LeishMANIAdb
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DUF4470 domain-containing protein

Quick info Annotations Function or PPIs Localization Phosphorylation Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
DUF4470 domain-containing protein
Gene product:
hypothetical protein - conserved
Species:
Leishmania infantum
UniProt:
E8NHC7_LEIIN
TriTrypDb:
LINF_030013500 *
Length:
798

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 10
NetGPI no yes: 0, no: 10
Could not find GO cellular_component term for this entry.

Phosphorylation

Promastigote: 708, 712

Expansion

Sequence features

E8NHC7
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E8NHC7

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 142 146 PF00656 0.582
CLV_C14_Caspase3-7 174 178 PF00656 0.546
CLV_C14_Caspase3-7 306 310 PF00656 0.480
CLV_C14_Caspase3-7 344 348 PF00656 0.677
CLV_C14_Caspase3-7 442 446 PF00656 0.510
CLV_NRD_NRD_1 355 357 PF00675 0.782
CLV_NRD_NRD_1 497 499 PF00675 0.461
CLV_NRD_NRD_1 538 540 PF00675 0.710
CLV_NRD_NRD_1 684 686 PF00675 0.428
CLV_NRD_NRD_1 715 717 PF00675 0.548
CLV_NRD_NRD_1 744 746 PF00675 0.472
CLV_NRD_NRD_1 780 782 PF00675 0.602
CLV_PCSK_FUR_1 745 749 PF00082 0.600
CLV_PCSK_KEX2_1 354 356 PF00082 0.722
CLV_PCSK_KEX2_1 497 499 PF00082 0.438
CLV_PCSK_KEX2_1 684 686 PF00082 0.428
CLV_PCSK_KEX2_1 747 749 PF00082 0.570
CLV_PCSK_KEX2_1 776 778 PF00082 0.613
CLV_PCSK_KEX2_1 780 782 PF00082 0.630
CLV_PCSK_KEX2_1 791 793 PF00082 0.552
CLV_PCSK_KEX2_1 795 797 PF00082 0.509
CLV_PCSK_PC1ET2_1 354 356 PF00082 0.722
CLV_PCSK_PC1ET2_1 747 749 PF00082 0.588
CLV_PCSK_PC1ET2_1 776 778 PF00082 0.601
CLV_PCSK_PC1ET2_1 791 793 PF00082 0.578
CLV_PCSK_PC1ET2_1 795 797 PF00082 0.555
CLV_PCSK_PC7_1 743 749 PF00082 0.599
CLV_PCSK_SKI1_1 155 159 PF00082 0.486
CLV_PCSK_SKI1_1 303 307 PF00082 0.528
CLV_PCSK_SKI1_1 539 543 PF00082 0.795
CLV_PCSK_SKI1_1 721 725 PF00082 0.547
CLV_PCSK_SKI1_1 748 752 PF00082 0.526
CLV_PCSK_SKI1_1 780 784 PF00082 0.600
CLV_PCSK_SKI1_1 792 796 PF00082 0.621
CLV_PCSK_SKI1_1 90 94 PF00082 0.530
DEG_SPOP_SBC_1 112 116 PF00917 0.563
DEG_SPOP_SBC_1 207 211 PF00917 0.697
DEG_SPOP_SBC_1 212 216 PF00917 0.784
DOC_CDC14_PxL_1 401 409 PF14671 0.460
DOC_MAPK_gen_1 497 505 PF00069 0.427
DOC_MAPK_gen_1 731 740 PF00069 0.625
DOC_MAPK_MEF2A_6 655 664 PF00069 0.448
DOC_MAPK_MEF2A_6 689 697 PF00069 0.572
DOC_PP1_RVXF_1 153 160 PF00149 0.496
DOC_PP1_RVXF_1 293 300 PF00149 0.433
DOC_PP1_RVXF_1 495 502 PF00149 0.526
DOC_PP1_RVXF_1 692 698 PF00149 0.647
DOC_PP2B_LxvP_1 204 207 PF13499 0.574
DOC_PP2B_LxvP_1 528 531 PF13499 0.685
DOC_PP4_FxxP_1 159 162 PF00568 0.589
DOC_PP4_FxxP_1 299 302 PF00568 0.489
DOC_USP7_MATH_1 112 116 PF00917 0.599
DOC_USP7_MATH_1 132 136 PF00917 0.396
DOC_USP7_MATH_1 207 211 PF00917 0.694
DOC_USP7_MATH_1 212 216 PF00917 0.722
DOC_USP7_MATH_1 225 229 PF00917 0.654
DOC_USP7_MATH_1 337 341 PF00917 0.618
DOC_USP7_MATH_1 349 353 PF00917 0.668
DOC_USP7_MATH_1 439 443 PF00917 0.474
DOC_USP7_MATH_1 531 535 PF00917 0.747
DOC_USP7_MATH_1 576 580 PF00917 0.682
DOC_USP7_MATH_1 588 592 PF00917 0.509
DOC_USP7_MATH_1 61 65 PF00917 0.722
DOC_USP7_MATH_1 86 90 PF00917 0.510
DOC_USP7_UBL2_3 731 735 PF12436 0.637
DOC_USP7_UBL2_3 747 751 PF12436 0.433
DOC_USP7_UBL2_3 783 787 PF12436 0.672
DOC_USP7_UBL2_3 791 795 PF12436 0.593
DOC_WW_Pin1_4 208 213 PF00397 0.703
DOC_WW_Pin1_4 376 381 PF00397 0.731
DOC_WW_Pin1_4 418 423 PF00397 0.475
DOC_WW_Pin1_4 84 89 PF00397 0.623
LIG_14-3-3_CanoR_1 113 120 PF00244 0.608
LIG_14-3-3_CanoR_1 18 22 PF00244 0.384
LIG_14-3-3_CanoR_1 546 551 PF00244 0.668
LIG_14-3-3_CanoR_1 90 100 PF00244 0.429
LIG_BIR_III_4 483 487 PF00653 0.526
LIG_BRCT_BRCA1_1 295 299 PF00533 0.407
LIG_BRCT_BRCA1_1 88 92 PF00533 0.542
LIG_deltaCOP1_diTrp_1 599 605 PF00928 0.524
LIG_FHA_1 100 106 PF00498 0.375
LIG_FHA_1 152 158 PF00498 0.543
LIG_FHA_1 377 383 PF00498 0.747
LIG_FHA_1 461 467 PF00498 0.536
LIG_FHA_1 50 56 PF00498 0.505
LIG_FHA_1 567 573 PF00498 0.628
LIG_FHA_1 602 608 PF00498 0.468
LIG_FHA_1 657 663 PF00498 0.487
LIG_FHA_1 688 694 PF00498 0.554
LIG_FHA_2 137 143 PF00498 0.539
LIG_FHA_2 164 170 PF00498 0.682
LIG_FHA_2 183 189 PF00498 0.594
LIG_FHA_2 304 310 PF00498 0.382
LIG_LIR_Apic_2 296 302 PF02991 0.469
LIG_LIR_Gen_1 181 190 PF02991 0.663
LIG_LIR_Nem_3 181 187 PF02991 0.689
LIG_LIR_Nem_3 263 269 PF02991 0.422
LIG_LIR_Nem_3 592 598 PF02991 0.546
LIG_LIR_Nem_3 599 605 PF02991 0.391
LIG_LIR_Nem_3 673 678 PF02991 0.378
LIG_MLH1_MIPbox_1 88 92 PF16413 0.542
LIG_PCNA_yPIPBox_3 613 627 PF02747 0.546
LIG_Pex14_2 428 432 PF04695 0.411
LIG_Pex14_2 652 656 PF04695 0.392
LIG_RPA_C_Fungi 446 458 PF08784 0.501
LIG_SH2_CRK 435 439 PF00017 0.539
LIG_SH2_CRK 482 486 PF00017 0.388
LIG_SH2_CRK 488 492 PF00017 0.421
LIG_SH2_GRB2like 397 400 PF00017 0.595
LIG_SH2_NCK_1 482 486 PF00017 0.388
LIG_SH2_PTP2 11 14 PF00017 0.473
LIG_SH2_PTP2 474 477 PF00017 0.386
LIG_SH2_SRC 368 371 PF00017 0.724
LIG_SH2_SRC 437 440 PF00017 0.478
LIG_SH2_STAP1 397 401 PF00017 0.594
LIG_SH2_STAT3 254 257 PF00017 0.490
LIG_SH2_STAT5 11 14 PF00017 0.514
LIG_SH2_STAT5 182 185 PF00017 0.684
LIG_SH2_STAT5 267 270 PF00017 0.498
LIG_SH2_STAT5 287 290 PF00017 0.185
LIG_SH2_STAT5 401 404 PF00017 0.522
LIG_SH2_STAT5 437 440 PF00017 0.473
LIG_SH2_STAT5 474 477 PF00017 0.318
LIG_SH2_STAT5 515 518 PF00017 0.484
LIG_SH2_STAT5 638 641 PF00017 0.424
LIG_SH2_STAT5 774 777 PF00017 0.532
LIG_SH2_STAT5 91 94 PF00017 0.496
LIG_SH3_3 135 141 PF00018 0.430
LIG_SH3_3 159 165 PF00018 0.741
LIG_SH3_3 364 370 PF00018 0.747
LIG_SH3_3 383 389 PF00018 0.439
LIG_SH3_3 628 634 PF00018 0.418
LIG_SH3_3 735 741 PF00018 0.615
LIG_SUMO_SIM_anti_2 185 193 PF11976 0.661
LIG_SUMO_SIM_par_1 135 142 PF11976 0.533
LIG_TRAF2_1 340 343 PF00917 0.593
LIG_TRAF2_1 390 393 PF00917 0.603
LIG_TRAF2_1 622 625 PF00917 0.421
LIG_TYR_ITIM 472 477 PF00017 0.478
LIG_TYR_ITIM 480 485 PF00017 0.461
LIG_WRC_WIRS_1 425 430 PF05994 0.481
MOD_CDC14_SPxK_1 87 90 PF00782 0.480
MOD_CDK_SPxK_1 84 90 PF00069 0.603
MOD_CK1_1 115 121 PF00069 0.627
MOD_CK1_1 210 216 PF00069 0.671
MOD_CK1_1 371 377 PF00069 0.741
MOD_CK1_1 384 390 PF00069 0.499
MOD_CK1_1 561 567 PF00069 0.753
MOD_CK1_1 74 80 PF00069 0.730
MOD_CK2_1 182 188 PF00069 0.694
MOD_CK2_1 337 343 PF00069 0.655
MOD_CK2_1 387 393 PF00069 0.493
MOD_CK2_1 564 570 PF00069 0.606
MOD_Cter_Amidation 785 788 PF01082 0.615
MOD_GlcNHglycan 102 105 PF01048 0.475
MOD_GlcNHglycan 108 111 PF01048 0.500
MOD_GlcNHglycan 120 123 PF01048 0.344
MOD_GlcNHglycan 14 17 PF01048 0.459
MOD_GlcNHglycan 204 207 PF01048 0.645
MOD_GlcNHglycan 22 25 PF01048 0.529
MOD_GlcNHglycan 339 342 PF01048 0.681
MOD_GlcNHglycan 343 346 PF01048 0.726
MOD_GlcNHglycan 35 38 PF01048 0.334
MOD_GlcNHglycan 383 386 PF01048 0.650
MOD_GlcNHglycan 389 392 PF01048 0.528
MOD_GlcNHglycan 451 454 PF01048 0.521
MOD_GlcNHglycan 467 470 PF01048 0.364
MOD_GlcNHglycan 591 594 PF01048 0.663
MOD_GlcNHglycan 766 770 PF01048 0.550
MOD_GSK3_1 111 118 PF00069 0.607
MOD_GSK3_1 122 129 PF00069 0.427
MOD_GSK3_1 132 139 PF00069 0.363
MOD_GSK3_1 178 185 PF00069 0.669
MOD_GSK3_1 202 209 PF00069 0.704
MOD_GSK3_1 337 344 PF00069 0.656
MOD_GSK3_1 368 375 PF00069 0.710
MOD_GSK3_1 558 565 PF00069 0.757
MOD_GSK3_1 576 583 PF00069 0.435
MOD_GSK3_1 601 608 PF00069 0.475
MOD_GSK3_1 67 74 PF00069 0.717
MOD_GSK3_1 683 690 PF00069 0.493
MOD_GSK3_1 705 712 PF00069 0.725
MOD_GSK3_1 761 768 PF00069 0.657
MOD_GSK3_1 77 84 PF00069 0.542
MOD_GSK3_1 86 93 PF00069 0.360
MOD_N-GLC_1 303 308 PF02516 0.568
MOD_N-GLC_1 337 342 PF02516 0.653
MOD_N-GLC_1 349 354 PF02516 0.518
MOD_N-GLC_1 71 76 PF02516 0.660
MOD_NEK2_1 111 116 PF00069 0.601
MOD_NEK2_1 126 131 PF00069 0.422
MOD_NEK2_1 136 141 PF00069 0.356
MOD_NEK2_1 265 270 PF00069 0.398
MOD_NEK2_1 372 377 PF00069 0.708
MOD_NEK2_1 409 414 PF00069 0.351
MOD_NEK2_1 49 54 PF00069 0.485
MOD_NEK2_1 580 585 PF00069 0.693
MOD_NEK2_1 656 661 PF00069 0.398
MOD_NEK2_1 729 734 PF00069 0.528
MOD_NEK2_2 293 298 PF00069 0.515
MOD_PIKK_1 562 568 PF00454 0.716
MOD_PK_1 546 552 PF00069 0.520
MOD_PKA_2 106 112 PF00069 0.564
MOD_PKA_2 17 23 PF00069 0.384
MOD_PKA_2 460 466 PF00069 0.545
MOD_PKA_2 561 567 PF00069 0.734
MOD_PKA_2 683 689 PF00069 0.442
MOD_PKA_2 715 721 PF00069 0.667
MOD_PKA_2 727 733 PF00069 0.581
MOD_Plk_1 293 299 PF00069 0.530
MOD_Plk_1 303 309 PF00069 0.467
MOD_Plk_1 501 507 PF00069 0.537
MOD_Plk_2-3 508 514 PF00069 0.501
MOD_Plk_4 122 128 PF00069 0.466
MOD_Plk_4 132 138 PF00069 0.392
MOD_Plk_4 274 280 PF00069 0.449
MOD_ProDKin_1 208 214 PF00069 0.706
MOD_ProDKin_1 376 382 PF00069 0.729
MOD_ProDKin_1 418 424 PF00069 0.468
MOD_ProDKin_1 84 90 PF00069 0.621
TRG_DiLeu_BaLyEn_6 317 322 PF01217 0.514
TRG_ENDOCYTIC_2 11 14 PF00928 0.539
TRG_ENDOCYTIC_2 184 187 PF00928 0.677
TRG_ENDOCYTIC_2 266 269 PF00928 0.496
TRG_ENDOCYTIC_2 401 404 PF00928 0.487
TRG_ENDOCYTIC_2 435 438 PF00928 0.555
TRG_ENDOCYTIC_2 474 477 PF00928 0.324
TRG_ENDOCYTIC_2 482 485 PF00928 0.397
TRG_ENDOCYTIC_2 595 598 PF00928 0.611
TRG_ENDOCYTIC_2 762 765 PF00928 0.539
TRG_ER_diArg_1 355 357 PF00400 0.705
TRG_ER_diArg_1 458 461 PF00400 0.441
TRG_ER_diArg_1 497 499 PF00400 0.533
TRG_ER_diArg_1 693 696 PF00400 0.563
TRG_ER_diArg_1 779 781 PF00400 0.719
TRG_NLS_MonoCore_2 352 357 PF00514 0.782
TRG_NLS_MonoCore_2 744 749 PF00514 0.595
TRG_NLS_MonoExtC_3 538 543 PF00514 0.644
TRG_NLS_MonoExtN_4 351 358 PF00514 0.783
TRG_NLS_MonoExtN_4 537 543 PF00514 0.755
TRG_NLS_MonoExtN_4 743 750 PF00514 0.475
TRG_Pf-PMV_PEXEL_1 290 294 PF00026 0.365
TRG_Pf-PMV_PEXEL_1 497 502 PF00026 0.532
TRG_Pf-PMV_PEXEL_1 748 752 PF00026 0.536

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1PBW4 Leptomonas seymouri 60% 82%
A0A1X0P9W0 Trypanosomatidae 42% 90%
A0A422NHM2 Trypanosoma rangeli 43% 94%
A0A451EJT3 Leishmania donovani 100% 82%
A4H3P6 Leishmania braziliensis 80% 100%
C9ZKH8 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 38% 92%
E9ACM9 Leishmania major 94% 100%
E9AJW8 Leishmania mexicana (strain MHOM/GT/2001/U1103) 88% 100%
V5BC86 Trypanosoma cruzi 41% 93%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS