Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

E8NHC8_LEIIN

TriTrypDb:

LINF_030013400

Length:

395

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E8NHC8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E8NHC8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	126	128	PF00675	0.420
CLV_NRD_NRD_1	141	143	PF00675	0.447
CLV_NRD_NRD_1	165	167	PF00675	0.528
CLV_NRD_NRD_1	79	81	PF00675	0.536
CLV_PCSK_KEX2_1	141	143	PF00082	0.569
CLV_PCSK_KEX2_1	165	167	PF00082	0.507
CLV_PCSK_KEX2_1	293	295	PF00082	0.527
CLV_PCSK_KEX2_1	79	81	PF00082	0.536
CLV_PCSK_PC1ET2_1	293	295	PF00082	0.572
CLV_PCSK_SKI1_1	116	120	PF00082	0.404
CLV_PCSK_SKI1_1	127	131	PF00082	0.392
CLV_PCSK_SKI1_1	165	169	PF00082	0.521
CLV_PCSK_SKI1_1	244	248	PF00082	0.396
CLV_PCSK_SKI1_1	251	255	PF00082	0.335
CLV_PCSK_SKI1_1	390	394	PF00082	0.558
CLV_PCSK_SKI1_1	46	50	PF00082	0.393
CLV_PCSK_SKI1_1	68	72	PF00082	0.402
CLV_PCSK_SKI1_1	79	83	PF00082	0.392
CLV_PCSK_SKI1_1	95	99	PF00082	0.263
DEG_APCC_DBOX_1	126	134	PF00400	0.531
DEG_APCC_DBOX_1	45	53	PF00400	0.392
DEG_APCC_DBOX_1	78	86	PF00400	0.533
DEG_Kelch_Keap1_1	224	229	PF01344	0.537
DEG_Nend_Nbox_1	1	3	PF02207	0.582
DEG_SPOP_SBC_1	184	188	PF00917	0.413
DEG_SPOP_SBC_1	24	28	PF00917	0.693
DOC_CYCLIN_RxL_1	125	134	PF00134	0.470
DOC_CYCLIN_RxL_1	160	171	PF00134	0.512
DOC_CYCLIN_RxL_1	241	252	PF00134	0.492
DOC_CYCLIN_RxL_1	92	100	PF00134	0.407
DOC_MAPK_gen_1	127	135	PF00069	0.544
DOC_MAPK_MEF2A_6	323	330	PF00069	0.528
DOC_USP7_MATH_1	174	178	PF00917	0.447
DOC_USP7_MATH_1	184	188	PF00917	0.486
DOC_USP7_MATH_1	24	28	PF00917	0.715
DOC_USP7_MATH_1	89	93	PF00917	0.470
DOC_WW_Pin1_4	185	190	PF00397	0.455
DOC_WW_Pin1_4	25	30	PF00397	0.681
DOC_WW_Pin1_4	277	282	PF00397	0.479
LIG_14-3-3_CanoR_1	173	183	PF00244	0.511
LIG_14-3-3_CanoR_1	56	65	PF00244	0.548
LIG_14-3-3_CanoR_1	6	12	PF00244	0.524
LIG_APCC_ABBA_1	129	134	PF00400	0.494
LIG_APCC_ABBA_1	347	352	PF00400	0.497
LIG_APCC_ABBAyCdc20_2	128	134	PF00400	0.490
LIG_BIR_III_4	252	256	PF00653	0.387
LIG_Clathr_ClatBox_1	130	134	PF01394	0.489
LIG_Clathr_ClatBox_1	246	250	PF01394	0.475
LIG_FAT_LD_1	239	247	PF03623	0.530
LIG_FHA_1	335	341	PF00498	0.434
LIG_FHA_1	85	91	PF00498	0.371
LIG_FHA_2	384	390	PF00498	0.546
LIG_GBD_Chelix_1	238	246	PF00786	0.539
LIG_Integrin_RGD_1	262	264	PF01839	0.538
LIG_LIR_Gen_1	100	110	PF02991	0.431
LIG_LIR_Gen_1	154	164	PF02991	0.546
LIG_LIR_Gen_1	177	185	PF02991	0.460
LIG_LIR_Gen_1	283	292	PF02991	0.464
LIG_LIR_Nem_3	154	159	PF02991	0.522
LIG_LIR_Nem_3	177	182	PF02991	0.438
LIG_LIR_Nem_3	252	257	PF02991	0.415
LIG_LIR_Nem_3	386	391	PF02991	0.573
LIG_PCNA_PIPBox_1	112	121	PF02747	0.443
LIG_Pex14_1	388	392	PF04695	0.494
LIG_PTB_Apo_2	381	388	PF02174	0.544
LIG_SH2_CRK	179	183	PF00017	0.440
LIG_SH2_SRC	190	193	PF00017	0.522
LIG_SH2_SRC	351	354	PF00017	0.512
LIG_SH2_STAP1	179	183	PF00017	0.419
LIG_SH2_STAT5	190	193	PF00017	0.488
LIG_SH2_STAT5	391	394	PF00017	0.567
LIG_SH2_STAT5	66	69	PF00017	0.477
LIG_SH3_1	323	329	PF00018	0.525
LIG_SH3_3	186	192	PF00018	0.517
LIG_SH3_3	323	329	PF00018	0.537
LIG_SH3_3	85	91	PF00018	0.378
LIG_SUMO_SIM_anti_2	245	250	PF11976	0.476
LIG_SUMO_SIM_par_1	245	250	PF11976	0.429
LIG_TRAF2_1	363	366	PF00917	0.542
LIG_UBA3_1	129	137	PF00899	0.515
LIG_UBA3_1	7	15	PF00899	0.530
MOD_CDK_SPK_2	277	282	PF00069	0.466
MOD_CK1_1	27	33	PF00069	0.707
MOD_CK2_1	359	365	PF00069	0.542
MOD_CK2_1	383	389	PF00069	0.494
MOD_GlcNHglycan	29	32	PF01048	0.689
MOD_GlcNHglycan	59	62	PF01048	0.550
MOD_GSK3_1	196	203	PF00069	0.417
MOD_GSK3_1	23	30	PF00069	0.663
MOD_GSK3_1	330	337	PF00069	0.431
MOD_GSK3_1	57	64	PF00069	0.539
MOD_N-GLC_1	383	388	PF02516	0.588
MOD_NEK2_1	133	138	PF00069	0.513
MOD_NEK2_1	183	188	PF00069	0.454
MOD_NEK2_1	268	273	PF00069	0.623
MOD_NEK2_1	330	335	PF00069	0.462
MOD_NEK2_1	380	385	PF00069	0.609
MOD_NEK2_1	7	12	PF00069	0.584
MOD_PIKK_1	10	16	PF00454	0.602
MOD_PK_1	282	288	PF00069	0.511
MOD_Plk_1	383	389	PF00069	0.547
MOD_Plk_1	44	50	PF00069	0.450
MOD_Plk_4	330	336	PF00069	0.574
MOD_Plk_4	61	67	PF00069	0.459
MOD_ProDKin_1	185	191	PF00069	0.455
MOD_ProDKin_1	25	31	PF00069	0.682
MOD_ProDKin_1	277	283	PF00069	0.474
TRG_DiLeu_BaLyEn_6	163	168	PF01217	0.400
TRG_DiLeu_BaLyEn_6	3	8	PF01217	0.540
TRG_DiLeu_BaLyEn_6	73	78	PF01217	0.502
TRG_ENDOCYTIC_2	179	182	PF00928	0.362
TRG_ER_diArg_1	141	143	PF00400	0.555
TRG_ER_diArg_1	164	166	PF00400	0.533
TRG_ER_diArg_1	4	7	PF00400	0.559
TRG_ER_diArg_1	78	80	PF00400	0.531
TRG_Pf-PMV_PEXEL_1	104	109	PF00026	0.448
TRG_Pf-PMV_PEXEL_1	113	117	PF00026	0.417
TRG_Pf-PMV_PEXEL_1	166	171	PF00026	0.370
TRG_Pf-PMV_PEXEL_1	95	100	PF00026	0.407

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P542	Leptomonas seymouri	62%	100%
A0A0S4IVU1	Bodo saltans	39%	100%
A0A1X0P922	Trypanosomatidae	49%	100%
A0A451EJT2	Leishmania donovani	100%	100%
A4H3P5	Leishmania braziliensis	86%	99%
C9ZKH7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	54%	100%
E9ACM8	Leishmania major	94%	100%
E9AJW7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
V5DTZ7	Trypanosoma cruzi	48%	99%