ESCRT-II complex subunit VPS36

Quick info Localization Phosphorylation Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

mitochondrial chaperone - putative

Species:

Leishmania infantum

UniProt:

E8NHC6_LEIIN

TriTrypDb:

LINF_220015300

Length:

330

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 2
NetGPI	no	yes: 0, no: 2

Could not find GO cellular_component term for this entry.

Phosphorylation

Promastigote/Amastigote: 212

Expansion

Sequence features

E8NHC6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E8NHC6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	83	87	PF00656	0.627
CLV_C14_Caspase3-7	9	13	PF00656	0.421
CLV_NRD_NRD_1	102	104	PF00675	0.708
CLV_NRD_NRD_1	209	211	PF00675	0.458
CLV_NRD_NRD_1	24	26	PF00675	0.477
CLV_NRD_NRD_1	29	31	PF00675	0.460
CLV_PCSK_KEX2_1	102	104	PF00082	0.622
CLV_PCSK_KEX2_1	209	211	PF00082	0.458
CLV_PCSK_KEX2_1	24	26	PF00082	0.477
CLV_PCSK_KEX2_1	29	31	PF00082	0.460
CLV_PCSK_PC7_1	25	31	PF00082	0.479
DEG_APCC_DBOX_1	182	190	PF00400	0.429
DEG_Nend_UBRbox_2	1	3	PF02207	0.434
DOC_CKS1_1	297	302	PF01111	0.396
DOC_MAPK_gen_1	176	186	PF00069	0.448
DOC_MAPK_MEF2A_6	179	186	PF00069	0.442
DOC_SPAK_OSR1_1	179	183	PF12202	0.431
DOC_SPAK_OSR1_1	295	299	PF12202	0.311
DOC_USP7_MATH_1	13	17	PF00917	0.379
DOC_USP7_MATH_1	239	243	PF00917	0.468
DOC_USP7_MATH_1	281	285	PF00917	0.489
DOC_WW_Pin1_4	296	301	PF00397	0.397
LIG_14-3-3_CanoR_1	179	183	PF00244	0.431
LIG_14-3-3_CanoR_1	34	41	PF00244	0.470
LIG_APCC_ABBA_1	5	10	PF00400	0.421
LIG_FHA_1	45	51	PF00498	0.569
LIG_FHA_1	66	72	PF00498	0.428
LIG_FHA_2	297	303	PF00498	0.391
LIG_LIR_Apic_2	168	172	PF02991	0.424
LIG_LIR_Gen_1	187	195	PF02991	0.385
LIG_NRBOX	141	147	PF00104	0.425
LIG_PCNA_PIPBox_1	310	319	PF02747	0.396
LIG_PDZ_Class_2	325	330	PF00595	0.358
LIG_Rb_pABgroove_1	2	10	PF01858	0.423
LIG_RPA_C_Fungi	19	31	PF08784	0.400
LIG_SH2_NCK_1	237	241	PF00017	0.472
LIG_SH2_STAT3	294	297	PF00017	0.410
LIG_SH3_3	150	156	PF00018	0.338
LIG_SUMO_SIM_par_1	159	165	PF11976	0.430
LIG_TYR_ITIM	200	205	PF00017	0.417
MOD_CK1_1	284	290	PF00069	0.496
MOD_CK1_1	80	86	PF00069	0.496
MOD_CK2_1	296	302	PF00069	0.394
MOD_Cter_Amidation	100	103	PF01082	0.557
MOD_GlcNHglycan	141	145	PF01048	0.341
MOD_GlcNHglycan	211	214	PF01048	0.506
MOD_GlcNHglycan	237	240	PF01048	0.496
MOD_GlcNHglycan	241	244	PF01048	0.458
MOD_GlcNHglycan	278	282	PF01048	0.523
MOD_GlcNHglycan	286	289	PF01048	0.554
MOD_GlcNHglycan	88	91	PF01048	0.537
MOD_GSK3_1	205	212	PF00069	0.423
MOD_GSK3_1	235	242	PF00069	0.473
MOD_GSK3_1	277	284	PF00069	0.458
MOD_LATS_1	207	213	PF00433	0.448
MOD_N-GLC_1	284	289	PF02516	0.499
MOD_NEK2_1	106	111	PF00069	0.535
MOD_NEK2_1	140	145	PF00069	0.351
MOD_NEK2_1	53	58	PF00069	0.544
MOD_NEK2_2	178	183	PF00069	0.435
MOD_PIKK_1	315	321	PF00454	0.375
MOD_PKA_1	209	215	PF00069	0.476
MOD_PKA_2	178	184	PF00069	0.439
MOD_PKA_2	209	215	PF00069	0.476
MOD_PKA_2	324	330	PF00069	0.432
MOD_PKA_2	33	39	PF00069	0.446
MOD_PKA_2	96	102	PF00069	0.639
MOD_Plk_1	65	71	PF00069	0.509
MOD_Plk_4	13	19	PF00069	0.541
MOD_Plk_4	190	196	PF00069	0.303
MOD_ProDKin_1	296	302	PF00069	0.394
TRG_DiLeu_BaEn_1	190	195	PF01217	0.384
TRG_DiLeu_BaEn_2	1	7	PF01217	0.434
TRG_ENDOCYTIC_2	188	191	PF00928	0.386
TRG_ENDOCYTIC_2	202	205	PF00928	0.330
TRG_ER_diArg_1	182	185	PF00400	0.451
TRG_ER_diArg_1	24	26	PF00400	0.415
TRG_NES_CRM1_1	190	204	PF08389	0.392
TRG_Pf-PMV_PEXEL_1	250	254	PF00026	0.425

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A4HCL1	Leishmania braziliensis	68%	96%