ATP synthase subunit beta

Quick info Localization Phosphorylation Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

ATP synthase subunit beta - mitochondrial - putative

Species:

Leishmania infantum

UniProt:

E8NHD0_LEIIN

TriTrypDb:

LINF_250017900

Length:

295

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 10

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 2
NetGPI	no	yes: 0, no: 2

Cellular components
Term	Name	Level	Count
GO:0032991	protein-containing complex	1	2
GO:0033178	proton-transporting two-sector ATPase complex, catalytic domain	3	2
GO:0045261	proton-transporting ATP synthase complex, catalytic core F(1)	4	2
GO:0098796	membrane protein complex	2	2

Phosphorylation

Promastigote: 154

Expansion

Sequence features

E8NHD0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E8NHD0

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	3
GO:0003824	catalytic activity	1	3
GO:0005215	transporter activity	1	3
GO:0005216	monoatomic ion channel activity	4	3
GO:0005261	monoatomic cation channel activity	5	3
GO:0005488	binding	1	3
GO:0005524	ATP binding	5	3
GO:0008324	monoatomic cation transmembrane transporter activity	4	3
GO:0009678	pyrophosphate hydrolysis-driven proton transmembrane transporter activity	5	3
GO:0015075	monoatomic ion transmembrane transporter activity	3	3
GO:0015078	proton transmembrane transporter activity	5	3
GO:0015252	proton channel activity	6	3
GO:0015267	channel activity	4	3
GO:0015318	inorganic molecular entity transmembrane transporter activity	3	3
GO:0015399	primary active transmembrane transporter activity	4	3
GO:0016874	ligase activity	2	3
GO:0017076	purine nucleotide binding	4	3
GO:0019829	ATPase-coupled monoatomic cation transmembrane transporter activity	3	3
GO:0022803	passive transmembrane transporter activity	3	3
GO:0022804	active transmembrane transporter activity	3	3
GO:0022853	active monoatomic ion transmembrane transporter activity	4	3
GO:0022857	transmembrane transporter activity	2	3
GO:0022890	inorganic cation transmembrane transporter activity	4	3
GO:0030554	adenyl nucleotide binding	5	3
GO:0032553	ribonucleotide binding	3	3
GO:0032555	purine ribonucleotide binding	4	3
GO:0032559	adenyl ribonucleotide binding	5	3
GO:0035639	purine ribonucleoside triphosphate binding	4	3
GO:0036094	small molecule binding	2	3
GO:0042625	ATPase-coupled ion transmembrane transporter activity	3	3
GO:0042626	ATPase-coupled transmembrane transporter activity	2	3
GO:0043167	ion binding	2	3
GO:0043168	anion binding	3	3
GO:0044769	ATPase activity, coupled to transmembrane movement of ions, rotational mechanism	4	3
GO:0046933	proton-transporting ATP synthase activity, rotational mechanism	3	3
GO:0046961	proton-transporting ATPase activity, rotational mechanism	4	3
GO:0097159	organic cyclic compound binding	2	3
GO:0097367	carbohydrate derivative binding	2	3
GO:0140657	ATP-dependent activity	1	3
GO:1901265	nucleoside phosphate binding	3	3
GO:1901363	heterocyclic compound binding	2	3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	126	130	PF00656	0.243
CLV_NRD_NRD_1	206	208	PF00675	0.275
CLV_NRD_NRD_1	283	285	PF00675	0.382
CLV_PCSK_KEX2_1	283	285	PF00082	0.382
CLV_PCSK_SKI1_1	13	17	PF00082	0.174
CLV_PCSK_SKI1_1	207	211	PF00082	0.486
CLV_PCSK_SKI1_1	263	267	PF00082	0.384
DEG_Nend_UBRbox_3	1	3	PF02207	0.400
DOC_CYCLIN_yClb1_LxF_4	48	54	PF00134	0.215
DOC_CYCLIN_yCln2_LP_2	213	219	PF00134	0.295
DOC_USP7_MATH_1	289	293	PF00917	0.387
DOC_USP7_MATH_2	149	155	PF00917	0.215
DOC_USP7_UBL2_3	9	13	PF12436	0.295
LIG_14-3-3_CanoR_1	211	216	PF00244	0.267
LIG_14-3-3_CanoR_1	30	38	PF00244	0.174
LIG_14-3-3_CanoR_1	59	67	PF00244	0.215
LIG_14-3-3_CanoR_1	94	103	PF00244	0.236
LIG_APCC_ABBA_1	50	55	PF00400	0.215
LIG_BRCT_BRCA1_1	213	217	PF00533	0.276
LIG_Clathr_ClatBox_1	51	55	PF01394	0.215
LIG_FHA_1	129	135	PF00498	0.253
LIG_FHA_1	208	214	PF00498	0.265
LIG_FHA_2	130	136	PF00498	0.215
LIG_FHA_2	35	41	PF00498	0.203
LIG_FHA_2	81	87	PF00498	0.215
LIG_GBD_Chelix_1	169	177	PF00786	0.272
LIG_LIR_Gen_1	123	133	PF02991	0.402
LIG_LIR_Gen_1	227	237	PF02991	0.554
LIG_LIR_Gen_1	247	256	PF02991	0.215
LIG_LIR_Nem_3	123	128	PF02991	0.470
LIG_LIR_Nem_3	141	147	PF02991	0.173
LIG_LIR_Nem_3	178	183	PF02991	0.475
LIG_LIR_Nem_3	227	233	PF02991	0.562
LIG_LIR_Nem_3	238	243	PF02991	0.338
LIG_LIR_Nem_3	247	251	PF02991	0.228
LIG_LIR_Nem_3	253	259	PF02991	0.212
LIG_LIR_Nem_3	40	45	PF02991	0.282
LIG_LYPXL_S_1	143	147	PF13949	0.215
LIG_LYPXL_yS_3	144	147	PF13949	0.215
LIG_PCNA_yPIPBox_3	59	71	PF02747	0.215
LIG_SH2_CRK	248	252	PF00017	0.285
LIG_SH2_NCK_1	167	171	PF00017	0.274
LIG_SH2_NCK_1	248	252	PF00017	0.285
LIG_SH2_PTP2	230	233	PF00017	0.309
LIG_SH2_SRC	110	113	PF00017	0.215
LIG_SH2_STAT5	110	113	PF00017	0.243
LIG_SH2_STAT5	230	233	PF00017	0.577
LIG_SH2_STAT5	41	44	PF00017	0.230
LIG_SH3_3	106	112	PF00018	0.339
LIG_SUMO_SIM_anti_2	185	191	PF11976	0.313
LIG_SUMO_SIM_par_1	160	165	PF11976	0.423
LIG_WRC_WIRS_1	237	242	PF05994	0.265
MOD_CK1_1	102	108	PF00069	0.215
MOD_CK1_1	34	40	PF00069	0.195
MOD_CK1_1	65	71	PF00069	0.215
MOD_CK2_1	261	267	PF00069	0.282
MOD_CK2_1	34	40	PF00069	0.203
MOD_CK2_1	80	86	PF00069	0.215
MOD_GlcNHglycan	140	143	PF01048	0.483
MOD_GlcNHglycan	240	243	PF01048	0.259
MOD_GlcNHglycan	33	36	PF01048	0.174
MOD_GlcNHglycan	66	70	PF01048	0.215
MOD_GSK3_1	207	214	PF00069	0.270
MOD_GSK3_1	58	65	PF00069	0.376
MOD_GSK3_1	95	102	PF00069	0.229
MOD_N-GLC_1	289	294	PF02516	0.579
MOD_NEK2_1	128	133	PF00069	0.323
MOD_NEK2_1	58	63	PF00069	0.282
MOD_PIKK_1	211	217	PF00454	0.273
MOD_PIKK_1	58	64	PF00454	0.215
MOD_PKA_1	207	213	PF00069	0.274
MOD_PKA_2	58	64	PF00069	0.215
MOD_PKA_2	93	99	PF00069	0.215
MOD_PKB_1	205	213	PF00069	0.274
MOD_Plk_1	128	134	PF00069	0.215
MOD_Plk_1	65	71	PF00069	0.215
MOD_Plk_2-3	129	135	PF00069	0.215
MOD_Plk_2-3	193	199	PF00069	0.334
MOD_Plk_4	129	135	PF00069	0.363
MOD_Plk_4	261	267	PF00069	0.375
MOD_SUMO_for_1	8	11	PF00179	0.304
MOD_SUMO_rev_2	193	202	PF00179	0.310
MOD_SUMO_rev_2	7	15	PF00179	0.290
TRG_DiLeu_BaEn_1	66	71	PF01217	0.215
TRG_ENDOCYTIC_2	144	147	PF00928	0.242
TRG_ENDOCYTIC_2	18	21	PF00928	0.255
TRG_ENDOCYTIC_2	180	183	PF00928	0.481
TRG_ENDOCYTIC_2	230	233	PF00928	0.577
TRG_ENDOCYTIC_2	248	251	PF00928	0.254
TRG_ER_diArg_1	28	31	PF00400	0.174
TRG_ER_diArg_1	283	286	PF00400	0.616
TRG_NES_CRM1_1	182	194	PF08389	0.310
TRG_Pf-PMV_PEXEL_1	211	215	PF00026	0.270

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A4HEJ3	Leishmania braziliensis	98%	100%
Q0QEP2	Mesocricetus auratus	71%	81%
V5BL70	Trypanosoma cruzi	29%	87%