 0.614
MOD_NEK2_1 50 55 PF00069 0.648
MOD_NEK2_1 571 576 PF00069 0.609
MOD_NEK2_2 138 143 PF00069 0.639
MOD_NEK2_2 445 450 PF00069 0.600
MOD_NMyristoyl 1 7 PF02799 0.769
MOD_PIKK_1 200 206 PF00454 0.585
MOD_PIKK_1 365 371 PF00454 0.772
MOD_PIKK_1 414 420 PF00454 0.665
MOD_PK_1 4 10 PF00069 0.750
MOD_PKA_1 577 583 PF00069 0.659
MOD_PKA_2 29 35 PF00069 0.642
MOD_PKA_2 3 9 PF00069 0.695
MOD_PKA_2 300 306 PF00069 0.507
MOD_PKA_2 414 420 PF00069 0.648
MOD_PKA_2 426 432 PF00069 0.534
MOD_PKA_2 490 496 PF00069 0.808
MOD_Plk_1 550 556 PF00069 0.635
MOD_Plk_4 100 106 PF00069 0.717
MOD_Plk_4 171 177 PF00069 0.601
MOD_Plk_4 208 214 PF00069 0.547
MOD_Plk_4 265 271 PF00069 0.650
MOD_Plk_4 445 451 PF00069 0.599
MOD_Plk_4 571 577 PF00069 0.586
MOD_ProDKin_1 387 393 PF00069 0.532
MOD_ProDKin_1 420 426 PF00069 0.550
MOD_SUMO_rev_2 141 148 PF00179 0.566
TRG_DiLeu_BaLyEn_6 163 168 PF01217 0.595
TRG_DiLeu_BaLyEn_6 337 342 PF01217 0.593
TRG_DiLeu_BaLyEn_6 395 400 PF01217 0.667
TRG_ENDOCYTIC_2 164 167 PF00928 0.564
TRG_ENDOCYTIC_2 175 178 PF00928 0.450
TRG_ENDOCYTIC_2 195 198 PF00928 0.593
TRG_ENDOCYTIC_2 20 23 PF00928 0.656
TRG_ENDOCYTIC_2 227 230 PF00928 0.681
TRG_ENDOCYTIC_2 282 285 PF00928 0.439
TRG_ENDOCYTIC_2 291 294 PF00928 0.442
TRG_ENDOCYTIC_2 299 302 PF00928 0.467
TRG_ENDOCYTIC_2 469 472 PF00928 0.708
TRG_ER_diArg_1 539 541 PF00400 0.590
TRG_NLS_Bipartite_1 524 542 PF00514 0.740
TRG_NLS_MonoCore_2 536 541 PF00514 0.691
TRG_NLS_MonoExtN_4 535 542 PF00514 0.698
TRG_Pf-PMV_PEXEL_1 166 170 PF00026 0.584

Homologs

Protein Taxonomy Sequence identity Coverage
A0A3Q8IFG5 Leishmania donovani 97% 96%
A0A3Q8ISI8 Leishmania donovani 98% 96%
A0A3S7X4A3 Leishmania donovani 97% 96%
A4HJ70 Leishmania braziliensis 62% 100%
A4HJ71 Leishmania braziliensis 65% 100%
A4HJ73 Leishmania braziliensis 65% 100%
A4HJW7 Leishmania braziliensis 60% 100%
A4I6I2 Leishmania infantum 98% 100%
A4I6L8 Leishmania infantum 98% 100%
E8NHD2 Leishmania infantum 100% 100%
E8NHE7 Leishmania mexicana (strain MHOM/GT/2001/U1103) 86% 100%
E8NHE8 Leishmania mexicana (strain MHOM/GT/2001/U1103) 88% 100%
E9B1P3 Leishmania mexicana (strain MHOM/GT/2001/U1103) 87% 100%
Q4Q6G7 Leishmania major 87% 100%
Q4Q6G8 Leishmania major 89% 100%
Q4Q6H0 Leishmania major 87% 100%
Q9BHE5 Leishmania major 89% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS